Gastric cancer is one of the most common malignant tumors,for patients with advanced gastric cancer,the traditional treatment is mainly chemotherapy or combined targeted therapy;however,these have not achieved ideal e...Gastric cancer is one of the most common malignant tumors,for patients with advanced gastric cancer,the traditional treatment is mainly chemotherapy or combined targeted therapy;however,these have not achieved ideal efficacy.However,with the continuous deepening of research on molecular targeted drugs and immunosuppressants,the treatment of advanced gastric cancer patients has made new progress,and some new technologies have also been continuously emerged and applied,which brings hope for the treatment of advanced gastric cancer.Recently,several multicenter randomized controlled phase III studies on immunotherapy for advanced gastric cancer yielded encouraging results,demonstrating its superior efficacy in the treatment of advanced gastric cancer.However,prospective data to support the acceptance of surgery and the R0 removal rate following conversion therapy with immune checkpoint inhibitors are lacking.In this study,a 58-year-old woman with advanced gastric cancer and positive PD-L1 expression,negative HER-2 expression,and microsatellite stable status received immunochemotherapy combined with traditional Chinese medicine to achieve R0 resection and satisfactory efficacy.展开更多
Colorectal cancer(CRC)is a major cause of morbidity and mortality and is closely associated with lipid metabolism,of which fatty acid metabolism,the release of fat factors and the abnormal level of blood lipids are al...Colorectal cancer(CRC)is a major cause of morbidity and mortality and is closely associated with lipid metabolism,of which fatty acid metabolism,the release of fat factors and the abnormal level of blood lipids are all important pathogenic mechanisms.With the increasing awareness of lipid metabolism,advances in lipid-regulating therapy have made it possible for anti-tumor effect in CRC.However,there are still many research gaps and limitations.Given the complexity and uncertainty of targeted lipid-regulating therapy for CRC,traditional Chinese medicine(TCM)may have a leg up when it comes to the theory of“holistic concept”and“treatment based on syndrome differentiation”.Meanwhile,proper dietary direction,healthy lifestyles,and normal serum lipid levels contribute directly to the prognosis of CRC patients.展开更多
Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which ...Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment.展开更多
Objective To assess the efficacy and safety of combining traditional Chinese medicine(TCM),specifically Chinese herbal medicine(CHM),with Western medicine(WM),compared to WM alone to treat breast cancer endocrine ther...Objective To assess the efficacy and safety of combining traditional Chinese medicine(TCM),specifically Chinese herbal medicine(CHM),with Western medicine(WM),compared to WM alone to treat breast cancer endocrine therapy-related osteoporosis(BCET-OP)by meta-analysis.Methods Thirty-eight randomized controlled trials involving 2170 participants were analyzed.Eight databases were searched for articles published between inception and December 2023.Quality assessment was performed using the Risk of Bias 2 tool.Results Significant increases were observed in the TCM-WM group in lumbar vertebrae bone mineral density(BMD)(P<.001,mean difference(MD)=0.07,95%confidence interval(CI):0.06 to 0.08),lumbar vertebrae T-score(P=.0005,MD=0.21,95%CI:0.09 to 0.33)and collum femoris BMD(P=.01,MD=0.10,95%CI:0.02 to 0.19).No significant difference was observed between the groups in the collum femoris T-score and estradiol levels.Bone gla-protein levels were significantly increased in the TCM-WM group(P=.0002,MD=0.52,95%CI:0.25 to 0.79).Beta-CrossLaps decreased significantly in the TCM-WM group(P=.0008,MD=−0.10,95%CI:−0.16 to−0.04).No significant difference was observed between the TCM-WM and WM groups in alkaline phosphatase,in procollagen type I N-terminal propeptide,and in the Kupperman index.The visual analog score(VAS)was decreased in the TCM-WM group compared to the WM group(P<.001,MD=−1.40,95%CI:−1.94 to−0.87).No significant difference in adverse events was observed between the two groups.Conclusion Combining CHM with WM in patients with BCET-OP significantly improved BMD,T-score,and certain bone turnover markers and reduced the VAS score,indicating potential benefits for bone health and related pain.Adverse event analysis revealed no differences between the groups,supporting the feasibility of the combination therapy.However,further research,particularly in diverse populations,is required.展开更多
Under the guidance of the theory of traditional Chinese medicine(TCM),the“Green Therapy”for tumors aims to“control”the condition,i.e.“When lethal treatments were adopted,they should be discontinued when six-tenth...Under the guidance of the theory of traditional Chinese medicine(TCM),the“Green Therapy”for tumors aims to“control”the condition,i.e.“When lethal treatments were adopted,they should be discontinued when six-tenths of the disease is eliminated;When treatments with moderate toxicity were chosen,they should be stopped when seven-tenths of the disease is eliminated;When treatments with mild toxicity were using,they should be discontinued when eight-tenths of the disease is eliminated;Even if using non-toxic treatments,they should be terminated when nine-tenths of the disease is wiped out..If the efficacy is below our expectation,we could repeat the treatments;But if go beyond the extent,healthy qi will be damaged and it will not be beneficial or even do harm to the repair capability of the body”,which underlines the end point of treatment,or“stop interventions when half of the disorder is gone”.Based on the Green Therapy theory,minimally invasive surgeries,TCM external treatments,natural medications and the biological target therapies are main approaches in our clinical cancer management.It differs from the modern treatment mode.The Green Therapy for cancers treats“patient’s quality of life”as our priority.This therapy system is particularly suitable for cancer patients who are aged and disqualified for or failed from classic anti-cancer treatments.This is a new trend of anti-cancer strategy characterized by effectiveness,minimally invasion,quick recovery,easy toleration and great sustainability.展开更多
文摘Gastric cancer is one of the most common malignant tumors,for patients with advanced gastric cancer,the traditional treatment is mainly chemotherapy or combined targeted therapy;however,these have not achieved ideal efficacy.However,with the continuous deepening of research on molecular targeted drugs and immunosuppressants,the treatment of advanced gastric cancer patients has made new progress,and some new technologies have also been continuously emerged and applied,which brings hope for the treatment of advanced gastric cancer.Recently,several multicenter randomized controlled phase III studies on immunotherapy for advanced gastric cancer yielded encouraging results,demonstrating its superior efficacy in the treatment of advanced gastric cancer.However,prospective data to support the acceptance of surgery and the R0 removal rate following conversion therapy with immune checkpoint inhibitors are lacking.In this study,a 58-year-old woman with advanced gastric cancer and positive PD-L1 expression,negative HER-2 expression,and microsatellite stable status received immunochemotherapy combined with traditional Chinese medicine to achieve R0 resection and satisfactory efficacy.
