Acute Toxicity of Jinchuan Formula Plum Wine Extract and Its Protective Effect on Mice with Liver Injury

[Objectives]To investigate the acute toxicity and hepatoprotective effect of Jinchuan formula plum wine extract on mice,determine its safety range,and evaluate its hepatoprotective effect.[Methods]The median lethal dose(LD_(50))was determined by acute toxicity test with the toxic reaction and mortality of mice as indexes.Sixty Kunming mice were randomly divided into 6 groups:normal control group,model group(ConA-induced liver injury model),Jinchuan formula plum wine high,medium and low dose groups(1.0,0.5,0.25 g/kg)and silybin group(0.1 g/kg).The levels of ALT,AST,LDH in serum and TG,VLDL in liver were measured.After HE staining,the pathological changes of liver tissue in mice were observed,and the liver protective effect of Jinchuan formula plum wine extract was analyzed and evaluated.[Results]LD_(50)was 11.18 g/kg,and the 95%confidence limit of LD_(50)was 10.31-12.05 g/kg.The high-dose group of Jinchuan formula plum wine extract could significantly reduce the serum ALT and AST activities of ConA-induced liver injury mice(P<0.05).[Conclusions]Jinchuan formula plum wine extract is relatively safe,and also has a protective effect on liver injury.

Stress Measurement with an Improved Hollow Inclusion Technique In Jinchuan Nickel Mine

Borehole overcoring stress measurement with an improved hollow inclusion technique was carried out at 10 points on 3 levels in Jinchuan nickel mine which is situated in north-west of China. Through the measurement, 3-D in situ stress state at the measuring points and distribution characteristics of the stress field in the mine were obtained. The stress state in Jinchuan mine is dominated by the horizontal tectonic stress field. The maximum principal stress is horizontal which is about twice the weight of the overburden and its orientation is approximately vertical to the regional tectonic line. The difference between two horizontal principal stresses is quite large which is an important reason to cause failure of underground excavations.

Feasibility Study on Continuous Mining Method in Deep Position of Jinchuan Nickel Mine, China

Jinchuan nickel mine is the largest nickel mine in China. Cut-and-fill mining method with high density cementing materials is used in the mine. The original mining design divided the mining operation into two steps. The first step stopped the mining rooms and the second step stopped the pillars. Because the two-step method made big trouble for finally mining pillars and strongly limited the mining speed and production, it was successfully changed to a continuous cut-and-fill method without pillars. However, the mining operation in the mine has been down to 800 m and the mining condition is getting worse and more complicated. Through systematical field investigations and 3-D FEM analysis, it is proved that the mining method without pillars is feasible for mining deeper orebodies in Jinchuan nickel mine.

Exhumation and Preservation of the Jinchuan Ni-Cu-PGE Deposit under the East Longshou Mountain Thermal Evolution,Revealed by Apatite Fission Track Thermochronology

Uplift and exhumation are important factors affecting the preservation of deposits.The anatomy of uplift-cooling evolution and exhumation in the East Longshou Mountain is of significant research value in understanding changes in the Jinchuan Ni-Cu-PGE deposit since its formation.This study uses apatite fission track(AFT)thermochronology to reconstruct the thermal history of the East Longshou Mountain,including the Jinchuan mine,revealing the uplift and exhumation history of the East Longshou Mountain and elucidating the preservation status of the Jinchuan deposit.The AFT ages in the East Longshou Mountain are distributed from 62.3±3.0 Ma to 214.7±14 Ma,with significant differences in ages in distinct areas,the central and pooled ages being consistent within the margin of error.Inverse thermal history models reveal two rapid cooling events associated with exhumation from the Early Jurassic to the Early Cretaceous(200–100 Ma)and since the Miocene(15–0 Ma),the former attributable to the far-afield response to the closure of the PaleoTethys Ocean and plate assembly at the southern margin of Eurasia,the latter associated with the initial India-Eurasia plate collision.A slow cooling event from the Early Cretaceous to the Miocene(100–15 Ma)is thought to be related to the arid environment in northwest China since the Cretaceous.These cooling events have diverse responses and cooling rates in different blocks of the East Longshou Mountain:the southwest and centre of which are mainly cooled over 200–120 Ma and 120–0 Ma,with cooling rates of~0.25 and~0.33°C/Ma(~1.25 and~0.33°C/Ma in the centre);the Jinchuan mine primarily cooled over 160–100 Ma,100–15 Ma and 15–0 Ma,with cooling rates of~1.33,~0.25 and~2.00°C/Ma.These differentiated coolings imply that the uplift of the East Longshou Mountain before the Miocene(~15 Ma)was integral.Strong uplift then occurred in the vicinity of the mining area,which is a critical period for the uplift of the Jinchuan deposit to the surface,meaning that the Jinchuan deposit was exposed no earlier than the Miocene(~15 Ma).Based on mineralization depth information obtained by previous researchers,in conjunction with the calculation and simulation results of this study,it can be seen that the bulk of the Jinchuan intrusion may still be preserved at depth.

