The Operating Revenue of Jinbo Bio-Pharmaceutical for 2023 Reaching 0.78 Billion yuan

In Mar.20th,2024,Jinbo Bio-Pharmaceutical released the first performance report since it was listed at Beijing Stock Exchange,with many data hitting a record high.The company realized an operating revenue of 0.78 billion yuan,with a year-on-year increase of 99.96%,and hitting a new high for the past five years.The net profit attributable to shareholders was 0.3 billion yuan,with a year-on-year increase of 174.6%.The net profit attributable to shareholders after deducting non recurring gains and losses was 0.286 billion yuan,with a year-on-year increase of 181.02%.

The Translation of Slangs in Two English Versions of Jin Ping Mei

The Chinese classical novel Jin Ping Mei abounds with a large number of slangs,which correspondingly leads to the difficulty of the novel’s English translation and also gives rise to the emergence of diversified English versions.The two English translators,Clement Egerton and David Roy,adopted completely different translation strategies when dealing with Chinese slangs in the novel.Their different translation purposes account for the significant disparity concerning the slang translation.Clement Egerton pays more attention to the novel’s plot in his English version The Golden Lotus,rather than the unique expressions of the original language,so that in the concrete translation process,a domestication strategy is adopted for the sake of the target language readers’understanding,resulting in distortion and omission of the slang expressions in the translated text.By contrast,the translation purpose which guides David Roy’translation The Plum in the Golden Vase is to convey the complexity and literariness of the original Chinese text,and hence the foreignization strategy is employed concerning slang translation,which aims to accurately reproduce the unique expressions of slangs in the original text.Comparatively speaking,David Roy’s translation succeeds in preserving the Chinese slangs to the greatest extent both in form and meaning,and can shed light for the slang translation in other Chinese literary works.

Xi Jinping stresses sci-tech modernization,innovation

A conference conflating the National Science and Technology Conference,the National Science and Technology Award Conference,the 21st General Assembly of Academicians of the Chinese Academy of Sciences,and the 17th General Assembly of Academicians of the Chinese Academy of Engineering,was held at the Great Hall of the People in Beijing on the morning of June 24.Xi Jinping,general secretary of the Communist Party of China (CPC) Central Committee,Chinese president,and chairman of the Central Military Commission,attended the conference,presented medals and certificates for China's top science and technology award to laureates and delivered an important speech.

A Study of the Treatment of Disfiguring Diseases in the “Qian Jin Fang”

Traditional Chinese medicine(TCM)has been passed down for more than 2,000 years.TCM beauty products driven by the principles of identification and treatment with various dosage forms and exhibit mild and safe efficacy are bound to become a main component of the beauty industry in the future.Xu once commented that“Qian Jin Fang”is different from the traditional prescription system,which emphasizes the use of medicines.In this paper,we mainly selected the prescriptions for the treatment of disfigurement diseases such as acne,scarring,black dryness,face hyperpigmentation,black mole,and rosacea from the article titled,“Upper Seven Orifices Disease-Facial Medicine IX”in the Bei Ji Qian Jin Yao Fang[1].By studying and analyzing the original composition of the formula,understanding the etiology and pathogenesis of the disease,and exploring the characteristics of the formula concerning the efficacy of TCM,their properties,flavors,and meridians,we summarized the characteristics of the Qian Jin Fang.It is based on the external treatment of disfigurement diseases,with a wide variety of drugs,flexibility,and accuracy.This method draws upon analogies while utilizing excipients and harmonizers to focus on the combined healing approach of treatment and nourishment.

The revenue of Jinbo Bio-pharmaceutical for the first three quarters of 2023 reaching the highest value of the past five years

On Oct.26th,2023,Shanxi Jinbo Bio-pharmaceutical Co.,Ltd(Stock Code:832982,hereafter referred to as Jinbo Bio-pharmaceutical)released the financial report for the third quarter of 2023 at Beijing Stock Exchange.According to the financial report,the revenue of Jinbo Bio-pharmaceutical for the third quarter was 0.201 billion yuan,with a year-on-year increase of 106.43%。

Full Text:2023 New Year Address by President Xi Jinping

BEIJING-On New Year’s eve,President Xi Jinping delivered his 2023 New Year Address through China Media Group and the Internet.The following is the full text of the address:Greetings to you all.The year 2023 is approaching.From Beijing,I extend my best New Year wishes to all of you.

