A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer prefe...A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer preferences.Nowadays,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’preferences.On the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested items.However,the cost of these computations increases nonlinearly as the number of items and users increases.To triumph over the issues,a novel expanded stacked autoencoder(ESAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two phases.In the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the ESAE approach and users are clustered using the KFCM approach.In the next phase of online,the top-N recommendation prediction is made by the ESAE approach involving only the most similar user from multiple clusters.Hence the ESAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation time.An experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the ESAE_KFCM model constantly outperforms conventional RS algorithms on a variety of assessment measures.展开更多
In the last decade, technical advancements and faster Internet speeds have also led to an increasing number ofmobile devices and users. Thus, all contributors to society, whether young or old members, can use these mo...In the last decade, technical advancements and faster Internet speeds have also led to an increasing number ofmobile devices and users. Thus, all contributors to society, whether young or old members, can use these mobileapps. The use of these apps eases our daily lives, and all customers who need any type of service can accessit easily, comfortably, and efficiently through mobile apps. Particularly, Saudi Arabia greatly depends on digitalservices to assist people and visitors. Such mobile devices are used in organizing daily work schedules and services,particularly during two large occasions, Umrah and Hajj. However, pilgrims encounter mobile app issues such asslowness, conflict, unreliability, or user-unfriendliness. Pilgrims comment on these issues on mobile app platformsthrough reviews of their experiences with these digital services. Scholars have made several attempts to solve suchmobile issues by reporting bugs or non-functional requirements by utilizing user comments.However, solving suchissues is a great challenge, and the issues still exist. Therefore, this study aims to propose a hybrid deep learningmodel to classify and predict mobile app software issues encountered by millions of pilgrims during the Hajj andUmrah periods from the user perspective. Firstly, a dataset was constructed using user-generated comments fromrelevant mobile apps using natural language processing methods, including information extraction, the annotationprocess, and pre-processing steps, considering a multi-class classification problem. Then, several experimentswere conducted using common machine learning classifiers, Artificial Neural Networks (ANN), Long Short-TermMemory (LSTM), and Convolutional Neural Network Long Short-Term Memory (CNN-LSTM) architectures, toexamine the performance of the proposed model. Results show 96% in F1-score and accuracy, and the proposedmodel outperformed the mentioned models.展开更多
Editors Yang Wang,Xi'an Jiaotong University Dongbo Shi,Shanghai Jiaotong University Ye Sun,University College London Zhesi Shen,National Science Library,CAS Topic of the Special Issue What are the top questions to...Editors Yang Wang,Xi'an Jiaotong University Dongbo Shi,Shanghai Jiaotong University Ye Sun,University College London Zhesi Shen,National Science Library,CAS Topic of the Special Issue What are the top questions towards better science and innovation and the required data to answer these questions?展开更多
The behavior issues of preschoolers are closely related to their parents'parenting styles.This editorial discusses the value and strategies for solving behavior issues in preschoolers from the perspectives of mind...The behavior issues of preschoolers are closely related to their parents'parenting styles.This editorial discusses the value and strategies for solving behavior issues in preschoolers from the perspectives of mindfulness and mindful parenting.We expect that upcoming studies will place greater emphasis on the behavioral concerns of preschoolers and the parenting practices that shape them,particularly focusing on proactive interventions for preschoolers'behavioral issues.展开更多
In response to the United Nations Sustainable Development Goals and China’s“Dual Carbon”Goals(DCGs means the goals of“Carbon Peak and carbon neutrality”),this paper from the perspective of the construction of Ch...In response to the United Nations Sustainable Development Goals and China’s“Dual Carbon”Goals(DCGs means the goals of“Carbon Peak and carbon neutrality”),this paper from the perspective of the construction of China’s Innovation Demonstration Zones for Sustainable Development Agenda(IDZSDAs),combines carbon emission-related metrics to construct a comprehensive assessment system for Urban Sustainable Development Capacity(USDC).After obtaining USDC assessment results through the assessment system,an approach combining Least Absolute Shrinkage and Selection Operator(LASSO)regression and Random Forest(RF)based on machine learning is proposed for identifying influencing factors and characterizing key issues.Combining Coupling Coordination Degree(CCD)analysis,the study further summarizes the systemic patterns and future directions of urban sustainable development.A case study on the IDZSDAs from 2015 to 2022 reveals that:(1)the combined identification method based on machine learning and CCD models effectively quantifies influencing factors and key issues in the urban sustainable development process;(2)the correspondence between influencing factors and key subsystems identified by the LASSO-RF combination model is generally consistent with the development situations in various cities;and(3)the machine learning-based combined recognition method is scalable and dynamic.It enables decision-makers to accurately identify influencing factors and characterize key issues based on actual urban development needs.展开更多
