The addition of pyridine-2-carboxaldoxime or α-furildioxime to dialkyl acety lenedicarboxy lates under neutral conditions in the presence of alkyl isocyanides leads to ketenimines and bis（ketenimines） in good yields.
A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates...A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.展开更多
文摘The addition of pyridine-2-carboxaldoxime or α-furildioxime to dialkyl acety lenedicarboxy lates under neutral conditions in the presence of alkyl isocyanides leads to ketenimines and bis（ketenimines） in good yields.
基金the National Natural Science Foundation of China(No.21572075)the 111 Project B17019+1 种基金the Research Project of Hubei Provincial Department of Education(No.Q20192806)the Doctoral Research Fund of Hubei University of Science and Technology(No.BK201808).
文摘A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been developed.The easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.