鸡传染性支气管炎病毒Jin13株的分离与鉴定

为了对近年从郑州郊区鸡群中分离到的1株传染性支气管炎病毒(Jin13株)进行定型鉴定,作者采用气管环(TOC)中和试验、血凝抑制(HI)试验、单抗交叉ELISA、序列分析和免疫试验对其进行了研究。气管环(TOC)中和试验和血凝抑制(HI)试验表明Jin13病毒只与M41阳性血清反应,而与其它ND、EDS76、H9AI、IBD标准阳性血清不发生反应,序列分析证实该分离毒Jin13株是IBV。在交叉气管环(TOC)中和试验和交叉血凝抑制(HI)试验中Jin13株与肾变型Y株不交叉(R≤0.25),而与马萨株血清型的M41株和H52株有明显交叉(0.25≤R≤0.8);单抗交叉ELISA结果显示Jin13株与针对M41株的J1单抗有很好的反应(≥640～1 280),而与针对肾变型Y株的单抗C2几乎不反应(≤40),这进一步证实了Jin13与呼吸型M41株、H52株属同一血清型。与M41株相比较,Jin13株S1氨基酸序列在第126,386,390,461位出现了突变,又在S1基因第1 166位出现一个新Aiu I酶切位点,是M41株的一个变异株。对Jin13株纯化后原代毒进行免疫效力检测证实其免疫原性优于M41株和H52株。Jin13毒株是一株免疫原性良好的IBV地方流行毒株。

JiniSolve:一种基于Jini的元计算架构的基本体系结构及其初步应用

随着不同种类体系结构高性能计算机系统的不断出现和网络技术的迅猛发展,人们越来越希望能够打破平台和地域的限制,共享分布在广域网上的各种高性能计算机的计算能力。但广域网络分布式计算平台的异构性和资源组织协调的复杂性一直困扰着这方面工作的发展。作者从Java字节码的平台无关性和Jini架构的网络资源运行时动态自组织能力中得到启发,提出了JiniSolve网络异构平台分布式计算架构(一种元计算架构),以克服这两个障碍。JiniSolve架构能够支持所有三种网络分布式计算的模式———远程计算、MobileAgent计算和代码下载计算,其中对MobileAgent计算的支持是以往类似元计算架构所不能做到的。同时,JiniSolve架构又具有运行时动态异步自组织能力,从而使整个系统具有更高的可适应性,可用性,可靠性和易用性。文章将介绍JiniSolve架构的基本体系结构,分析其优点并给出一个实验性的应用举例。

Application of Grey Relational Analysis in Regional Water Environment Assessment——Taking Jin River Basin as An Example

According to the data from four water monitoring stations at Meihewan, Shimawan, Tanwan and Jinbin, the water environment at the downstream basin of Jin River was evaluated through grey reIational analysis in this study. The resuIts showed that the water environment was severeIy contaminated by phosphorus, am-monia nitrogen and permanganate.

Jin-Xin模型初边值问题整体光滑解的存在性

运用特征线法和一阶拟线性双曲系统极大值原理 ,在松弛时间ε充分小的条件下 ,对初值不做任何小性假设 ,得到解的先验估计 ,证明了 Jin- Xin模型初边值问题整体光滑解的存在性 .

Re-analysis on Heidan Disease (Black Jaundice) in Synopsis of Golden Chamber (Jin Gui Yao Lue)

Heidan disease(black jaundice)is a kind of jaundice,which is caused by lingering and chronic jaundice,often with blood stasis and damp-heat,etc.The clinical symptoms of Heidan disease(black jaundice)are similar to those of cirrhosis caused by multiple chronic liver diseases in Western medicine.Heidan disease(black jaundice)generally belongs to yin jaundice type,and the pathogenesis is mostly related to blood stasis and dampness stagnation,often with damp-heat residue.According to Zhongjing Zhang,the prescription Xiaoshi Fanshi powder for the treatment of Heidan disease(black jaundice)is based on the understanding that the nature of Heidan disease(black jaundice)is inseparable from the two key pathological factors of dampness and blood stasis.The treatment of jaundice should be based on removing blood stasis and dampness,supplemented by soothing the liver and promoting the transportation function of spleen,removing blood stasis and harmonizing the collaterals,and promoting diuresis and reducing jaundice.In the treatment of jaundice,removing blood stasis and purging turbidity should be stressed,and powerful tonification should be used with caution.Since blood stasis and turbidity are always intermingling and often complicated with damp heat,the method of warm drying should be used with caution.For promoting blood circulation,removing blood stasis,and dredging the liver-biliarycollaterals,drasticmedicine shouldbeused withcaution.

