丝裂原活化的蛋白激酶（mitogen—activated protein kinase，MAPK）是一组可被多种信号激活的丝／苏氨酸激酶。经双重磷酸化激活后可参与细胞的多种生物活性，如调节基因转录，诱导细胞凋亡、调节细胞周期等。而MAPK对细胞凋亡的诱导...丝裂原活化的蛋白激酶（mitogen—activated protein kinase，MAPK）是一组可被多种信号激活的丝／苏氨酸激酶。经双重磷酸化激活后可参与细胞的多种生物活性，如调节基因转录，诱导细胞凋亡、调节细胞周期等。而MAPK对细胞凋亡的诱导作用，是近年来研究的重点，尤其是对肿瘤细胞凋亡的诱导作用，更是人们关注的焦点。现已发现p38，ERK5，ERK以及JNK4个亚族。其中ERK，JNK，p38MAPK三条通路与肿瘤细胞凋亡关系密切。细胞凋亡是在特定时空发生的、受机体严密调控的细胞“自杀”现象。在肿瘤细胞中，活化的p38可增强c—myc表达、磷酸化p53、参与Fas／Fasl介导的凋亡；可增强TNF-α表达；作用于Caspase家族的上游而诱导肿瘤细胞凋亡。某些作用丁p38通路的化疗药物，也是通过诱导凋亡，产生抗肿瘤作用。JNK信号转导通路参与多种凋亡反应，现阶段研究表明，JNK通路介导肿瘤细胞凋亡的机制是通过磷酸化Bcl-2和Bcl-xL，促进线粒体释放细胞色素C，进而激活Caspase级联反应，最终作用于Caspase-3，导致细胞凋亡。展开更多
The c-Jun N-terminal kinases （JNKs） are important regulators of a variety of physiological and pathological processes both in the central and in the peripheral nervous systems. JNKs are considered as crucial mediato...The c-Jun N-terminal kinases （JNKs） are important regulators of a variety of physiological and pathological processes both in the central and in the peripheral nervous systems. JNKs are considered as crucial mediators of neuronal cell death in response to stress and injury. However, recent studies have provided substantial evidence that the JNK pathway plays an important role in neuronal migration. Here, we will give a brief introduction of the JNK signaling pathway and put more emphasis on its role in nettronal migration.展开更多
文摘丝裂原活化的蛋白激酶（mitogen—activated protein kinase，MAPK）是一组可被多种信号激活的丝／苏氨酸激酶。经双重磷酸化激活后可参与细胞的多种生物活性，如调节基因转录，诱导细胞凋亡、调节细胞周期等。而MAPK对细胞凋亡的诱导作用，是近年来研究的重点，尤其是对肿瘤细胞凋亡的诱导作用，更是人们关注的焦点。现已发现p38，ERK5，ERK以及JNK4个亚族。其中ERK，JNK，p38MAPK三条通路与肿瘤细胞凋亡关系密切。细胞凋亡是在特定时空发生的、受机体严密调控的细胞“自杀”现象。在肿瘤细胞中，活化的p38可增强c—myc表达、磷酸化p53、参与Fas／Fasl介导的凋亡；可增强TNF-α表达；作用于Caspase家族的上游而诱导肿瘤细胞凋亡。某些作用丁p38通路的化疗药物，也是通过诱导凋亡，产生抗肿瘤作用。JNK信号转导通路参与多种凋亡反应，现阶段研究表明，JNK通路介导肿瘤细胞凋亡的机制是通过磷酸化Bcl-2和Bcl-xL，促进线粒体释放细胞色素C，进而激活Caspase级联反应，最终作用于Caspase-3，导致细胞凋亡。
基金This work was supported in part by the National Natural Sciences Foundation of China (No.30530660)the Chinese Academy of Sciences Knowledge Innovation Program (No.KSCX1-YW-R-62)the National Basic Research of China (No.2006CB504100 and No. 2006CB500701).
文摘The c-Jun N-terminal kinases （JNKs） are important regulators of a variety of physiological and pathological processes both in the central and in the peripheral nervous systems. JNKs are considered as crucial mediators of neuronal cell death in response to stress and injury. However, recent studies have provided substantial evidence that the JNK pathway plays an important role in neuronal migration. Here, we will give a brief introduction of the JNK signaling pathway and put more emphasis on its role in nettronal migration.
