目的利用自适应合成抽样(adaptive synthetic sampling,ADASYN)与类别逆比例加权法处理类别不平衡数据,结合分类器构建模型对阿尔茨海默病(alzheimer′s disease,AD)患者疾病进程进行分类预测。方法数据源自阿尔茨海默病神经影像学计划(...目的利用自适应合成抽样(adaptive synthetic sampling,ADASYN)与类别逆比例加权法处理类别不平衡数据,结合分类器构建模型对阿尔茨海默病(alzheimer′s disease,AD)患者疾病进程进行分类预测。方法数据源自阿尔茨海默病神经影像学计划(Alzheimer′s disease neuroimaging initiative,ADNI),经随机森林填补缺失值,弹性网络筛选特征子集后,利用ADASYN与类别逆比例加权法处理类别不平衡数据。分别结合随机森林(random forest,RF)、支持向量机(support vector machine,SVM)构建四种模型:ADASYN-RF、ADASYN-SVM、加权随机森林(weighted random forest,WRF)、加权支持向量机(weighted support vector machine,WSVM),与RF、SVM比较分类性能。模型评价指标为宏观平均精确率(macro-average of precision,macro-P)、宏观平均召回率(macro-average of recall,macro-R)、宏观平均F1值(macro-average of F1-score,macro-F1)、准确率(accuracy,ACC)、Kappa值和AUC(area under the ROC curve)。结果ADASYN-RF的分类性能最优(Kappa值为0.938,AUC为0.980),ADASYN-SVM次之。利用ADASYN-RF预测得到的重要分类特征分别为CDRSB、LDELTOTAL、MMSE,在临床上均可得到证实。结论ADASYN与类别逆比例加权法都能辅助提升分类器性能,但ADASYN算法更优。展开更多
This paper is a purely mathematical one dealing with a common possible foundation of Fuzzy Set Theory and Rough Set Theory.It begins with a generalization of Obtulowicz's paper,rough sets and Heyting algebra value...This paper is a purely mathematical one dealing with a common possible foundation of Fuzzy Set Theory and Rough Set Theory.It begins with a generalization of Obtulowicz's paper,rough sets and Heyting algebra valued sets,published in Bull.Polish Acad Sc.(math),198.In this paper Obtulowicz proposes a special subcategory展开更多
Tess is a pure girl in Hardy's eyes, as it shows in the book's subtitle. She is sinned in Victorian's time, however, she is still pure in Kant's eyes.Key words: Tesss purity;
Robert Mills Gagne's five categories of learning have a profound influence on the many aspects of educational field.This essay attempts to differentiate and analyze the five categories of learning:motor skills,ver...Robert Mills Gagne's five categories of learning have a profound influence on the many aspects of educational field.This essay attempts to differentiate and analyze the five categories of learning:motor skills,verbal information,intellectual skills,cognitive strategies,and attitudes.And then applies Gagne's five categories of learning to design English teaching objectives.展开更多
目的:探讨S-Detect技术与常规超声不同联合方案在乳腺结节评估中的应用价值。方法:收集2019年5月-2020年4月175个乳腺结节的常规超声图像,术前由低、中、高年资的超声医师各自进行常规超声乳腺影像报告和数据系统(breast imaging report...目的:探讨S-Detect技术与常规超声不同联合方案在乳腺结节评估中的应用价值。方法:收集2019年5月-2020年4月175个乳腺结节的常规超声图像,术前由低、中、高年资的超声医师各自进行常规超声乳腺影像报告和数据系统(breast imaging report and data system,BI-RADS),分类,并分别以4种不同方案联合S-Detect结果进行调整,术后以病理结果为金标准,评估S-Detect的诊断价值,同时比较不同年资医师联合不同方案前后的诊断效能。结果:单用S-Detect的诊断特异性高于超声医师,差异均有统计学意义(P <0.01)。低、中年资医师联合诊断的AUC值显著提高,且差异有统计学意义(P<0.01),其中联合方案三、四显著优于方案一、二(P<0.05);高年资医师联合后AUC值降低。结论:S-Detect技术具有较高的诊断特异性,低、中年资医师联合S-Detect技术进行BI-RADS分类可以提高诊断效能,其中联合方案三、四较优。展开更多
We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was d...We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients＇ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg＇s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected.展开更多
A recent review publication presented an extensive and comprehensive assessment of the phenomenological relations of Poisson’s ratios (PRs) to the behavior and responses of contemporary materials under specific loadi...A recent review publication presented an extensive and comprehensive assessment of the phenomenological relations of Poisson’s ratios (PRs) to the behavior and responses of contemporary materials under specific loading conditions. The present review and analysis paper is intended as a theoretical mechanics complement covering mathematical and physical modeling of a single original elastic and of six time and process (i.e. path and stress) dependent viscoelastic PR definitions as well as a seventh special path independent one. The implications and consequences of such models on material characterization are analyzed and summarized. Indeed, PRs based on experimentally obtained 2-D strains under distinct creep and/or relaxation processes exhibit radically different time responses for identical material specimen. These results