Background Brown adipose tissue(BAT)is known to be capable of non-shivering thermogenesis under cold stimulation,which is related to the mortality of animals.In the previous study,we observed that goat BAT is mainly l...Background Brown adipose tissue(BAT)is known to be capable of non-shivering thermogenesis under cold stimulation,which is related to the mortality of animals.In the previous study,we observed that goat BAT is mainly located around the kidney at birth,and changes to white adipose tissue(WAT)in the perirenal adipose tissue of goats within one month after birth.However,the regulatory factors underlying this change is remain unclear.In this study,we systematically studied the perirenal adipose tissue of goat kids in histological,cytological,and accompanying molecular level changes from 0 to 28 d after birth.Results Our study found a higher mortality rate in winter-born goat kids,with goat birthing data statistics.Then we used thermal imaging revealing high temperature in goat hips at postnatal 0 d and gradually decrease during 28 d.This is consistent with the region of perirenal BAT deposition and highlights its critical role in energy expenditure and body temperature regulation in goat kids.Additionally,we found a series of changes of BAT during the first 28 d after birth,such as whitening,larger lipid droplets,decreased mitochondrial numbers,and down-regulation of key thermogenesis-related genes(UCP1,DIO2,UCP2,CIDEA,PPARGC1a,C/EBPb,and C/EBPa).Then,we used RNA-seq found specific marker genes for goat adipose tissue and identified 12 new marker genes for BAT and 10 new marker genes for WAT of goats.Furthermore,12 candidate genes were found to potentially regulate goat BAT thermogenesis.The mechanism of the change of this biological phenomenon does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.While apoptosis may play a limited role,it is largely not critical in this transition process.Conclusions We concluded that perirenal BAT plays a crucial role in thermoregulation in newborn goat kids,with notable species differences in the expression of adipose tissue marker genes,and we highlighted some potential marker genes for goat BAT and WAT.Additionally,the change from BAT to WAT does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.展开更多
Nuonuo Kids Bookstore is a dreamlike reading kingdom,established by Zhaci and his team with boundless enthusiasm and considerate design.In such a magical space,laughters and exclamations of kids harmonize into the mos...Nuonuo Kids Bookstore is a dreamlike reading kingdom,established by Zhaci and his team with boundless enthusiasm and considerate design.In such a magical space,laughters and exclamations of kids harmonize into the most beautiful melody.Here,they learn to think,feel,love and also be loved.展开更多
In recent years, the demand for goat products has been growing due to the fact that goat milk has a number of advantages over cow milk, for example, it is low in lactose, and is considered less allergenic and easier t...In recent years, the demand for goat products has been growing due to the fact that goat milk has a number of advantages over cow milk, for example, it is low in lactose, and is considered less allergenic and easier to digest. To increase production during both breeding and non-breeding seasons and reduce the price of dairy products, it is necessary to effectively use reproductive management and assisted reproductive technologies. In vitro embryo production makes it possible to obtain a large number of eggs from goats, which for some reason are unable to conceive, but have genetic value. Afterward in vitro produced embryos can be transferred into recipient goats of other less genetically valuable breeds, such as the Ukrainian local breed. Therefore, the aim of the present study was to investigate the effectiveness of transfers of in vitro produced embryos of Saanen goats into surrogate sires of the Ukrainian local breed in different seasons. All manipulations with animals were carried out following ethical standards (Strasbourg, 1986). Six Saanen goats were selected as the oocyte donors. After the hormonal stimulation oocytes were retrieved by laparoscopic ovum pick-up. In vitro produced embryos were transferred laparotomically into 24 recipients of Ukrainian local breed. Fifty days after embryo transfers, pregnancies were determined by ultrasound diagnostics. Although the embryo development rate in the breeding season was 20% higher than in the non-breeding season, there was no difference in pregnancy and kidding rates between seasons. In conclusion, the transfer of in vitro produced Saanen goat embryos to recipients of the Ukrainian local breed gives the opportunity to achieve pregnancy and kidding regardless of the breeding season, which will enable a faster and more efficient increase in the livestock of highly productive goats in Ukraine in the post-war period.展开更多