The development of this technology has favored the advances noted in recent years in the field of precise positioning. It has also paved the way for a wide range of research into the evaluation of their performance an...The development of this technology has favored the advances noted in recent years in the field of precise positioning. It has also paved the way for a wide range of research into the evaluation of their performance and reliability, their potential use in different fields, the improvement of performance and combined systems, etc. Single-frequency GNSS receivers, which for a long time remained the only category of low-cost GNSS receivers, often limited by their level of accuracy (metric) mainly due to their single-frequency nature, have been joined in the last decade by dual-frequency GNSS receivers developed by certain manufacturers of positioning equipment. These receivers now offer possible alternatives to the relatively expensive conventional (topographic quality) or geodetic receivers and. In this study, the performance of these low-cost dual-frequency receivers was evaluated in static and real-time kinematic GNSS positioning modes. Static positioning was carried out on three points with sessions of 2 h and 4 h over three days with antenna swapping (CHC i50, Leica GS14 and Emlid Reach RS2+). Real-time observations were carried out on eleven (11) points in open, poorly open and not at all open environments, in order to assess not only performance but also receiver sensitivity in environments with a high risk of multipath. The results obtained showed an average agreement of 2 cm in planimetry between the low-cost Emlid RS2+ receiver and the Leica GS14 and CHC i50 receivers. The differences in altimetry are nevertheless greater (sometimes up to decimetres for certain points). Real-time positioning results provided an average convergence of around 1 cm on the E, N and H components with the results from the low-cost Emlid Reach RS2+ and Ublox ZED-F9P receivers and the CHC i50 receiver. Analysis of the results obtained has enabled us to highlight the various issues and challenges associated with this new generation of GNSS receivers, with a view to enhancing their appropriation and optimal integration in the professional and research worlds.展开更多
Objective To study the content of China’s guiding principles on multiplicity issues in clinical trials,and to provide reference for the revision of China’s relevant guiding principles.Methods Based on ICH E9,the sim...Objective To study the content of China’s guiding principles on multiplicity issues in clinical trials,and to provide reference for the revision of China’s relevant guiding principles.Methods Based on ICH E9,the similarities and differences of the guiding principles of US Food and Drug Administration(FDA),European Medicines Agency(EMA),and National Medical Products Administration(NMPA)on the multiplicity issues in clinical trials were compared one by one.Results and Conclusion In general,NMPA guidelines are based on ICH E9,but in detail,the guidelines of FDA and EMA focus differently on the multiplicity issues.Therefore,NMPA guidelines need to be detailed and comprehensive.NMPA guidelines can be refined by referring to foreign guidelines to improve the practical guiding significance for clinical research and promote the level of domestic clinical trials in line with international standards.展开更多
This article aims to share an innovative experience of organizing and funding research involving those most directly affected:patients.The“ECLAIR”working group of the Canceropole Lyon Auvergne-Rhone-Alpes(CLARA)was ...This article aims to share an innovative experience of organizing and funding research involving those most directly affected:patients.The“ECLAIR”working group of the Canceropole Lyon Auvergne-Rhone-Alpes(CLARA)was created at the end of 2020 with the goal of contributing to the development of a call for projects on the patient experience in oncology,which was launched in January 2021.Initially composed of 8 members,including 7 patients,coordinated by a project manager from CLARA,the ECLAIR working group actively participated in drafting the specifications of the call for projects,developing the eligibility criteria for applications,revising the evaluation and selection criteria for projects,and monitoring the selected projects.This experience was repeated twice.With significant freedom of action,the working group made two decisions that strongly demonstrate the commitment to supporting research partnerships and the active involvement of those affected:firstly,by making partnership a mandatory requirement for the eligibility of applications,and secondly,by conducting the selection of projects themselves,after an independent scientific evaluation phase.Seeking to shed light on the“black box”of partnership,the article also presents the concrete modalities of interaction among the working group members,the adjustments made between different editions of the call for projects,and the relationships maintained with CLARA.展开更多