confirm the PR’s implicit path dependence in addition to their separate intrinsic time reliance. Such non-uniqueness of viscoelastic PRs renders them unsuitable as universal material descriptors. Analytical formulations and experimental measurements also examine the physical impossibility of instantaneously achieving time independent loads or strains or their rates thus making certain PR definitions based on constant state variables, while mathematically valid, physically unrealistic and unachievable. A newly developed theoretical/experimental protocol for the determination of the time when loading patterns reach stead-state conditions based on strain accelerations demonstrates the capability to measure this time from experimental data. Due to the process dependent PRs, i.e. stress and stress history paths, the non-existence of a unique viscoelastic PR and of a universal elastic-viscoelastic correspondence principle or analogy (EVCP) in terms of PRs is demonstrated. Additionally and independently, the required double convolution integral construction of linear viscoelastic constitutive relations with the inclusion of PRs is cumbersome analytically and computationally needlessly highly CPU intensive. Furthermore, there is no theoretical fundamental hint as to what loading path is required to produce a unique universal viscoelastic PR definition necessary for formulating a PR based constitutive relation or an EVCP protocol. The analysis associated with an additional Class VII viscoelastic PR establishes it as a universal representation which is loading path and strain independent while still remaining time dependent. This Class PR can be the one used if it is desired to express constitutive relations in terms of PRs, subject to the caveat applying to all PR Classes regarding the CPU intensiveness in the time space due to triple product and double convolution integral constitutive relations. However, the use PRs is unnecessary since any set of material behavior can be uniquely and completely defined in terms of only moduli and/or compliances. The mathematical model of instantaneous initial loading paths, based on Heavi-side functions, is examined in detail and shown to lead to infinite velocities and accelerations. Additionally, even if non-instantaneous gradual loading functions are employed the resulting PRs are still load and load history dependent. Consequently, they represent specialized PR responses applicable and limited to those particular load and history combinations. Although the analyses contained herein are generalized to non-homogeneous linear viscoelastic materials, the main focus is on PR time and process dependence. The non-homogeneous material results and conclusions presented herein apply equally to homogeneous viscoelasticity and per se do not influence the results or conclusions of the analytical development regarding viscoelastic PRs. In short, these PR analyses apply to all linear viscoelastic material characterization.展开更多
Inferences of subtle cerebral injury and dysfunction have been historically dependent upon psychometric tests from which clinical neuropsychological profiles are generated. In addition to being secondary, over-inclusi...Inferences of subtle cerebral injury and dysfunction have been historically dependent upon psychometric tests from which clinical neuropsychological profiles are generated. In addition to being secondary, over-inclusive and crude indicators of cerebral activity, psychometric tests are subject to economic incentives to “re-norm” traditional methods under the pretense of “ensuring” contemporary representations that are sanctioned by regulating organizations dominated by agendas of control over the interpretations of clinicians. The validity of neuropsychological tests is essential for their perspicacious application and interpretations. We measured the quantitative electroen-cephalographic profiles and calculated s-LORETA (standardized Low Resolution Electromagnetic Tomography) profiles in real time for normal men and women while they engaged in both traditional and novel neuropsychological