JDA软件公司联手全球领先的品牌策划公司Lippincott近日对外公布了JDA最新的品牌徽标,其中包含了全新的公司品牌标语：＂Plan to deliver TM＂。在当今快速变化的零售和制造市场环境下,与最出色的解决方案提供商展开合作、获得持续的竞...JDA软件公司联手全球领先的品牌策划公司Lippincott近日对外公布了JDA最新的品牌徽标,其中包含了全新的公司品牌标语：＂Plan to deliver TM＂。在当今快速变化的零售和制造市场环境下,与最出色的解决方案提供商展开合作、获得持续的竞争优势变得愈发重要。基于这一市场现状,JDA联手Lippincott设计了全新徽标,彰显JDA的市场领导地位。展开更多
JDA软件集团公司近日宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group Sp A）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升...JDA软件集团公司近日宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group Sp A）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升供应链响应性,满足快速变化的产品组合的高度季节性和离散化需求。陆逊梯卡集团是全球领先的高档、奢侈及运动型眼镜的设计、制造和经销商。展开更多
近日,JDA软件集团公司宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group SpA）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升...近日,JDA软件集团公司宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group SpA）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升供应链响应性,满足快速变化的产品组合的高度季节性和离散化需求。陆逊梯卡集团是全球领先的高档、奢侈及运动型眼镜的高度季节性和离散化需求。展开更多
Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently r...Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment.展开更多
文摘JDA软件公司联手全球领先的品牌策划公司Lippincott近日对外公布了JDA最新的品牌徽标,其中包含了全新的公司品牌标语：＂Plan to deliver TM＂。在当今快速变化的零售和制造市场环境下,与最出色的解决方案提供商展开合作、获得持续的竞争优势变得愈发重要。基于这一市场现状,JDA联手Lippincott设计了全新徽标,彰显JDA的市场领导地位。
文摘JDA软件集团公司近日宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group Sp A）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升供应链响应性,满足快速变化的产品组合的高度季节性和离散化需求。陆逊梯卡集团是全球领先的高档、奢侈及运动型眼镜的设计、制造和经销商。
文摘近日,JDA软件集团公司宣布,全球最大的眼镜制造商陆逊梯卡集团（Luxottica Group SpA）选择实施的JDA供应链计划方案正式上线,帮助提升其全球范围的生产与产能管理能力。JDA解决方案将与陆逊梯卡现有的ERP系统进行集成,帮助该公司提升供应链响应性,满足快速变化的产品组合的高度季节性和离散化需求。陆逊梯卡集团是全球领先的高档、奢侈及运动型眼镜的高度季节性和离散化需求。
基金supported by grants from the National Natural Science Foundation of China (Nos. 81773562, 82020108030, and U1904163)National Key Research and Development Project (No. 2018YFE0195100, China)the Science and Technology Program of Henan Province (No. 202102310152, China)。
文摘Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment.