Background:This infrastructure delivers biological material necessary for several research projects to Vision Health Research Network investigators(VHRN).Methods:Héma-Québec is the organism in charge obtaini...Background:This infrastructure delivers biological material necessary for several research projects to Vision Health Research Network investigators(VHRN).Methods:Héma-Québec is the organism in charge obtaining consent and retrieving donor eyes for patient treatment or for research.In Quebec City,donor eyes are sent to the eye bank of the“Centre Universitaire d’Ophtalmologie”(CUO)of Saint-Sacrement hospital.Technicians at the eye bank evaluate the quality of the tissues.Those unfit for graft are transferred to the infrastructure where the coordinator encodes samples prior to their distribution.Results:Between 2013 and 2017,27 fundamental investigators,clinical investigators and collaborators supported by 60 students,trainees and laboratory assistants used this infrastructure to move forward their projects.Since 2013,results from those projects generated 21 scientific publications and 232 presentations.The infrastructure helped VHRN investigators obtain near 4 million dollars in grants from many organisms(CIHR,NSERC,Foundations,etc.).These grants allowed recruitment and formation of highly qualified personnel.Last year(April 2016 to March 2017),189 corneas and 23 eyes transited through the infrastructure.Conclusions:This infrastructure is available for all investigators that are members of the VHRN.Many original projects have been elaborated thanks to the human ocular tissues provided by this infrastructure.These projects will advance our knowledge in vision health.A better understanding of eye functions will lead to new treatments for eye diseases.展开更多
Concrete has traditionally been regarded as a durable material requiring little or no maintenance. However, over the past several decades, a number of durability related problems have emerged and stimulated research i...Concrete has traditionally been regarded as a durable material requiring little or no maintenance. However, over the past several decades, a number of durability related problems have emerged and stimulated research into the factors relating to concrete durability globally. The challenge now facing practicing engineers is how to design and build structures that not only satisfy the specified structural requirements, but also achieve the performance levels required from a durability standpoint. Research works on concrete structural durability have been widely reported in the literature over the last several decades. In this paper, reviews of four stages of research work on durability, i e, environments, materials, components, and structures, were presented. Afterwards, the key scientific issues in this field were also pointed out.展开更多
The seismic waveforms may present subtle changes related to the external loadings such as earthquakes(Pei Shunping et al.,2019)and landslides(Larose E.et al.,2015).Monitoring subtle changes provides a complementary to...The seismic waveforms may present subtle changes related to the external loadings such as earthquakes(Pei Shunping et al.,2019)and landslides(Larose E.et al.,2015).Monitoring subtle changes provides a complementary tool for studying the dynamic processes(e.g.,Niu Fenglin et al.,2008),which has long been a major subject in seismology.The subsurface can be monitored by using natural repetitive events including repeated earthquakes(e.g.,Song Xiaodong et al.,1996)and ambient seismic noises(e.g.,Mao Shujuan et al.,2019).展开更多
With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have be...With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,展开更多
The whitefly Bemisia tabaci species complex and the begomoviruses they transmit are devastating agricultural pests worldwide.With the rapid and further inva-sions by some members of the whitefly species complex into n...The whitefly Bemisia tabaci species complex and the begomoviruses they transmit are devastating agricultural pests worldwide.With the rapid and further inva-sions by some members of the whitefly species complex into new regions,their impacts on human society are likely to increase in the years to come.展开更多
Neuronal trauma remains to be a serious medical condition with few established treatments despite decades of effort. The current research has been focused on using multiple disciplinary techniques to enhance the recov...Neuronal trauma remains to be a serious medical condition with few established treatments despite decades of effort. The current research has been focused on using multiple disciplinary techniques to enhance the recovery in different stages of trauma and recovery. This special issue aims to provide a platform to facilitate a review by communicating and synergizing the current state of neurotrauma research. It is our goal to stimulate and galvanize new ideas towards the establishment of effective treatments for neuronal injury. Potential topics include, but are not limited to:展开更多
Somatic stem cells (SSCs), being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are i...Somatic stem cells (SSCs), being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells (CSCs) which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated (1).展开更多
