Adult-Type Granulosa Cell Tumor with Similar Clinical Findings Seen during Ovarian Cystectomy Performed at the Same Time as Laparoscopic Ovarian Drilling for Polycystic Ovarian Syndrome: An Extremely Rare Case

Polycystic ovary syndrome (PCOS) is a major cause of anovulatory infertility. Laparoscopic ovarian drilling (LOD) is a treatment for PCOS that allows the laparoscopic identification of other intra-abdominal lesions and the provision of diagnostic treatment. This study reports a case of PCOS with an ovarian mass in which LOD was aggressively used and a granulosa cell tumor (GCT) was found. A 34-year-old woman with secondary amenorrhea and irregular menstrual cycles presented to the emergency department with abdominal pain of unknown etiology. Imaging studies revealed a 6-cm left ovarian mass with an internal appearance suggestive of a hemorrhage. The patient’s secondary amenorrhea was subsequently diagnosed as PCOS, and LOD was performed to preserve her fertility. Simultaneously, a cystectomy was performed to evaluate the tumor in the left ovary;the diagnosis was adult-type GCT. Although concomitant GCT and PCOS are extremely rare, the two conditions have similar clinical manifestations. In women of reproductive age, the impact of surgery on future fertility should be considered, and the initial surgical technique should be chosen carefully.

Apoptosis and Expression of Protein TRAIL in Granulosa Cells of Rats with Polycystic Ovarian Syndrome

The relationship between apoptosis of granulosa cells and follicle development arrest in polycystic ovarian syndrome (PCOS) rats, and the contribution of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in apoptosis of granulosa cells were explored. By using sodium prasterone sulfate rat PCOS model was induced. The apoptosis of granulosa cells in ovaries of rats was observed by TdT-mediated dUTP-biotin nick end-labeling (TUNEL), and the expression of TRAIL protein and mRNA in granulosa cells was detected by using immunhistochemical staining and reverse transcription polymerase chain reaction (RT-PCR) respectively. The apoptotic rate and the expression of protein TRAIL in granulosa cells were significantly higher in antral follicles from the PCOS rats than in those from the control rats (P<0.01, P<0.05). There was no significant difference in apoptotic rate and the expression of TRAIL protein in granulosa cells of preantral follicles between the PCOS rats and the control rats (P>0.05). No apoptosis and the expression of TRAIL protein in granulosa cells of primordial follicles were found in the two groups. The expression of TRAIL mRNA was significantly stronger in granulosa cells from the PCOS rats than in those from the con- trol rats (P<0.01). It was suggested that the apoptotic rate in granulosa cells was significantly higher in antral follicle from the PCOS rats than in those from the control rats. TRAIL played a role in regu- lating the apoptosis of granulosa cells in PCOS rats.

Ovarian Sex Cord-Stromal Tumors in Postmenopausal Women and Total Laparoscopical Management

BACKGROUND: Ovarian sex-cord stromal tumors (SCST) take up 5% of the ovarian neoplasm and may develop in?to?an ovarian mass or a haemoperitoneum. The surgical management of SCST in early-stage adult patients is not well?defined. CASE REPORT: A 69 year-old postmenopausal woman was admitted for metrorrhagia, a right ovary mass and?increasing pelvic pain. Preoperative clinical and instrumental examination suspected an ovarian tumor, and the?laparoscopic right ophorectomy and the frozen section suggested an ovarian SCST. To fast restore and preserve woman?integrity, total laparoscopic hysterectomy (TLH) plus left salpingo-ophorectomy (SO) were performed, without complications?in the short and long term follow-up. CONCLUSION: In the authors’ opinion, the minimally invasive management?of SCST by TLH plus bilateral SO followed by a prolonged surveillance and without intensive surgical staging,?could be an appropriate clinical and surgical choice in elder patient at early stage, since these tumors are slow at?growth, recurring locally and only a long time after initial treatment. We suggest, after a minimally invasive treatment,?a possible “wait and see” option, as in our case report.

