Objective:To observe the clinical effect of Jianpi Liqi Decoction on diabetic gastroparesis.Methods:80 patients were randomly divided into 2 groups,Treatment and control groups,40 cases per group,The treatment group u...Objective:To observe the clinical effect of Jianpi Liqi Decoction on diabetic gastroparesis.Methods:80 patients were randomly divided into 2 groups,Treatment and control groups,40 cases per group,The treatment group used Jianpi Liqi recipe,One dose a day,Take it twice,Six times a week,For 4 weeks;Control group with mosapride citrate,5 mg,each Three times a day,Take continuously for 4 weeks.Observe the two groups before treatment,2 weeks after treatment,4 weeks after treatment,Subjective symptoms(early satiety,abdominal distention,upper abdomen burning,upper abdomen pain)score;Before and after treatment,The contents of FBG,2 hPG,HbA1c,TC,GAS,MLT in the two groups.Results:The scores of early satiety,abdominal distention,burning sensation of upper abdomen and pain of upper abdomen were decreased,Intra-group comparisons,Differences were statistically significant(P<0.05);After treatment,the gastric emptying rate increased in both groups,A more significant increase in the treatment group(P<0.05);Treatment group after treatment TC,TG,LDL-C decreased more significantly(P<0.05);After treatment,the GAS,MLT content of both groups increased significantly,Intergroup comparisons,and the difference was statistically significant(P<0.05).Conclusion:Jianpi Liqi Decoction is effective in treating Diabetic gastroparesis,High security,it is worth clinical use.展开更多
Objective： To study the intervention effects of Jianpi Liqi Huoxue Decoction （健脾理气活血汤, JLHD） on lipid peroxidative liver injury induced by alcohol. Methods： The rat alcoholic model of liver disease （ALD） ...Objective： To study the intervention effects of Jianpi Liqi Huoxue Decoction （健脾理气活血汤, JLHD） on lipid peroxidative liver injury induced by alcohol. Methods： The rat alcoholic model of liver disease （ALD） induced by Lieber-DeCarli liquid diet was established. Thirty-two male SD rats were randomly divided into 4 groups ： the normal group （ n = 5）, the control group （ n = 9）, the model group （ n = 9） and the JLHD group （ n =9）. From the 4th week after modeling, the rats were given JLHD or distilled water by gastrogavage respectively, and the samples of blood and liver tissues were taken out from the rats for determination by the end of the 8th week. The hepatic pathological changes were observed with HE staining; the liver injury related indices, including activity of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in serum, γ-glutamyl transpeptidase （γ-GT） activity and triglyceride （TG） content in liver tissues, as well as the lipid peroxidation related indices, including malonaldehyde （MDA） content and nitric oxide synthase （NOS） activity in liver tissue, serum Fe^2＋ level, and the anti-peroxidation capacity related indices, including superoxide dismutase （SOD） activity, glutathion （GSH） content and reactive oxygen species （anti- ROS） activity in liver tissues were determined. Results： （ 1 ） There were obvious figures of fatty degeneration and inflammatory infiltration in liver tissues of the model group. As compared with the control group, in the model group, the activity of ALT and AST, and Fe^2＋ content in serum, γ-GT and NOS activity, TG and MDA content in liver tissues were significantly higher （ P〈0. 01 ）, while the activity of SOD, GSH and anti-ROS in liver tissues were significantly lower （P〈0.01）. （2） The fatty degeneration and inflammatory infiltration of liver tissues in the JLHD group were significantly lessen as compared with those in the model group; and the abnormalities of all the indexes revealed in the model rats were restored to certain extent in the JLHD group, and especially significant were the levels of ALT activity, MDA content and Fe^2＋ , which were nearly normal. Conclusion： JLHD has significant effects against alcoholic liver injury, the acting mechanism of which is likely to be related with its anti-lipid peroxidative effect.展开更多
