Understanding the educational inequalities in suicide attempts and their mediators:a Mendelian randomisation study

Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.

STRONGLY CONVERGENT INERTIAL FORWARD-BACKWARD-FORWARD ALGORITHM WITHOUT ON-LINE RULE FOR VARIATIONAL INEQUALITIES

This paper studies a strongly convergent inertial forward-backward-forward algorithm for the variational inequality problem in Hilbert spaces.In our convergence analysis,we do not assume the on-line rule of the inertial parameters and the iterates,which have been assumed by several authors whenever a strongly convergent algorithm with an inertial extrapolation step is proposed for a variational inequality problem.Consequently,our proof arguments are different from what is obtainable in the relevant literature.Finally,we give numerical tests to confirm the theoretical analysis and show that our proposed algorithm is superior to related ones in the literature.

A RELAXED INERTIAL FACTOR OF THE MODIFIED SUBGRADIENT EXTRAGRADIENT METHOD FOR SOLVING PSEUDO MONOTONE VARIATIONAL INEQUALITIES IN HILBERT SPACES

In this paper,we investigate pseudomonotone and Lipschitz continuous variational inequalities in real Hilbert spaces.For solving this problem,we propose a new method that combines the advantages of the subgradient extragradient method and the projection contraction method.Some very recent papers have considered different inertial algorithms which allowed the inertial factor is chosen in[0;1].The purpose of this work is to continue working in this direction,we propose another inertial subgradient extragradient method that the inertial factor can be chosen in a special case to be 1.Under suitable mild conditions,we establish the weak convergence of the proposed algorithm.Moreover,linear convergence is obtained under strong pseudomonotonicity and Lipschitz continuity assumptions.Finally,some numerical illustrations are given to confirm the theoretical analysis.

NEW DOOB'S MAXIMAL INEQUALITIES FOR MARTINGALES

Let 1≤q≤∞,b be a slowly varying function and letΦ:[0,∞)■[0,∞)be an increasing convex function withΦ(0)=0 and■Φ(r)=∞.In this paper,we present a new class of Doob’s maximal inequality on Orlicz-Lorentz-Karamata spaces LΦ,q,b.The results are new,even for the Lorentz-Karamata spaces withΦ(t)=tp,the Orlicz-Lorentz spaces with b≡1,and weak Orlicz-Karamata spaces with q=∞in the framework of LΦ,q,b-Moreover,we obtain some even stronger qualitative results that can remove the△2-condition of Liu,Hou and Wang(Sci China Math,2010,53(4):905-916).

Generalization of Inequalities in Metric Spaces with Applications

In this paper, which serves as a continuation of earlier work, we generalize the idea of inequalities in metric spaces and use them to demonstrate that the incomplete metric space can be used to obtain a Banach space.

What in Fact Proves the Violation of the Bell-Type Inequalities?

A. Peres constructed an example of particles entangled in the state of spin singlet. He claimed to have obtained the CHSH inequality and concluded that the violation of this inequality shows that in a measurement in which some variables are tested, other variables, not tested, have no defined value. In the present paper is proved that the correct conclusion of the violation of the CHSH inequality is different. It is proved that the classical calculus of probabilities of test results, obeying the Kolmogorov axioms, is unfit for the quantum formalism, dominated by probability amplitudes.

HARNACK TYPE INEQUALITIES FOR SDES DRIVEN BY FRACTIONAL BROWNIAN MOTION WITH MARKOVIAN SWITCHING

In this paper, by constructing a coupling equation, we establish the Harnack type inequalities for stochastic differential equations driven by fractional Brownian motion with Markovian switching. The Hurst parameter H is supposed to be in(1/2, 1). As a direct application, the strong Feller property is presented.

A Note on Sharp Affine Poincaré-Sobolev Inequalities and Exact in Minimization of Zhang’s Energy on Bounded Variation and Exactness

As for the affine energy, Edir Junior and Ferreira Leite establish the existence of minimizers for particular restricted subcritical and critical variational issues on BV(Ω). Similar functionals exhibit deeper weak* topological traits including lower semicontinuity and affine compactness, and their geometry is non-coercive. Our work also proves the result that extremal functions exist for certain affine Poincaré-Sobolev inequalities.

