A Case Report of Kissing Molars Class II

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

基于Kissinger方法的3,4-双(4-硝基呋咱-3-基)氧化呋咱的热分解反应动力学参数和热稳定性研究（英文）

采用差示扫描量热法研究了DNTF和TNT在不同升温速率下的热分解特性;利用Kissinger方法计算和对比分析了DNTF和TNT的热分解反应动力学参数、热爆炸临界温度和热力学参数。结果表明,DNTF的热分解过程不同于TNT,DNTF的热分解经历了两个阶段,其中第1阶段为主要部分。DNTF的活化能为168.85kJ/mol,比TNT高约58kJ/mol,表明DNTF在低温下有良好的热稳定性。然而,除自由活化能外,DNTF的其他热力学参数均比TNT高。DNTF的热分解峰温和热爆炸临界温度都比TNT小。因此,与TNT相比,DNTF的热稳定性差。

用Kissinger方法测定非晶材料晶化激活能时应注意的问题

应用 Kissinger方法测定非晶材料晶化激活能时应确保所选温度对应的晶化分数相差不大 ,否则将会引入较大误差。以 Ni Ti非晶薄膜为例对此作了讨论。

胰十二指肠切除Kissing式胰肠吻合术后并发症的观察及护理

目的探讨胰十二指肠切除Kissing式胰肠吻合[1]术后并发症的护理观察及对策。方法对81例行胰十二指肠切除Kissing式胰肠吻合术并发症患者的术后护理进行回顾性分析。结果术后21例患者发生并发症,其中胰瘘3例,消化道出血1例,乳糜瘘2例,肠梗阻4例,胃排空延迟3例,肺部感染5例,切口感染3例。结论严密的病情观察,有针对性的护理,可以减少Kissing式胰肠吻合术后并发症的发生率及死亡率。

Kissing技术临床应用18例分析

Ｋｉｓｓｉｎｇ技术临床应用１８例分析蔡尚郎ＨａｓｉｎＹＭｏｓｓｅｒｉＭＬｏｔａｎＣ经皮冠状动脉腔内成形术（ＰＴＣＡ）的成功率与病变血管的解剖学特征有明显的关系。本文对１８例血管分叉处病变应用Ｋｉｓｓｉｎｇ技术进行ＰＴＣＡ作一初步分析，探讨其临床应用问...

Baastrup's disease: The kissing spine

A 67-year-old male presented with a gradually progressive low back pain of 2 years duration. The patient was leading a retired life and there was no history of chronic fever or significant trauma. There was no radiation of pain or any features suggestive of claudication. There was no history of any comorbidity. The pain was aggravated with extension of the spine and relieved with flexion. There was no swelling or neurological deficit, but muscle spasm was present. Radiographs of the spine revealed degenerative changes in the lumbosacral spine, along with articulation of spinous processes at in lumbar spine at all levels level suggestive of Baastrup's disease, commonly known as "kissing spine". Routine blood investigations were within normal limits. The patient was managed conservatively. He was given a week's course of analgesics and muscle relaxants and then started on spinal flexion exercises, with significant improvement being noted at 6 months follow up.

Vertical direction impaction of kissing molars:A case report

BACKGROUND Kissing molars(KMs)are a scarcely reported form of molar impaction in which the occlusal surfaces contact each other within a single dental follicle and the roots point in opposite directions.The direction of KMs impaction is generally tilted.KMs with vertical direction impaction have not been reported in the literature.CASE SUMMARY A 25-year-old female visited a dentist for right maxillary wisdom teeth extraction and was diagnosed with two vertically impacted KMs in the left mandible on panoramic radiography.After cone-beam computed tomography examination confirmed no secondary complication,the patient chose to undergo observation and regular follow-up.A literature review of KMs revealed that vertical impacted KMs are rare;high-quality evidence regarding their prevalence is still lacking.At present,the causality of KMs is controversial.In this study,we have tried to provide a detailed definition of KMs to allow an accurate evaluation of their prevalence and classification based on their impaction direction which may be related to their pathogenesis.The treatment plan of KMs depends on the condition and location of the affected teeth and associated complications;they may be either directly extracted or treated using a multidisciplinary approach including maxillofacial surgeons and orthodontists.CONCLUSION KMs are a rare clinical condition of impacted teeth with unclear pathogenesis.Vertically impacted KMs were seldom reported.Reasonable definition and classification of KMs can help in the understanding of their causes and prevalence.

