Objective： To evaluate the effects of Jiashen Prescription （加参方, JSP） on myocardial infarction （MI） size and cardiac function at the early stage of MI in rats. Methods： One hundred male Sprague-Dawley rats we...Objective： To evaluate the effects of Jiashen Prescription （加参方, JSP） on myocardial infarction （MI） size and cardiac function at the early stage of MI in rats. Methods： One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/（kg.d）, or Iosartan 10 mg/（kg.d） for 1 week. Results： Compared with the vehicle-treated MI rats, 6 g/（kg-d） 3SP reduced MI size 3 days after MI （P〈0.05）, and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI （P〈0.05）. In addition, 6 g/（kg·d） JSP and Iosartan were equally effective in reducing MI size and enhancing cardiac functional recovery. Conclusion： JSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.展开更多
基金Supported by National Natural Science Foundation of China(No.81173410)
文摘Objective： To evaluate the effects of Jiashen Prescription （加参方, JSP） on myocardial infarction （MI） size and cardiac function at the early stage of MI in rats. Methods： One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/（kg.d）, or Iosartan 10 mg/（kg.d） for 1 week. Results： Compared with the vehicle-treated MI rats, 6 g/（kg-d） 3SP reduced MI size 3 days after MI （P〈0.05）, and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI （P〈0.05）. In addition, 6 g/（kg·d） JSP and Iosartan were equally effective in reducing MI size and enhancing cardiac functional recovery. Conclusion： JSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.
