Quality Standard of Tibetan Medicine Nardostachys jatamansi Herba Based on"An Integrated Plant but Multi-purpose"

[Objectives]To establish the quality standard of Nardostachys jatamansi Herba.[Methods]The characters and microscopical identification of N.jatamansi Herba were carried out.The contents of moisture,total ash,acid-insoluble ash and extract were determined according to the relevant methods of the Chinese Pharmacopoeia(2020 edition).Using chlorogenic acid and 3,5-O-dicaffeoylquinic acid as quality control indexes,TLC and HPLC methods were established for qualitative and quantitative determination,and HPLC fingerprints were established.[Results]The characteristics of character identification,microscopic identification and thin layer identification were obvious.The moisture content ranged from 2.7%to 7.8%,with an average value of 5.4%.The total ash content ranged from 6.7%to 16.2%,with an average of 11.0%.The acid-insoluble ash content ranged from 0.7%to 8.5%,with an average of 3.6%.Extractives content ranged from 20.9%to 34.4%,with an average of 29.7%.Chlorogenic acid content was between 0.45%and 1.30%,with an average value of 0.77%.The content of 3,5-O-dicaffeoylquinic acid ranged from 0.18%to 0.58%,with an average of 0.31%.The similarity of each batch was between 0.930 and 0.994,indicating that the quality of medicinal materials from different producing areas was stable.[Conclusions]The quality standard of N.jatamansi Herba was established,which could provide quality control basis for rational,comprehensive and efficient utilization of N.jatamansi DC.resources and clinical use.

Reviewing the medicinal potential of Valeriana jatamansi Jones:its traditional uses,phytochemistry,and pharmacological activities

Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as traditional folk remedy.It contains a variety of secondary metabolites that give it a high medicinal and therapeutic values.For the purpose of collecting relevant information on V.jatamansi,a comprehensive literature search was conducted.Based on ethnobotanical sources and historical records,traditional uses were compiled.Scientific articles and databases were consulted for phytochemical data.In order to assess the plant’s therapeutic properties,pharmacological studies were reviewed.Summary:The botanical is known for its ethnobotanical uses ranging from sedative and anxiolytic effects to treating insomnia,epilepsy,and gastrointestinal disorders.Indigenous healing practices rely heavily on its traditional uses.Based on the phytochemical analysis,it contains a diverse array of bioactive compounds,including sesquiterpenoids and iridoids.Valerenic acid and jatamansinol,among other compounds,contribute to its therapeutic potential.A broad spectrum of pharmacological activities is found including anxiety-relieving,sedative,anti-inflammatory,neuroprotective,and antimicrobial effects.Outlook:Based on the evidence supporting ethnomedicinal uses of V.jatamansi,its immense biopotential and multiple pharmacological roles,standard clinical trials are required to evaluate its therapeutic potential.

Anti-anxiety effect of Valeriana jatamansi Jones extract via regulation of the hypothalamus-pituitary-adrenal axis

BACKGROUND： Hypothalamus-pituitary-adrenal （HPA） axis dysfunction has been closely linked to anxiety. Previous studies have shown that Valeriana jatamansi Jones extract exhibits clear anxiolytic effects, but it is unclear about the mechanism underlying regulation of the HPA axis dysfunction in these anxiolytic effects. OBJECTIVE： To observe the effects of Valeriana jatamansi Jones （Zhizhu Xiang） extract on HPA axis function in a rat model of anxiety, and to compare these effects with positive control estazolam. DESIGN, TIME AND SETTING： Randomized, controlled, animal experiment was performed at Chengdu University of Traditional Chinese Medicine, China, between February and September in 2006. MATERIALS： Estazolam was purchased from Shanghai Jiufu Pharmaceutical, China; Valeriana jatamansiJones was purchased from the Lotus Pond Market for Chinese Herbal Medicine in Chengdu. It consisted of iridoids and flavonoid components. METHODS： A total of 72 Sprague Dawley rats, aged 2 months, were randomly assigned to 6 groups low-, medium-, and high-dose Valerianajatamansi Jones groups intragastrically injected with 0.3, 0.6, and 0.9 g/kg per day Valerianajatamansi Jones extract, respectively; estazolam group intragastrically injected with 1.5 mg/kg per day estazolam; model and normal groups administered 5 mL physiological saline. Anxiety was established in all groups, except the normal group, through the use of elevated plus-maze test at 7 days following drug administration. MAIN OUTCOME MEASURES： Blood β-endorphin and corticosterone levels were determined using enzyme-linked immunosorbent assay following treatment with ValerianajatamansiJones extract. Expressions of HPA axis-related genes were measured by cDNA microarray. RESULTS： Blood β-endorphin and corticosterone levels were significantly greater in the model group than in the normal group. Compared with the model group, levels decreased with Valeriana jatamansi Jones extract or estazolam treatment, particularly in the low-dose Valeriana jatamansi Jones group （P〈 0.01）. cDNA microarray results demonstrated that corticotropin-releasing hormone and Orexin, which are associated with HPA axis function, were differentially expressed; expression increased in the model group, but decreased in rats treated with Valerianajatamansi Jones extract. CONCLUSION： Valerianajatamansi Jones extract plays a role in regulating HPA axis function in a rat model of anxiety, and this effect was superior to estazolam.

Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were completely abolished when mice were pretreated with NJE. Inhibition of streptozotocin-induced hyperglycemia by NJE was mediated by suppression of nuclear factor (NF)-κB activation. In addition, NJE protected against cytokine-mediated cytotoxicity. Incubation of RINm5F cells and islets with NJE resulted in a signif icant reduction in cytokine-induced NF-κB activation and downstream events, inducible nitric oxide synthase expression and nitric oxide production. The protective effect of NJE was further demonstrated by the normal insulin secretion of cytokine-treated islets in response to glucose. CONCLUSION: NJE provided resistance to pancreatic β-cell damage from cytokine or streptozotocin treatment. The β-cell protective effect of NJE is mediated by suppressing NF-κB activation.

Interaction Effect of Auxin and Cytokinin on in Vitro Shoot Regeneration and Rooting of Endangered Medicinal Plant Valeriana jatamansi Jones through Tissue Culture

Micropropagation of Valeriana jatamansi Jones by using small segments of rhizome on full strength MS medium having various concentrations and combinations of auxin Naphthaleneacetic acid (NAA) and cytokinin Benzylaminopurine (BAP) was conducted. The highest mean shoot length (3.71 cm) was achieved when media was fortified with BAP 2 mg/L in combination with NAA 1 mg/L. The highest mean leaf number i.e. 6.00 was observed when BAP was used alone at 2 mg/L. Average root length (0.77 cm) was recorded when BAP 1.5 mg/L along with NAA 0.5 mg/L was used. Maximum mean root numbers 2.57 were obtained when BAP and NAA were used at equal concentrations i.e. 1.5 mg/L. Observed data demonstrated that BAP up to 1 mg/L, 1.5 mg/L and 2 mg/L promotes shoot length, leaf number and leaf growth when used along with NAA at 0 mg/L, 0.5 mg/L and 1 mg/L. However lower quantities of both NAA (0 mg/L, 0.5 mg/L) and BAP (1 mg/L and 1.5 mg/L) produced significantly higher root length of Valeriana jatamansi Jones but the higher concentrations of plant growth hormones BAP (2 mg/L, 3 mg/L) and NAA (1 mg/L, 1.5 mg/L) were found unfavorable for increase in root length but the root number increases at higher concentration of NAA (1 mg/L and 1.5 mg/L).

Identification of Volatile Oil Components of Nardostachys jatamansi DC. Root and Rhizome,Herb

[Objectives] Volatile oil components of traditional drug use site " root and rhizome" of N. jatamansi and herb were identified and contrasted,which aimed to provide the basis for rationally using wild N. jatamansi resource. [Methods]Volatile oil components from different sites of N. jatamansi were identified and isolated by GC-MS. [Results] There were 56 kinds of volatile oil components from different sites of N. jatamansi,in which 39 components from herb of N. jatamansi,39 components from root and rhizome of N. jatamansi,and there were 22 common components. But 1 component in higher concentration had obvious difference. [Conclusions] The herb of N. jatamansi could not completely replace " root and rhizome" of N. jatamansi as the medicine,which was consistent with prior detection result of each physicochemical index from different sites of N. jatamansi. The research could provide the reference for making quality standard of N. jatamansi medicine and rational basis for its further research and development.