镍渣—全尾砂混合骨料配比试验研究

为实现固废循环利用,降低尾砂和镍渣的固废堆存,开展了镍渣—全尾砂混合骨料配比试验。通过扫描电镜和X射线荧光光谱测定(XRF)方法分析了镍渣和全尾砂的粒级分布和化学成分,利用骨料堆积密实度理论确定了镍渣—尾砂的配比优化范围为4∶6、5∶5和6∶4;考虑料浆的流动性、和易性及充填体强度,最终推荐镍渣—全尾砂的最优配合比为5∶5,料浆的质量浓度为77%~79%,水泥添加量为310 kg/m^(3);针对镍渣—全尾砂充填,镍渣利用量最高不超过50%,最大质量浓度为79%,对应的剪切应力为112.634 Pa,黏度为0.938 Pa·s。

金川二矿区3个中段协同开采巷道变形破坏特征研究

为研究金川二矿区3个中段协同开采巷道变形破坏特征,通过现场调查、数值计算及理论分析,对二矿区3个中段协同开采巷道位移变化规律、应力分布特征、塑性破坏范围以及巷道变形破坏原因进行研究。结果表明:金川二矿区3个中段协同开采过程中,中间中段巷道变形破坏最显著,下部中段次之,上部中段最小;不同中段巷道变形破坏具有区域性,上部中段与中间中段巷道中部变形破坏明显,下部中段巷道东西部变形显著;各中段巷道变形破坏呈明显非对称性,巷道近扰动侧边帮变形破坏较远扰动侧边帮更显著;协同开采扰动、地应力及矿岩条件是导致协同开采巷道变形破坏的主要因素。研究结果可为金川二矿区3个中段协同开采巷道安全控制提供一定理论依据。

Geochemical Characteristics,Genesis of Concealed Cu-rich Ore Body in the Jinchuan Deposit,Northwestern China,and Its Prospecting

The Jinchuan deposit is hosted by the olivine-rich ultramafic rock body, which is the thirdlargest magmatic sulfide Ni-Cu deposit in the world currently being exploited. Seeking new relaying resources in the deep and the border of the deposit becomes more and more important. The ore body, ore and geochemistry characteristics of the concealed Cu-rich ore body are researched. Through spatial analysis and comparison with the neighboring II1 main ore body, the mineralization rule of the concealed Cu-rich ore body is summed up. It is also implied that Cu-rich magma may exist between Nirich magma and ore pulp during liquation differentiation in deep-stage chambers, which derives from deep-mantle Hi-MgO basalt magma. It is concluded that the type of ore body has features of both magmatic liquation and late reconstruction action. It has experienced three stages： deep liquation and pulsatory injection of the Cu- and PPGE-rich magma, concentration of tectonic activation, and the later magma hydrothermal superimposition. In addition, the Pb and S isotopes indicate the magma of I6 concealed Cu-rich ore body originates predominantly from mantle; however, it is interfused by minute crust material. Finally, it is inferred that the genesis of the Cu-Ni sulfide deposit is complex and diverse, and the prospect of seeking new deep ore bodies within similar deposits is promising, especially Cu-rich ore bodies.

Geotectonic Settings of Large and Superlarge Mineral Deposits on the Southwestern Margin of the North China Plate

The geotectonic setting refers to the three-dimensional space and relatedevents based on which a metallogenic system is formed and an ore-forming process takes place. Thispaper discusses the tectonic evolution of the southwestern margin of the North China paleocontinentand related geotectonic settings in which large or superlarge deposits are formed. Emphasis is puton the geodynamic conditions of the Jinchuan nickel-copper deposit, the Baiyin copper-polymetallicdeposit and the Hanshan gold deposit. It is significant that the three deposits occur together as a'trinity' on the same paleocontinental margin. The Jinchuan nickel-copper deposit was formed duringthe early stage of rifting of the paleocontinental margin; the Baiyin copper-polymetallic depositwas formed during the splitting stage of a continental-margin arc. The continental-margin arcspitting resulted in an 'island arc rift' in the early stage of evolution. The Hanshan gold depositwas formed within the Altun sinistral strike-slip fault system and its provenance is the'intraoceanic arc' volcanic rocks.

Fluctuation of Body Size and Body Weight of Jinchuan Female Yak within One Year

To understand the exact changes in body size and body weight of Jinchuan female yaks within one year,the body size and body weight of 30 Jinchuan female yaks were measured from July 2015 to July 2016. The results showed that the body weight of Jinchuan female yak declined continuously since October 2015,and the weight loss in November 2015 was the largest. The body weight started to increase in May 2016,and the body weight increased significantly in June and July of 2016.