This Special Issue presents the progress of research and development on geodesy in China during the time period from January 2019 to June 2023.It was submitted,on behalf of the Chinese National Committee for Internati...This Special Issue presents the progress of research and development on geodesy in China during the time period from January 2019 to June 2023.It was submitted,on behalf of the Chinese National Committee for International Association of Geodesy(CNC-IAG),to the IAG General Assembly at the 28th IUGG General Assembly held in Berlin,Germany,July 11—20,2023.It is hoped that this national report would be of help for Chinese scientists in exchanging the results and ideas in the research,development and application of geodesy with scientists all over the world.展开更多
Dear Colleagues, We would like to invite you to submit manuscripts to a special issue entitled "Current Research on Atmospheric Aerosols and Trace Gases over the Polar Regions" of the Journal Advances in Polar Scie...Dear Colleagues, We would like to invite you to submit manuscripts to a special issue entitled "Current Research on Atmospheric Aerosols and Trace Gases over the Polar Regions" of the Journal Advances in Polar Science (APS). APS is an international, peer-reviewed journal jointly sponsored by the Polar Research Institute of China (PRIC) and the Chinese Arctic and Antarctic Administration (CAA). It is a quarterly journal published in March, June, September and December by Science Press of China and circulated internationally (ISSN 1674-9928, CN 31-2050/P). Articles published in APS are free of charge with generous funding from PRIC. For more details, please visit the APS's websites. Thank you in advance for your consideration to submit manuscripts to this special issue, and we encourage you to share this announcement broadly with interested colleagues.展开更多
All-solid-state Li metal batteries(ASSLBs)using inorganic solid electrolyte(SE)are considered promising alternatives to conventional Li-ion batteries,offering improved safety and boosted energy density.While significa...All-solid-state Li metal batteries(ASSLBs)using inorganic solid electrolyte(SE)are considered promising alternatives to conventional Li-ion batteries,offering improved safety and boosted energy density.While significant progress has been made on improving the ionic conductivity of SEs,the degradation and instability of Li metal/inorganic SE interfaces have become the critical challenges that limit the coulombic efficiency,power performance,and cycling stability of ASSLBs.Understanding the mechanisms of complex/dynamic interfacial phenomena is of great importance in addressing these issues.Herein,recent studies on identifying,understanding,and solving interfacial issues on anode side in ASSLBs are comprehensively reviewed.Typical issues at Li metal/SE interface include Li dendrite growth/propagation,SE cracking,physical contact loss,and electrochemical reactions,which lead to high interfacial resistance and cell failure.The causes of these issues relating to the chemical,physical,and mechanical properties of Li metal and SEs are systematically discussed.Furthermore,effective mitigating strategies are summarized and their effects on suppressing interfacial reactions,improving interfacial Li-ion transport,maintaining interfacial contact,and stabilizing Li plating/stripping are highlighted.The in-depth mechanistic understanding of interfacial issues and complete investigations on current solutions provide foundations and guidance for future research and development to realize practical application of high-performance ASSLB.展开更多
With the development of urbanization,metropolises and megapolises are emerging.Urbanization is being completed with the driving force of capital;meanwhile,technology has achieved the quest of capital.In this thesis,in...With the development of urbanization,metropolises and megapolises are emerging.Urbanization is being completed with the driving force of capital;meanwhile,technology has achieved the quest of capital.In this thesis,in light of Henri Lefebvre’s ideology of technology rational critique,Chinese urban modernity issues under the perspective of technology rational critique were analyzed,including issues like eroded urban texture,urban mechanization,and urban segregation.The technology rational root of Chinese urban modernity issues was discussed from the turn of technical artifacts from design intention to application intention.In the end,possible methods to solve these Chinese urban modernity issues were illustrated based on Henri Lefebvre’s urban development theory.展开更多
文摘A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer preferences.Nowadays,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’preferences.On the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested items.However,the cost of these computations increases nonlinearly as the number of items and users increases.To triumph over the issues,a novel expanded stacked autoencoder(ESAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two phases.In the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the ESAE approach and users are clustered using the KFCM approach.In the next phase of online,the top-N recommendation prediction is made by the ESAE approach involving only the most similar user from multiple clusters.Hence the ESAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation time.An experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the ESAE_KFCM model constantly outperforms conventional RS algorithms on a variety of assessment measures.