Mechanism of Inhibitory Effect of Essential Oil from Valerianae Jatamansi Rhizoma et Radix on Activation of Microglia

[Objectives]To investigate the inhibitory effect and possible mechanism of essential oil from Valerianae Jatamansi Rhizoma et Radix on microglia activation induced by lipopolysaccharide(LPS).[Methods]The LPS-induced microglia activation model was established and treated with different doses of essential oil from Valerianae Jatamansi Rhizoma et Radix.MTT assay was used to detect cell viability,ELISA to detect IL-6 secretion,RT-PCR to detect mRNA expression levels of IL-6,IL-1β,NF-κB,and IκBα,Western blotting to detect the protein expression of IL-6,IL-1β,NF-κB,IκBα,and their phosphorylated products.[Results]Compared with the normal control group,the model group showed increased IL-6 content(P<0.01),upregulated mRNA and protein levels of IL-6,IL-1β,and NF-κB(P<0.01),and elevated ratio of P-IκBα/IκBα(P<0.05).Compared with the model group,4 and 2μg/L essential oil from Valerianae Jatamansi Rhizoma et Radix reduced the content of IL-6(P<0.05),while 4,2,and 1μg/L essential oil from Valerianae Jatamansi Rhizoma et Radix down-regulated the mRNA and protein levels of IL-6,IL-1β,and NF-κB to varying degrees(P<0.05 or P<0.01),up-regulate the mRNA expression of IκBα(P<0.05 or P<0.01),and decreased the ratio of P-IκBα/IκBα(P<0.05 or P<0.01).[Conclusions]Essential oil from Valerianae Jatamansi Rhizoma et Radix can inhibit LPS-induced microglia activation,and its mechanism may be related to the inhibition of the NF-κB/IκBαsignaling pathway.

不同提取方法对甘松精油品质和成分的影响

目的:探究不同提取方法对甘松精油品质和成分的影响。方法:比较溶剂萃取法(SE)、水蒸气蒸馏法(SD)、盐析水蒸气蒸馏法(SSD)、亚临界萃取法(SFE)、超临界萃取法(SCFE)提取甘松精油的得率、理化性质、清除DPPH自由基能力差异,采用GC-MS和OPLS-DA分析比较不同甘松精油挥发性成分差异。结果:SCFE精油得率最高、清除DPPH自由基能力最强,SD精油感官品质最优、酸值和酯值最低、碘值最高。5种方法提取精油主要成分均为倍半萜,SCFE精油中倍半萜类成分含量最高,SD精油中酚、醇、酯、醛、单萜类最高,SE精油中酮类最高。OPLS-DA结果表明,SD、SE、SFE和SCFE甘松精油成分组成存在区别,而SD和SSD组成接近。VIP结果筛选出1-[6,6-二甲基-1,2-环氧环己基]-1-丁炔-3-酮、白菖烯、桉叶-4(15),7-二烯-1β-醇等13种关键差异成分。结论:5种方法中,SCFE提取甘松精油最高效,SD精油品质最优。

基于HPLC和化学计量法分析蜘蛛香不同部位3类化合物10种成分差异研究

目的 对蜘蛛香不同部位中酚酸类(新绿原酸、绿原酸、咖啡酸、异绿原酸B、异绿原酸A、异绿原酸C),黄酮类(橙皮苷、蒙花苷)及缬草三酯类(乙酰缬草三酯、缬草三酯)化合物含量进行测定,结合化学模式识别比较含量差异。方法 采用HPLC法对蜘蛛香地上部位(叶)和地下部位(根茎和根)中10种成分含量进行测定,对结果进行聚类分析、主成分分析和正交偏最小二乘判别分析。结果 地上部位10种成分平均含量绿原酸>异绿原酸A>蒙花苷>缬草三酯>橙皮苷>异绿原酸C>乙酰缬草三酯>异绿原酸B>新绿原酸>咖啡酸,地下部位10种成分平均含量缬草三酯>异绿原酸A>橙皮苷>绿原酸>乙酰缬草三酯>异绿原酸C>异绿原酸B>蒙花苷>新绿原酸>咖啡酸;蜘蛛香不同部位酚酸类和黄酮类含量均为地上部位>地下部位,缬草三酯类含量为地下部位>地上部位;造成蜘蛛香不同部位差异的标志物为缬草三酯、蒙花苷、橙皮苷。结论 蜘蛛香各部位样品中10个成分的含量存在较大差异;蜘蛛香的非药用部位也含有大量的酚酸类、黄酮类和缬草三酯类,应充分利用,避免中药资源的浪费。