Dynamic Magma Conduit System Related to the Jinchuan Ni-Cu Sulfide Deposit,NW China

The Jinchuan Ni-Cu sulfide deposits,NW China,are hosted in small ultramafic intrusions that were emplaced into Paleoproterozoic metamorphic rocks. The ultramafic intrusions were previously thought to be the segments of a single elongate intrusion that was dismembered by late faults into eastern and western portions,each of which have distinct stratigraphic sequences.

甘肃金川矿区古构造应力场恢复及演化研究

金川矿区经历了复杂的构造演化历史,目前其成矿期后的构造变形特征和应力场演化阶段仍缺乏精细剖析。文章运用构造解析方法对金川矿区地表基岩中的断层进行了分期和配套,确定了构造变形序列,认为矿区存在4组重要的断层组合,包括北东向逆冲断层和北西向走滑断层、北东向走滑断层和北西向逆冲断层、北西向正断层以及北东东向走滑断层。通过研究断层破裂面及擦痕构造,利用赤平投影法恢复了断层的古构造应力场,结合区域大地构造演化历史,准确限定了金川矿区成矿期后的应力场演化阶段,对认识区域构造演化和开发新远景区具有重要意义。结果显示,金川矿区在成矿期后经历了4期古构造应力场作用,表现为多阶段不同方向的挤压和伸展过程,分别响应了区域中生代以来的一系列构造热事件,Ⅰ期表现为早—中侏罗世的北西—南东向挤压应力场,Ⅱ期为晚侏罗世的北东—南西向挤压应力场,Ⅲ期为早白垩世的北东—南西向伸展应力场,Ⅳ期为晚白垩世以来的北东—南西向挤压应力场。

工程地质预报在金川矿山不良地质条件下管理运用与方法探讨

就工程地质预报的概念,结合金川矿山不良地质条件,阐述了金川矿山工程地质预报的主要工作与注意事项,在服务的矿山工程地质预报取得了较为不错的成果。总结归纳出的经验、理论,可用于探索与推广更好的地质预报方法,以此服务矿山安全生产。

金川矿区复杂地层钻探孔壁失稳机理与对策研究

金川矿区目前资源开采逐渐向深部转移,采用的主要探矿方式为在采矿巷道中布设中深钻孔,由于矿区地质条件复杂,常出现钻孔垮孔、造浆、地层涌水、破碎等情况,影响了勘察效率。为了解矿区复杂地层影响钻孔孔壁稳定性的原因,对从矿区采取的岩样进行理化分析、微观分析和力学性质分析,结果表明金川矿区钻孔孔壁失稳主要是因为钻探过程中遇强水敏性、强破碎、强涌水和高地应力地层。通过对矿区钻孔孔壁进行稳定性评价,从冲洗液技术和工程技术等方面制定了钻探技术对策,为矿区钻探施工提供了技术支撑。

金川二矿深部1000m中段地应力测量及应力状态研究

金川镍矿是我国最大的硫化铜镍矿,而二矿又是金川镍矿的主力矿山。目前二矿已进入深部开采阶段,由于矿岩破碎、剧烈开采扰动以及巷道采场结构越来越复杂,加之应力状态的改变,围岩稳定性问题更加突出。为此在二矿深部1000m中段进行了系统的地应力测量,以了解深部应力分布特征及其变化规律。现场测试采用空心包体应力解除法,共获得7个测点的三维应力数据。地应力测量成果表明,在井下700～800m深度范围内,最大主应力量值基本为20～30MPa,大部分测点最大主应力方位为NNE～NE向,最大主应力倾角在40°以上,以水平应力为主导的应力作用特征发生改变。

不同骨料固结粉胶结充填体强度试验与对比分析

为了将固结粉新型胶凝材料在金川矿山推广应用,针对目前矿山采用的4种充填骨料,开展固结粉胶结充填体强度试验研究.首先,针对龙首矿充填系统以及工业技术参数,进行4种充填骨料、3种胶凝材料和5种充填料浆浓度的试验方案设计.然后,针对4种充填骨料开展不同料浆浓度的充填体强度试验,获得了不同配比条件下胶结充填体强度.最后,针对固结粉胶凝材料进行4种骨料胶结充填体强度分析和对比研究.结果显示,除了戈壁粗砂骨料的胶结充填体3d和28d强度低于矿山设计强度外,其他3种骨料胶结充填体强度均满足金川矿山充填体设计强度.由此可见,固结粉新型胶凝材料可以替代水泥在金川矿山推广应用.