A Retrospective Study of Ovarian Sex Cord Stromal Tumors at the Egyptian National Cancer Institute

Background: Ovarian sex cord-stromal tumors are an uncommon heterogeneous group of tumors with different biological behaviors and clinico-patho- logic aspects. Aim of the Work: This study will review the clinico-pathologic aspects of sex-cord stromal ovarian tumors at the National Cancer Institute (NCI), Cairo University, Egypt, as well as their management and follow-up regarding disease free survival and overall survival. Patients and Methods: This retrospective study was conducted at the National Cancer Institute Cairo University, Egypt on female patients with ovarian sex cord stromal tumors in the period from January 2008 to December 2012 with a follow-up period of 24 to 84 months. The age of the patients, different clinical presentations, radiological findings, associated uterine bleeding (need for endometrial biopsy), pre-operative CA125 levels, surgical management done, different histopathological types, different biological behaviors, presence of ascites (and its correlation with the histopathology), Adjuvant chemotherapy (according to biological behavior and pathological type), and follow-up of non-benign cases for up to 84 months will all be documented and studied. Results: The mean age at presentation was 47.34;abdominal pain and mass were the commonest presentations 54.5% and 53.2% respectively;the main radiologic findings were a pelvic mass +/- ascites which had no correlation to the pathological type (p = 0.075). Endometrial hyperplasia and endometrial carcinoma were associated with 22% and 2.5% of cases respectively. Stages I and II represented 95% of patients with non-benign tumors (48 patients). Panhysterectomy +/- infracolic omentectomy or fertility sparing surgery were done in 70.1% and 29.9% of patients respectively. AGCTs were the commonest pathological type (49.4%). Adjuvant chemotherapy was given to 14 patients (46.7%) with non-benign tumors. 6 recurrences (20%) in 30 patients with non-benign tumors on regular follow-up were documented. The median of disease free survival (DFS) was 50.5 months. The median overall survival was 49.5 months. Conclusion: Ovarian SCSTs are uncommon neoplasms with different biological behaviors where AGCTs are the commonest among Egyptian females. Hormonal manifestations are uncommon where abnormal vaginal bleeding is the commonest one. The presence of ascitic fluid has no correlation with the pathological type of the tumor. Early stages (I and II) represented about 95% of non-benign tumors. Surgical management without lymphadenectomy +/- adjuvant chemotherapy is the main line of treatment at our institute. The OS was shorter than that documented in the literature. A small number of patients, reluctance of follow-up and unavailability of some patients’ data were the main drawbacks in this study.

Premature Puberty Revealing an Ovarian Tumor in a Five-Year-Old Girl

Background: Ovarian tumors in the girl child are sometimes revealed by the development of secondary sexual characteristics. The authors report the case of a five-year-old girl in whom the disease was revealed by early puberty. Case presentation: A five-year-old girl with an enlarged abdomen for about four months. The onset of pain and the sensation of a mass prompted the consultation. The development of secondary sexual characteristics (SSC) noted by the family had not been mentioned. The patient was classified as pubertal stage 2 according to the Tanner classification. An abdominal ultrasound and a CT scan showed a large left ovarian mass, an enlarged uterus for the patient’s age and a normal right ovary. The hormonal workup was not contributive. The treatment consisted only of a left salpingo-ovarectomy, without complementary chemotherapy. Anatomic pathological examination of the surgical specimen concluded to a juvenile tumor of the granulosa. The evolution was good with a beginning of regression of the HSC one month after the ovarectomy. Discussion: Granulosa tumors are sometimes secretory cancers, generally with a low potential for malignancy and therefore a very good prognosis. Surgery based on total adnexectomy is the first-line treatment. The large size of the tumor, the presence of ascites and capsular rupture are factors of poor prognosis, hence the importance of early diagnosis. Conclusion: Routine comprehensive physical examination should be de rigueur for abdominal masses in girls, especially in the context of various beliefs that may impede early referral to care.

