Objective: To study the therapeutic effect of Com pound Biejia Ruangan prescription (CBRP) on rat model with pulmonary fibrosis in duced by bleomycin. Methods: Fifty four male Sprague Dawley rats were rando mly divide...Objective: To study the therapeutic effect of Com pound Biejia Ruangan prescription (CBRP) on rat model with pulmonary fibrosis in duced by bleomycin. Methods: Fifty four male Sprague Dawley rats were rando mly divided into 6 groups (9 rats in each group). From the first day to the 28th day of the experiment, except to those in the sham model control group that were treated with normal saline, the same amount of bleomycin injection as the n ormal saline given to the control group was given through endotracheal instillat ion to all the rats in all the other groups. From the 29th day of the modeling, CBRP solution of different dosages was respectively injected into the rats in th e high, moderate and low CBRP dose group, while equal volume of normal saline w as given to those in the sham model control group and the model control group , and an equal volume of prednisone solution was given to rats in the prednisone group. On the 80th day, the high resolution computerized tomographic (HRCT) images were observed on an equal footing, and HRCT pathology was correlativel y studied. Results: Different HRCT pathological changes were shown in th e rats with pulmonary fibrosis, such as lung consolidation, thickening of interl obular septum and interlobular mesenchyma as well as lobular deformation, nodule shadow, abnormal brochiovascular tract, thickened pleura with irregular junctio n and polished glass like dense shadows. Honeycomb lung was observed in some cases. Pathological sections showed fibrotic proliferation of lung tissues and noticeable pulmonary interstitial fibrosis. CBRP could improve HRCT images of rats with pulmonary fibrosis, and lower fibrotic p roliferation of the lung tissue.Conclusion: CBRP plays its therapeutic role possibly through its effect on the structure of the lung in rats with pulmonary fibrosis.展开更多
A practical synthesis of (S)-N-(2-ethyl-6-methylphenyl)alanine, a key intermediate for (S)-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the r...A practical synthesis of (S)-N-(2-ethyl-6-methylphenyl)alanine, a key intermediate for (S)-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the remaining ester. The effects of operating temperature and enzyme concentration on the activity and enantioselectivity of enzyme were initially studied, and it was found that the enantioselectivity of CAL-B towards the resolution was not high enough to obtain enantiomerically pure compound(E=12.1). When diethyl ether(15%, volume fraction) was added in the reaction medium, the lipase gave an excellent enantioselectivity(E=117.8), which is about 9.7-fold that in pure buffered aqueous solution. For overcoming the limitation of a maximum theoretical yield of 50%, the acid product was separated from the remaining ester by a simple extraction procedure and the remaining ester was racemized with aldehyde and acetic acid under microwave irradiation or conventional heating condition, The results show the microwave irradiation was more effective than the conventional heating method and gave the desired (R,S)-N-(2- ethyl-6-methylphenyl)alanine methyl ester a high yield(92%) with R/S=50/50 in 1 h.展开更多
This is a series of studies on Wu's conjecture and on its resolution to be presented herein. Both are devoted to expound all the comprehensive properties of Cauchy's function f(z) (z = x + iy) and its integral ...This is a series of studies on Wu's conjecture and on its resolution to be presented herein. Both are devoted to expound all the comprehensive properties of Cauchy's function f(z) (z = x + iy) and its integral J[f(z)]≡(2πi)-∮cf(t)(t-z)-1dt taken along the unit circle as contour C,inside which(the open domain D+) f(z) is regular but has singularities distributed in open domain Doutside C. Resolution is given to the inverse problem that the singularities of f(z) can be determined in analytical form in terms of the values f(t) of f(z) numerically prescribed on C(|t| = 1) ,as so enunciated by Wu's conjecture. The case of a single singularity is solved using complex algebra and analysis to acquire the solution structure for a standard reference. Multiple singularities are resolved by reducing them to a single one by elimination in principle,for which purpose a general asymptotic method is developed here for resolution to the conjecture by induction,and essential singularities are treated with employing the generalized Hilbert transforms. These new methods are applicable to relevant problems in mathematics,engineering and technology in analogy with resolving the inverse problem presented here.展开更多
