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Blood F_2-isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis
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作者 Man-Jie Zhu Li-Juan Sun +4 位作者 Yue-Qin Liu Yan-Ling Feng Hai-Tao Tong Ying-He Hu Zheng Zhao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第29期4677-4683,共7页
AIM: To investigate oxidative stress and lipid peroxi-dation in hepatic steatosis and the underlying implica-tions in pathological mechanisms of non-alcoholic fatty liver disease (NAFLD). METHODS: F_2-isoprostanes (i... AIM: To investigate oxidative stress and lipid peroxi-dation in hepatic steatosis and the underlying implica-tions in pathological mechanisms of non-alcoholic fatty liver disease (NAFLD). METHODS: F_2-isoprostanes (iPF2α-) in blood and liver samples from steatotic (n = 9) and control (n = 7) rats were measured as in vivo marker of lipid peroxida-tion by a mass spectrometric approach. The lipid pro-fi le and endogenous antioxidant status (SOD and CAT) in the rats were also analyzed. RESULTS: Signifi cantly higher levels of iPF2α-(mean 3.47 vs 2.40 pmol/mg tissue, P = 0.004) and lower activities of SOD (mean 1.26 U vs 1.40 U, P < 0.001) and CAT (mean 1026.36 U/mg vs 1149.68 U/mg pro-tein, without signifi cance) were observed in the livers of steatotic rats. Plasma total iPF2α-was signifi cantly correlated with the abnormalities of blood lipids as well as alanine aminotransferase (ALT) levels in the rats with simple steatosis, whereas no similar tendencies were observed in the control rats. CONCLUSION: Enhancement of hepatic oxidative imbalance occurring at the steatotic stage of NAFLD suggests a possibility that manifestation of the local ⅢⅢⅢoxidative damage precedes that of systemic oxidative imbalance. Predominant metabolic features of the in-creased lipid peroxidation further suggest a close asso-ciation of the oxidative imbalance and the dyslipidemia with functional deterioration of the steatotic liver. The fi ndings need to be further evaluated, especially in hu-man studies. 展开更多
关键词 isoprostanes Oxidative stress Lipid per-oxidation STEATOSIS Non-alcoholic fatty liver disease
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40例慢性阻塞性肺部疾病患者氧化应激8-isoprostane变化 被引量:1
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作者 于进洪 李军涛 +1 位作者 何新梅 石玉珍 《重庆医学》 CAS CSCD 2008年第21期2461-2462,共2页
目的旨在以8-isoprostane为指标,研究慢性阻塞性肺部疾病(COPD)患者氧化应激状态。方法选择住院的急性加重期COPD患者40例,用酶免疫法测定患者入院第2天和第15天空腹血浆8-isoprostane含量,另选20例健康不吸烟者作为对照组。结果急性期C... 目的旨在以8-isoprostane为指标,研究慢性阻塞性肺部疾病(COPD)患者氧化应激状态。方法选择住院的急性加重期COPD患者40例,用酶免疫法测定患者入院第2天和第15天空腹血浆8-isoprostane含量,另选20例健康不吸烟者作为对照组。结果急性期COPD患者血清8-isoprostane水平〔(159.92±24.45)pg/mL〕明显高于治疗后〔(96.74±10.24)pg/mL〕及健康对照组〔(18.53±3.53)pg/mL〕,P<0.05。结论8-isoprostane是一种可靠灵敏的氧化应激生物指标,能反映患者不同状态下的氧化应激水平,并可在一定程度上反映疾病严重程度。 展开更多
关键词 COPD 8 ISOPROSTANE 氧化应激
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Beneficial effect of refined red palm oil on lipid peroxidation and monocyte tissue factor in HCV-related liver disease: a randomized controlled study 被引量:1
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作者 Roberto Catanzaro Nicola Zerbinati +5 位作者 Umberto Solimene Massimiliano Marcellino Dheeraj Mohania Angelo Italia Antonio Ayala Francesco Marotta 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2016年第2期165-172,共8页