THE MODIFIED RADIOIMMUNOASSAY OF SERUM INHIBIN AND ITS VALUE IN MONITORING OVARIAN TUMOR

Objectives and Methods: A modified radioimmunoassay (RIA) of serum inhibin (INH) was developed and applied to measure serum INH contents in 39 fertile and 16 postmenopausal women. Thirty-three cases of ovarian tumors, including granulosa cell tumors and other kinds of ovarian tumors, were monitored by serum INH RIA. Results: The mean value of serum INH contents in follicular, peri-ovulatory and mid-luteal phases of fertile women were 9.48±7.10 pg/ml (2.04～18.53pg/ml), 19.04±9.73 pg/ml (3.49～33.26 pg/ml) and 131.13±110.81 pg/ml (3.49～ 341.10 pg/ml), respectively. Serum INH concentration was negatively correlated with serum FSH concentration, (rs=?0.483,P<0.01). Serum IHN contents were less than 3.6 pg/ml in normal postmenopausal women. The mean value of serum INH contents in ovarian granulosa cell tumor, thecoma, mucinous cystadenocarcinoma and malignant teratoma cases were significantly higher than that of other ovarian tumors, (P<0.01). Serum INH contents were elevated in ovarian granulosa cell tumor, thecoma, mucinous cystadenocaricinoma and endometrioid carcinoma cases with serum CA-125 values in normal range before operation, but serum INH contents decreased to normal range within one week after operation. And consecutive serum INH RIA could be a valuable tool in monitoring for therapeutic effect. Conclusion: Modified INH RIA was of convenient, time-saving and quantitative characteristics, especially with its high sensitivity (<1 pg/ml). There was a regular change of serum INH concentrations during menstrual cycle. INH could inhibit the synthesis and secretion of follicle stimulating hormone (FSH). INH would become a valuable marker for ovarian tumor. INH RIA combined with the measurement of serum CA-125 would be helpful to the early diagnosis, treatment and follow-up for ovarian cancer.

Clinicopathological Evaluation of Ovarian Juvenile Granulosa Cell Tumor: Is Fertility-Sparing Surgery Safe?

Objective:To retrospectively investigate the clinicopathological characteristics of ovarian juvenile granulosa cell tumors(JGCTs)and to evaluate the safety of fertility-sparing surgery.Methods:In this study,surgically treated patients with JGCTs diagnosed between January 2004 and October 2018 in our center were identified.Clinicopathological data,survival outcomes,and recurrence rates were examined in these patients.Results:A total of 8 patients were included.All patients were premenarchal girls or young women(age range,9-32 years).Irregular vaginal bleeding was the most common presenting symptom.Of them,seven patients were classified with Stage I JGCTs,and they underwent fertility-sparing surgery.One patient who had Stage IIIC JGCT and had completed childbearing underwent complete surgery.Seven patients received adjuvant chemotherapy.The median follow-up duration in the total cohort was 64 months(range,2-117 months).The overall survival rate in the fertility-sparing group was 100%,whereas the patient with Stage IIIC JGCT died 1 month after the treatment.Conclusions:Fertility-sparing surgery might not show a negative impact on oncologic outcomes.Fertility sparing could be considered a modified option for patients with Stage I JGCTs.However,due to the limited number of patients,the conclusion must be interpreted with caution,and larger or multicenter studies are needed before conclusions can be drawn.

Investigation of the Cause of Precocious Puberty in an 8-Year-Old Girl Ended up in Juvenile Granulosa and Theca Cell Tumor of the Ovary

Isosexual precocious puberty in girls has several etiologies. Juvenile granulose cell tumor is one of the rarest causes that only stands for 1.5% of ovarian cancers. This tumor mostly encounters in first 2 decades of life. This paper is a report of an 8-year-old girl with precocious puberty that within five months developed breast enlargement followed by menarche. Works which are done to find the underlying cause of precocious puberty revealed juvenile granulosa cell tumor in her left ovary. She then under went laparoscopic surgery and 3 courses of chemotherapy. She did not experience any vaginal bleeding after that and the serum level of estradiol lay among its normal ranges, but after that the tumor relapsed and presented as abdominal pain and a huge mass which under went resection of all afflicted tissues. After 2 courses of chemotherapy, her status deteriorated and unfortunately she died after 6 months from the time of diagnosis. Treatment for this disease is consists of resection surgery and chemotherapy. If this tumor is diagnosed in its early stages, it will be curable, but in its advanced stages, up to 80% of patients die from recurrent tumors. The reported patient was diagnosed at stage IIIC that had poor prognosis.

复发性卵巢颗粒细胞瘤的治疗选择及预后

目的探讨复发性卵巢颗粒细胞瘤(ovarian granulosa cell tumor,OGCT)的临床特征,分析其预后影响因素,评估治疗方案。方法回顾性研究38例复发性OGCT患者的临床特征、复发后治疗方法及生存情况。结果38例复发性OGCT患者的中位复发时间为62.5个月(12~308个月),复发后中位生存时间为33个月(9~106个月)。复发性OGCT患者的1年生存率92%,3年生存率71.9%,5年生存率55.5%。单因素分析显示,复发病灶数目、复发后手术治疗是复发性OGCT患者生存预后的影响因素(P>0.05),多因素生存分析结果显示,复发后手术治疗是复发性OGCT患者生存预后的影响因素(P<0.05)。对27例接受手术治疗的复发性患者单因素分析显示,手术残留病灶是复发性OGCT患者术后再次复发的独立危险因素(P<0.05)。结论复发性OGCT的化疗敏感性较低,手术是复发性OGCT最主要的治疗方法,尽可能完整切除可以降低再次复发风险,提高生存率。

