In the government work report for Two Sessions 2019, key words about E-commerce and internet were mentioned lots of times. This included terms such as Internet+, cross-border E-commerce,industrial internet, digital ec...In the government work report for Two Sessions 2019, key words about E-commerce and internet were mentioned lots of times. This included terms such as Internet+, cross-border E-commerce,industrial internet, digital economy,sharing economy, online and offline consumption, Internet+education and soon.Keywords No.1:Internet+Work Report:1. Internet+was advanced across the board and new technologies and models were used to transform traditional industries. 2. We will speed up efforts to pursue Internet+in all industries and sectors.展开更多
BACKGROUND Post-traumatic stress disorder(PTSD)is a serious stress-related disorder.AIM To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods.METHODS Gene expr...BACKGROUND Post-traumatic stress disorder(PTSD)is a serious stress-related disorder.AIM To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods.METHODS Gene expression profiles were obtained from the Gene Expression Omnibus database.The differentially expressed genes(DEGs)were identified by using GEO2R.Gene functional annotation and pathway enrichment were then conducted.The gene-pathway network was constructed with Cytoscape software.Quantitative real-time polymerase chain reaction(qRT-PCR)analysis was applied for validation,and text mining by Coremine Medical was used to confirm the connections among genes and pathways.RESULTS We identified 973 DEGs including 358 upregulated genes and 615 downregulated genes in PTSD.A group of centrality hub genes and significantly enriched pathways(MAPK,Ras,and ErbB signaling pathways)were identified by using gene functional assignment and enrichment analyses.Six genes(KRAS,EGFR,NFKB1,FGF12,PRKCA,and RAF1)were selected to validate using qRT-PCR.The results of text mining further confirmed the correlation among hub genes and the enriched pathways.It indicated that these altered genes displayed functional roles in PTSD via these pathways,which might serve as key signatures in the pathogenesis of PTSD.CONCLUSION The current study identified a panel of candidate genes and important pathways,which might help us deepen our understanding of the underlying mechanism of PTSD at the molecular level.However,further studies are warranted to discover the critical regulatory mechanism of these genes via relevant pathways in PTSD.展开更多
Titles、Abstracts and Key Words(1 th) Lu Guoyao A Brief Comment on "Documentary Linguistics"Abstract: Two thousand and five hundred years ago, Confucius attached great importance to "Document". We ...Titles、Abstracts and Key Words(1 th) Lu Guoyao A Brief Comment on "Documentary Linguistics"Abstract: Two thousand and five hundred years ago, Confucius attached great importance to "Document". We suggest that knowledge that regards both literature and oral material as the major resources should be respected. These knowledge interrelates and completes each other.展开更多
expressions like "socialism with Chinese character- istics" and "comprehensively deepening reform?" Then help is at hand with a program launched in December to enable foreigners understand politi- cal and cultura...expressions like "socialism with Chinese character- istics" and "comprehensively deepening reform?" Then help is at hand with a program launched in December to enable foreigners understand politi- cal and cultural phrases,展开更多
A proxy signature scheme with message recovery using self-certified public key is proposed, which withstands public key substitution attacks, active attacks, and forgery attacks. The proposed scheme accomplishes the t...A proxy signature scheme with message recovery using self-certified public key is proposed, which withstands public key substitution attacks, active attacks, and forgery attacks. The proposed scheme accomplishes the tasks of public key verification, proxy signature verification, and message recovery in a logically single step. In addition, the proposed scheme satisfies all properties of strong proxy signature and does not use secure channel in the communication between the original signer and the proxy signature signer.展开更多
文摘In the government work report for Two Sessions 2019, key words about E-commerce and internet were mentioned lots of times. This included terms such as Internet+, cross-border E-commerce,industrial internet, digital economy,sharing economy, online and offline consumption, Internet+education and soon.Keywords No.1:Internet+Work Report:1. Internet+was advanced across the board and new technologies and models were used to transform traditional industries. 2. We will speed up efforts to pursue Internet+in all industries and sectors.
基金Supported by the National Natural Science Foundation of China,No.81603529,81673982,and 81704084the Natural Science Foundation of the Jiangsu Higher Education Institutions,No.16KJB360002+3 种基金the Advantages of the Nursing Discipline Project of Jiangsu Province,No.2019YSHL005China Scholarship Council,No.201908320373the Jiangsu Government Scholarship for Overseas Studiesand the Qing Lan Project,No.014000773/2018-00376.
文摘BACKGROUND Post-traumatic stress disorder(PTSD)is a serious stress-related disorder.AIM To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods.METHODS Gene expression profiles were obtained from the Gene Expression Omnibus database.The differentially expressed genes(DEGs)were identified by using GEO2R.Gene functional annotation and pathway enrichment were then conducted.The gene-pathway network was constructed with Cytoscape software.Quantitative real-time polymerase chain reaction(qRT-PCR)analysis was applied for validation,and text mining by Coremine Medical was used to confirm the connections among genes and pathways.RESULTS We identified 973 DEGs including 358 upregulated genes and 615 downregulated genes in PTSD.A group of centrality hub genes and significantly enriched pathways(MAPK,Ras,and ErbB signaling pathways)were identified by using gene functional assignment and enrichment analyses.Six genes(KRAS,EGFR,NFKB1,FGF12,PRKCA,and RAF1)were selected to validate using qRT-PCR.The results of text mining further confirmed the correlation among hub genes and the enriched pathways.It indicated that these altered genes displayed functional roles in PTSD via these pathways,which might serve as key signatures in the pathogenesis of PTSD.CONCLUSION The current study identified a panel of candidate genes and important pathways,which might help us deepen our understanding of the underlying mechanism of PTSD at the molecular level.However,further studies are warranted to discover the critical regulatory mechanism of these genes via relevant pathways in PTSD.
文摘Titles、Abstracts and Key Words(1 th) Lu Guoyao A Brief Comment on "Documentary Linguistics"Abstract: Two thousand and five hundred years ago, Confucius attached great importance to "Document". We suggest that knowledge that regards both literature and oral material as the major resources should be respected. These knowledge interrelates and completes each other.
文摘expressions like "socialism with Chinese character- istics" and "comprehensively deepening reform?" Then help is at hand with a program launched in December to enable foreigners understand politi- cal and cultural phrases,
文摘A proxy signature scheme with message recovery using self-certified public key is proposed, which withstands public key substitution attacks, active attacks, and forgery attacks. The proposed scheme accomplishes the tasks of public key verification, proxy signature verification, and message recovery in a logically single step. In addition, the proposed scheme satisfies all properties of strong proxy signature and does not use secure channel in the communication between the original signer and the proxy signature signer.