Post-bulbar duodenal ulcer with anterior perforation with kissing ulcer and duodenocaval fistula:A case report and review of literature

BACKGROUND A post-bulbar duodenal ulcer(PBDU)is an ulcer in the duodenum that is distal to the duodenal bulb.PBDU may coexist with a synchronous posterior ulcer in rare occurrences,resulting in a kissing ulcer(KU).Duodenocaval fistula(DCF)is another uncommon but potentially fatal complication related to PBDU.There is limited knowledge of the scenarios in which PBDU is complicated by KU and DCF simultaneously.CASE SUMMARY A 22-year-old man was admitted to the emergency department with abdominal pain,stiffness,and vomiting.The X-ray showed pneumoperitoneum,suggesting a perforated viscus.Laparotomy revealed a KU with anterior perforation and a DCF.After Kocherization,venorrahphy was used to control caval bleeding.Due to the critical condition of the patient,only primary duodenorrahphy with gastrojejunostomy was performed as a damage control strategy.However,later,the patient developed obstructive jaundice and leakage,and two additional jejunal perforations were detected.Due to the poor condition of the duodenum and the involvement of the ampulla in the posterior ulcer,neither primary repair nor pancreatic-free duodenectomy and ampull-oplasty/ampullary reimplantation were considered viable;therefore,an emergency pancreaticoduodenectomy was performed,along with resection and anastomosis of the two jejunal perforations.The patient had a smooth recovery after surgery and was discharged after 27 d.CONCLUSION The timely diagnosis of PBDU and radical surgery can aid in the smooth recovery of patients,even in the most complex cases.

Necessity and proper way of intermediate kissing balloon dilation for culotte stenting: further insights from bench testing

Objective: The aim of this study was to investigate whether intermediate kissing balloon dilation(IKBD) is necessary during mini-culotte stenting(MCS) and how it can be properly conducted. Methods: MCS was emulated in a bifurcation model with a branch diameter difference(BDD) in three-step sizes of 0.50, 0.75 and 1.00 mm, and with intermediate balloon dilation(IBD) in three treatments of routine intermediate solo balloon dilation(rISBD), concurrent IKBD(cIKBD) or sequential IKBD. Microcomputed tomography was performed to assess stent under-expansion(SUE) around the polygon of confluence(POC), residual ostial stenosis(ROS) at the ostial side-branch(SB) and main-branch(MB) and stent cell distortion(SCD) in the bifurcation segments. Results: There were both main and interactive effects of IBD and BDD on ROS at the ostial SB and SCD in the ostial SB, but there were only main effects of IBD or BDD on SUE around the POC, ROS at the ostial MB and SCD in the ostial MB. Analysis of the main effects showed that SUE around the POC or ROS at the ostial SB was significantly different between sI KBD and rISBD and between cI KBD and rISBD. There was also a significant difference in SCD in the ostial SB between sI KBD and rI SBD and between sI KBD and cIKBD. Analysis of the interactive effects showed that ROS at the ostial SB or SCD in the ostial SB was affected by all IBD treatments in all BDD step-sizes. Moreover, increasing the BDD step-sizes significantly increased ROS at the ostial SB as treated by rISBD and SCD in the ostial SB as treated by rISBD or cIKBD. Conclusions: SIKBD was shown to be essential and superior to rISBD or cIKBD, resulting in better bifurcated stent expansion and coverage when using MCS.

A Case Report of Kissing Molars Class III

Kissing molars (KMs), first reported by Van Hoof in 1973, refer to molars with occlusal surfaces that contact each other in a single follicular space while their roots extend in opposite directions. This is a case of a 20-year-old male who presented with complaints of right mandibular molar pain with cold water contact and occlusion. Panoramic and cone-beam computed tomography (CBCT) images revealed impaction of the right mandibular third and fourth molars, with the occlusal surfaces contacting each other while the roots extended in opposite directions. KMs are classified according to the impaction of the mandibular first and second molars (Class I), second and third molars (Class II), and third and fourth molars (Class III). Our patient was considered Class III. Given the patient’s preference for surgical treatment, successful teeth extraction and extirpation were performed under intravenous sedation. The patient’s postoperative course was unremarkable. We describe a case of KMs Class III with a cystic variant assessed by panoramic and CBCT images. We additionally review all KMs Class III reported in the literature.