BACKGROUND: A large amount of endotoxin can be detected in the peripheral venous blood of patients with liver cirrhosis, contributing to the pathogenesis of hepatotoxicity because of its role in oxidative stress. The... BACKGROUND: A large amount of endotoxin can be detected in the peripheral venous blood of patients with liver cirrhosis, contributing to the pathogenesis of hepatotoxicity because of its role in oxidative stress. The present study aimed to test the effect of the supplementation with red palm oil(RPO), which is a natural oil obtained from oil palm fruit(Elaeis guineensis) rich in natural fat-soluble tocopherols, tocotrienols and carotenoids, on lipid peroxidation and endotoxemia with plasma endotoxin-inactivating capacity, proinflammatory cytokines profile, and monocyte tissue factor in patients with chronic liver disease. METHODS: The study group consisted of sixty patients(34 males and 26 females; mean age 62 years, range 54-75) with Child A/B, genotype 1 HCV-related cirrhosis without a history of ethanol consumption, randomly enrolled into an 8-week oral daily treatment with either vitamin E or RPO. All patients had undergone an upper gastrointestinal endoscopy 8 months before, and 13 out of them showed esophageal varices.RESULTS: Both treatments significantly decreased erythrocyte malondialdehyde and urinary isoprostane output, only RPO significantly affected macrophage-colony stimulating factor and monocyte tissue factor. Liver ultrasound imaging did not show any change. CONCLUSIONS: RPO beneficially modulates oxidative stress and, not least, downregulates macrophage/monocyte inflammatory parameters. RPO can be safely advised as a valuable nutritional implementation tool in the management of chronic liver diseases. 展开更多
关键词 endotoxin isoprostane macrophage-colony stimulating factor monocyte tissue factor oxidative stress red palm oil
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The Effects of Low Intensity Endurance Activity on Various Physiological Parameters and Exercise Induced Oxidative Stress in Dogs
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作者 Janice L. Huntingford Corri B. Levine +3 位作者 Debbie J. Mustacich Devin Corrigan Robert L. Downey Joseph J. Wakshlag 《Open Journal of Veterinary Medicine》 2014年第7期134-144,共11页
The study of canine athlete physiology has focused on endurance sled dog racing and high intensity short duration Greyhound racing, yet the number of dogs competing in low intensity endurance activities is rising due ... The study of canine athlete physiology has focused on endurance sled dog racing and high intensity short duration Greyhound racing, yet the number of dogs competing in low intensity endurance activities is rising due to the increased numbers of hunting and companion dog activities. There is little information on the physiological effect of longer duration low intensity endurance activities. We set out to evaluate the serum biochemistry, oxidative stress, and cortisol response before and after two consecutive days of exercise in ten healthy unconditioned male dogs. Exercise sessions consisted of 120 minutes on an exercise wheel at 11 km/hour on 2 consecutive days. Blood was collected at four time points: 24 hours pre-exercise (sample 1, Day 0, resting);2 min post-exercise on days 1 and 2, (samples 2 and 3, respectively);and 20 hours post-exercise, collected on day 3(sample 4). Hematocrit, blood gases, serum chemistry, uric acid, cortisol, and F2-isoprostanes were determined. Serum biochemistry and hematocrit suggested hemoconcentration, mild muscle damage and respiratory alkalosis during exercise, which was expected in the unconditioned canine athlete. In addition, plasma indices of oxidative damage (F2-isoprostanes) increased, as did plasma uric acid (an endogenous antioxidant). Importantly, similar to human studies, plasma F2-isoprostanes decreased 24 hours after exercise suggesting a protective effect of exercise. Serum cortisol concentrations were also markedly elevated at the end of exercise on both days suggesting that timing of sampling may play a role in interpreting cortisol results when looking at previous field studies. 展开更多
关键词 EXERCISE CORTISOL ISOPROSTANE DEHYDRATION Uric Acid
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