Extensional basins include mainly grabens and half grabens displaced along a lower detachment. Based on area balance theory, there is a linear relationship between a height of regional and the lower detachment h on th...Extensional basins include mainly grabens and half grabens displaced along a lower detachment. Based on area balance theory, there is a linear relationship between a height of regional and the lower detachment h on the outside of the basin and "lost area S " from the regional in the basin. The pre-growth beds above lower detachment are of the same extensional displacement so that an " S-h diagram" can be used to determine the depth to lower detachment and to calculate the total extensional displacement of the beds above the lower detachment. The extensional displacement is dominated by the heave of various scale normal faults. The displacement of obvious faults can be immediately figured out from the measured bed-length. The requisite extension calculated by area balance is the layer-parallel strain, which could be accommodated by displacement on sub-resolution faults. Accordingly, the layer-parallel strain can help us predict the magnitude and distribution of sub-resolution faults on the basis of analysis of the structural style and rheological behavior.展开更多
RS-3-chloro-2-oxy-propyltrimethylammonium-chloride 1, an important inter- mediate of carnitine and acetylcholine, has been synthesized and resolved by using R,R-tartric acid. Di-(S-3-chloro-2-oxy-propyltrimethylammoni...RS-3-chloro-2-oxy-propyltrimethylammonium-chloride 1, an important inter- mediate of carnitine and acetylcholine, has been synthesized and resolved by using R,R-tartric acid. Di-(S-3-chloro-2-oxy-propyltrimethylammonium)-R,R-tartrate 2, with optical purity of 81.76%, has been obtained. Compound 2 was characterized by IR spectroscopy, MS, NMR and X-ray diffrac- tion, and it crystallizes in orthorhombic, space group P212121, absolute structure parameter 0.56(8), with cell parameters a = 8.323(2), b = 10.203(2), c = 26.178(5) ? C16H34Cl2N2O8, Mr = 453.272, V = 2223.0(8) ?, Z = 4, Dc = 1.354 g/cm3, m = 0.335 mm-1, F(000) = 968, R = 0.0534 and wR = 0.1274 for 4376 observed reflections (I > 2s(I)). The lattice is composed of two S-3-chloro- 2-oxy-propyltrimethylammonium cations and one R,R-tartrate dianion which are arranged in separate stacks linked via hydrogen bonds.展开更多
High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability o...High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability of the transition from 6s5d3D2 to 5d6p3F3 at 728.0 nm and the tensor polarizability of the 3F3 level have been determined for the first time, to be αs = -89.8 (12) kHz/(kV/cm)2 and αt = -133.7 (20) kHz/(kV/cm)2, respectively.展开更多
基金This study was supported by National Funds of Natur al Science (No.30130220)and Administration of Education against SARS(No.15)
文摘Objective: To study the therapeutic effect of Com pound Biejia Ruangan prescription (CBRP) on rat model with pulmonary fibrosis in duced by bleomycin. Methods: Fifty four male Sprague Dawley rats were rando mly divided into 6 groups (9 rats in each group). From the first day to the 28th day of the experiment, except to those in the sham model control group that were treated with normal saline, the same amount of bleomycin injection as the n ormal saline given to the control group was given through endotracheal instillat ion to all the rats in all the other groups. From the 29th day of the modeling, CBRP solution of different dosages was respectively injected into the rats in th e high, moderate and low CBRP dose group, while equal volume of normal saline w as given to those in the sham model control group and the model control group , and an equal volume of prednisone solution was given to rats in the prednisone group. On the 80th day, the high resolution computerized tomographic (HRCT) images were observed on an equal footing, and HRCT pathology was correlativel y studied. Results: Different HRCT pathological changes were shown in th e rats with pulmonary fibrosis, such as lung consolidation, thickening of interl obular septum and interlobular mesenchyma as well as lobular deformation, nodule shadow, abnormal brochiovascular tract, thickened pleura with irregular junctio n and polished glass like dense shadows. Honeycomb lung was observed in some cases. Pathological sections showed fibrotic proliferation of lung tissues and noticeable pulmonary interstitial fibrosis. CBRP could improve HRCT images of rats with pulmonary fibrosis, and lower fibrotic p roliferation of the lung tissue.Conclusion: CBRP plays its therapeutic role possibly through its effect on the structure of the lung in rats with pulmonary fibrosis.
