Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
为了简化医院发票报销流程,提高财务管理效率,基于J2EE平台和改进ResNet模型构建医院智能化财务报销管理系统。系统在HTML、Java、JDBC、SQL Server 2019技术支持下,划分为3个技术层和5个功能模块。针对不同类型发票的报销问题,提出改进...为了简化医院发票报销流程,提高财务管理效率,基于J2EE平台和改进ResNet模型构建医院智能化财务报销管理系统。系统在HTML、Java、JDBC、SQL Server 2019技术支持下,划分为3个技术层和5个功能模块。针对不同类型发票的报销问题,提出改进ResNet模型对发票进行分类识别,从而解决传统卷积神经网络存在过度拟合的缺陷。通过对比各种模型的使用效果,改进ResNet模型参数少,识别准确率更高,在训练时间和测试时间上也相对较少。对系统进行高并发访问情况下的性能检测,结果表明,系统在100人、点击率800次/s的高并发应用情况下,平均响应时间能保持在35 s左右,稳定性较好,可在实际工作中予以应用。展开更多
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
文摘为了简化医院发票报销流程,提高财务管理效率,基于J2EE平台和改进ResNet模型构建医院智能化财务报销管理系统。系统在HTML、Java、JDBC、SQL Server 2019技术支持下,划分为3个技术层和5个功能模块。针对不同类型发票的报销问题,提出改进ResNet模型对发票进行分类识别,从而解决传统卷积神经网络存在过度拟合的缺陷。通过对比各种模型的使用效果,改进ResNet模型参数少,识别准确率更高,在训练时间和测试时间上也相对较少。对系统进行高并发访问情况下的性能检测,结果表明,系统在100人、点击率800次/s的高并发应用情况下,平均响应时间能保持在35 s左右,稳定性较好,可在实际工作中予以应用。