The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals...The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals aid use in the pedagogy. The study is to appraise the opinion of toddlers/teachers about the helpfulness of 3D-visuals (ergonomic board);the clarity of the intended functions of the 3D-visuals in the toddler’s lessons instruction and support from the producers in using them;and why visuals (conventional visual aids) in schoolroom instruction are misjudged/misinterpreted;their view about the functions in specific (conventional visuals) for the instruction pedagogy;and other sources of visuals provided other than the lesson’s instruction. Four nursery/primary schools participated in the study. Seventy-two (72) toddler’s/teachers participated in the study. The study examined using quantitative and qualitative approach for statistical analysis (using pie-chart and histogram). The findings suggested that the aspects of visuals items selected for comment and description are to some extent circumscribed by toddler’s learners’ linguistic resources. Understandably, the point made by researchers referred that visuals often fail to support learning as effectively as they might because they are not regarded as a full-fledged information mode that requires the same careful processing as verbal text, is borne out by the findings. Recommendation, the accountability is above all on producers of kid’s instructional materials: authors, editors, designers and illustrators of the materials. The implication of this is that toddlers’ instructional materials should, as in the case of illustrated books include both an overt explanation of the overall philosophy toward visuals and overview of their use.展开更多
自杀是当前全球重大公共卫生问题之一,预防自杀已刻不容缓。经过30年的发展,加拿大自杀预防中心(Kids Help Phone)开展的青少年自杀预防教育在加拿大处于领导力地位。KHP下设咨询服务与项目部、收入发展部、财务与行政部、创新科技部、...自杀是当前全球重大公共卫生问题之一,预防自杀已刻不容缓。经过30年的发展,加拿大自杀预防中心(Kids Help Phone)开展的青少年自杀预防教育在加拿大处于领导力地位。KHP下设咨询服务与项目部、收入发展部、财务与行政部、创新科技部、新闻编辑室五个部门;借助这些部门,KHP聘用专业的雇员和志愿者,开发线上和线下实体项目、参与国家战略、加强与其他相关机构的联系,为青少年,尤其是大中小学生提供专业化的自杀预防服务和教育活动。KHP及其开展的青少年自杀预防教育对完善我国自杀预防机构、推进自杀预防教育专业化等,提供了借鉴意义。展开更多
Worries ＂I had not known that my kid had a nearsightedness of 800 degrees. Consequences would have been unthinkable if eye specialists from the city had not treated him,＂ said Yun Za, father of a student attending ...Worries ＂I had not known that my kid had a nearsightedness of 800 degrees. Consequences would have been unthinkable if eye specialists from the city had not treated him,＂ said Yun Za, father of a student attending the No.5 Middle School of Jarud Banner （county） in Tongliao Municipality, Inner Mongolia. He is all gratitude tor doctors of the Tongliao Prevention and Treatment Center for Students＇ Eye Diseases （Tongliao Eye Center）.展开更多
In this study,the decay of maternal peste des petits ruminants virus(PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed t...In this study,the decay of maternal peste des petits ruminants virus(PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids.Serum samples collected from kids born to vaccinated,unvaccinated and infected goats at different time intervals were tested by PPR competitive ELISA and serum neutralization test(SNT).Maternal antibodies in kids were detectable up to 6 months with a decline trend from the third month onwards and receded below the protective level by the fourth month.The kid with an SN titre of 1:8 at the time of immunization showed significant PPRV specific antibody response(percentage inhibition of 76;SN titers >1:16),when tested on 21 day post-vaccination and was completely protected from infection upon virulent PPRV challenge.Similarly,the kid with 1:8 SN titers was completely protected from PPR infection on active challenge.Therefore,PPR vaccination is recommended in kids,aged 4 months and born to immunized or exposed goats.This could be a suitable period to avoid window of susceptibility in kids to PPRV and the effort to eliminate PPR infection from susceptible populations.展开更多
Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic met...Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic method. The resultsshowed that the main factor affecting kid rennet activity during extraction was ultrasound intensity, and then NaClconcentration, extracting time and ratio of abomasums to extracting solution in order. Kid rennet activity reached peakwith ultrasound intensity 30 W cm-2, extraction time 40 min, NaCl concentration 8%, pH value 3.0, ratio of abomasums toextracting solution 1:15.展开更多
1.Introduction Daily physical activity（PA）participation is crucial to the health and well-being of young children.Along with total physical activity（TPA;all-intensity）,moderate-to-vigorous physical activity（MVPA...1.Introduction Daily physical activity（PA）participation is crucial to the health and well-being of young children.Along with total physical activity（TPA;all-intensity）,moderate-to-vigorous physical activity（MVPA）,or energetic play,is associated with greater health benefits,particularly for preschoolers（3-4 years）,including but not limited to improved bone and skeletal properties and cognitive and psychosocial health.1 Centered on this,both Canada and Australia have recently established 24-Hour Movement Guidelines for the Early Years,recommending that.展开更多
目的:通过系统的文献检索和整理分析,总结介绍国际足球联合会医学评估与研究中心(FIFA Medical Assessment and Research Center,F-MARC)和国际知名专家共同制定的具有年龄特异性的FIFA 11+儿童版(FIFA 11+kids)综合热身练习对儿童足球...目的:通过系统的文献检索和整理分析,总结介绍国际足球联合会医学评估与研究中心(FIFA Medical Assessment and Research Center,F-MARC)和国际知名专家共同制定的具有年龄特异性的FIFA 11+儿童版(FIFA 11+kids)综合热身练习对儿童足球运动员的影响。方法:按照预先制定的检索策略和文献纳入、排除标准,对相关文献进行检索和筛选,对符合要求的文献进行定性分析和叙述性总结。纳入文献的质量通过PEDro量表进行评估。结果:经过检索和筛选,共计8篇英文文献被纳入本系统综述,进行最后的分析、评价和总结归纳,未纳入中文文献。所纳入研究的质量评价得分在4至7分(满分11分)的范围内,研究的平均得分为6.75分,表明所纳入文献的质量中等。结论:1)FIFA 11+kids综合热身练习可有效预防儿童足球运动员的运动损伤,降低其损伤风险;2)FIFA 11+kids可提高儿童足球运动员跳高、跳远、平衡、敏捷性等运动能力和身体素质,改善其运动表现;3)与常规的热身活动相比,FIFA 11+kids大大降低了与医疗保健相关的成本。展开更多
基金This work was financially supported by The National Key Research and Development Program of China(No.2022YFD1300202)The National Natural Science Foundation of China(No.32372834)+2 种基金Chongqing Modern Agricultural Industry Technology System(CQMAITS202313)the Collection,Utilization and Innovation of Germplasm Resources by Research Institutes and Enterprises of Chongqing,China(cqnyncw-kqlhtxm)the Chongqing Postgraduate Research Innovation Project(CYB22141).
文摘Background Brown adipose tissue(BAT)is known to be capable of non-shivering thermogenesis under cold stimulation,which is related to the mortality of animals.In the previous study,we observed that goat BAT is mainly located around the kidney at birth,and changes to white adipose tissue(WAT)in the perirenal adipose tissue of goats within one month after birth.However,the regulatory factors underlying this change is remain unclear.In this study,we systematically studied the perirenal adipose tissue of goat kids in histological,cytological,and accompanying molecular level changes from 0 to 28 d after birth.Results Our study found a higher mortality rate in winter-born goat kids,with goat birthing data statistics.Then we used thermal imaging revealing high temperature in goat hips at postnatal 0 d and gradually decrease during 28 d.This is consistent with the region of perirenal BAT deposition and highlights its critical role in energy expenditure and body temperature regulation in goat kids.Additionally,we found a series of changes of BAT during the first 28 d after birth,such as whitening,larger lipid droplets,decreased mitochondrial numbers,and down-regulation of key thermogenesis-related genes(UCP1,DIO2,UCP2,CIDEA,PPARGC1a,C/EBPb,and C/EBPa).Then,we used RNA-seq found specific marker genes for goat adipose tissue and identified 12 new marker genes for BAT and 10 new marker genes for WAT of goats.Furthermore,12 candidate genes were found to potentially regulate goat BAT thermogenesis.The mechanism of the change of this biological phenomenon does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.While apoptosis may play a limited role,it is largely not critical in this transition process.Conclusions We concluded that perirenal BAT plays a crucial role in thermoregulation in newborn goat kids,with notable species differences in the expression of adipose tissue marker genes,and we highlighted some potential marker genes for goat BAT and WAT.Additionally,the change from BAT to WAT does not involve a large-scale death of brown adipocytes and subsequent proliferation of white adipocytes.
