基于监督学习的Takagi Sugeno Kang模糊系统图像融合方法研究

该文针对图像融合领域内难于对先验知识加以利用的问题提出一种新的有监督学习的Takagi Sugeno Kang(TSK)模糊系统图像融合方法。该方法通过引入TSK模糊系统构建标准图像融合图像库进行学习,将学习准则记录下来形成融合模型,并指导新的图像融合过程。不同于传统方法,该方法可以有效地避免模型参数择优的难题,在融合图像质量和适用范围方面表现出一定的优势。从单一类型图像融合和多种类型图像融合两个角度进行了实验研究,实验结果说明该方法的有效性。

基于Takagi-Sugeno-Kang模糊集合的噪声干扰检测方法

为识别混合在接收机热噪声中的人为噪声干扰信号,提出了基于TSK(Takagi-SugenoKang)模糊集合的干扰检测方法。首先将无干扰环境下信道热噪声数据和有人为噪声干扰下的混合噪声数据组合成训练数据序列,利用训练序列对TSK模糊集合模型进行训练,调节模型中规则的多项式系数,使TSK模糊模型对接收信号中的噪声特性与干扰判决之间建立确定函数关系,实现对噪声干扰的检测。通信电台的实验验证表明:尽管接收机的自动增益控制将外部噪声干扰缩小到与本机噪声相当水平,所提方法仍能有效检测出信道中是否有人为噪声干扰存在。

Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency

Objective:To investigate effects of herbal compound Yi Tang Kang on the spleen deficiency metabolic syndrome.Methods:Forty male Wistar rats were randomly divided into two groups:the normal control group and the MS spleen deficiency syndrome group.The control group rats were fed with standard diet and water,while MS spleen deficiency syndrome group with high fat diet and low dose intraperitoneal injection of slreptozocin.which swam to the endurance limit.After 12 weeks,the MS spleen deficiency syndrome group was randomly divided into two groups,with 13 rats in each group.Flats in model group were fed with high fat diet and conlinuouly administered with daily saline,and rats in intervention group with high fat diet were trated with traditional Chinese medicines Yi Tang Kang by gavage,2 mL/200 g at the same lime every day.10 weeks later,the expression of serum proteomics was investigated through abdominal aortic puncture and separation of serum,using isotope labeling technique,high performance liquid chromatography and four bar-Orbitrap mass spectrometer.Results:After treatment with traditional Chinese medicine yitangkang,in the model group,important carboxylesterase and retinal guanylate cyclase 2 precursor were upregulated.As for intervention group,these indesxes were raised,but immunoglobulin IgG,carnitine acetyltransferase,tubulin beta-5,and Gan Lu sugar binding protein C were down-regulated.At the same time,some new biological active substances,such as protein tyrosine kinase,beta glucosidase were also found.Conclusions:Traditional Chinese medicines Yi Tang Kang could regulate glucose and lipid metabolism in rats with spleen deficiency syndrome.

Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2

BACKGROUND:Kang-Lai-Te(KLT)is extracted from the traditional Chinese herbal medicine Semen Coicis,which has been used in China as an effective clinical drug for over a thousand years.It contains numerous ingredients with anti-tumor effects.In our previous studies on transplanted hepatomas in rats,KLT could stop the cells in the G2+M stage of cell cycle and then reduce the number of cells entering the stage G0 and G1,but the mechanism of the anti-proliferative effect was unknown.In this experiment,we examined whether KLT inhibits HepG2 cell growth,if so,tried to explore its mechanism. METHODS:KLT at different concentrations was used for the treatment of hepatocellular carcinoma cells in vitro,respectively.The proliferation inhibitory rate was evaluated by MTT assay,induction of cell apoptosis rate and the protein levels of Fas and Fas ligand(FasL)were determined by flow cytometry(FCM),and the expression of Fas and FasL mRNA was detected by real-time fluorescent quantitative RT-PCR. RESULTS:KLT produced an obvious time and dose- dependent inhibitory effect on HepG2 cells,and marked apoptosis was detected by FCM.The protein of Fas increased by 11.01%,18.71%,28.71%and 37.15%;the protein of FasL increased by 1.49%,1.91%,3.27%and 3.38%in comparison with the control(P<0.05).Real-time fluorescent quantitative RT-PCR showed that treating HepG2 cells with KLT caused the upregulation of Fas and FasL mRNA.CONCLUSION:KLT inhibits HepG2 growth by inducing apoptosis,which may be mediated through activation of the Fas/FasL pathway.