金川矿山深部采掘条件下岩石力学研究与实践

金川矿山经过几十年开采,开采深度已达1 000 m,复杂的工程地质条件、高地应力以及高渗透压导致深部开采工程的稳定性问题愈加突出。对金川二矿区深部850～1 000 m水平进行大量的现场地质调查研究,测试深部典型岩石的物理力学参数、膨胀与软化特性,研究岩石力学性质和地应力随埋深的变化规律。采用岩体地质力学(RMR)分类法和岩体质量(Q值)分类法,绘制二矿区深部各分段水平的岩体质量分区图。在深入调查金川矿区深部巷道变形和破坏特征的基础上,对高地应力、高渗透压下深部巷道开挖支护稳定性进行研究,结果表明,U型钢和锚杆联合支护效果最佳。全面总结金川矿区深部巷道支护经验,对巷道掘进和支护技术提出几点新的想法。研究不同开采方式对金川矿区深部充填体和围岩稳定性的影响,优化矿体回采方式,建议采用"隔三采一"布置回采进路,有助于控制围岩的变形,减弱上部充填体的下沉。

金川二矿区大体积充填体变形的三维数值模拟

充填法采矿是维护矿山稳定、控制地压变化以及限制围岩变形的最有效的手段方法,这种方法被大量地应用于金属矿山的开采工程当中。充填体作为矿体采出后的替代物,充入地下采空区后经过相变-固结-承压-提供反力-与围岩相互作用等阶段,与上覆岩层、下部矿体以及周围围岩形成了一个共同抵抗外部压力又相互作用的系统。这个系统在矿山开采状态下如何维护自身稳定以及相互作用所产生的变形破坏等都是需要进行研究的问题。金川镍矿二矿区已经进行了几十年的充填开采作业,逐渐形成了体积非常巨大的充填体,而进入深部开采工程后,上覆巨大充填体的受力稳定问题直接关系到矿山的安全生产。本文结合金川二矿区开采实际,在精确刻画充填体三维形态特征的基础上,采用数值模拟方法分析了大型充填矿山充填体的力学行为。模拟结果表明:充填体在开采时会出现整体受压变形,最大剪应力是导致充填体与围岩发生局部破坏的主要因素,对此根据充填体整体塑性屈服区域的分布和剪应力分布情况,确定了破坏失稳的危险区域。

充填法开采引起地表移动、变形和破坏的过程分析与机理研究

基于地表GPS监测及地下围岩变形破坏的调查取证等大量数据资料,以金川二矿区为例,针对由充填法开采引起的地表移动、变形和破坏的现状,分别对其进行了滞后于开采的分析、对矿山井巷工程安全影响的后效性分析及空间发展过程分析。指出导致金川二矿采用充填法开采引起地表移动、变形和破坏的滞后期长、后效性强烈的原因,如充填支护作用与间断面的摩擦作用等等,并指出矿体采出至充填体充入期间围岩发生的移动、变形和破坏与整个矿山的地表岩移、变形和破坏的关系,所得的结论与现场基本一致,对今后的生产具有一定的指导意义。

金属矿充填开采岩体移动对竖井围岩的变形破坏

采用数值模拟和地质力学分析的方法,对甘肃金川二矿区地下开采条件下,#14行风井变形破坏问题进行了研究,研究结果表明:#14行风井位于地下开采引起的岩体移动盆地的拉张区,受岩体移动变形影响剧烈,地下开采已经成为了影响竖井安全稳定的主要因素;无论是富矿开采还是贫矿富矿联合开采,竖井井壁的位移和应力分布规律大体相同,其大小与分布特征受断层影响突出,断层所在的部位仍然是竖井井壁的脆弱部位;地下开采引起的#14行风井的破坏是以穿过井筒的断层出现活化为触发因素,以井壁发生错动、破裂、冒落为主要形式的断层效应的集中体现,这也将成为现阶段生产条件下竖井可能再次发生变形、破坏的模式。

金川铜镍硫化物岩浆矿床前锋岩浆与岩浆通道

金川铜镍矿床是世界第三大镍、铜硫化物岩浆矿床,长期以来备受国内外矿床地质学家的关注。金川铜镍矿床Ⅳ矿区是金川矿床的有机组成部分,由于品位低(Ni 0.71%、Cu 0.48%)并且隐伏于地下140 m以下,生产与研究工作相对滞后。由于F23断裂构造的影响,金川矿床勘查以来,研究者均将其作为Ⅱ矿区2#岩体的东延部分。最近的详查钻探工程获得了较系统的样品测试,结果显示Ⅳ矿区含矿岩体是一个具有单独演化过程的独立含矿岩体,其Ni/Cu比值远高于其他矿区各个岩体,PGE强烈亏损,并且"R"因子数值低(30),微量、稀土元素配分也显示出独立的、复杂的演化过程,岩石结构与岩相变化显著,具有典型的岩浆通道前锋岩浆的特点。文章通过对比金川矿床几个主要含矿岩体的成矿元素与PGE特征,初步确定了金川铜镍硫化物成矿岩浆通道的空间位置,指出了金川深部资源勘查的关键问题与勘查方向。