Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems inconsistent.In this study,we investigated whether celecoxib would increase the antiproliferative effects of cis...Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems inconsistent.In this study,we investigated whether celecoxib would increase the antiproliferative effects of cisplatin in human lung cancer cells.Our data demonstrated the synergistic effects of celecoxib with cisplatin in wild-type p53 cells and their antagonistic effects inmutated or deleted p53 cells.Combination indices of 0.82 to 0.93 reflected a synergistic effect between celecoxib and cisplatin in lung cancer cells with wild-type p53.Combination indices of 1.63 to 3.00 reflected antagonism between celecoxib and cisplatin in lung cancer cells with mutated or deleted p53.Compared with that in cells with mutated or deleted p53,apoptosis significantly increased with the addition of celecoxib and cisplatin in wild-type p53 cells(P<0.05).Moreover,the results in vivo were similar to those in vitro:celecoxib combinedwith cisplatin slowed tumor growth in wild-type p53 groups and not in mutated or deleted p53 groups.In addition,celecoxib promoted p53 translocation into the nucleus and upregulated active p53 expression in wild-type p53 cells.Celecoxib combined with cisplatin upregulated PUMA(PUMA is a downstream gene of p53)after active p53 increased in wild-type p53 cells.In summary,the combination of celecoxib and cisplatin demonstrates clear synergistic effects in wild-type p53 cells and antagonistic effects inmutated or deleted p53 cells.The synergistic effect was achieved by apoptosis,induced by upregulating PUMA.Our results will provide a new treatment strategy for patients carrying wild-type p53,insensitive to cisplatin.展开更多
使用Visual Basic编程,采用正则表达式批量提取由Web of Science导出的Bib Tex题录中所有Keywords字段关键词,按需合并所得关键词的同义词、近义词及词形变化词,然后将出现频度的统计数据写入Excel表,并编制Excel宏自动生成折线图,实现...使用Visual Basic编程,采用正则表达式批量提取由Web of Science导出的Bib Tex题录中所有Keywords字段关键词,按需合并所得关键词的同义词、近义词及词形变化词,然后将出现频度的统计数据写入Excel表,并编制Excel宏自动生成折线图,实现关键词分布的简单可视化。情报工作者后续可借助Excel功能对该程序生成的Excel表执行复杂的数据组合分析,以提高工作效率。展开更多
In this paper, an improved algorithm, web-based keyword weight algorithm （WKWA）, is presented to weight keywords in web documents. WKWA takes into account representation features of web documents and advantages of t...In this paper, an improved algorithm, web-based keyword weight algorithm （WKWA）, is presented to weight keywords in web documents. WKWA takes into account representation features of web documents and advantages of the TF＊IDF, TFC and ITC algorithms in order to make it more appropriate for web documents. Meanwhile, the presented algorithm is applied to improved vector space model （IVSM）. A real system has been implemented for calculating semantic similarities of web documents. Four experiments have been carried out. They are keyword weight calculation, feature item selection, semantic similarity calculation, and WKWA time performance. The results demonstrate accuracy of keyword weight, and semantic similarity is improved.展开更多
To save the local storage,users store the data on the cloud server who offers convenient internet services.To guarantee the data privacy,users encrypt the data before uploading them into the cloud server.Since encrypt...To save the local storage,users store the data on the cloud server who offers convenient internet services.To guarantee the data privacy,users encrypt the data before uploading them into the cloud server.Since encryption can reduce the data availability,public-key encryption with keyword search(PEKS)is developed to achieve the retrieval of the encrypted data without decrypting them.However,most PEKS schemes cannot resist quantum computing attack,because the corresponding hardness assumptions are some number theory problems that can be solved efficiently under quantum computers.Besides,the traditional PEKS schemes have an inherent security issue that they cannot resist inside keywords guessing attack(KGA).In this attack,a malicious server can guess the keywords encapsulated in the search token by computing the ciphertext of keywords exhaustively and performing the test between the token and the ciphertext of keywords.In the paper,we propose a lattice-based PEKS scheme that can resist quantum computing attacks.To resist inside KGA,this scheme adopts a lattice-based signature technique into the encryption of keywords to prevent the malicious server from forging a valid ciphertext.Finally,some simulation experiments are conducted to demonstrate the performance of the proposed scheme and some comparison results are further shown with respect to other searchable schemes.展开更多
A search strategy over encrypted cloud data based on keywords has been improved and has presented a method using different strategies on the client and the server to improve the search efficiency in this paper. The cl...A search strategy over encrypted cloud data based on keywords has been improved and has presented a method using different strategies on the client and the server to improve the search efficiency in this paper. The client uses the Chinese and English to achieve the synonym construction of the keywords, the establishment of the fuzzy-syllable words and synonyms set of keywords and the implementation of fuzzy search strategy over the encryption of cloud data based on keywords. The server side through the analysis of the user’s query request provides keywords for users to choose and topic words and secondary words are picked out. System will match topic words with historical inquiry in time order, and then the new query result of the request is directly gained. The analysis of the simulation experiment shows that the fuzzy search strategy can make better use of historical results on the basis of privacy protection for the realization of efficient data search, saving the search time and improving the efficiency of search.展开更多
