In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and it...In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and its preparations.One case of long-term taking Jingwu capsule and Huolisu oral liquid,which led to the drug-induced liver injury,was reported.The other case took Runzaozhiyang capsule for a long time,which also led to drug-induced liver injury.Jingwu capsule,Huolisu oral liquid,and Runzaozhiyang capsule all contained Polygonum multiflorum,which could result in liver injury when used long-term.Moreover,we explored the clinical features and toxicity of liver damage induced by Polygonum multiflorum.Liver damage in serum transaminase was significantly increased,and the increasing rate of ALT was more than that of AST.Jaundice appeared obviously.The liver damage mechanisms included drug metabolism,immune response,physical fitness,and many other reasons.Corresponding suggestions on rational use of Polygonum multiflorum and its preparations were presented.The dosage and period should be regulated.The index of liver function should be monitored during the medication periods.Collectively,patients with a history of liver disease or a history of allergies should pay more attention when using the above-mentioned drugs.展开更多
基金Traditional Chinese Medical Science and Technology Projects of Zhejiang Province(Grant No.2016ZQ017 and 2015ZB044)Clinical pharmacy of TCM in the 13th five years plan of Zhejiang Administration of traditional Chinese Medicine(Zhejiang health office TCM(2019)No.1)the Clinical Pharmacy Research Fund of Chinese Integrative Medicine Association of Zhejiang Province(Grant No.2013LYSX018)。
文摘In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and its preparations.One case of long-term taking Jingwu capsule and Huolisu oral liquid,which led to the drug-induced liver injury,was reported.The other case took Runzaozhiyang capsule for a long time,which also led to drug-induced liver injury.Jingwu capsule,Huolisu oral liquid,and Runzaozhiyang capsule all contained Polygonum multiflorum,which could result in liver injury when used long-term.Moreover,we explored the clinical features and toxicity of liver damage induced by Polygonum multiflorum.Liver damage in serum transaminase was significantly increased,and the increasing rate of ALT was more than that of AST.Jaundice appeared obviously.The liver damage mechanisms included drug metabolism,immune response,physical fitness,and many other reasons.Corresponding suggestions on rational use of Polygonum multiflorum and its preparations were presented.The dosage and period should be regulated.The index of liver function should be monitored during the medication periods.Collectively,patients with a history of liver disease or a history of allergies should pay more attention when using the above-mentioned drugs.