文摘Nuonuo Kids Bookstore is a dreamlike reading kingdom,established by Zhaci and his team with boundless enthusiasm and considerate design.In such a magical space,laughters and exclamations of kids harmonize into the most beautiful melody.Here,they learn to think,feel,love and also be loved.
文摘In recent years, the demand for goat products has been growing due to the fact that goat milk has a number of advantages over cow milk, for example, it is low in lactose, and is considered less allergenic and easier to digest. To increase production during both breeding and non-breeding seasons and reduce the price of dairy products, it is necessary to effectively use reproductive management and assisted reproductive technologies. In vitro embryo production makes it possible to obtain a large number of eggs from goats, which for some reason are unable to conceive, but have genetic value. Afterward in vitro produced embryos can be transferred into recipient goats of other less genetically valuable breeds, such as the Ukrainian local breed. Therefore, the aim of the present study was to investigate the effectiveness of transfers of in vitro produced embryos of Saanen goats into surrogate sires of the Ukrainian local breed in different seasons. All manipulations with animals were carried out following ethical standards (Strasbourg, 1986). Six Saanen goats were selected as the oocyte donors. After the hormonal stimulation oocytes were retrieved by laparoscopic ovum pick-up. In vitro produced embryos were transferred laparotomically into 24 recipients of Ukrainian local breed. Fifty days after embryo transfers, pregnancies were determined by ultrasound diagnostics. Although the embryo development rate in the breeding season was 20% higher than in the non-breeding season, there was no difference in pregnancy and kidding rates between seasons. In conclusion, the transfer of in vitro produced Saanen goat embryos to recipients of the Ukrainian local breed gives the opportunity to achieve pregnancy and kidding regardless of the breeding season, which will enable a faster and more efficient increase in the livestock of highly productive goats in Ukraine in the post-war period.
文摘The caprice for the study came from an indigenous designed instructional board for teaching learners in nursery/primary schools (2 - 10 years) and the task whose overall topic is the reminiscence, retention of visuals aid use in the pedagogy. The study is to appraise the opinion of toddlers/teachers about the helpfulness of 3D-visuals (ergonomic board);the clarity of the intended functions of the 3D-visuals in the toddler’s lessons instruction and support from the producers in using them;and why visuals (conventional visual aids) in schoolroom instruction are misjudged/misinterpreted;their view about the functions in specific (conventional visuals) for the instruction pedagogy;and other sources of visuals provided other than the lesson’s instruction. Four nursery/primary schools participated in the study. Seventy-two (72) toddler’s/teachers participated in the study. The study examined using quantitative and qualitative approach for statistical analysis (using pie-chart and histogram). The findings suggested that the aspects of visuals items selected for comment and description are to some extent circumscribed by toddler’s learners’ linguistic resources. Understandably, the point made by researchers referred that visuals often fail to support learning as effectively as they might because they are not regarded as a full-fledged information mode that requires the same careful processing as verbal text, is borne out by the findings. Recommendation, the accountability is above all on producers of kid’s instructional materials: authors, editors, designers and illustrators of the materials. The implication of this is that toddlers’ instructional materials should, as in the case of illustrated books include both an overt explanation of the overall philosophy toward visuals and overview of their use.