卵巢颗粒细胞瘤的MRI诊断

目的 分析卵巢颗粒细胞瘤的MRI特征。资料与方法 回顾性分析 15例卵巢颗粒细胞瘤的MRI特征 ,并与手术及病理对照研究。结果 15例中 ,囊实性肿块 8例 ,内有多发大小不等的囊性变 ,囊内壁光滑 ,囊内容物MRT1WI呈等低混杂信号 ,T2 WI呈混杂高信号 ,囊与囊间有厚壁分隔 ;实性肿块 3例 ,T1WI及T2 WI信号均高于肌肉 ;单一较大的囊性病灶 4例。 13例子宫均匀增大 ,内膜增厚 ,1例并有子宫内膜癌。结论 诊断卵巢颗粒细胞瘤的可靠依据为 :(1)肿瘤内多发囊变 ,间有厚壁分隔 ,囊内壁光滑 ;(2 )合并子宫体积增大 ,内膜增生。

卵巢粒层细胞瘤临床病理特点及相关因素分析

目的探讨成人型和幼年型粒层细胞瘤的发病率及其不同临床病理特征,对卵巢粒层细胞瘤的诊治提供一定参考意见。方法回顾性分析2001年4月至2009年9月我院收治的42例粒层细胞瘤病例,分析成人型及幼年型粒层细胞瘤患者的临床病理特征、治疗方法及随访结果。结果 42例中4例为2001年以前初发,2001年后复发的患者。38例初诊患者(成人型29例,幼年型9例)占我院同期卵巢恶性肿瘤患者的3.13%。成人型中位发病年龄为53岁,幼年型25岁,差异有统计学意义(z=-2.990,P=0.003)。临床最常见的症状和体征分别为腹痛腹胀(44.7%)、阴道不规则流血或月经紊乱(42.1%)及盆腹腔包块(76.3%);最常见的合并症是宫内膜单纯性或复杂性增生(52.6%);其次为子宫肌瘤(21.1%)。38例初诊患者Ⅰ期占73.7%,Ⅱ期23.7%,Ⅲ期2.6%。根据患者年龄、分期、病情等行单侧附件切除或肿瘤剥除者10例,子宫加双附件切除者20例,肿瘤细胞减灭术者8例。42例患者随访7～175月,失访14例,随访中无患者死亡。免疫组化检测结果示抑制素、钙视网膜蛋白、波形蛋白阳性有助于诊断该病。结论卵巢粒层细胞瘤为低度恶性肿瘤的功能性肿瘤,发病率低,多为单侧发病。与上皮性卵巢癌相比,粒层细胞瘤腹水征较少,但也可出现急腹症。粒层细胞瘤较易早期发现,预后较好,但易远期复发,应坚持长期随访监测。

卵巢颗粒细胞瘤的MRI和CT特征性表现及与病理对照

目的探讨卵巢颗粒细胞瘤的MRI及CT特点,提高诊断与鉴别诊断能力。方法回顾性分析12例经手术病理证实的卵巢颗粒细胞瘤MRI及CT表现,并与病理对照,总结其MRI及CT特征。结果 12例肿瘤均为单侧,类圆形,包膜完整的囊实性肿块。其中11例行MR平扫,实性部分呈等/稍长T1稍长T2信号;1例行CT检查、呈等密度影。肿瘤内含较多囊腔,小囊呈"蜂窝状"或"海绵状",较大的囊腔囊壁和间隔厚而均匀。9例肿瘤部分囊腔内含血性信号/密度。增强扫描肿瘤实性部分明显强化,MRI平均信号强度略低于子宫肌层(病变信号值约为476.10±73.33,子宫肌层信号值为505.73±64.99)。所有患者子宫内膜均有不同程度增厚。大体病理标本切面与MRI/CT表现相符合,12例肿瘤部分囊腔内均见暗红色血液或血凝块。病理诊断:10例为成年型卵巢颗粒细胞瘤,其中低分化3例,2例腹膜、肠壁、输卵管见转移灶;中分化2例。2例为幼年型颗粒细胞瘤。子宫内膜均为增生期改变,部分患者见息肉、子宫内膜癌。结论卵巢颗粒细胞瘤的MRI/CT具有一定特征,结合性激素所致的临床症状,能明确诊断。