[目的]观察仁术健脾理气颗粒对阿托品致胃肠动力障碍大鼠胃肠运动的影响。[方法]SD大鼠72只,随机分为正常组、模型组、仁术健脾理气颗粒高、中、低剂量组、吗丁啉组,每组各12只。各组大鼠予生理盐水或相应剂量药物10 m L/kg灌胃,持续5 ...[目的]观察仁术健脾理气颗粒对阿托品致胃肠动力障碍大鼠胃肠运动的影响。[方法]SD大鼠72只,随机分为正常组、模型组、仁术健脾理气颗粒高、中、低剂量组、吗丁啉组,每组各12只。各组大鼠予生理盐水或相应剂量药物10 m L/kg灌胃,持续5 d。末次给药20 min后正常组大鼠予腹腔注射生理盐水,其余各组均予腹腔注射硫酸阿托品注射液(2 mg/kg),20 min后以半固体营养糊灌胃法检测各组大鼠胃残留率和小肠推进率。[结果]与模型组相比,仁术健脾理气颗粒各剂量组和吗丁啉组胃残留率均显著降低(P<0.05,P<0.01),小肠推进率显著升高(P<0.01)。[结论]仁术健脾理气颗粒可改善胃肠动力障碍大鼠胃肠运动功能。展开更多
基金National natural science foundation of China(No.81704178)。
文摘Objective:To observe the clinical effect of Jianpi Liqi Decoction on diabetic gastroparesis.Methods:80 patients were randomly divided into 2 groups,Treatment and control groups,40 cases per group,The treatment group used Jianpi Liqi recipe,One dose a day,Take it twice,Six times a week,For 4 weeks;Control group with mosapride citrate,5 mg,each Three times a day,Take continuously for 4 weeks.Observe the two groups before treatment,2 weeks after treatment,4 weeks after treatment,Subjective symptoms(early satiety,abdominal distention,upper abdomen burning,upper abdomen pain)score;Before and after treatment,The contents of FBG,2 hPG,HbA1c,TC,GAS,MLT in the two groups.Results:The scores of early satiety,abdominal distention,burning sensation of upper abdomen and pain of upper abdomen were decreased,Intra-group comparisons,Differences were statistically significant(P<0.05);After treatment,the gastric emptying rate increased in both groups,A more significant increase in the treatment group(P<0.05);Treatment group after treatment TC,TG,LDL-C decreased more significantly(P<0.05);After treatment,the GAS,MLT content of both groups increased significantly,Intergroup comparisons,and the difference was statistically significant(P<0.05).Conclusion:Jianpi Liqi Decoction is effective in treating Diabetic gastroparesis,High security,it is worth clinical use.
基金Supported by the National Natural Science Foundation of China (No.30371818) and Project of Key Subject Construction of Shanghai (Y0302)
文摘Objective： To study the intervention effects of Jianpi Liqi Huoxue Decoction （健脾理气活血汤, JLHD） on lipid peroxidative liver injury induced by alcohol. Methods： The rat alcoholic model of liver disease （ALD） induced by Lieber-DeCarli liquid diet was established. Thirty-two male SD rats were randomly divided into 4 groups ： the normal group （ n = 5）, the control group （ n = 9）, the model group （ n = 9） and the JLHD group （ n =9）. From the 4th week after modeling, the rats were given JLHD or distilled water by gastrogavage respectively, and the samples of blood and liver tissues were taken out from the rats for determination by the end of the 8th week. The hepatic pathological changes were observed with HE staining; the liver injury related indices, including activity of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in serum, γ-glutamyl transpeptidase （γ-GT） activity and triglyceride （TG） content in liver tissues, as well as the lipid peroxidation related indices, including malonaldehyde （MDA） content and nitric oxide synthase （NOS） activity in liver tissue, serum Fe^2＋ level, and the anti-peroxidation capacity related indices, including superoxide dismutase （SOD） activity, glutathion （GSH） content and reactive oxygen species （anti- ROS） activity in liver tissues were determined. Results： （ 1 ） There were obvious figures of fatty degeneration and inflammatory infiltration in liver tissues of the model group. As compared with the control group, in the model group, the activity of ALT and AST, and Fe^2＋ content in serum, γ-GT and NOS activity, TG and MDA content in liver tissues were significantly higher （ P〈0. 01 ）, while the activity of SOD, GSH and anti-ROS in liver tissues were significantly lower （P〈0.01）. （2） The fatty degeneration and inflammatory infiltration of liver tissues in the JLHD group were significantly lessen as compared with those in the model group; and the abnormalities of all the indexes revealed in the model rats were restored to certain extent in the JLHD group, and especially significant were the levels of ALT activity, MDA content and Fe^2＋ , which were nearly normal. Conclusion： JLHD has significant effects against alcoholic liver injury, the acting mechanism of which is likely to be related with its anti-lipid peroxidative effect.