文摘自杀是当前全球重大公共卫生问题之一,预防自杀已刻不容缓。经过30年的发展,加拿大自杀预防中心(Kids Help Phone)开展的青少年自杀预防教育在加拿大处于领导力地位。KHP下设咨询服务与项目部、收入发展部、财务与行政部、创新科技部、新闻编辑室五个部门;借助这些部门,KHP聘用专业的雇员和志愿者,开发线上和线下实体项目、参与国家战略、加强与其他相关机构的联系,为青少年,尤其是大中小学生提供专业化的自杀预防服务和教育活动。KHP及其开展的青少年自杀预防教育对完善我国自杀预防机构、推进自杀预防教育专业化等,提供了借鉴意义。
文摘Worries ＂I had not known that my kid had a nearsightedness of 800 degrees. Consequences would have been unthinkable if eye specialists from the city had not treated him,＂ said Yun Za, father of a student attending the No.5 Middle School of Jarud Banner （county） in Tongliao Municipality, Inner Mongolia. He is all gratitude tor doctors of the Tongliao Prevention and Treatment Center for Students＇ Eye Diseases （Tongliao Eye Center）.
基金Project Directorate on Animal Disease Monitoring and Surveillance(PD_ADMAS)
文摘In this study,the decay of maternal peste des petits ruminants virus(PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids.Serum samples collected from kids born to vaccinated,unvaccinated and infected goats at different time intervals were tested by PPR competitive ELISA and serum neutralization test(SNT).Maternal antibodies in kids were detectable up to 6 months with a decline trend from the third month onwards and receded below the protective level by the fourth month.The kid with an SN titre of 1:8 at the time of immunization showed significant PPRV specific antibody response(percentage inhibition of 76;SN titers >1:16),when tested on 21 day post-vaccination and was completely protected from infection upon virulent PPRV challenge.Similarly,the kid with 1:8 SN titers was completely protected from PPR infection on active challenge.Therefore,PPR vaccination is recommended in kids,aged 4 months and born to immunized or exposed goats.This could be a suitable period to avoid window of susceptibility in kids to PPRV and the effort to eliminate PPR infection from susceptible populations.
基金The study was supported by Natural Science Founda—tion of Shaanxi Province of China (2003C134)．
文摘Using 2-3 weeks kid abomasums as materials, the ultrasound intensity, extracting time, NaCl concentration and pH valuein extracting solution and ratio of abomasums to extracting solution were studied by ultrasonic method. The resultsshowed that the main factor affecting kid rennet activity during extraction was ultrasound intensity, and then NaClconcentration, extracting time and ratio of abomasums to extracting solution in order. Kid rennet activity reached peakwith ultrasound intensity 30 W cm-2, extraction time 40 min, NaCl concentration 8%, pH value 3.0, ratio of abomasums toextracting solution 1:15.
文摘1.Introduction Daily physical activity（PA）participation is crucial to the health and well-being of young children.Along with total physical activity（TPA;all-intensity）,moderate-to-vigorous physical activity（MVPA）,or energetic play,is associated with greater health benefits,particularly for preschoolers（3-4 years）,including but not limited to improved bone and skeletal properties and cognitive and psychosocial health.1 Centered on this,both Canada and Australia have recently established 24-Hour Movement Guidelines for the Early Years,recommending that.
文摘目的:通过系统的文献检索和整理分析,总结介绍国际足球联合会医学评估与研究中心(FIFA Medical Assessment and Research Center,F-MARC)和国际知名专家共同制定的具有年龄特异性的FIFA 11+儿童版(FIFA 11+kids)综合热身练习对儿童足球运动员的影响。方法:按照预先制定的检索策略和文献纳入、排除标准,对相关文献进行检索和筛选,对符合要求的文献进行定性分析和叙述性总结。纳入文献的质量通过PEDro量表进行评估。结果:经过检索和筛选,共计8篇英文文献被纳入本系统综述,进行最后的分析、评价和总结归纳,未纳入中文文献。所纳入研究的质量评价得分在4至7分(满分11分)的范围内,研究的平均得分为6.75分,表明所纳入文献的质量中等。结论:1)FIFA 11+kids综合热身练习可有效预防儿童足球运动员的运动损伤,降低其损伤风险;2)FIFA 11+kids可提高儿童足球运动员跳高、跳远、平衡、敏捷性等运动能力和身体素质,改善其运动表现;3)与常规的热身活动相比,FIFA 11+kids大大降低了与医疗保健相关的成本。