卵巢幼年型粒层细胞瘤临床病理观察

目的探讨卵巢幼年型粒层细胞瘤(juvenile granulosa cell tumor,JGCT)的临床病理特征、早期诊断与预后的关系。方法报道2例少见的幼年型卵巢粒层细胞瘤,并结合国内外文献进行讨论。结果 2例均为青年女性,分别为21岁和27岁。例1为肩胛骨软骨肉瘤术后3年出现腹胀,术后诊断为JGCT,FIGOⅢ期,随访26个月死亡。例2表现为月经失调,临床诊断为FIGOⅠA期,术后随访29个月未见复发。镜下全部为弥漫生长和不典型滤泡样结构,未见Call-Exner小体。肿瘤细胞核小、较圆、深染,极少见核沟,例1细胞重度异型,核分裂象>10/10 HPF;例2细胞轻度异型,核分裂象<5/10 HPF。免疫组化2例vimentin均强阳性,CD99散在弱阳性;例1滤泡内物质黏液卡红染色阳性,例2α抑制素(α-inhibin)小灶阳性;CK18阳性,其余一抗细胞角蛋白(cytokeratin pan,CKpan)、S-100蛋白、蛋白基因产物(protein gene product,PGP)9.5、平滑肌肌动蛋白(smooth muscle actin,SMA)、上皮膜抗原(epithelial membrane anti-gen,EMA)、肌源性标记物结蛋白(desmin)、肌细胞生成素(myogenin)、血管内皮细胞生长因子(vascular endothelialgrowth factor,VEGF)、胎盘碱性磷酸酶(placental alkaline phosphatase,PLAP)、人体绒毛膜促性腺激素(human chori-onic gonagotropin,HCG)、甲胎蛋白(alpha-fetoprotein,AFP)、CD45、Calretinin均阴性。结论 JGCT属于交界性或低度恶性肿瘤,但少数病例恶性程度较高,早期诊断是预后的重要因素,需要与卵巢成年型粒层细胞瘤、高血钙型小细胞癌、恶性黑色素瘤等进行鉴别。

卵巢幼年性粒层细胞瘤伴Maffucci综合征

目的 探讨幼年性粒层细胞瘤和Maffucci综合征的临床病理特征及两者伴发的原因。方法 对 1例伴Maffucci综合征的幼年性粒层细胞瘤进行HE、组织化学及免疫组织化学染色观察 ,并复习文献。结果 幼年性粒层细胞瘤多发生于 2 0岁以下患者 ,儿童患者常表现为青春期前假性性早熟 ,生育期妇女常表现为月经紊乱。组织学上具特征性滤泡结构 ,丰富的嗜酸性或空泡化胞质 ,无核沟及Call Exner小体 ,核分裂象多见。Inhibin免疫组化染色有助于诊断和鉴别诊断。Maffucci综合征为先天性软骨发育异常 ,易合并恶性肿瘤。 14例卵巢幼年性粒层细胞瘤伴Maffucci综合征或Ollier病中卵巢肿瘤和骨病变有同侧分布倾向。

卵巢幼年型粒层细胞瘤8例临床病理分析

目的探讨卵巢幼年型粒层细胞瘤(juvenile granulosa cell tumor,JGCT)的临床病理特点、诊断及鉴别诊断。方法回顾本院诊治的8例JGCT的临床、病理特征及免疫表型特点,并进行随访获知其预后情况。结果8例JGCT患者发病年龄6～21岁,平均15.1岁。临床主要表现为腹部包块、腹水及女性假性性早熟。巨检表现为囊实性肿块。光镜下肿瘤细胞呈实性巢状,片状弥漫性排列,部分可排列成多个圆形或椭圆形大小不等的滤泡,少数可形成巨滤泡结构,有的滤泡腔内还可见均质红染物质。瘤细胞呈圆形、多边形,中等大小或较大,胞质丰富,空淡或微嗜酸性,核圆形,染色质均质状,无明显核沟,有一定异型性,可见核分裂象。免疫表型:瘤细胞均表达inhibin-α、CD99、vimentin,部分病例Melan-A、calretinin、S-100阳性,瘤细胞不表达CKpan、EMA、PLAP、Syn和CgA。结论JGCT非常少见,属于低度恶性肿瘤,预后较好。确诊依赖于临床特点、组织形态学及免疫组化标记。病理诊断时要与卵巢的成人型粒层细胞瘤、高钙血症型小细胞癌、类癌、无性细胞瘤等肿瘤相鉴别。