Keywords with the retrieval value clearly show the main contents, enhance the influence of academic periodicals, highlight specific information, and generalize information, but because of the ignorance of the value of...Keywords with the retrieval value clearly show the main contents, enhance the influence of academic periodicals, highlight specific information, and generalize information, but because of the ignorance of the value of keywords from some authors and editors, the lack of canonical guidance, and limitations of the editorial knowledge structure, there are some problems concerning keywords in academic papers, such as papers containing too many or too few keywords, or keywords being used in a way that is too general or colloquial. According to academic principle, accurate principle, logical principle, comprehensive principle, it is imperative to discuss how to choose keywords properly.展开更多
BACKGROUND Celecoxib has been used to treat hip discomfort and functional difficulties associated with osteonecrosis of the femoral head(ONFH),although significant adverse reactions often follow long-term use.Extracor...BACKGROUND Celecoxib has been used to treat hip discomfort and functional difficulties associated with osteonecrosis of the femoral head(ONFH),although significant adverse reactions often follow long-term use.Extracorporeal shock wave therapy(ESWT)can delay the progression of ONFH,alleviate the pain and functional limitations it causes,and avoid the adverse effects of celecoxib.AIM To investigate the effects of individual ESWT,a treatment alternative to the use of celecoxib,in alleviating pain and dysfunction caused by ONFH.METHODS This was a randomized,controlled,double-blinded,non-inferiority trial.We examined 80 patients for eligibility in this study;8 patients were excluded based on inclusion and exclusion criteria.A total of 72 subjects with ONFH were randomly assigned to group A(n=36;celecoxib+alendronate+sham-placebo shock wave)or group B(n=36;individual focused shock wave[ESWT based on magnetic resonance imaging three-dimensional(MRI-3D)reconstruction]+alendronate).The outcomes were assessed at baseline,at the end of treatment,and at an 8-wk follow-up.The primary outcome measure was treatment efficiency after 2 wk of intervention using the Harris hip score(HHS)(improvement of 10 points or more from the baseline was deemed sufficient).Secondary outcome measures were post-treatment HHS,visual analog scale(VAS),and Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)scores.RESULTS After treatment,the pain treatment efficiency of group B was greater than that of group A(69%vs 51%;95%CI:4.56%to 40.56%),with non-inferiority thresholds of-4.56%and-10%,respectively.Furthermore,the HHS,WOMAC,and VAS scores in group B dramatically improved during the follow-up period as compared to those in group A(P<0.001).After therapy,the VAS and WOMAC in group A were significantly improved from the 2nd to 8th wk(P<0.001),although HHS was only significantly altered at the 2 wk point(P<0.001).On the 1st d and 2nd wk after treatment,HHS and VAS scores were different between groups,with the difference in HHS lasting until week 4.Neither group had severe complications such as skin ulcer infection or lower limb motorsensory disturbance.CONCLUSION Individual shock wave therapy(ESWT)based on MRI-3D reconstruction was not inferior to celecoxib in managing hip pain and restrictions associated with ONFH.展开更多
Editor’s Note:The column China Keywords aims to facilitate readers’understanding of China’s political thinking,policies,and approach to development.Its content mainly comes from the“China Keywords”platform,a nati...Editor’s Note:The column China Keywords aims to facilitate readers’understanding of China’s political thinking,policies,and approach to development.Its content mainly comes from the“China Keywords”platform,a national-level project undertaken by the China International Publishing Group,Academy of Contemporary China and World Studies,and China Academy of Translation.This issue continues to center on the book Keywords to Understand China:The Belt and Road Initiative,briefing our readers about cooperation priorities of the initiative.展开更多
基金the Beijing Municipal Science and Technology Commission(grant Z211100002921013)the Tongzhou District Science and Technology Committee Project to Tongzhou(grant KJ2020CX010).
文摘Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems inconsistent.In this study,we investigated whether celecoxib would increase the antiproliferative effects of cisplatin in human lung cancer cells.Our data demonstrated the synergistic effects of celecoxib with cisplatin in wild-type p53 cells and their antagonistic effects inmutated or deleted p53 cells.Combination indices of 0.82 to 0.93 reflected a synergistic effect between celecoxib and cisplatin in lung cancer cells with wild-type p53.Combination indices of 1.63 to 3.00 reflected antagonism between celecoxib and cisplatin in lung cancer cells with mutated or deleted p53.Compared with that in cells with mutated or deleted p53,apoptosis significantly increased with the addition of celecoxib and cisplatin in wild-type p53 cells(P<0.05).Moreover,the results in vivo were similar to those in vitro:celecoxib combinedwith cisplatin slowed tumor growth in wild-type p53 groups and not in mutated or deleted p53 groups.In addition,celecoxib promoted p53 translocation into the nucleus and upregulated active p53 expression in wild-type p53 cells.Celecoxib combined with cisplatin upregulated PUMA(PUMA is a downstream gene of p53)after active p53 increased in wild-type p53 cells.In summary,the combination of celecoxib and cisplatin demonstrates clear synergistic effects in wild-type p53 cells and antagonistic effects inmutated or deleted p53 cells.The synergistic effect was achieved by apoptosis,induced by upregulating PUMA.Our results will provide a new treatment strategy for patients carrying wild-type p53,insensitive to cisplatin.