文摘In the last decade, technical advancements and faster Internet speeds have also led to an increasing number ofmobile devices and users. Thus, all contributors to society, whether young or old members, can use these mobileapps. The use of these apps eases our daily lives, and all customers who need any type of service can accessit easily, comfortably, and efficiently through mobile apps. Particularly, Saudi Arabia greatly depends on digitalservices to assist people and visitors. Such mobile devices are used in organizing daily work schedules and services,particularly during two large occasions, Umrah and Hajj. However, pilgrims encounter mobile app issues such asslowness, conflict, unreliability, or user-unfriendliness. Pilgrims comment on these issues on mobile app platformsthrough reviews of their experiences with these digital services. Scholars have made several attempts to solve suchmobile issues by reporting bugs or non-functional requirements by utilizing user comments.However, solving suchissues is a great challenge, and the issues still exist. Therefore, this study aims to propose a hybrid deep learningmodel to classify and predict mobile app software issues encountered by millions of pilgrims during the Hajj andUmrah periods from the user perspective. Firstly, a dataset was constructed using user-generated comments fromrelevant mobile apps using natural language processing methods, including information extraction, the annotationprocess, and pre-processing steps, considering a multi-class classification problem. Then, several experimentswere conducted using common machine learning classifiers, Artificial Neural Networks (ANN), Long Short-TermMemory (LSTM), and Convolutional Neural Network Long Short-Term Memory (CNN-LSTM) architectures, toexamine the performance of the proposed model. Results show 96% in F1-score and accuracy, and the proposedmodel outperformed the mentioned models.
文摘Editors Yang Wang,Xi'an Jiaotong University Dongbo Shi,Shanghai Jiaotong University Ye Sun,University College London Zhesi Shen,National Science Library,CAS Topic of the Special Issue What are the top questions towards better science and innovation and the required data to answer these questions?
基金Supported by The Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University,No.CMER202305The Natural Science Foundation of Tibet Autonomous Region,No.XZ2024ZR-ZY100(Z).
文摘The behavior issues of preschoolers are closely related to their parents'parenting styles.This editorial discusses the value and strategies for solving behavior issues in preschoolers from the perspectives of mindfulness and mindful parenting.We expect that upcoming studies will place greater emphasis on the behavioral concerns of preschoolers and the parenting practices that shape them,particularly focusing on proactive interventions for preschoolers'behavioral issues.
基金supported by the National Key Research and Development Program of China under the sub-theme“Research on the Path of Enhancing the Sustainable Development Capacity of Cities and Towns under the Carbon Neutral Goal”[Grant No.2022YFC3802902-04].