Different Voice --On Wang Suo Challenging Jin Yong

Wang Suo’s criticism on Jin Yong’s novels has attracted himself more criticism,for Jin Yong is much worshipped.However,different voice calls on us to reflect on our tolerance on divergence, which sometimes is more valusble than conformith.

Discovery of Jinning Cycle Magmatism in Eastern Part of Eastern Kunlun Orogenic Belt and Its Significance

From the isotopic dating study of gneissic granodiorite, the authors discovered magmatism of the Jinning cycle. Intrusive rocks were formed in the Neoproterozoic, whose Pb Pb ages range from (913±4) Ma to (1 011±4) Ma and U Pb concordia age is (703±15) Ma. The tectonic settings of the rocks are volcanic arc or syn collision. After the formation of the intrusive rocks, these rocks also experienced reconstruction of Caledonian metamorphism. Based on the Ar Ar dating of metamorphic mineral of muscovite, the metamorphic time is determined to range from (386.8±0.8) Ma to (389.44±3.70) Ma.

Case-control study on regular Ba Duan Jin practice for patients with chronic neck pain

Purpose:To observe the long-term effects of regular Ba Duan Jin exercises for patients with chronic neck pain.Methods:Participants with chronic neck pain were instructed to perform
30 min/d of Ba Duan Jin exercises(n?36)or assigned to a control group(n?36)for six months.Data from a visual analogue scale,Northwick Park Neck Pain Questionnaire,and the 36-item Shortform Health Survey(SF-36)were collected before,and three and six months after intervention began.Results:Participants undergoing Ba Duan Jin exercises achieved significantly greater improvement than the controls in visual analogue scale,Northwick Park Neck Pain Questionnaire and SF-36 health transition scores(all p<0.05).However,no significant differences were observed in SF-36 physical or mental component summaries.Conclusion:Regular Ba Duan Jin practice reduces suffering and pain,and increases health satisfaction in individuals with chronic neck pain.

Compound Chai Jin Jie Yu Tablets,Acts as An Antidepressant by Promoting Synaptic Function in the Hippocampal Neurons

Objective To investigate the effectiveness of compound Chai Jin Jie Yu Tablets(CJJYT)in ameliorating cognitive impairment associated with depression and its potential mechanism of action.Methods In vitro experiments,the hippocampus was isolated from the whole brain of the fetal rat and cultured into hippocampal neuron cells.50μM corticosterone(CORT)was added to each group 18 h before the experiment for modeling depression,with the exception of the control group.After modeling,the blank serum group was added with 10%blank serum,the CJJYT group and the venlafaxine group were added with the corresponding 10%drug-containing serum,and the control group and the model group were added with equal volumes of culture medium.The intracellular Ca^2+mean fluorescence intensity,miniature excitatory postsynaptic current(mEPSC)current amplitude,and frequency of different hippocampal neurons were evaluated as indicators of synaptic function in the hippocampal neurons.In addition,the expression of synaptic plasticity related proteins,synaptophysin-α(SYN-α),N-methyl-D-aspartate receptor 2A(NR2A),N-methyl-Daspartate receptor 2B(NR2B),post synaptic density 95 protein(PSD-95),calcium/calmodulin dependent protein kinaseⅡ(CaMKⅡ)and synaptic associated protein(SynGAP)were detected in the hippocampal neurons by immunofluorescence staining and high content analysis(HCA)system.Then,reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the mRNA expression levels of SYN-α,NR2A,NR2B,PSD-95,CaMKⅡand SynGAP.For in vivo experiments,except for those in the blank control group,all rats were treated within a single cage for chronic unpredictable stress-induced depression modeling and subjected to corresponding drug interventions.Behavioral tests were used to detect depressive behavior and determine learning,memory and other cognitive abilities,whereas enzyme-linked immunosorbent assay(ELISA)was used to detect the CORT levels.Golgi-Cox staining was used to observe changes in the synaptic morphology of parahippocampal gyrus CA1 area(CA1)and dentategyrus(DG).Results In vitro,CJJYT treatment reduced the intracellular Ca^2+mean flurorescence intensity in the hippocampal neurons(P<0.05),causing a reduction in the frequency and current amplitude of mEPSC(P<0.05),and thus inhibited the excessive activation of post-synaptic receptors.CJJYT treatment reduced the protein and mRNA expression of SYN-α,NR2A,NR2B and PSD-95 in the hippocampal neurons(P<0.05),increased the mRNA and protein expression of CaMKⅡand SynGAP(P<0.05),and thereby improved the synaptic plasticity of the hippocampal neurons.In vivo,CJJYT intervention improved sucrose preference,voluntary activity,learning and memory ability of Morris water maze test,and suppressed appetite(P<0.05),and increased the despair feeling of forced swimming test(P<0.05).The CORT level was reduced(P<0.05),leading to the repair of synaptic damage in the hippocampal neurons.Conclusions CJJYT can improve the synaptic function of hippocampal neurons and has obvious protective effects on neurons.It can repair the structural damage in the hippocampal neurons,improving the cognitive ability of the depressed model rats.The mechanism of CJJYT improving cognition in depressed rats may be related to the transmission and function of SYN-α/NR and its downstream neurotransmitters.

