Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of l...Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.展开更多
Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute in...Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute infection before developing GBS.Immunotherapy and supportive therapies are widely used to treat GBS;however,one in three patients experiences neurologic sequelae.In China,acupuncture-moxibustion has shown unique benefits for the treatment of neurological diseases and has a wide range of applications in neurology.Case presentation:We treated an elderly Russian female patient diagnosed with GBS.The chief complaints were upper limb weakness,lower limb paralysis,and inability to self-care.The traditional Chinese medicine diagnosis was flaccidity syndrome (Wei Zheng).After 5 weeks of acupuncture and moxibustion combined with Chinese patent medicine treatment,the patient's limb muscle strength was significantly improved and her ability to self-care was largely restored.Conclusion:The present findings demonstrated that acupuncture and moxibustion combined with Chinese patent medicine can alleviate muscle weakness caused by GBS.However,clinical randomized controlled trials are warranted to verify the precise clinical efficacy.展开更多
Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology ...Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.展开更多
目的探究金匮肾气汤加减联合复方木芙蓉涂鼻软膏对变应性鼻炎(allergic rhinitis,AR)(脾肾亏虚)患儿的临床应用效果。方法选取2021年1月—2021年12月该院就诊的AR患儿110例作为观察对象,采用随机数字表法分为观察组和对照组,每组55例。...目的探究金匮肾气汤加减联合复方木芙蓉涂鼻软膏对变应性鼻炎(allergic rhinitis,AR)(脾肾亏虚)患儿的临床应用效果。方法选取2021年1月—2021年12月该院就诊的AR患儿110例作为观察对象,采用随机数字表法分为观察组和对照组,每组55例。对照组给予糠酸莫米松鼻喷雾剂进行治疗,观察组在其基础上使用金匮肾气汤加减联合复方木芙蓉涂鼻软膏进行治疗。比较在治疗前、治疗1个月后两组患儿中医证候积分、鼻部客观体征(黏膜水肿、分泌物量、鼻甲肥大、黏膜苍白)评分、鼻分泌物炎症因子[白细胞介素(IL-2、IL-4、IL-10、IL-17)、嗜酸性粒细胞趋化因子(Eotaxin)]水平、生活质量[生活质量测定表(world health organization quality of life questionaire,WHOQOL-BREF)]的变化,治疗1个月后,对比在两组患儿治疗效果、不良反应发生情况。结果治疗1个月后,观察组治疗有效率显著高于对照组(P<0.05),不良反应发生率两组比较差异无显著统计学意义(P>0.05)。治疗1个月后两组患儿中医证候积分、鼻部客观体征评分均明显降低,且观察组显著低于对照组(均P<0.05);两组患儿治疗后IL-2、IL-4、IL-17、Eotaxin水平均明显降低,且观察组显著低于对照组(P均<0.05),IL-10水平、WHOQOL-BREF评分均明显升高,观察组显著高于对照组(P均<0.05)。结论针对AR(脾肾亏虚)患儿,金匮肾气汤加减联合复方木芙蓉涂鼻软膏的临床应用效果较好,复方木芙蓉涂鼻软膏能直接缓解患儿鼻塞症状,金匮肾气汤能助阳利水、强脾补肾从根本上治疗AR患儿,二者联用标本同治有效促进患儿康复。复方木芙蓉涂鼻软膏还能缓解糠酸莫米松鼻导致不良反应,有助于提高患儿依从性。此外考虑患儿服药依从性较差,金匮肾气汤可煎至约500 mL,分早中晚3次服用,每次约150 mL。展开更多
文摘Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.
文摘Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute infection before developing GBS.Immunotherapy and supportive therapies are widely used to treat GBS;however,one in three patients experiences neurologic sequelae.In China,acupuncture-moxibustion has shown unique benefits for the treatment of neurological diseases and has a wide range of applications in neurology.Case presentation:We treated an elderly Russian female patient diagnosed with GBS.The chief complaints were upper limb weakness,lower limb paralysis,and inability to self-care.The traditional Chinese medicine diagnosis was flaccidity syndrome (Wei Zheng).After 5 weeks of acupuncture and moxibustion combined with Chinese patent medicine treatment,the patient's limb muscle strength was significantly improved and her ability to self-care was largely restored.Conclusion:The present findings demonstrated that acupuncture and moxibustion combined with Chinese patent medicine can alleviate muscle weakness caused by GBS.However,clinical randomized controlled trials are warranted to verify the precise clinical efficacy.
基金National Natural Science Foundation of China(Nos.81803979,81741130,81673979 and 81473688)Natural Science Foundation of Guangdong Province(Nos.2018A030313393,2016A030313114)+3 种基金Science and Technology Program of Guangzhou(Nos.201803010051,201707010245,201704020117)Science and Technology Program of Guangdong(No.2014A020212672)the Fourth Batch of TCM Clinical Outstanding Talent Program of China(No.444258)Scientific Research and Innovation Fund of Jinan University/the Fundamental Research Funds for the Central Universities,China(Nos.21617467,21615412).
文摘Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.
文摘目的探究金匮肾气汤加减联合复方木芙蓉涂鼻软膏对变应性鼻炎(allergic rhinitis,AR)(脾肾亏虚)患儿的临床应用效果。方法选取2021年1月—2021年12月该院就诊的AR患儿110例作为观察对象,采用随机数字表法分为观察组和对照组,每组55例。对照组给予糠酸莫米松鼻喷雾剂进行治疗,观察组在其基础上使用金匮肾气汤加减联合复方木芙蓉涂鼻软膏进行治疗。比较在治疗前、治疗1个月后两组患儿中医证候积分、鼻部客观体征(黏膜水肿、分泌物量、鼻甲肥大、黏膜苍白)评分、鼻分泌物炎症因子[白细胞介素(IL-2、IL-4、IL-10、IL-17)、嗜酸性粒细胞趋化因子(Eotaxin)]水平、生活质量[生活质量测定表(world health organization quality of life questionaire,WHOQOL-BREF)]的变化,治疗1个月后,对比在两组患儿治疗效果、不良反应发生情况。结果治疗1个月后,观察组治疗有效率显著高于对照组(P<0.05),不良反应发生率两组比较差异无显著统计学意义(P>0.05)。治疗1个月后两组患儿中医证候积分、鼻部客观体征评分均明显降低,且观察组显著低于对照组(均P<0.05);两组患儿治疗后IL-2、IL-4、IL-17、Eotaxin水平均明显降低,且观察组显著低于对照组(P均<0.05),IL-10水平、WHOQOL-BREF评分均明显升高,观察组显著高于对照组(P均<0.05)。结论针对AR(脾肾亏虚)患儿,金匮肾气汤加减联合复方木芙蓉涂鼻软膏的临床应用效果较好,复方木芙蓉涂鼻软膏能直接缓解患儿鼻塞症状,金匮肾气汤能助阳利水、强脾补肾从根本上治疗AR患儿,二者联用标本同治有效促进患儿康复。复方木芙蓉涂鼻软膏还能缓解糠酸莫米松鼻导致不良反应,有助于提高患儿依从性。此外考虑患儿服药依从性较差,金匮肾气汤可煎至约500 mL,分早中晚3次服用,每次约150 mL。
