期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Discovery of novel dual inhibitors of VEGFR and PI3K kinases containing 2-ureidothiazole scaffold 被引量:1
1
作者 Lin Li Cun-Long Zhang +3 位作者 Hong-Rui Song Chun-Yan Tan Huai-Wei Ding Yu-Yang Jiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第1期1-6,共6页
A series of compounds possessing 2-(3-phenyl)ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against... A series of compounds possessing 2-(3-phenyl)ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against both MDA-MB-231 and Hep G2 cell lines using Sorafenib as the positive control.Compounds 6i showed a good to moderate inhibition on VEGFR-2 and PI3Ka which was proved by further molecular docking study. This study suggests that compound 6i is a potential dual inhibitor of VEGFR-2 and PI3Ka and is applicable for further investigation. 展开更多
关键词 2-AMINOTHIAZOLE VEGFR PI3 kanticancer
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部