Quality Analysis and High-Performance Liquid Chromatographic Fingerprint Analysis of New Cultivated Kind of <i>Lonicerae japonicae</i>Flos “Hua Jin 6” from Different Harvest Times

Lonicerae japonicaeFlos (LJF) is widely used in traditional Chinese medicines for the treatment of various diseases, which is now in great demand every year and has a broad development prospect. However, the flowering phase of common LJF varieties is so short, which seriously restricts the development of LJF industry. As a new cultivated kind of Lonicerae japonicae Flos, “Hua Jin 6” has characteristics in long flowering phase and conveniently picking, which makes it have a broad development prospect. The aim of this study is to provide scientific guidance for its suitable harvest period by measuring yield and quality of “Hua Jin 6” from different harvest time. Studies show that flower size had a slowly rising trend from the first day to the seventh day, and then slowly declined or kept stable. There were no significant differences of total phenolic acid contents in different samples from different days, but contents of total flavonoids were on the rise and up to maximum in the ninth day. The contents of total iridoids had an increasing tendency from the first day to the fifth day and then kept relatively stable in other days. We demonstrated that the quality of “Hua Jin 6” is relatively stable and suitable for harvesting in all flower buds white stage in term of HPLC fingerprints. Our findings can make it possible to select the suitable time for different harvest purpose.

The characteristics and correlative research of“Jin Shang”associated with chronic neck pain in young adults based on ultrasound imaging

Objective:To investigate the characteristics of'Jin Shang',a specialized term in traditional Chinese medicine(TCM)theory,in young adults with chronic neck pain(CNP)and investigated the correlation of'Jin Shang'with pain intensity and living disabilities using cross-section study.Methods:The thickness of the bilateral splenius capitis and semispinalis capitis were measured by ultrasound imaging(USI)as the objective performance of'Jin Shang'.The visual analogue scale(VAS)and Northwick Park Questionnaire(NPQ)were used to assess pain intensity and living disability.The Student's t test was used to investigate the difference in neck extensor muscle(NEM)thickness between CNP patients and healthy controls.Pearson's correlation and multiple linear regression were applied to investigate the relationship between NEM thickness,pain intensity and disability.Results:Fifty-nine young adult CNP patients and 16 healthy controls were recruited in this study,in accordance with specific inclusion and exclusion criteria.The student's t test showed that in CNP patients,the thickness of the semispinalis capitis during isometric contraction was significantly thinner than that of healthy controls(P=.04).Pearson's correlation analysis also revealed significant relationships between NEM thickness,VAS,and NPQ,while multiple linear regression showed that the thickness of the NEM in CNP patients was a significant predictor of pain intensity and disability.Conclusion:There was a significant difference in the thickness of the NEM in young adults with CNP when compared to healthy controls.Alterations in the NEM thickness in both rest and contraction are moderately related to neck pain and living disabilities.Our results investigated the characteristics of'Jin Shang'using USI and revealed a correlation between'Jin Shang'and CNP symptoms,which demonstrates that NEM plays an important role in CNP.