文摘In response to the United Nations Sustainable Development Goals and China’s“Dual Carbon”Goals(DCGs means the goals of“Carbon Peak and carbon neutrality”),this paper from the perspective of the construction of China’s Innovation Demonstration Zones for Sustainable Development Agenda(IDZSDAs),combines carbon emission-related metrics to construct a comprehensive assessment system for Urban Sustainable Development Capacity(USDC).After obtaining USDC assessment results through the assessment system,an approach combining Least Absolute Shrinkage and Selection Operator(LASSO)regression and Random Forest(RF)based on machine learning is proposed for identifying influencing factors and characterizing key issues.Combining Coupling Coordination Degree(CCD)analysis,the study further summarizes the systemic patterns and future directions of urban sustainable development.A case study on the IDZSDAs from 2015 to 2022 reveals that:(1)the combined identification method based on machine learning and CCD models effectively quantifies influencing factors and key issues in the urban sustainable development process;(2)the correspondence between influencing factors and key subsystems identified by the LASSO-RF combination model is generally consistent with the development situations in various cities;and(3)the machine learning-based combined recognition method is scalable and dynamic.It enables decision-makers to accurately identify influencing factors and characterize key issues based on actual urban development needs.
文摘The development of this technology has favored the advances noted in recent years in the field of precise positioning. It has also paved the way for a wide range of research into the evaluation of their performance and reliability, their potential use in different fields, the improvement of performance and combined systems, etc. Single-frequency GNSS receivers, which for a long time remained the only category of low-cost GNSS receivers, often limited by their level of accuracy (metric) mainly due to their single-frequency nature, have been joined in the last decade by dual-frequency GNSS receivers developed by certain manufacturers of positioning equipment. These receivers now offer possible alternatives to the relatively expensive conventional (topographic quality) or geodetic receivers and. In this study, the performance of these low-cost dual-frequency receivers was evaluated in static and real-time kinematic GNSS positioning modes. Static positioning was carried out on three points with sessions of 2 h and 4 h over three days with antenna swapping (CHC i50, Leica GS14 and Emlid Reach RS2+). Real-time observations were carried out on eleven (11) points in open, poorly open and not at all open environments, in order to assess not only performance but also receiver sensitivity in environments with a high risk of multipath. The results obtained showed an average agreement of 2 cm in planimetry between the low-cost Emlid RS2+ receiver and the Leica GS14 and CHC i50 receivers. The differences in altimetry are nevertheless greater (sometimes up to decimetres for certain points). Real-time positioning results provided an average convergence of around 1 cm on the E, N and H components with the results from the low-cost Emlid Reach RS2+ and Ublox ZED-F9P receivers and the CHC i50 receiver. Analysis of the results obtained has enabled us to highlight the various issues and challenges associated with this new generation of GNSS receivers, with a view to enhancing their appropriation and optimal integration in the professional and research worlds.
基金supported by the Special Foundation of Research Institute of Drug Regulatory Science,Shenyang Pharmaceutical University(2021jgkx004).
文摘Objective To study the content of China’s guiding principles on multiplicity issues in clinical trials,and to provide reference for the revision of China’s relevant guiding principles.Methods Based on ICH E9,the similarities and differences of the guiding principles of US Food and Drug Administration(FDA),European Medicines Agency(EMA),and National Medical Products Administration(NMPA)on the multiplicity issues in clinical trials were compared one by one.Results and Conclusion In general,NMPA guidelines are based on ICH E9,but in detail,the guidelines of FDA and EMA focus differently on the multiplicity issues.Therefore,NMPA guidelines need to be detailed and comprehensive.NMPA guidelines can be refined by referring to foreign guidelines to improve the practical guiding significance for clinical research and promote the level of domestic clinical trials in line with international standards.
文摘This article aims to share an innovative experience of organizing and funding research involving those most directly affected:patients.The“ECLAIR”working group of the Canceropole Lyon Auvergne-Rhone-Alpes(CLARA)was created at the end of 2020 with the goal of contributing to the development of a call for projects on the patient experience in oncology,which was launched in January 2021.Initially composed of 8 members,including 7 patients,coordinated by a project manager from CLARA,the ECLAIR working group actively participated in drafting the specifications of the call for projects,developing the eligibility criteria for applications,revising the evaluation and selection criteria for projects,and monitoring the selected projects.This experience was repeated twice.With significant freedom of action,the working group made two decisions that strongly demonstrate the commitment to supporting research partnerships and the active involvement of those affected:firstly,by making partnership a mandatory requirement for the eligibility of applications,and secondly,by conducting the selection of projects themselves,after an independent scientific evaluation phase.Seeking to shed light on the“black box”of partnership,the article also presents the concrete modalities of interaction among the working group members,the adjustments made between different editions of the call for projects,and the relationships maintained with CLARA.