文摘Colorectal cancer(CRC)is a major cause of morbidity and mortality and is closely associated with lipid metabolism,of which fatty acid metabolism,the release of fat factors and the abnormal level of blood lipids are all important pathogenic mechanisms.With the increasing awareness of lipid metabolism,advances in lipid-regulating therapy have made it possible for anti-tumor effect in CRC.However,there are still many research gaps and limitations.Given the complexity and uncertainty of targeted lipid-regulating therapy for CRC,traditional Chinese medicine(TCM)may have a leg up when it comes to the theory of“holistic concept”and“treatment based on syndrome differentiation”.Meanwhile,proper dietary direction,healthy lifestyles,and normal serum lipid levels contribute directly to the prognosis of CRC patients.
基金the National Natural Science Foundation of China(No.81773170)BeijingNovaProgram(No.Z1511000003150121)Beijing Talents Fund(No.2015000021223ZK23).
文摘Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment.
基金supported by the Program of Introducing Talents of Discipline to Universities(111 Project)-TCM Prevention and Treatment of Major Chronic Diseases(Tumor-B21028).
文摘Objective To assess the efficacy and safety of combining traditional Chinese medicine(TCM),specifically Chinese herbal medicine(CHM),with Western medicine(WM),compared to WM alone to treat breast cancer endocrine therapy-related osteoporosis(BCET-OP)by meta-analysis.Methods Thirty-eight randomized controlled trials involving 2170 participants were analyzed.Eight databases were searched for articles published between inception and December 2023.Quality assessment was performed using the Risk of Bias 2 tool.Results Significant increases were observed in the TCM-WM group in lumbar vertebrae bone mineral density(BMD)(P<.001,mean difference(MD)=0.07,95%confidence interval(CI):0.06 to 0.08),lumbar vertebrae T-score(P=.0005,MD=0.21,95%CI:0.09 to 0.33)and collum femoris BMD(P=.01,MD=0.10,95%CI:0.02 to 0.19).No significant difference was observed between the groups in the collum femoris T-score and estradiol levels.Bone gla-protein levels were significantly increased in the TCM-WM group(P=.0002,MD=0.52,95%CI:0.25 to 0.79).Beta-CrossLaps decreased significantly in the TCM-WM group(P=.0008,MD=−0.10,95%CI:−0.16 to−0.04).No significant difference was observed between the TCM-WM and WM groups in alkaline phosphatase,in procollagen type I N-terminal propeptide,and in the Kupperman index.The visual analog score(VAS)was decreased in the TCM-WM group compared to the WM group(P<.001,MD=−1.40,95%CI:−1.94 to−0.87).No significant difference in adverse events was observed between the two groups.Conclusion Combining CHM with WM in patients with BCET-OP significantly improved BMD,T-score,and certain bone turnover markers and reduced the VAS score,indicating potential benefits for bone health and related pain.Adverse event analysis revealed no differences between the groups,supporting the feasibility of the combination therapy.However,further research,particularly in diverse populations,is required.
文摘Under the guidance of the theory of traditional Chinese medicine(TCM),the“Green Therapy”for tumors aims to“control”the condition,i.e.“When lethal treatments were adopted,they should be discontinued when six-tenths of the disease is eliminated;When treatments with moderate toxicity were chosen,they should be stopped when seven-tenths of the disease is eliminated;When treatments with mild toxicity were using,they should be discontinued when eight-tenths of the disease is eliminated;Even if using non-toxic treatments,they should be terminated when nine-tenths of the disease is wiped out..If the efficacy is below our expectation,we could repeat the treatments;But if go beyond the extent,healthy qi will be damaged and it will not be beneficial or even do harm to the repair capability of the body”,which underlines the end point of treatment,or“stop interventions when half of the disorder is gone”.Based on the Green Therapy theory,minimally invasive surgeries,TCM external treatments,natural medications and the biological target therapies are main approaches in our clinical cancer management.It differs from the modern treatment mode.The Green Therapy for cancers treats“patient’s quality of life”as our priority.This therapy system is particularly suitable for cancer patients who are aged and disqualified for or failed from classic anti-cancer treatments.This is a new trend of anti-cancer strategy characterized by effectiveness,minimally invasion,quick recovery,easy toleration and great sustainability.
基金National Natural Science Foundation of China Regional Science Fund Project(81460697)Guizhou Provincial Postgraduate Workstation Program(Educational Department)(JYSZ[2014]018)+3 种基金National Natural Science Foundation Regional Science Fund Project(81460691)Guizhou Provincial Science and Technology Department((2016)4032)National Natural Science Foundation of China Regional Science Fund Project(81660833)Guizhou Provincial Department of Education(GZS[2016]08).