tests that were employed to infer localized brain injury. Conspicuous alterations in source current density within specific frequency bands occurred within various regions of the right prefrontal region during performance of the Category, Design Fluency and Conditioned Spatial Association Test, the prefrontal medial surface during Toe Graphaesthesia, the caudal medial surface during Toe Gnosis, the left temporal region during Speech-Sounds, and within the right retrosplenial-parahippocampal region for Seashore Rhythms. Results supported the well established regional associations with the classic neuropsychological tests, verified the cerebral localization with more recent procedures, and emphasized the utility of modern real-time, direct cerebral imaging procedures.展开更多
Georg Cantor’s absolute infinity, the paradoxical class Ω of all ordinals, a non-entity for which being called a “class” is an undeserved dignity, must be the ultimate vexation for mathematical philosophers who ho...Georg Cantor’s absolute infinity, the paradoxical class Ω of all ordinals, a non-entity for which being called a “class” is an undeserved dignity, must be the ultimate vexation for mathematical philosophers who hold on to some residual realism in set theory. By careful use of Ω, we can rescue Georg Cantor’s 1899 “proof” sketch of the Well-Ordering Theorem (being generous, considering his declining health) by taking the contrapositive of his suggestion and adding Zermelo’s choice function, resulting in a concise and uncomplicated proof of the Well-Ordering Theorem.展开更多
Conscious existence is the product of a neural brain mechanism,which is largely identical with Immanuel Kant’s Oneness Function,a service performed by 200 million neurons in the prefrontal lobe,&makes possible ou...Conscious existence is the product of a neural brain mechanism,which is largely identical with Immanuel Kant’s Oneness Function,a service performed by 200 million neurons in the prefrontal lobe,&makes possible our interior cosmos,the record of our interconnected,or general,experience.Essential for us humans is the well-being of our interior cosmos,or Saint Teresa of Avila’s interior castle,in all interactions with each other&the greater environment.Any disorders of our cosmos are liable to make us fall ill,setting our existence on a path of psychosomatic etiology of a large class of mysterious undiagnosed diseases.展开更多
The aim of this paper is to contribute to the identification and characterization of the various types of intuition put forward by Poincar6, taking his texts as a laboratory for looking for what intuition might be. I ...The aim of this paper is to contribute to the identification and characterization of the various types of intuition put forward by Poincar6, taking his texts as a laboratory for looking for what intuition might be. I will stress that these diverse conceptions are mainly formulated in the context of Poincar6＇s controversies in opposition to logicism, to formalism, and in the context of Poincar6＇s very peculiar conventionalism. I will try to demonstrate that, in each case, Poincar~ comes close to a specific tradition （Kant, of course, but also Leibniz and Peirce）.展开更多
The essay brings a summation of human efforts seeking to understand our existence.Plato and Kant&cognitive science complete reduction of philosophy to a neural mechanism,evolved along elementary Darwinian principl...The essay brings a summation of human efforts seeking to understand our existence.Plato and Kant&cognitive science complete reduction of philosophy to a neural mechanism,evolved along elementary Darwinian principles.Plato in his famous Cave Allegory explains that between reality and our experience of it there exists a great chasm,a metaphysical gap,fully confirmed through particle-wave duality of quantum physics.Kant found that we have two kinds of perception,two senses:By the spatial outer sense we perceive phenomena,objects in space.Our temporal inner sense lets us perceive our inner state,noumena.Kant’s two senses are fully confirmed through bilateral brain duality