Problem and Improvement of Kissinger Method──New Method on Measuring Crystallization Activation Energy of Amorphous Alloy

By measuring and analyzing the crystallization activation energy (CAE) of Fe-based amorphous alloy Fe79B16Si5 and Fe78B13Si9, it is reconfirmed and further analyzed that the conventional Kissinger method does not conform with the premise of Kissinger equation, namely, samples with different heating rates should keep a constant fraction of transformation at the exothermal peak temperature Tp of DSC thermogram. The XRD equal first peak height (EFPH) method is applied to CAE measurement of Fe-based amorphous alloy for the first time. It is shown again that the EFPH method coincides with the premise of Kissinger equation. The procedure of EFPH method is introduced in detail in this paper. The accuracy in determining CAE of amorphous alloy may be improved by applying the EFPH method. As a result, the mechanism of embrittlement of amorphous alloy may be better elucidated.

Ultrasonic Testing Combined with Pattern Recognition for the Detection of Kissing Bonds

Kissing bonds are defects in the adhesive bonds with intimate contact of touching surface but considerably lowered shear strength. Their detection specifically in the aerospace area is so not satisfactory. Usually, kissing bonds are inconspicuous in ultrasonic C-scans. However, the determination of attributes in the time domain and the frequency domain of an ultrasound signal provides the opportunity to derive a pattern for bonded area. Deviations from the pattern found in inconspicuous bonding areas indicate kissing bonds. The survey described here deals with the manufacturing of adhesively joint samples that purposefully include kissing bonds, as well as potential solutions for detecting them through ultrasonic testing combined with pattern recognition. The properties of the epoxy-based adhesive were varied by changing the mixing ratios between resin and hardener. Samples with a mixing ratio far apart from the manufacturer’s recommendation with an inconspicuous appearance in a C-scan, but low shear strength values were taken for further evaluation. After a definition and learning phase, a 100 percent hit rate to separate good bondings from kissing bonds could be derived in a blind test. The discriminating feature found is due to the frequency shift between good and kissing bonds as well as the relative amplitude of the second peak.

下丘脑Kiss1系统在产前应激诱导男性后代生殖功能异常中的潜在作用

下丘脑Kiss1系统是下丘脑-垂体-性腺轴中的一个重要组成部分,其通过促进促性腺激素释放激素的分泌,来调节生殖功能。最近研究发现,产前应激对男性后代生殖功能具有影响。然而,产前应激诱导的男性后代生殖功能下降的机制仍未阐明。通过对下丘脑Kiss1系统的治疗可能改善产前应激,诱导男性后代的生殖功能,该综述将讨论下丘脑Kiss1系统在产前应激诱导男性后代生殖功能异常中的潜在作用。