文摘Background:This infrastructure delivers biological material necessary for several research projects to Vision Health Research Network investigators(VHRN).Methods:Héma-Québec is the organism in charge obtaining consent and retrieving donor eyes for patient treatment or for research.In Quebec City,donor eyes are sent to the eye bank of the“Centre Universitaire d’Ophtalmologie”(CUO)of Saint-Sacrement hospital.Technicians at the eye bank evaluate the quality of the tissues.Those unfit for graft are transferred to the infrastructure where the coordinator encodes samples prior to their distribution.Results:Between 2013 and 2017,27 fundamental investigators,clinical investigators and collaborators supported by 60 students,trainees and laboratory assistants used this infrastructure to move forward their projects.Since 2013,results from those projects generated 21 scientific publications and 232 presentations.The infrastructure helped VHRN investigators obtain near 4 million dollars in grants from many organisms(CIHR,NSERC,Foundations,etc.).These grants allowed recruitment and formation of highly qualified personnel.Last year(April 2016 to March 2017),189 corneas and 23 eyes transited through the infrastructure.Conclusions:This infrastructure is available for all investigators that are members of the VHRN.Many original projects have been elaborated thanks to the human ocular tissues provided by this infrastructure.These projects will advance our knowledge in vision health.A better understanding of eye functions will lead to new treatments for eye diseases.
基金Funded by the National Natural Science Foundation of China (No.50538070)
文摘Concrete has traditionally been regarded as a durable material requiring little or no maintenance. However, over the past several decades, a number of durability related problems have emerged and stimulated research into the factors relating to concrete durability globally. The challenge now facing practicing engineers is how to design and build structures that not only satisfy the specified structural requirements, but also achieve the performance levels required from a durability standpoint. Research works on concrete structural durability have been widely reported in the literature over the last several decades. In this paper, reviews of four stages of research work on durability, i e, environments, materials, components, and structures, were presented. Afterwards, the key scientific issues in this field were also pointed out.
文摘The seismic waveforms may present subtle changes related to the external loadings such as earthquakes(Pei Shunping et al.,2019)and landslides(Larose E.et al.,2015).Monitoring subtle changes provides a complementary tool for studying the dynamic processes(e.g.,Niu Fenglin et al.,2008),which has long been a major subject in seismology.The subsurface can be monitored by using natural repetitive events including repeated earthquakes(e.g.,Song Xiaodong et al.,1996)and ambient seismic noises(e.g.,Mao Shujuan et al.,2019).
文摘With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,
基金the National Natural Science Foundation of China(projects30730061 and 31021003)the National Basic Research Programme of China(2009CB119203)for support to the International Symposium on Future Directions in Bemisia Research held in Hangzhou and thepublication of this special issue
文摘The whitefly Bemisia tabaci species complex and the begomoviruses they transmit are devastating agricultural pests worldwide.With the rapid and further inva-sions by some members of the whitefly species complex into new regions,their impacts on human society are likely to increase in the years to come.
文摘Neuronal trauma remains to be a serious medical condition with few established treatments despite decades of effort. The current research has been focused on using multiple disciplinary techniques to enhance the recovery in different stages of trauma and recovery. This special issue aims to provide a platform to facilitate a review by communicating and synergizing the current state of neurotrauma research. It is our goal to stimulate and galvanize new ideas towards the establishment of effective treatments for neuronal injury. Potential topics include, but are not limited to:
文摘Somatic stem cells (SSCs), being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells (CSCs) which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated (1).
