Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the pho...Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.展开更多
Based on the Mach＇s principle and the characteristic mass of the present universe, Mo a c3/2GHo, it is noticed that, ＇rate of decrease in the laboratory fine structure ratio＇ is a measure of the cosmic rate of expa...Based on the Mach＇s principle and the characteristic mass of the present universe, Mo a c3/2GHo, it is noticed that, ＇rate of decrease in the laboratory fine structure ratio＇ is a measure of the cosmic rate of expansion. If the observed laboratory fine structure ratio is a constant, then, independent of the cosmic red shift and CMBR observations, it can be suggested that, at present there is no cosmic acceleration. Obtained value of the present Hubble constant is 70.75 Km/sec/Mpc. If it is true that, rate of decrease in temperature is a measure of cosmic rate of expansion, then from the observed cosmic isotropy it can also be suggested that, at present there is no cosmic acceleration. At present if the characteristic mass of the universe is, Mo = c3/2GHo and if the primordial universe is a natural setting for the creation of black holes and other non-perturbative gravitational entities, it is also possible to assume that throughout its journey, the whole universe is a primordial growing and light speed rotating black hole. At any time, if cot is the angular velocity, then cosmic radius is c/ω1 and cosmic mass is c3/2Gω1 Instead of the Planck mass, initial conditions can be addressed with the Coulomb mass = Mc = √/4xeoG At present, if ω1= H0 the cosmic black hole＇s volume density, observed matter density and the thermal energy density are in geometric series and the geometric ratio is 1 ＋ ln（M0 ＋Mc）.展开更多
文摘依据FFT→优化窗→IFFT思路,突破线性时频变换的窗函数积分性能桎梏,实现高性能优化窗函数的线性时频变换应用,建立新型时频变换算法——K-S变换.对信号x(t)的FFT频谱向量进行频移处理后,与该频移点下Kaiser优化窗的频谱向量进行Hadamard乘积,再将乘积结果进行FFT逆变换(IFFT),构造出K-S变换复时频矩阵,由此获得x(t)的时间-频率-幅值、时间-频率-相位三维信息;给出逆变换的数学推导与局部性质、线性性质和变分辨率特性;0~150 kHz电网的稳态与时变超谐波信号仿真实验表明,K-S变换的时域、频域分辨能力均优于流行的短时傅里叶变换、S变换,具有优良的变分辨率性能;0~40 kHz超谐波信号的实测证明,基于K-S变换的超谐波电压幅值测量绝对误差均小于0.032 3 V.
基金supported by the European Regional Development Funds-European Union(ERDF-EU),FATZHEIMER project(EU-LAC HEALTH 2020,16/T010131 to FRdF),“Una manera de hacer Europa”Ministerio de Economía,Industria y Competitividad,Gobierno de Espa?a,Programa Estatal de Investigación,Desarrollo e Innovación Orientada a los Retos de la Sociedad(RTC2019-007329-1 to FRdF)+2 种基金Consejería de Economía,Conocimiento y Universidad,Junta de Andalucía,Plan Andaluz de Investigación,Desarrollo e Innovación(P18TP-5194 to FRdF)Instituto de Salud CarlosⅢ(DTS22/00021 to FRdF)DMV(FI20/00227)holds a“PFIS’’predoctoral contract from the National System of Health,EU-ERDF-Instituto de Salud CarlosⅢ。
文摘Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.
文摘Based on the Mach＇s principle and the characteristic mass of the present universe, Mo a c3/2GHo, it is noticed that, ＇rate of decrease in the laboratory fine structure ratio＇ is a measure of the cosmic rate of expansion. If the observed laboratory fine structure ratio is a constant, then, independent of the cosmic red shift and CMBR observations, it can be suggested that, at present there is no cosmic acceleration. Obtained value of the present Hubble constant is 70.75 Km/sec/Mpc. If it is true that, rate of decrease in temperature is a measure of cosmic rate of expansion, then from the observed cosmic isotropy it can also be suggested that, at present there is no cosmic acceleration. At present if the characteristic mass of the universe is, Mo = c3/2GHo and if the primordial universe is a natural setting for the creation of black holes and other non-perturbative gravitational entities, it is also possible to assume that throughout its journey, the whole universe is a primordial growing and light speed rotating black hole. At any time, if cot is the angular velocity, then cosmic radius is c/ω1 and cosmic mass is c3/2Gω1 Instead of the Planck mass, initial conditions can be addressed with the Coulomb mass = Mc = √/4xeoG At present, if ω1= H0 the cosmic black hole＇s volume density, observed matter density and the thermal energy density are in geometric series and the geometric ratio is 1 ＋ ln（M0 ＋Mc）.