Protective Effects of Jin Bai Mei Yan Prescription on Oxidative Damage and Photoaging Induced by Ultraviolet B in HaCaT Cells

Objective Ultraviolet B(UVB)mainly acts on the skin epidermis,causing oxidative damage and apoptosis of keratinocytes.Jin Bai Mei Yan Prescription(JBMYP)comprises a variety of antioxidant traditional Chinese medicines(TCM).In this study,we aimed to evaluate the effects of JBMYP on the oxidative damage induced by UVB in human immortalized epidermal keratinocytes(HaCaT)cells.Methods HaCaT cells were divided into six groups:control group,model(UVB)group,positive(UVB+vitamin E)group,UVB+JBMYP low dose group(160μg/mL),UVB+JBMYP moderate dose group(800μg/mL),and UVB+JBMYP high dose group(1600μg/mL).HaCaT cells were irradiated with UVB and treated with JBMYP for 24 h.Methyl thiazolyl tetrazolium(MTT)assay and real-time unlabeled cell function analyzer were used to assess the cell survival and proliferation rates,respectively.At the same time,the levels of intracellular reactive oxygen species(ROS),lipid peroxide malondialdehyde(MDA),glutathione(GSH),and hydroxyproline(HYP),as well as the activities of antioxidant enzyme superoxide dismutase(SOD)and catalase(CAT)were evaluated using enzyme linked immunosorbent assay(ELISA).Results Compared with the model group,the survival rate of HaCaT cells in each dosage group of JBMYP was significantly improved(P<0.05).Further,JBMYP could promote the proliferation of HaCaT cells,leading to a reduction in the contents of MDA and ROS,and increase in the contents of SOD,CAT,GSH and HYP in HaCaT cells.Conclusions JBMYP has enhanced protective effect on oxidative damage induced by UVB in HaCaT cells.

Simultaneous quantification of five major active components in capsules of the traditional Chinese medicine 'Shu-Jin-Zhi-Tong' by high performance liquid chromatography

A simple and reliable high performance liquid chromatography （HPLC） method has been developed for the simultaneous quantification of five major bioactive components in ＇Shu-Jin- Zhi-Tong＇ capsules （SJZTC）, for the purposes of quality control of this commonly prescribed traditional Chinese medicine. Under the optimum conditions, excellent separation was achieved, and the assay was fully validated in terms of linearity, precision, repeatability, stability and accuracy. The validated method was applied successfully to the determination of the five compounds in SJZTC samples from different production batches. The HPLC method can be used as a valid analytical method to evaluate the intrinsic quality of SJZTC.

Detection of Berberine Hydrochloride in Jin Weng Zhili Particle Using TLC and HPLC

[Objectives]To screen optimum conditions of HPLC and TLC for qualitative discrimination of berberine hydrochloride contained in Jin Weng Zhili Particle,thus providing basis for quality standard. [Methods]According to the method described in Chinese Veterinary Pharmacopoeia,thin layer chromatography and high performance liquid chromatography were used respectively for qualitative and quantitative identification of berberine hydrochloride contained in Jin Weng Zhili Particle by improving the conditions of extraction and purification. [Results]After optimizing TLC conditions of Jin Weng Zhili Particle,the separation effect of TLC of test samples was favorable. The spot color was clear,reproducibility was good,and precision was high. Under the conditions of mobile phase constituted by acetonitrile-water-glacial acetic acid-triethylamine( 28∶ 70∶ 1∶ 1),detection wavelength of 265 nm,flow rate of 1. 0 m L min^(-1)and column temperature of 35℃,the resolution of berberine hydrochloride was good; the injection volume in the range of 3. 15-50 μg· m L^(-1)had good linear relationship with the peak area( R^2= 0. 998); the average sample recovery rate(n=6) was 5. 672%,and RSD was 0. 864%; the content of berberine hydrochloride contained in Jin Weng Zhili Particle was 4. 023 mg. [Conclusions]The method was of good feasibility,reproducibility and specificity,and could be used for qualitative and quantitative detection of berberine hydrochloride contained in Jin Weng Zhili Particle.