甘松的化学成分及其药理活性的研究进展

目的对甘松(Nardostachys jatamansi DC.)近5年的化学成分及其药理活性的相关研究进行系统综述,为甘松的有效成分及药理、毒理学及临床应用的研究提供参考。方法使用《中华人民共和国药典》(以下简称《中国药典》)2020年版工具书,检索中国知网、PubMed、万方、经纶知识资源系统等数据库。结果综述了近5年甘松研究中新发现的64种化学成分,包括倍半萜类、五环三萜类、环烯醚萜类、木脂素类等。现代药理学研究显示,甘松提取物及活性成分具有广泛的生物活性,包括调节神经、抗炎、抑菌、抗氧化、调节代谢等。其中临床应用效果显著,主要集中在治疗心律失常、心绞痛、冠心病等心血管系统疾病以及糖尿病等。结论甘松是一种常用藏药,具有广泛的生物活性,且成分复杂,结构新颖;临床应用效果良好。

ICP-MS法结合化学计量学分析甘松不同药用部位无机元素的差异

建立电感耦合等离子体质谱法(Inductively Coupled Plasma Mass Spectrometry,ICP-MS)同时测定甘松不同药用部位中25种无机元素.通过ICP-MS对甘松样品中的25个无机元素进行定量分析,并运用主成分分析(Principal Component Analysis,PCA)和正交偏最小二乘判别分析(Orthogonal Partial Least Squares Discriminant Analysis,OPLS-DA)方法综合分析评估甘松不同药用部位的无机元素分布特征.结果显示:常量元素K,Ca,Na和Mg在甘松各部位中质量分数均较高,叶中的K,Ca质量分数分别为根及根茎中的1.57和1.19倍.微量元素及其他元素在根及根茎的丰富度高于叶部.OPLS-DA分析表明:Al,K,Fe,Na,Ca为甘松的特征元素,根及根茎中Na,Al,Fe的质量分数分别为叶部的3.15,2.71和2.48倍.青海省久治县索呼日麻乡、黄南州河南县赛尔龙乡、果洛州久治县智青松多镇,四川省阿坝州红原县邛溪镇、麦洼乡、阿木乡、安曲镇、若尔盖县班佑乡以及甘肃省甘南州玛曲县欧拉镇的根及根茎样品中As元素超出现行《药用植物及制剂进出口绿色行业标准》限度.甘松不同药用部位独特的组成特征可为甘松药材的质量控制及安全性评价提供依据.

蜘蛛香的主要药效物质、药理作用和临床应用研究进展

蜘蛛香药效物质主要包括全草粗提取物、环烯醚萜类、挥发油、木脂素、有机酸、黄酮及甾醇等,其在抗肿瘤、抗炎、抗氧化、抗焦虑、抗抑郁、改善胃肠道功能和改善脊髓损伤等方面发挥不同作用。本文整理近年来蜘蛛香的相关研究成果,以其主要药效物质为分类依据,分析、总结不同物质在疾病治疗中的作用机制,综述蜘蛛香作为中药材在临床应用和开发利用情况。

Antibacterial activity of Valeriana jatamansi against extended-spectrum β-lactamase producing Gram-negative bacteria causing urinary tract infections

Objective:To find out the antibacterial activity of Valeriana jatamansi(V.jatamansi)rhizomes against the extended-spectrumβ-lactamases(ESBLs)producing isolates of Enterobacteriaceae family.Methods:Confirmation of ESBLs producing Escherichia coli,Enterobacter aerogenes,Klebsiella pneumoniae and Hafnia alvei isolated from urinary tract infections was performed by double disc diffusion assay.Antimicrobial susceptibility of all ESBLs producing isolates was determined by disc diffusion method following guidelines of Clinical and Laboratory Standards Institute.Successive extraction of rhizomes of V.jatamansi was performed with hexane,chloroform and methanol using Soxhelt apparatus.These extracts were tested against the ESBLs producing isolates using well diffusion method.Results:Hexane extract showed significant results as compared to chloroform and methanol extracts with the maximum zone of inhibition(21 mm)while ciprofloxacin and amikacin were used as standard drugs.Conclusions:Findings of the study suggested that hexane extract of V.jatamansi can be used in combination with other antibiotics as alternative treatment for urinary tract infections caused by ESBLs producing strains of Enterobacteriaceae.