of cognitive science.The bilateral brain serves inner,temporal sense,logic&noumena in the left hemisphere.The right brain half is for the outer,spatial sense,geometry&phenomena.Weform awhole system,a bilateral interior cosmos,a kind of world model,expressing what may lie beyond the metaphysical gap.In the right brain we build a phenomenal cosmos,to resemble the outer environment.In the brain’s left hemisphere a noumenal cosmos,amodel of our private world including Saint Teresa of Avila’s castillo interior.The cosmos is regularly updated with novel sense data integrated into our memory banks.This was recognized early by Helmholtz(1860s).Our lives,health&well-being depend on us keeping our interior cosmos in good order.This used to be seen as saving one’s precious soul from perdition.While we endeavour to keep our phenomenal cosmos neat&orderly by protecting the environment from harm,our noumenal cosmos to be livable requires us to engage in ethical conduct.This bilateral cosmos is responsible for our common sense judgment power,that we depend on for being able to lead a good&benign life.The 200 million neurons of BA10 in the prefrontal lobe have global access to the interior cosmos,&apply massive feedback to identify environmental conditions rapidly.The global access also gives conscious presence of the individual to itself,all that is present in the interior cosmos,for total freedom of action.In the left brain private ego,we are guarded by faith in divine mercy,&guided to choose the best course of action,able to survive under themost adverse conditions.For this,wereceive directions from the Holy Ghost in Saint Teresa’s castillo interior.展开更多
文摘目的利用自适应合成抽样(adaptive synthetic sampling,ADASYN)与类别逆比例加权法处理类别不平衡数据,结合分类器构建模型对阿尔茨海默病(alzheimer′s disease,AD)患者疾病进程进行分类预测。方法数据源自阿尔茨海默病神经影像学计划(Alzheimer′s disease neuroimaging initiative,ADNI),经随机森林填补缺失值,弹性网络筛选特征子集后,利用ADASYN与类别逆比例加权法处理类别不平衡数据。分别结合随机森林(random forest,RF)、支持向量机(support vector machine,SVM)构建四种模型:ADASYN-RF、ADASYN-SVM、加权随机森林(weighted random forest,WRF)、加权支持向量机(weighted support vector machine,WSVM),与RF、SVM比较分类性能。模型评价指标为宏观平均精确率(macro-average of precision,macro-P)、宏观平均召回率(macro-average of recall,macro-R)、宏观平均F1值(macro-average of F1-score,macro-F1)、准确率(accuracy,ACC)、Kappa值和AUC(area under the ROC curve)。结果ADASYN-RF的分类性能最优(Kappa值为0.938,AUC为0.980),ADASYN-SVM次之。利用ADASYN-RF预测得到的重要分类特征分别为CDRSB、LDELTOTAL、MMSE,在临床上均可得到证实。结论ADASYN与类别逆比例加权法都能辅助提升分类器性能,但ADASYN算法更优。
文摘This paper is a purely mathematical one dealing with a common possible foundation of Fuzzy Set Theory and Rough Set Theory.It begins with a generalization of Obtulowicz's paper,rough sets and Heyting algebra valued sets,published in Bull.Polish Acad Sc.(math),198.In this paper Obtulowicz proposes a special subcategory
文摘Tess is a pure girl in Hardy's eyes, as it shows in the book's subtitle. She is sinned in Victorian's time, however, she is still pure in Kant's eyes.Key words: Tesss purity;
文摘Robert Mills Gagne's five categories of learning have a profound influence on the many aspects of educational field.This essay attempts to differentiate and analyze the five categories of learning:motor skills,verbal information,intellectual skills,cognitive strategies,and attitudes.And then applies Gagne's five categories of learning to design English teaching objectives.
文摘目的:探讨S-Detect技术与常规超声不同联合方案在乳腺结节评估中的应用价值。方法:收集2019年5月-2020年4月175个乳腺结节的常规超声图像,术前由低、中、高年资的超声医师各自进行常规超声乳腺影像报告和数据系统(breast imaging report and data system,BI-RADS),分类,并分别以4种不同方案联合S-Detect结果进行调整,术后以病理结果为金标准,评估S-Detect的诊断价值,同时比较不同年资医师联合不同方案前后的诊断效能。结果:单用S-Detect的诊断特异性高于超声医师,差异均有统计学意义(P <0.01)。低、中年资医师联合诊断的AUC值显著提高,且差异有统计学意义(P<0.01),其中联合方案三、四显著优于方案一、二(P<0.05);高年资医师联合后AUC值降低。结论:S-Detect技术具有较高的诊断特异性,低、中年资医师联合S-Detect技术进行BI-RADS分类可以提高诊断效能,其中联合方案三、四较优。
基金supported by the Basic Scientific Research Program of National Research Foundation of Korea Funded by Ministry of Education, Science and Technology, No.2011-0003426
文摘We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients＇ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg＇s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected.