3种去势疫苗的构建及稳定性研究

【目的】试验旨在构建不同种类的新型免疫去势DNA疫苗,分别为KISS1、神经激肽B(NKB)单表达基因疫苗和促性腺激素释放激素(GnRH)、KISS1和NKB 3个基因共表达的三表达基因疫苗,注射到动物体内后能激发免疫反应,产生相应的抗体,从而达到通过调控生殖轴来降低雄激素的目的。【方法】选取下丘脑-垂体-性腺轴(hypothalamic pituitary gonadal axis)上的GnRH及其上游调控基因KISS1和NKB作为靶标,并引入平衡致死系统代替抗生素筛选构建重组质粒,其中三表达重组质粒借助2A肽的自剪切功能使目的基因共表达。将重组质粒转染293T细胞后提取细胞RNA,验证其能否在机体内正常表达,随后将构建成功的质粒电转到减毒猪霍乱沙门菌(Salmonella Choleraesuis)C500感受态细胞中,获得重组活菌疫苗,构建的工程菌在体外连续传代50次,选取第0、2、5、10、20、30、40、50代的菌株进行稳定性研究。【结果】重组质粒pVAX-2A/KISS1-asd、pVAX-2A/S-NKB-asd和pVAX-S/GnRH-2A/S-NKB-2A/KISS1-asd酶切分别获得大小为498、1 146和2 622 bp的条带,与目的基因一致;测序结果与目的序列比对后显示大小、方向一致,目的基因的插入方向和序列完全正确。将上述重组质粒转染293T细胞后进行RT-PCR,获得大小分别为498、1 146、1 349 bp的目的条带,表明目的基因在真核细胞内能正常转录。上述重组质粒电转到减毒猪霍乱沙门菌C500感受态细胞后,提取质粒酶切后获得大小分别为498、1 146和2 622 bp的条带,测序结果与目的序列比对后显示大小、方向一致,表明重组质粒成功导入减毒猪霍乱沙门菌C500中。每2 h检测的工程菌和减毒猪霍乱沙门菌C500对照菌D600 nm值接近,差异不显著;生长曲线检测结果显示,工程菌在体外连续传代50次的过程中,工程菌和减毒猪霍乱沙门菌对照菌C500对数生长期均在0~10 h, 10~14 h为生长平缓期,约16 h以后进入平台期,工程菌生长特性与减毒猪霍乱沙门菌C500的生长特性一致,未因携带质粒而改变。同时,各代菌液沙门菌种属标志基因invA和毒力基因crp的扩增条带大小均分别为580和599 bp,表明工程菌多次传代后仍具有沙门菌的特性,其减毒特性也无变化。各代质粒酶切片段大小均分别为498、1 146和2 622 bp,表明多次传代并不影响质粒的稳定性,且重组质粒能在沙门菌C500中维持正常拷贝功能。【结论】本研究构建的重组质粒和工程菌疫苗均具有良好的稳定性,且在导入机体后能正常表达,可用于动物免疫去势的研究。

Mechanisms and clinical significance of quality of final kissing balloon inflation in patients with true bifurcation lesions treated by crush stenting technique

Background The mechanisms responsible for the occurrence of a kissing unsatisfied （KUS） result after classical crush stenting remain unclear. The present study aimed at analyzing the mechanisms and clinical significance of KUS. Methods Two hundred and thirteen patients with true bifurcation lesions treated with classical crush stenting and final kissing balloon inflation （FKBI） were assigned to upper, middle, and lower groups according to the position of the side branch re-wiring assessed by visual estimation, quantitative coronary analysis （QCA） and intravascular ultrasound （IVUS）. Angiographic follow-up was indexed at 12 months. Results The upper group was characterized by a larger bifurcation angle of 55.53°±25.25° （P=0,030） and a longer procedural time （42.43±23.92） minutes （P=0.015）. The overall rate of KUS by visual estimation was 10.48%, with 5.4% in the upper group, 3.9% in middle group, and 36.1% in lower group （P 〈0.001）. For the diagnosis of KUS, visual inspection demonstrated a good correlation with both QCA and IVUS. Smaller stent diameter was the main reason for KUS in the upper group, while extra-stent side wire location, or re-wire in a low position was the main mechanism attributed to KUS in the lower group. The Lower group had more restenosis, with most restenotic lesions at a lower position of the side branch ostium. KUS （HR 1.652, 95% Cl 1.332-2.088, P 〈0.001） and re-wiring position （HR 2.341, 95% Cl 1.780-4.329, P 〈0.001） were two independent predictors of side branch restenosis. Re-wiring position （OR 0.458, 95%C/0.336-0.874, P=0.001） and side stent expansion （OR 3.122, 95%C/2.883-5.061, P=0.014） were factors predicting the findings of KUS. Conclusions Side wire outside side stents resulted in more KUS and restenosis. Different restenotic lesion types reflected individual mechanisms contributing to the development of plaque proliferation.