Evaluation of anti-inflammatory potential of Nardostachys jatamansi rhizome in experimental rodents

Objective:To evaluate the anti-inflammatory effect of Nardostachys jatamansi(N.jatamansi)rhizome against acute,subacute and chronic models of inflammation in experimental animals.Methods:N.jatamansi rhizome extract(150 and 300 mg/kg,p.o.)and the reference drugs phenylbutazone(100 mg/kg,p.o.)and acetylsalicylic acid(300 mg/kg,p.o.)were evaluated using models for inflammation(autacoids induced hind paw oedema,formaldehyde induced hind paw oedema,carrageenin-induced paw oedema,cotton pellet granuloma and subcutaneous air pouch model).Results:In acute inflammation as produced by carrageenin 29.06%and 55.81%,by histamine 25.0%and 39.28%,by 5-hydroxytryptamine 21.37%and 36.95%and by prostaglandin E2-induced hind paw oedema 31.03%and 44.82%protection was observed.While in subacute anti-inflammatory models using formaldehyde-induced hind paw oedema(after 1.5 h)13.88%and 33.33%and in chronic anti-inflammatory model using cotton pellet granuloma 7.4%and 17.58%protection from inflammation was observed.N.jatamansi rhizome extract also inhibited the inflammatory mediators(nitric oxide by 12.81%and 38.41%,by prostaglandin E212.58%and 47.82%while by TNF-α13.51%and 41.89%)produced in the pouch.Conclusions:The results of this study strongly indicate the protective effect of N.jatamansi rhizome extract against acute,subacute and chronic models of inflammation,which may be attributed to its anti-inflammatory potential.

蜘蛛香不同提取物抗轮状病毒的作用研究

目的研究蜘蛛香不同提取物抗轮状病毒(Rotavirus,RV)的作用。方法采用RV-Wa株感染MA104细胞模型,MTT染色法测定病毒抑制率,考察蜘蛛香水提物、70%乙醇提取物(ZZX-1)及90%乙醇提取后经大孔吸附树脂法纯化所得提取物(ZZX-2)体外抗RV的作用;采用免疫荧光和实时荧光定量PCR(qRT-PCR)检测RV结构蛋白VP6的表达变化,验证蜘蛛香抗RV作用;采用RV-Wa株感染Caco-2细胞,qRT-PCR检测蜘蛛香对神经营养因子GDNF、紧密连接蛋白ZO-1和促炎因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)]的影响。结果蜘蛛香水提物无抗RV的作用;蜘蛛香醇提物ZZX-1和ZZX-2具有抗RV生物合成作用。免疫荧光和qRT-PCR实验结果表明,ZZX-1和ZZX-2均能够抑制VP6蛋白的合成以及降低VP6 mRNA的表达,抑制RV的合成。与RV组相比,ZZX-1和ZZX-2能够显著提高GDNF、ZO-1 mRNA的相对表达量(P<0.001或0.01),降低TNF-α、IL-1β、IL-6 mRNA的相对表达量(P<0.0001或0.001)。结论蜘蛛香醇提物ZZX-1和ZZX-2具有抗RV生物合成作用,可能通过提高GDNF、ZO-1基因表达,降低炎症因子IL-1β、IL-6、TNF-α的基因表达发挥抗RV感染作用。

Investigation on phytochemical,antimicrobial activity and essential oil constituents of Nardostachys jatamansi DC.in different regions of Nepal

Objective:To study chemical constituents of essential oil of the roots of Nardostachys jatamansi found in different regions of Nepal and also to investigate phytochemical as well as antimicrobial activity of the sample with high yield of essential oil.Methods:The essential oils of roots of plant from five different regions were extracted by hydro-distillation and analyzed by gas chromatography-mass spectroscopy for their chemical constituents.The root samples were also subjected to hydro-alcoholic extraction and then fractionated with hexane,chloroform,n-butanol and water so as to perform phytochemical screening and antimicrobial activity.Results:The essential oil yield of sample from Jumla was found to be the highest followed by a sample from Nepalgunj,Surkhet and Kathmandu whereas that of sample from Dharan was found to be the lowest.Gas chromatography-mass spectrometer analysis of essential oil of five samples showed that“2-beta pinene”appeared dominated in three samples,namely,6VJ Nepalgunj,9VJA Jumla and 10VJ Surkhet.Similarly“alkohol aus neoclovenoxid”in 8VJ Dharan and“methoxy phenyloxime”in 13VJA Kathmandu was found to be present in the highest amount.Phytochemical screening of different fractions of sample 9VJA Jumla showed the presence of alkaloids,terpenoids,glycosides,proteins and amino acids,and carbohydrates etc.Antimicrobial susceptibility test of same fractions showed the n-butanol fraction potent against all pathogens and most affected one was Escherichia coli.Conclusions:Our study suggests that the essential oil of Nardostachys jatamansi found in Nepal contains more than 80 compounds with their quality and quantity differing from place to place.