文摘A recent review publication presented an extensive and comprehensive assessment of the phenomenological relations of Poisson’s ratios (PRs) to the behavior and responses of contemporary materials under specific loading conditions. The present review and analysis paper is intended as a theoretical mechanics complement covering mathematical and physical modeling of a single original elastic and of six time and process (i.e. path and stress) dependent viscoelastic PR definitions as well as a seventh special path independent one. The implications and consequences of such models on material characterization are analyzed and summarized. Indeed, PRs based on experimentally obtained 2-D strains under distinct creep and/or relaxation processes exhibit radically different time responses for identical material specimen. These results confirm the PR’s implicit path dependence in addition to their separate intrinsic time reliance. Such non-uniqueness of viscoelastic PRs renders them unsuitable as universal material descriptors. Analytical formulations and experimental measurements also examine the physical impossibility of instantaneously achieving time independent loads or strains or their rates thus making certain PR definitions based on constant state variables, while mathematically valid, physically unrealistic and unachievable. A newly developed theoretical/experimental protocol for the determination of the time when loading patterns reach stead-state conditions based on strain accelerations demonstrates the capability to measure this time from experimental data. Due to the process dependent PRs, i.e. stress and stress history paths, the non-existence of a unique viscoelastic PR and of a universal elastic-viscoelastic correspondence principle or analogy (EVCP) in terms of PRs is demonstrated. Additionally and independently, the required double convolution integral construction of linear viscoelastic constitutive relations with the inclusion of PRs is cumbersome analytically and computationally needlessly highly CPU intensive. Furthermore, there is no theoretical fundamental hint as to what loading path is required to produce a unique universal viscoelastic PR definition necessary for formulating a PR based constitutive relation or an EVCP protocol. The analysis associated with an additional Class VII viscoelastic PR establishes it as a universal representation which is loading path and strain independent while still remaining time dependent. This Class PR can be the one used if it is desired to express constitutive relations in terms of PRs, subject to the caveat applying to all PR Classes regarding the CPU intensiveness in the time space due to triple product and double convolution integral constitutive relations. However, the use PRs is unnecessary since any set of material behavior can be uniquely and completely defined in terms of only moduli and/or compliances. The mathematical model of instantaneous initial loading paths, based on Heavi-side functions, is examined in detail and shown to lead to infinite velocities and accelerations. Additionally, even if non-instantaneous gradual loading functions are employed the resulting PRs are still load and load history dependent. Consequently, they represent specialized PR responses applicable and limited to those particular load and history combinations. Although the analyses contained herein are generalized to non-homogeneous linear viscoelastic materials, the main focus is on PR time and process dependence. The non-homogeneous material results and conclusions presented herein apply equally to homogeneous viscoelasticity and per se do not influence the results or conclusions of the analytical development regarding viscoelastic PRs. In short, these PR analyses apply to all linear viscoelastic material characterization.
文摘Inferences of subtle cerebral injury and dysfunction have been historically dependent upon psychometric tests from which clinical neuropsychological profiles are generated. In addition to being secondary, over-inclusive and crude indicators of cerebral activity, psychometric tests are subject to economic incentives to “re-norm” traditional methods under the pretense of “ensuring” contemporary representations that are sanctioned by regulating organizations dominated by agendas of control over the interpretations of clinicians. The validity of neuropsychological tests is essential for their perspicacious application and interpretations. We measured the quantitative electroen-cephalographic profiles and calculated s-LORETA (standardized Low Resolution Electromagnetic Tomography) profiles in real time for normal men and women while they engaged in both traditional and novel neuropsychological tests that were employed to infer localized brain injury. Conspicuous alterations in source current density within specific frequency bands occurred within various regions of the right prefrontal region during performance of the Category, Design Fluency and Conditioned Spatial Association Test, the prefrontal medial surface during Toe Graphaesthesia, the caudal medial surface during Toe Gnosis, the left temporal region during Speech-Sounds, and within the right retrosplenial-parahippocampal region for Seashore Rhythms. Results supported the well established regional associations with the classic neuropsychological tests, verified the cerebral localization with more recent procedures, and emphasized the utility of modern real-time, direct cerebral imaging procedures.
