目的:探究动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术定量容积运转常数(Ktrans)、速率常数(K_(ep))指导肝脏肿块定性诊断的价值。方法:选取2018年1月—2022年12月期间苏州市相城区中...目的:探究动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术定量容积运转常数(Ktrans)、速率常数(K_(ep))指导肝脏肿块定性诊断的价值。方法:选取2018年1月—2022年12月期间苏州市相城区中医医院收治的肝脏不明肿块患者共计92例,全部研究对象均接受DCE-MRI定量的Ktrans、K_(ep)检测,以组织病理学活检结果作为金标准,评估DCE-MRI定量的K^(trans)、K_(ep)检测应用于肝脏肿块定性诊断的价值。结果:在92例研究对象中,最终确诊为恶性病变者28例;非恶性病变者64例。两组研究对象的DCE-MRI检测结果显示,恶性病变组患者的Ktrans、K_(ep)水平均高于非恶性病变组,差异存在统计学意义(P<0.05);ROC曲线显示,DCE-MRI定量K^(trans)、K_(ep)应用于肝脏肿块定性检查的曲线下面积(AUC)分别为0.878、0.922,两项指标联合诊断的AUC为0.972。由此可见,K^(trans)、K_(ep)应用于肝脏肿块定性均具有较高的评估价值(P<0.05),且联合检测的评估效果优于单项检测。结论:DCE-MRI定量K^(trans)、K_(ep)应用于肝脏肿块定性均具有较高的评估价值,且联合检测的评估效果优于单项检测,值得借鉴应用。展开更多
In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusio...In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from the intravascular space to the capillary bed due to leaky capillaries associated with tumor neovascularity. DCE-MRI has the potential to provide information regarding blood flow, areas of hypoperfusion, and variations in endothelial permeability and microvessel density to aid treatment selection, enable frequent monitoring during treatment and assess response to targeted therapy following treatment. This review will discuss the current status of DCE-MRI in cancer imaging, with a focus on its use in imaging prostate malignancies as well as weaknesses that limit its widespread clinical use. The latest techniques for quantification of DCE-MRI parameters will be reviewed and compared.展开更多
文摘目的:探究动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术定量容积运转常数(Ktrans)、速率常数(K_(ep))指导肝脏肿块定性诊断的价值。方法:选取2018年1月—2022年12月期间苏州市相城区中医医院收治的肝脏不明肿块患者共计92例,全部研究对象均接受DCE-MRI定量的Ktrans、K_(ep)检测,以组织病理学活检结果作为金标准,评估DCE-MRI定量的K^(trans)、K_(ep)检测应用于肝脏肿块定性诊断的价值。结果:在92例研究对象中,最终确诊为恶性病变者28例;非恶性病变者64例。两组研究对象的DCE-MRI检测结果显示,恶性病变组患者的Ktrans、K_(ep)水平均高于非恶性病变组,差异存在统计学意义(P<0.05);ROC曲线显示,DCE-MRI定量K^(trans)、K_(ep)应用于肝脏肿块定性检查的曲线下面积(AUC)分别为0.878、0.922,两项指标联合诊断的AUC为0.972。由此可见,K^(trans)、K_(ep)应用于肝脏肿块定性均具有较高的评估价值(P<0.05),且联合检测的评估效果优于单项检测。结论:DCE-MRI定量K^(trans)、K_(ep)应用于肝脏肿块定性均具有较高的评估价值,且联合检测的评估效果优于单项检测,值得借鉴应用。
文摘In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from the intravascular space to the capillary bed due to leaky capillaries associated with tumor neovascularity. DCE-MRI has the potential to provide information regarding blood flow, areas of hypoperfusion, and variations in endothelial permeability and microvessel density to aid treatment selection, enable frequent monitoring during treatment and assess response to targeted therapy following treatment. This review will discuss the current status of DCE-MRI in cancer imaging, with a focus on its use in imaging prostate malignancies as well as weaknesses that limit its widespread clinical use. The latest techniques for quantification of DCE-MRI parameters will be reviewed and compared.