儿童卵巢颗粒细胞瘤CT及临床表现

目的分析儿童卵巢颗粒细胞瘤的CT特征及临床表现。方法回顾性分析经病理证实的12例女性卵巢颗粒细胞瘤患儿的术前CT和相关临床表现,观察卵巢肿物的性质、大小、钙化、强化程度、有无瘤内血管、子宫大小、盆腔积液及增大淋巴结等影像学特征。结果12例卵巢颗粒细胞瘤患儿以腹痛、性早熟或男性化等相关症状就诊;9例术前血清雌二醇水平升高,2例血清睾酮水平升高。CT平扫表现为实性肿物2例、囊实性8例、囊性肿物2例,长径中位数为82.50(46.75,111.00)mm;肿瘤内钙化1例;盆腔内大量积液2例,子宫增大9例。增强扫描肿物实性成分明显强化,9例内见纡曲血管影,囊性肿物均无明显强化;未见淋巴结明显增大。结论结合特异性内分泌症状及相关激素水平、肿瘤标记物改变,CT发现儿童血供丰富的卵巢肿物、伴子宫体积增大高度提示卵巢颗粒细胞瘤。

复发卵巢成人型颗粒细胞瘤13例临床分析

目的：探讨复发卵巢成人型颗粒细胞瘤（GCT）的临床特点及治疗方案选择.方法：回顾性分析我院诊治的13例复发卵巢成人型GCT患者的临床资料.结果：13例患者确诊复发距离初次治疗的中位间隔时间为6年（0.5 ～20年）,远期复发（≥10年）患者5例,近期复发（＜10年）患者8例.5例远期复发患者均为Ⅰ期肿瘤,80.0％患者的核分裂相≤5/10 HPF.8例近期复发患者中晚期（Ⅱ～Ⅲ期）患者占62.5％,75.0％患者的核分裂相＞5/10 HPF,3例≥10/10HPF.13例患者中单纯盆腔局限复发4例,盆腔合并腹腔广泛转移5例,腹膜后转移4例.9例接受再次手术治疗,3例接受单纯化疗（1例联合内分泌治疗）,1例接受单纯放疗.接受手术治疗的患者8例接受术后辅助化疗,1例接受术后辅助放疗.13例患者确诊复发后的中位生存时间为23个月（6 ～ 49个月）;接受手术治疗的9例患者,确诊复发后的中位生存时间为27个月（18 ～49个月）;行非手术治疗4例患者,确诊复发后的中位生存时间为10.5个月（6～16个月）.结论：复发卵巢成人型GCT复发时间间隔较长,需长期随访.晚期、核分裂相高的患者可能易出现近期复发.盆腔以外为常见的转移部位.手术为主的综合治疗为首选的治疗方案.

卵巢颗粒细胞瘤的诊疗进展

卵巢颗粒细胞瘤是相对少见的卵巢性索间质细胞肿瘤,因发病初期多有内分泌相关症状,而使得该肿瘤容易被早期发现。各种分子生物学指标在该病的诊断及随访中发挥着重要的作用。手术是其重要的治疗措施,化疗、放疗、激素治疗及分子生物靶向治疗也是重要的治疗方法。对这类患者采取合理的治疗手段,相对于其他的卵巢恶性肿瘤,可以达到较高的存活率。

卵巢颗粒细胞瘤的CT诊断

目的探讨卵巢颗粒细胞瘤的CT特点。方法回顾分析11例经手术病理证实的卵巢颗粒细胞瘤的CT表现。结果 11例肿块均为单侧,肿块边界清晰,形态规则,5例肿块表现为多房蜂窝状囊实性肿块,6例肿块表现为实性成为主,其内散在小囊腔,实性成分的密度与肌肉相近,增强扫描大多呈中度强化,11例中伴腹水4例,合并子宫增大、子宫内膜增厚10例,子宫肌瘤6例。结论卵巢颗粒细胞瘤的CT表现有一定特征性,结合临床症状有助于正确诊断。