Well-differentiated systemic mastocytosis with KIT K509I mutation and uterus infiltration in an Asian woman with good response to imatinib

To the Editor: We report a 27-year-old woman with a 2-month history of irregular uterine bleeding between periods. Blistering on the head was noted in the patient at the age of 2 months, and she gradually developed red maculopapular lesions over her neck and back during puberty, which were itchy after exposure to physical friction. On admission, physical examination had revealed diffuse faint maculopapular rash mainly on the neck and back [Figure 1]. Pelvic examination showed a smooth red lump (5 cm) on the cervix. No abnormality was detected in the complete blood count. Afterwards, the cervical lump was resected and confirmed to be the infiltration of mature mast cells (MCs) after careful pathological investigation. Additionally, a skin nodule biopsy also indicated mass aggregation of MCs, and a bone marrow (BM) biopsy showed a mass of round MCs with abundant cytoplasmic granules. The MCs accounted for about 22.5% of all cells in the aspirate smears. Flow cytometry immunophenotypic analysis on BM suggested that an aberrant MC population had represented 10% of the total analyzed cells, which was positive for CD117, CD33, and CD9, partially positive for CD2 and CD68, and negative for CD25. Genetic test through exome-wide sequencing for the receptor tyrosine kinase (KIT) gene had revealed K509I mutation.

屏蔽箱室内窥视窗玻璃选材研究

传统屏蔽箱室的内窥视窗材质常选用耐辐照光学玻璃,但这种玻璃较脆,尺寸较大时破碎的风险高,需要从常用玻璃中选出更适合大尺寸内窥视窗的玻璃材质。对聚碳酸酯(PC)、有机玻璃和K509玻璃进行γ辐照和中子辐照试验,对比各材质的变色和透光率变化情况,分析γ辐照前后玻璃抗拉、抗弯和抗冲击性能,得出PC玻璃透光率高,韧性好,抗冲击性能优异,是更合适的大尺寸内窥视窗玻璃材质,可为今后类似的屏蔽箱室设计提供参考。