Efficacy of intra- tumor injection of Kang-Lai-Te in treating transplanted hepatoma in rats

BACKGROUND: Non-operative therapy takes an impor- tant position in comprehensive therapy of liver cancer. De- spite some effects by using ethanol, acetic acid and heat sa- line for intra-tumor injection in the treatment of liver canc- er, it is difficult to attain a complete cure but bring about injury to the liver to some extent. Hence, searching for other drugs for the local treatment of liver tumor is an im- portant option. This study was designed to set up rat mo- dels of transplanted liver cancer, intra-tumor injection of Kang-Lai-Te (KLT), and negative control (saline) and positive control (ethanol). The effect of intra-tumor injec- tion of KLT in treating transplanted hepatoma in rats and its advantages and disadvantages were assessed and the pos- sibility of its use in treating patients with liver cancer was evaluated. METHODS: Forty rats were divided into 4 groups ( G1, G2, G3 and G4, 10 rats in each group). Different drugs were injected into their implanted hepatoma (G1 with 0.2 ml saline as control, G2 with 10 mg KLT, G3 with 20 mg KLT, G4 with 0.2 ml ethanol). After 3 and 8 days, the hepa- toma volume (HV), the serum levels of albumin, alanine aminotransferase(ALT), aspartate aminotransferase alkaline phosphatase( ALP) and creatinine, as well as the expression of proliferation cell nuclear antigen (PCNA) in hepatoma were detected. RESULTS: After 3 days, the HVs were smaller in G3 and G4 than in G1 (P <0.05), the serum levels of albumin were higher in G2 and G3 than in Gl and G4 (P <0.05), the se- rum levels of ALT and AST were lower in G2 and G3 than in G4 (P<0.05), the serum levels of ALP was lower in G2 and G3 than in Gl and G4 (P <0. 05), the PCNA labeling indexes (PCNA LI) were lower in G2 and G3 than in Gl and GA (P <0.05). After 8 days, the HVs were smaller in G2, G3 and G4 than in Gl (P <0.05), and the differences of HVs among G2, G3 and G4 were not significant. The serum levels of ALP were lower in G1, G2 and G3 than in G4 (P <0.05), and the PCNA LI were lower in G3 than in Gl andG4 (P<0.05). CONCLUSION: Intra-tumor injection of KLT into implan- ted hepatoma is evidently effective, but it is less effective than ethanol. The effect of KLT on liver function is markedly lower than that of ethanol.

Efficacy and safety of Kang’ai injection adjunct with TP chemotherapy for the treatment of non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials

Background:Combination therapy with traditional Chinese medicine and chemotherapy was proposed as a therapeutic strategy for non-small cell lung cancer patients.Therefore,we performed a systematic review and metaanalysis of randomized controlled trials to assess effects of this combination therapy on non-small cell lung cancer.To evaluate the efficacy and safety of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the treatment of non-small cell lung cancer.Methods:A randomized controlled study of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the databases of China National Knowledge Infrastructure Database,WanFang Database,VIP Database,Sino-Med Database,PUBMED,EMBASE and Cochrane library was searched by computer.The literatures published from the database establishment to July 1,2020 were included in the search scope.After 2 evaluators independently evaluated and cross checked the quality of the study,Revman 5.3 was used to meta analyze the clinical effect of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy on patients with non-small cell lung cancer.Results:A total of 1,370 lung cancer patients were included in 20 RCTs.The results of meta-analysis showed that there were significant differences between the 2 groups in clinical efficacy(RR=1.32,95%CI(1.20,1.44)),quality of life(RR=1.44,95%CI(1.32,1.57)),immune function(MD=0.53,95%CI(0.23–0.83)),adverse reactions(RR=0.49,95%CI(0.41,0.58)).Conclusion:The Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy is effective and safe in the treatment of non-small cell lung cancer,and has great prospects for further development.However,the quality of evidence was very low-to-moderate.Considering the poor quality of evidence,we are not very confident in the results.We look forward to more research and update results in the future and improve the evidence quality.

Anti-inflammatory and antipyretic properties of Kang 601 heji,a traditional Chinese oral liquid dosage form

Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.