Regularization Methods to Approximate Solutions of Variational Inequalities

In this paper, we study the regularization methods to approximate the solutions of the variational inequalities with monotone hemi-continuous operator having perturbed operators arbitrary. Detail, we shall study regularization methods to approximate solutions of following variational inequalities: and with operator A being monotone hemi-continuous form real Banach reflexive X into its dual space X*, but instead of knowing the exact data (y0, A), we only know its approximate data satisfying certain specified conditions and D is a nonempty convex closed subset of X;the real function f defined on X is assumed to be lower semi-continuous, convex and is not identical to infinity. At the same time, we will evaluate the convergence rate of the approximate solution. The regularization methods here are different from the previous ones.

THE LOGARITHMIC SOBOLEV INEQUALITY FOR A SUBMANIFOLD IN MANIFOLDS WITH ASYMPTOTICALLY NONNEGATIVE SECTIONAL CURVATURE

In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality,this inequality contains a term involving the mean curvature.

Weak and Strong Convergence of Self Adaptive Inertial Subgradient Extragradient Algorithms for Solving Variational Inequality Problems

Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious advantages.Two different algorithms are given for solving variational inequality problem in this paper.The problem we study is defined in a real Hilbert space and has L-Lipschitz and pseudomonotone condition.Two new algorithms adopt inertial technology and non-monotonic step size rule,and their convergence can still be proved when the value of L is not given in advance.Finally,some numerical results are designed to demonstrate the computational efficiency of our two new algorithms.

A Study of Triangle Inequality Violations in Social Network Clustering

Clustering a social network is a process of grouping social actors into clusters where intra-cluster similarities among actors are higher than inter-cluster similarities. Clustering approaches, i.e. , k-medoids or hierarchical, use the distance function to measure the dissimilarities among actors. These distance functions need to fulfill various properties, including the triangle inequality (TI). However, in some cases, the triangle inequality might be violated, impacting the quality of the resulting clusters. With experiments, this paper explains how TI violates while performing traditional clustering techniques: k-medoids, hierarchical, DENGRAPH, and spectral clustering on social networks and how the violation of TI affects the quality of the resulting clusters.

AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

NEW SIMPLE SMOOTH MERIT FUNCTION FOR BOX CONSTRAINED VARIATIONAL INEQUALITIES AND DAMPED NEWTON TYPE METHOD

By introducing a smooth merit function for the median function, a new smooth merit function for box constrained variational inequalities (BVIs) was constructed. The function is simple and has some good differential properties. A damped Newton type method was presented based on it.Global and local superlinear/quadratic convergence results were obtained under mild conditions, and the finite termination property was also shown for the linear BVIs. Numerical results suggest that the method is efficient and promising.

MIXED VARIATIONAL INEQUALITIES DRIVEN BY FRACTIONAL EVOLUTIONARY EQUATIONS

The goal of the present paper is to investigate an abstract system, called fractional differential variational inequality, which consists of a mixed variational inequality combined with a fractional evolution equation in the framework of Banach spaces. Using discrete approximation approach, an existence theorem of solutions for the inequality is established under some suitable assumptions.

QUASI-VARIATIONAL INEQUALITIES AND SOCIAL EQUILIBRIUM

A quasi-variational inequality is proved in paracompact setting which generalizes the results of Zhou Chen andAubin. As applications, two existence theorems on the solutions of optimization problems and social equilibria ofmetagames are showed which improve and extend the recent results of Kaczynski-Zeidan and Aubin.

SOME INEQUALITIES OF HERMITE-HADAMARD TYPE FOR s-CONVEX FUNCTIONS

In this paper several inequalities of the left-hand side of Hermite-Hadamard’s inequality are obtained for s-convex functions.

On Some Fundamental Integrodifferential Inequalities

The aim of this present paper is to establish some new integrodifferential inequalities of Gronwall type involving functions of one independent variable which provide explicit bounds on unknown functions. The inequalities given here can be used in the analysis of a class of differential equations as handy tools.

DIFFERENTIAL VARIATIONAL INEQUALITIES IN INFINITE BANACH SPACES

In this paper,we consider a new differential variational inequality（DVI,for short）which is composed of an evolution equation and a variational inequality in infinite Banach spaces.This kind of problems may be regarded as a special feedback control problem.Based on the Browder＇s theorem and the optimal control theory,we show the existence of solutions to the mentioned problem.

DIFFERENTIAL INVERSE VARIATIONAL INEQUALITIES IN FINITE DIMENSIONAL SPACES

In this article, a new differential inverse variational inequality is introduced and studied in finite dimensional Euclidean spaces. Some results concerned with the linear growth of the solution set for the differential inverse variational inequalities are obtained under different conditions. Some existence theorems of Caratheodory weak solutions for the differential inverse variational inequality are also established under suitable conditions. An application to the time-dependent spatial price equilibrium control problem is also given.