基金Supported by the National Natural Science Foundation of China(No.20802025)the Hi-Tech Research and Development Program of China(No.2007AA021306)Jilin Provincial Science & Technology Sustentation Program,China(No.20070553)
文摘A practical synthesis of (S)-N-(2-ethyl-6-methylphenyl)alanine, a key intermediate for (S)-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the remaining ester. The effects of operating temperature and enzyme concentration on the activity and enantioselectivity of enzyme were initially studied, and it was found that the enantioselectivity of CAL-B towards the resolution was not high enough to obtain enantiomerically pure compound(E=12.1). When diethyl ether(15%, volume fraction) was added in the reaction medium, the lipase gave an excellent enantioselectivity(E=117.8), which is about 9.7-fold that in pure buffered aqueous solution. For overcoming the limitation of a maximum theoretical yield of 50%, the acid product was separated from the remaining ester by a simple extraction procedure and the remaining ester was racemized with aldehyde and acetic acid under microwave irradiation or conventional heating condition, The results show the microwave irradiation was more effective than the conventional heating method and gave the desired (R,S)-N-(2- ethyl-6-methylphenyl)alanine methyl ester a high yield(92%) with R/S=50/50 in 1 h.
文摘This is a series of studies on Wu's conjecture and on its resolution to be presented herein. Both are devoted to expound all the comprehensive properties of Cauchy's function f(z) (z = x + iy) and its integral J[f(z)]≡(2πi)-∮cf(t)(t-z)-1dt taken along the unit circle as contour C,inside which(the open domain D+) f(z) is regular but has singularities distributed in open domain Doutside C. Resolution is given to the inverse problem that the singularities of f(z) can be determined in analytical form in terms of the values f(t) of f(z) numerically prescribed on C(|t| = 1) ,as so enunciated by Wu's conjecture. The case of a single singularity is solved using complex algebra and analysis to acquire the solution structure for a standard reference. Multiple singularities are resolved by reducing them to a single one by elimination in principle,for which purpose a general asymptotic method is developed here for resolution to the conjecture by induction,and essential singularities are treated with employing the generalized Hilbert transforms. These new methods are applicable to relevant problems in mathematics,engineering and technology in analogy with resolving the inverse problem presented here.
文摘Extensional basins include mainly grabens and half grabens displaced along a lower detachment. Based on area balance theory, there is a linear relationship between a height of regional and the lower detachment h on the outside of the basin and "lost area S " from the regional in the basin. The pre-growth beds above lower detachment are of the same extensional displacement so that an " S-h diagram" can be used to determine the depth to lower detachment and to calculate the total extensional displacement of the beds above the lower detachment. The extensional displacement is dominated by the heave of various scale normal faults. The displacement of obvious faults can be immediately figured out from the measured bed-length. The requisite extension calculated by area balance is the layer-parallel strain, which could be accommodated by displacement on sub-resolution faults. Accordingly, the layer-parallel strain can help us predict the magnitude and distribution of sub-resolution faults on the basis of analysis of the structural style and rheological behavior.
文摘RS-3-chloro-2-oxy-propyltrimethylammonium-chloride 1, an important inter- mediate of carnitine and acetylcholine, has been synthesized and resolved by using R,R-tartric acid. Di-(S-3-chloro-2-oxy-propyltrimethylammonium)-R,R-tartrate 2, with optical purity of 81.76%, has been obtained. Compound 2 was characterized by IR spectroscopy, MS, NMR and X-ray diffrac- tion, and it crystallizes in orthorhombic, space group P212121, absolute structure parameter 0.56(8), with cell parameters a = 8.323(2), b = 10.203(2), c = 26.178(5) ? C16H34Cl2N2O8, Mr = 453.272, V = 2223.0(8) ?, Z = 4, Dc = 1.354 g/cm3, m = 0.335 mm-1, F(000) = 968, R = 0.0534 and wR = 0.1274 for 4376 observed reflections (I > 2s(I)). The lattice is composed of two S-3-chloro- 2-oxy-propyltrimethylammonium cations and one R,R-tartrate dianion which are arranged in separate stacks linked via hydrogen bonds.
文摘High-resolution atomic-beam laser spectroscopy has been performed to study Stark effect of Ba atom. Stark spectra have been observed at various electric fields for Ba highly excited states. The scalar polarizability of the transition from 6s5d3D2 to 5d6p3F3 at 728.0 nm and the tensor polarizability of the 3F3 level have been determined for the first time, to be αs = -89.8 (12) kHz/(kV/cm)2 and αt = -133.7 (20) kHz/(kV/cm)2, respectively.