Effect of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced NSCLC

Objective: To study the effects of Kang Ai injection + conventional chemotherapy on tumor markers, apoptotic molecules and immune response in patients with advanced non-small cell lung cancer (NSCLC). Methods: Patients diagnosed as advanced NSCLC in our hospital during March 2015 - October 2017 were randomly divided into the experimental group receiving Kang Ai injection + conventional chemotherapy and the control group receiving conventional chemotherapy. The contents of tumor markers, apoptotic molecules and immunologic cytokines in serum and the contents of immune cells in peripheral blood were determined before and after chemotherapy. Results: after chemotherapy, the content of CEA, CYFRA21-1, SCC-Ag, GDF15 and Livin in the serum of the two groups decreased significantly, and the content of PDCD5, P53 and Bax increased significantly, and the content of CEA, CYFRA21-1, SCC-Ag, GDF15, Livin in the serum of the experimental group were lower than those of the control group, and the content of PDCD5, P53 and Bax were higher than those of the control group;the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of control group significantly decreased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly increased after chemotherapy;while the content of CD3+ and CD4+ cells in peripheral blood and the content of IFN-γ, IL-2 in serum of experimental group significantly increased, whereas the content of CD8+ cells in peripheral blood and the content of IL-4, IL-5 in serum significantly decreased after chemotherapy. Conclusion: Kang Ai injection + conventional chemotherapy in the treatment of advanced NSCLC can more significantly decrease the serum tumor markers, regulate the secretion of apoptotic molecules and anti-tumor immune response than conventional chemotherapy.

Network pharmacology to predicting therapy targets of traditional Chinese medicine Kang’ai injection on breast cancer

Background:To predict the effective targets of Kang’ai injection and analyze the pharmacological mechanism for the treatment of breast cancer based on the method of network pharmacology.Methods:The Traditional Chinese Medicine Systems Pharmacology database was used to predict the effective components of the Chinese patent medicine Kang’ai injection,and GeneCards database,Online Mendelian Inheritance in Man database and the Therapeutic Target Database were used to predict the therapeutic targets of breast cancer.Cytoscape 3.7.2 was used to construct active ingredient-disease-target network.String database and Cytoscape 3.7.2 software were used to draw the protein-protein interaction network and obtain the core target.Bioconductor and R language were used to analyze the effective action target for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.Results:There were 42 effective active ingredients in the Chinese patent medicine Kang’ai injection,which acted on 105 targets,and it had 32 components that acted on 96 targets associated with breast cancer.The target regulates various biological processes such as inflammation,angiogenesis,apoptosis and cell proliferation,and regulates pathways such as PI3K-Akt signaling pathway,MAPK signaling pathway,AGE-RAGE signaling pathway in diabetic complications and thyroid hormone signaling pathway through gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis.Conclusion:The treatment of breast cancer with the Chinese patent medicine Kang’ai injection is a complex mechanism process with multiple targets,multiple pathways,and multiple choices,which provides a theoretical basis for the further extraction of effective components in the treatment of breast cancer.

Meta-analysis of therapy of Kang’ai injection combined with chemotherapy in the treatment of non-small cell lung cancer

Objective:To compare the safety and efficacy of Kang’ai injection combined with chemotherapy and chemotherapy alone in the treatment of non-small cell lung cancer.Methods:The related control and randomized studies from 1966 to October 01,2022,were retrieved in the following databases:China National Knowledge Infrastructure,Wanfang databases,Value In Paper,SinoMed,PubMed,Embase and Cochrane Library.A comprehensive literature search was conducted in 7 electronic databases identifying all the relevant randomized controlled trials.Cochrane handbook 5.2.3 was applied to evaluate the quality of included trials,and the RevMan 5.3 software was used to analyze data and assess the publication bias.Results:From the 16 studies reviewed,a total of 1,398 patients were included.Compared with docetaxel+cis-platinum chemotherapy alone,Kang’ai injection combined with docetaxel+cis-platinum chemotherapy showed significant effects in improving clinical response rate(RR:1.40,95%confidence interval(CI)(1.25,1.58)),quality of life score(Karnofsky score)(RR:1.53,95%CI(1.32,1.78)),traditional Chinese medicine syndrome(RR:2.01,95%CI(1.43,2.83))and safety(RR:0.62,95%CI(0.54,0.71)),the differences were statistically significant.Conclusion:Kang’ai injection may increase the therapeutic effectiveness,improve the quality of life,and reduce the toxicity of chemotherapy in patients with non-small cell lung cancer.These results require confirmation by further rigorously designed randomized controlled trials(PROSPERO registration number:CRD42020176917).

Kang Ta

·Kang Ta的鼻梁中间有一块骨头比较突出,从右边看很明显,左边看不太出来,所以他照相时喜欢别人拍他的左脸。·他一直爱听张国荣的歌。·他对爱情的心得是:爱是眼泪的种子。目前他希望找眼睛漂亮(因为他觉得透过眼睛能看到对方的内心)又体谅人的女孩作伴。·他说自己做过的最疯狂的事。

The Energy Consumption of Heatingin the Northeast Rural Area of China from the Perspective of the Kang and Agricultural Waste

In China,the heating energy consumption patterns of rural housing are changing due to economic development.This study investigated domestic heating in rural areas of Dalian,a city in northeast China.In rural areas of the country,heating devices such as coal boiler,radiator,and/or air-conditioner are typically used.The Kang,as the main heating system,has been used together with other heating methods for a long time in detached houses,one-story buildings,and quadrangles.Use of the Kang in collective housing is no longer observed.In addition to coal,agricultural wastes have been used to fuel the Kang;the associated CO2 emissions with agricultural fuels are lower than from other heating equipment.Even when a combination of the Kang and other equipment is used,with agricultural waste as fuel,CO2 emissions remain relatively low.