基于非靶向代谢组学的蜘蛛香不同部位差异代谢物分析

目的:研究蜘蛛香不同部位的代谢物差异,促进蜘蛛香资源的综合利用。方法:利用非靶向代谢组学技术,对蜘蛛香的根茎、根和叶3个部位的代谢物进行差异性比较分析。结果:从蜘蛛香的根茎、根和叶中共鉴定出491个代谢物,主要代谢物有挥发油、多糖、氨基酸等。蜘蛛香根茎、根和叶中的代谢物差异显著,根与叶、根茎与叶、根与根茎之间的差异代谢物分别为145、109、122个,根茎和叶中含莪术烯醇、4-羟基肉桂酸、芥子酸胆碱、5-羟基-1-四氢萘酮、4-乙基苯甲醛、松脂醇4-O-β-D-吡喃葡萄糖苷和5-胸苷酸二钠盐较少,而根中较多;根和根茎中含茶碱、芹菜素和阿尔泊酚酸较少,而叶中较多。根茎、根和叶的差异代谢物主要富集在类苯丙酸生物合成通路,氨酰tRNA生物合成通路和丙氨酸、天冬氨酸与谷氨酸代谢通路。结论:蜘蛛香的根茎、根和叶中含有挥发油、多糖、氨基酸等大量的差异代谢物,研究结果可为蜘蛛香不同部位关键代谢物的挖掘和充分利用提供参考。

不同来源甘松化学成分含量分析与抗氧化活性研究

目的测定不同来源甘松药材挥发油、总黄酮、甘松新酮含量及挥发油体外抗氧化活性,为甘松资源开发利用提供科学依据。方法以水蒸气蒸馏法测定甘松挥发油含量,超声波提取法测定甘松总黄酮含量,高效液相色谱法测定甘松新酮含量,以甘松挥发油对DPPH^(●)、ABTS^(●+)清除能力、总还原能力和铁还原能力评价其体外抗氧化活性。结果在不同来源野生甘松样品中,以G15挥发油含量最高,达8.13%;总黄酮和甘松新酮含量则以G16最高,分别达到20.66 mg/g和2.17%;甘松挥发油对DPPH^(●)、ABTS^(●+)最大清除率分别为48.15%和31.66%,总还原能力吸光度值为0.602 L·g^(-1)·cm^(-1),铁还原能力吸光度值为0.355 L·g^(-1)·cm^(-1)。结论不同来源野生甘松药材中挥发油、甘松新酮含量均符合《中国药典》(2020版)标准,甘松挥发油具有较好的抗氧化能力。

彝族药蜘蛛香的研究进展及质量标志物的预测分析

彝族药蜘蛛香(Valeriana jatamansi Jones)中含有多种化学成分,主要为环烯醚萜类、挥发油类、木脂素类和黄酮类。据现代药学研究表明,蜘蛛香有多种药理作用,如中枢抑制作用、抗菌和抗病毒作用、细胞毒性和抗肿瘤作用等。本文基于中药质量标志物的概念,从蜘蛛香化学成分特有性、传统药效、传统药性、化学成分可测性等几个方面,对蜘蛛香的中药质量标志物成分进行预测分析,以期为蜘蛛香的质量控制和合理应用提供新思路。

甘松化学成分及药理活性研究进展

甘松Nardostachys jatamansi为败酱科甘松属多年生草本植物,广泛分布于喜马拉雅山脉地区,属于高原植物,是藏医特色药材。甘松中主要含有萜类、黄酮类、香豆素类、木脂素类和挥发油类等化学成分,这些成分具有良好的镇静、降压、抗心律失常和抑菌等药理活性。但目前对于甘松的合理有效的开发与利用未形成,而造成了资源的浪费及野生资源的匮乏。对此笔者查阅近十年文献对甘松化学成分、药理活性的研究进展进行综述,以期为甘松进一步研究和合理开发利用提供参考。