Three new triterpenes, 3β,21α-dihydroxylupen-18（19）-en （1）, 3β,25-dihydroxytirucalla- 7,23（24）-dien （2）, and 21α-hydroxy-19α-hydrogentaraxastero1-20（30）-en （3） were obtained from an ethyl acetate extr...Three new triterpenes, 3β,21α-dihydroxylupen-18（19）-en （1）, 3β,25-dihydroxytirucalla- 7,23（24）-dien （2）, and 21α-hydroxy-19α-hydrogentaraxastero1-20（30）-en （3） were obtained from an ethyl acetate extract of the whole plant of Siyekucai （Ixeris chinensis）. The structures of 1-3 were determined by spectroscopic methods （EIMS, IR, 1D and 2D NMR）.展开更多
The chemical investigation of Ixeris polycephala afforded two new norsesquiterpenes, named as ixerols A and B （1-2）. Their structures were established based on spectroscopic methods including 2D NMR experiments. The...The chemical investigation of Ixeris polycephala afforded two new norsesquiterpenes, named as ixerols A and B （1-2）. Their structures were established based on spectroscopic methods including 2D NMR experiments. The absolute structure of ixerol B was determined by its CD spectrum.展开更多
Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml IS...Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein Ⅱb/Ⅲa compound (GPⅡb/Ⅲa), granular membrane protein-140 (GMP-140), platelet aggregation rate (PAgR) and hemorrheology were observed. Results: After treatment with ISH, the GPⅡb/Ⅲa compound positive rate of 33 type 2 DM patients were lowered (P<0.05), GMP-140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment,it showed significant difference (P<0.05, P<0.01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. Conclusion: ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.展开更多
Objective: To summarize a decade of research on various aspects of Sowthistle-leaf Ixeris seedling for acute cerebral infarction. Methods: Thirty-six papers were collected from searches of CNKI, Wanfang, PubMed, and o...Objective: To summarize a decade of research on various aspects of Sowthistle-leaf Ixeris seedling for acute cerebral infarction. Methods: Thirty-six papers were collected from searches of CNKI, Wanfang, PubMed, and other databases and then they were summarized. Results: Researchers have carried out widespread and various pharmacological studies of Sowthistle-leaf Ixeris seedling, and have pursued different research directions on its etiology and pathogenesis, syndrome differentiation and treatment methods for acute cerebral infarction (ischemic stroke). With the development of Chinese medicine, its safety and non-toxic side effects have been recognized by the majority of scholars. The research results have contributed significantly to the treatment of acute cerebral infarction by Sowthistle-leaf Ixeris seedling. Conclusion: Sowthistle-leaf Ixeris seedling has extensive medicinal value and unique advantages in the treatment of acute cerebral infarction, especially in expanding brain vessels, increasing blood flow, reducing thrombosis, protecting brain cells, improving neurological impairment, and it has no toxic side effects.展开更多
文摘Three new triterpenes, 3β,21α-dihydroxylupen-18（19）-en （1）, 3β,25-dihydroxytirucalla- 7,23（24）-dien （2）, and 21α-hydroxy-19α-hydrogentaraxastero1-20（30）-en （3） were obtained from an ethyl acetate extract of the whole plant of Siyekucai （Ixeris chinensis）. The structures of 1-3 were determined by spectroscopic methods （EIMS, IR, 1D and 2D NMR）.
文摘The chemical investigation of Ixeris polycephala afforded two new norsesquiterpenes, named as ixerols A and B （1-2）. Their structures were established based on spectroscopic methods including 2D NMR experiments. The absolute structure of ixerol B was determined by its CD spectrum.
文摘Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein Ⅱb/Ⅲa compound (GPⅡb/Ⅲa), granular membrane protein-140 (GMP-140), platelet aggregation rate (PAgR) and hemorrheology were observed. Results: After treatment with ISH, the GPⅡb/Ⅲa compound positive rate of 33 type 2 DM patients were lowered (P<0.05), GMP-140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment,it showed significant difference (P<0.05, P<0.01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. Conclusion: ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.
基金the National Natural Science Foundation of the People's Republic of China (Grant Nos. 81704051, 81173233)the Scientific Research Foundation for Returned Oversea Chinese Scholars, State Education Ministry (2014)+1 种基金the TCM Standardization Project of the State Administration of Traditional Chinese Medicine (No. ZYYS-2013PJ07)the Talent Cultivation Project of Dongfang Hospital, Beijing University of Chinese Medicine (2015–2017).
文摘Objective: To summarize a decade of research on various aspects of Sowthistle-leaf Ixeris seedling for acute cerebral infarction. Methods: Thirty-six papers were collected from searches of CNKI, Wanfang, PubMed, and other databases and then they were summarized. Results: Researchers have carried out widespread and various pharmacological studies of Sowthistle-leaf Ixeris seedling, and have pursued different research directions on its etiology and pathogenesis, syndrome differentiation and treatment methods for acute cerebral infarction (ischemic stroke). With the development of Chinese medicine, its safety and non-toxic side effects have been recognized by the majority of scholars. The research results have contributed significantly to the treatment of acute cerebral infarction by Sowthistle-leaf Ixeris seedling. Conclusion: Sowthistle-leaf Ixeris seedling has extensive medicinal value and unique advantages in the treatment of acute cerebral infarction, especially in expanding brain vessels, increasing blood flow, reducing thrombosis, protecting brain cells, improving neurological impairment, and it has no toxic side effects.