采用压缩感知采样的Takagi-Sugeno-Kang(TSK)功率模型(英文)

More and more information are needed in social life and commercial production, causing significant pressure on the sampling and too much time spent on signal sampling. Compressed sensing is one emerging hotspot in signal processing which employs a special sampling method to capture and represent compressible signals at a rate significantly below the Nyquist rate. In this paper, a Takagi-Sugeno-Kang (TSK) Model based on compressed-sensing sampling theorem is proposed for grinding power. It is further tested by using the actual production data, and the algorithm performance in grinding power model is also analyzed. The experiments show the validity and effectiveness of the proposed modeling method and its bright application foreground in other fields with similar features, such as power, metallurgy and so on.

Burning Cave-Pipe Coil-Kang Coupled Heating System Research

Nowadays,people still rely on traditional heating methods in rural areas of northern China,such as Kang(bed-stoves) and burning caves in cold winter.Field measurements of indoor environment were carried out in several rural houses with burning-cave-coil-Kang coupling heating system in northern China.The results show that this system is able to realize the graded use of internal energy of burning cave.The temperature of supply pipe water ranged from 30 ℃ to 50 ℃ which met the demands in 74.7% of time.The surface temperature of Kang maintained at above 25 ℃.Compared with traditional burning cave,using burning-cave-coil-Kang coupled with heating system has a higher thermal efficiency of 48.9%,which is 8.32% higher than the traditional one.

The Vigorous, Forceful, Extensive and Profound Style of Calligraphy——Kang Wanli, Inheritance of Beipai Kangti Calligraphy

中国书法家康万里以其粗狂、豪放、厚重、泼辣的书写风格确立了享誉海内外的北派康体书法。本文回顾了康万里成长经历和艺术成就,真实呈现了康万里在推进中国书法艺术事业中所起到的积极努力。笔者希望通过此文能让更多的人了解北派康体书法。

TUDE DE ENCPHALE ATLAS DANS PR-TRAITEMENT ET POST-TRAITEMENT DE TUMEUR CRBRAL PAR "KANG NO LIU KOU FU YE"

目的:探讨脑电地形图在脑瘤疗效判断上的应用价值。方法:通过对30例脑瘤治疗 前后脑电地形图改变进行对比研究。结果:脑电地形图在治疗前后有明显改变。结论:脑电地形图 可以作为脑瘤疗效评价的一个有价值的指标。<正>Objectif: De explorer valeure appliq6e de encephale adas dan evaluation de effet cur atif de tumeur cerebral. Methode: Etude comparative de encephale adas de 30 malades avec tumeur cerebral avant et apr6s traitement est realise. Resultat: Encephale adas est change manifestement avant et apres traitement. Conclusion: Encephale adas est un index valable de jugement de effet curatif dans tumeur cerebral.

康县香菇产业现状及发展建议

香菇生产是康县农业农村经济重要的优势产业和支柱性产业之一。基于实地调研,分析了康县香菇的产业基础、品牌建设、产业模式、技术特色等方面的优势。针对康县香菇产业发展中存在的主要问题,提出了扶持龙头企业、研发推广新技术新产品、开展地理标志认证、扩大林地规模等发展建议。

康县长坝镇运动康养小镇建设

康县长坝镇是我国第一批全国乡村旅游重点镇之一,也是“一带一路”美丽乡村论坛会址,是甘肃境内的康养富集地,具有丰富的文旅康养内涵。文章主要利用文献资料、访谈、实地考察等研究方法,结合我国当前运动休闲小镇建设基本政策和培育经验认为:康县长坝镇运动康养特色小镇建设,应该以“健康”为主题,辐射康县全域美丽乡村游为抓手,依托花桥旅游景区和青龙山冰雪运动基地,打造绿色山水户外运动品牌,将康县长坝镇建设成为集“运动康养、文化旅游、健身休闲、田园旅居、康复疗养、户外露营”等多功能于一体的“宜养、宜旅、宜居”康养小镇,为地方经济及体育、文旅、康养等产业的高质量融合发展提供参考和借鉴。