文摘This Special Issue presents the progress of research and development on geodesy in China during the time period from January 2019 to June 2023.It was submitted,on behalf of the Chinese National Committee for International Association of Geodesy(CNC-IAG),to the IAG General Assembly at the 28th IUGG General Assembly held in Berlin,Germany,July 11—20,2023.It is hoped that this national report would be of help for Chinese scientists in exchanging the results and ideas in the research,development and application of geodesy with scientists all over the world.
文摘Dear Colleagues, We would like to invite you to submit manuscripts to a special issue entitled "Current Research on Atmospheric Aerosols and Trace Gases over the Polar Regions" of the Journal Advances in Polar Science (APS). APS is an international, peer-reviewed journal jointly sponsored by the Polar Research Institute of China (PRIC) and the Chinese Arctic and Antarctic Administration (CAA). It is a quarterly journal published in March, June, September and December by Science Press of China and circulated internationally (ISSN 1674-9928, CN 31-2050/P). Articles published in APS are free of charge with generous funding from PRIC. For more details, please visit the APS's websites. Thank you in advance for your consideration to submit manuscripts to this special issue, and we encourage you to share this announcement broadly with interested colleagues.
基金supported by the Outstanding Youth Fund Project by the Department of Science and Technology of Jiangsu Province(Grant No.BK20220045)the Key R&D Project funded by the Department of Science and Technology of Jiangsu Province(Grant No.BE2020003)+6 种基金Key Program-Automobile Joint Fund of National Natural Science Foundation of China(Grant No.U1964205)General Program of National Natural Science Foundation of China(Grant No.51972334)General Program of National Natural Science Foundation of Beijing(Grant No.2202058)Cultivation project of leading innovative experts in Changzhou City(CQ20210003)National Overseas High-level Expert recruitment Program(Grant No.E1JF021E11)Talent Program of Chinese Academy of Sciences,“Scientist Studio Program Funding”from Yangtze River Delta Physics Research Center,and Tianmu Lake Institute of Advanced Energy Storage Technologies(Grant No.TIESSS0001)Science and Technology Research Institute of China Three Gorges Corporation(Grant No.202103402)
文摘All-solid-state Li metal batteries(ASSLBs)using inorganic solid electrolyte(SE)are considered promising alternatives to conventional Li-ion batteries,offering improved safety and boosted energy density.While significant progress has been made on improving the ionic conductivity of SEs,the degradation and instability of Li metal/inorganic SE interfaces have become the critical challenges that limit the coulombic efficiency,power performance,and cycling stability of ASSLBs.Understanding the mechanisms of complex/dynamic interfacial phenomena is of great importance in addressing these issues.Herein,recent studies on identifying,understanding,and solving interfacial issues on anode side in ASSLBs are comprehensively reviewed.Typical issues at Li metal/SE interface include Li dendrite growth/propagation,SE cracking,physical contact loss,and electrochemical reactions,which lead to high interfacial resistance and cell failure.The causes of these issues relating to the chemical,physical,and mechanical properties of Li metal and SEs are systematically discussed.Furthermore,effective mitigating strategies are summarized and their effects on suppressing interfacial reactions,improving interfacial Li-ion transport,maintaining interfacial contact,and stabilizing Li plating/stripping are highlighted.The in-depth mechanistic understanding of interfacial issues and complete investigations on current solutions provide foundations and guidance for future research and development to realize practical application of high-performance ASSLB.
文摘With the development of urbanization,metropolises and megapolises are emerging.Urbanization is being completed with the driving force of capital;meanwhile,technology has achieved the quest of capital.In this thesis,in light of Henri Lefebvre’s ideology of technology rational critique,Chinese urban modernity issues under the perspective of technology rational critique were analyzed,including issues like eroded urban texture,urban mechanization,and urban segregation.The technology rational root of Chinese urban modernity issues was discussed from the turn of technical artifacts from design intention to application intention.In the end,possible methods to solve these Chinese urban modernity issues were illustrated based on Henri Lefebvre’s urban development theory.