Hemodynamic changes of fractional flow reserve after double kissing crush and provisional stenting technique for true bifurcation lesions

Background Fractional flow reserve （FFR）-guided percutaneous coronary intervention （PCI） is associated with fewer unfavorable events. However, the hemodynamic change in FFR after different stenting approaches for bifurcation lesions is still not fully studied. The aim of this study was to analyze the hemodynamic changes in FFR after double kissing （DK） crush and provisional side branch （SB） stenting （PS） for true coronary bifurcation lesions. Methods Seventy-five patients with true bifurcated lesions were randomly divided into DK （n=38） and PS （n=37） groups. Additional SB stenting in the PS group was required if there was any pinched SB ostium 〉70% stenosis, or ≥ type B dissection, or TIMI flow 〈grade 3. FFR at hyperemia in the main vessel （MV） and SB was measured prior- and post-stenting, and at 8 months follow-up. Results Baseline clinical, angiographic and lesion characteristics were matched well between the two groups, with the exception of the final kissing balloon inflation （FKBI, 100.0% in the DK vs. 83.8% in the PS group, P 〈0.001）. Baseline FFR was comparable between the DK and the PS groups, however, the acute gain and late loss of SB FFR at 8-month follow-up in the DK group were 0.18±0.15 and -0.06±0.11, compared to 0.12±0.18 （P=0.044） and -0.002±0.07 （P=-0.037） in the PS group, respectively. MV FFR post-stenting 〉0.94 was seen in about 40% of patients. There was no significant difference in the clinical events at 1-year follow-up between the two groups. Conclusions DK crush was associated with improved acute gain and late loss of SB FFR. The lower rate of FFR 〉0.94 after stenting underscored the further improvement of stentinq quality.

眼轮匝肌-白线固定法(Kiss技术)在亚洲人重睑成形术中的应用

目的:探究Kiss技术(采用眼轮匝肌-白线固定法的亚洲人重睑术)的应用效果。方法:选取2020年10月-2023年3月于笔者医院接受Kiss重睑术的97例就医者。在术后3~24个月对就医者进行随访评估,并统计就医者满意率及并发症发生情况。结果:就医者总满意度为97.5%,大多数就医者在术后2周内消肿。术后3~6个月手术痕迹基本消失。无一例就医者术后出现重睑松脱变浅的情况。结论:Kiss重睑术是一个简洁而有效的方法,美学效果良好,并发症少,就医者术后恢复较快,满意度高。

Double kissing crush technique for treatment of true coronary bifurcation lesions： two-year clinical outcomes from DKCRUSH-1 study

Standards for treating bifurcation lesions are crucial due to poor outcomes by percutaneous implantation of either bare metal stents or drug-eluting stents, even with several modified double-stent techniques including ＂T＂, ＂V＂, ＂Y＂, ＂culotte＂ and ＂simultaneous kissing stents （SKS）＂. Understanding the drawbacks in classical crush techniques, we proposed a novel double kissing （DK） crush technique being testified in our previous serial studies]＇2 The results from these randomized and pilot studies are describing a fantastic story---DK crush technique, by final kissing balloon inflation （FKBI） in 100% of lesions and high quality of kissing as assessed by both angiography and intravascular ultrasound, significantly improved the clinical outcome at a relative short-term follow-up. However, whether the advantage of the DK crush technique was sustained or not at a long-term remains unclear. The present study aimed to extend clinical follow-up and verify the differences between DK and classic crush techniques.

遗传缺陷致中枢性性早熟病因学的研究新进展

中枢性性早熟(central precocious puberty,CPP)是下丘脑-垂体-性腺轴提早激活所导致的发育异常性疾病,其发病率快速增加,但发病机制尚未完全明确。既往研究发现KISS1R、KISS1基因的功能获得性突变,以及MKRN3、LIN28和DLK1基因的功能缺失性突变可导致青春发育期启动时间提前。新近研究发现表观遗传因素如DNA甲基化、微小核糖核酸在促性腺激素释放激素神经元的调控中起重要作用;基因网络中多个变异基因的协同作用也可影响青春发育启动。该文综述了导致CPP的遗传学病因进展及其致病机制。

A Review of Double Kissing Crush Stenting in Coronary Bifurcation Lesions

Double kissing(DK)crush stenting for coronary bifurcation lesions has gain popularity worldwide because of its superior randomized studies data and excellent clinical outcomes.This review evaluates all DK crush clinical trials and studies.It also reveals the contemporary technique steps by steps as well as the trouble shooting with illustrated clinical scenarios.Among all the available evidence,the DK crush technique is superior when compared to the provisional stenting technique for complex bifurcation lesion.DK crush stenting provides the best evidence-based approach to complex bifurcation lesions especially the left main coronary artery bifurcation lesions.Future direction of how to make this DK crush technique better is also proposed.