文摘Georg Cantor’s absolute infinity, the paradoxical class Ω of all ordinals, a non-entity for which being called a “class” is an undeserved dignity, must be the ultimate vexation for mathematical philosophers who hold on to some residual realism in set theory. By careful use of Ω, we can rescue Georg Cantor’s 1899 “proof” sketch of the Well-Ordering Theorem (being generous, considering his declining health) by taking the contrapositive of his suggestion and adding Zermelo’s choice function, resulting in a concise and uncomplicated proof of the Well-Ordering Theorem.
文摘Conscious existence is the product of a neural brain mechanism,which is largely identical with Immanuel Kant’s Oneness Function,a service performed by 200 million neurons in the prefrontal lobe,&makes possible our interior cosmos,the record of our interconnected,or general,experience.Essential for us humans is the well-being of our interior cosmos,or Saint Teresa of Avila’s interior castle,in all interactions with each other&the greater environment.Any disorders of our cosmos are liable to make us fall ill,setting our existence on a path of psychosomatic etiology of a large class of mysterious undiagnosed diseases.
文摘The aim of this paper is to contribute to the identification and characterization of the various types of intuition put forward by Poincar6, taking his texts as a laboratory for looking for what intuition might be. I will stress that these diverse conceptions are mainly formulated in the context of Poincar6＇s controversies in opposition to logicism, to formalism, and in the context of Poincar6＇s very peculiar conventionalism. I will try to demonstrate that, in each case, Poincar~ comes close to a specific tradition （Kant, of course, but also Leibniz and Peirce）.
文摘The essay brings a summation of human efforts seeking to understand our existence.Plato and Kant&cognitive science complete reduction of philosophy to a neural mechanism,evolved along elementary Darwinian principles.Plato in his famous Cave Allegory explains that between reality and our experience of it there exists a great chasm,a metaphysical gap,fully confirmed through particle-wave duality of quantum physics.Kant found that we have two kinds of perception,two senses:By the spatial outer sense we perceive phenomena,objects in space.Our temporal inner sense lets us perceive our inner state,noumena.Kant’s two senses are fully confirmed through bilateral brain duality of cognitive science.The bilateral brain serves inner,temporal sense,logic&noumena in the left hemisphere.The right brain half is for the outer,spatial sense,geometry&phenomena.Weform awhole system,a bilateral interior cosmos,a kind of world model,expressing what may lie beyond the metaphysical gap.In the right brain we build a phenomenal cosmos,to resemble the outer environment.In the brain’s left hemisphere a noumenal cosmos,amodel of our private world including Saint Teresa of Avila’s castillo interior.The cosmos is regularly updated with novel sense data integrated into our memory banks.This was recognized early by Helmholtz(1860s).Our lives,health&well-being depend on us keeping our interior cosmos in good order.This used to be seen as saving one’s precious soul from perdition.While we endeavour to keep our phenomenal cosmos neat&orderly by protecting the environment from harm,our noumenal cosmos to be livable requires us to engage in ethical conduct.This bilateral cosmos is responsible for our common sense judgment power,that we depend on for being able to lead a good&benign life.The 200 million neurons of BA10 in the prefrontal lobe have global access to the interior cosmos,&apply massive feedback to identify environmental conditions rapidly.The global access also gives conscious presence of the individual to itself,all that is present in the interior cosmos,for total freedom of action.In the left brain private ego,we are guarded by faith in divine mercy,&guided to choose the best course of action,able to survive under themost adverse conditions.For this,wereceive directions from the Holy Ghost in Saint Teresa’s castillo interior.