文摘使用Visual Basic编程,采用正则表达式批量提取由Web of Science导出的Bib Tex题录中所有Keywords字段关键词,按需合并所得关键词的同义词、近义词及词形变化词,然后将出现频度的统计数据写入Excel表,并编制Excel宏自动生成折线图,实现关键词分布的简单可视化。情报工作者后续可借助Excel功能对该程序生成的Excel表执行复杂的数据组合分析,以提高工作效率。
基金Project supported by the Science Foundation of Shanghai Municipal Commission of Science and Technology （Grant No.055115001）
文摘In this paper, an improved algorithm, web-based keyword weight algorithm （WKWA）, is presented to weight keywords in web documents. WKWA takes into account representation features of web documents and advantages of the TF＊IDF, TFC and ITC algorithms in order to make it more appropriate for web documents. Meanwhile, the presented algorithm is applied to improved vector space model （IVSM）. A real system has been implemented for calculating semantic similarities of web documents. Four experiments have been carried out. They are keyword weight calculation, feature item selection, semantic similarity calculation, and WKWA time performance. The results demonstrate accuracy of keyword weight, and semantic similarity is improved.
基金The authors would like to thank the support from Fundamental Research Funds for the Central Universities(No.30918012204)The authors also gratefully acknowledge the helpful comments and suggestions of other researchers,which has improved the presentation.
文摘To save the local storage,users store the data on the cloud server who offers convenient internet services.To guarantee the data privacy,users encrypt the data before uploading them into the cloud server.Since encryption can reduce the data availability,public-key encryption with keyword search(PEKS)is developed to achieve the retrieval of the encrypted data without decrypting them.However,most PEKS schemes cannot resist quantum computing attack,because the corresponding hardness assumptions are some number theory problems that can be solved efficiently under quantum computers.Besides,the traditional PEKS schemes have an inherent security issue that they cannot resist inside keywords guessing attack(KGA).In this attack,a malicious server can guess the keywords encapsulated in the search token by computing the ciphertext of keywords exhaustively and performing the test between the token and the ciphertext of keywords.In the paper,we propose a lattice-based PEKS scheme that can resist quantum computing attacks.To resist inside KGA,this scheme adopts a lattice-based signature technique into the encryption of keywords to prevent the malicious server from forging a valid ciphertext.Finally,some simulation experiments are conducted to demonstrate the performance of the proposed scheme and some comparison results are further shown with respect to other searchable schemes.
文摘A search strategy over encrypted cloud data based on keywords has been improved and has presented a method using different strategies on the client and the server to improve the search efficiency in this paper. The client uses the Chinese and English to achieve the synonym construction of the keywords, the establishment of the fuzzy-syllable words and synonyms set of keywords and the implementation of fuzzy search strategy over the encryption of cloud data based on keywords. The server side through the analysis of the user’s query request provides keywords for users to choose and topic words and secondary words are picked out. System will match topic words with historical inquiry in time order, and then the new query result of the request is directly gained. The analysis of the simulation experiment shows that the fuzzy search strategy can make better use of historical results on the basis of privacy protection for the realization of efficient data search, saving the search time and improving the efficiency of search.
文摘Keywords with the retrieval value clearly show the main contents, enhance the influence of academic periodicals, highlight specific information, and generalize information, but because of the ignorance of the value of keywords from some authors and editors, the lack of canonical guidance, and limitations of the editorial knowledge structure, there are some problems concerning keywords in academic papers, such as papers containing too many or too few keywords, or keywords being used in a way that is too general or colloquial. According to academic principle, accurate principle, logical principle, comprehensive principle, it is imperative to discuss how to choose keywords properly.
文摘BACKGROUND Celecoxib has been used to treat hip discomfort and functional difficulties associated with osteonecrosis of the femoral head(ONFH),although significant adverse reactions often follow long-term use.Extracorporeal shock wave therapy(ESWT)can delay the progression of ONFH,alleviate the pain and functional limitations it causes,and avoid the adverse effects of celecoxib.AIM To investigate the effects of individual ESWT,a treatment alternative to the use of celecoxib,in alleviating pain and dysfunction caused by ONFH.METHODS This was a randomized,controlled,double-blinded,non-inferiority trial.We examined 80 patients for eligibility in this study;8 patients were excluded based on inclusion and exclusion criteria.A total of 72 subjects with ONFH were randomly assigned to group A(n=36;celecoxib+alendronate+sham-placebo shock wave)or group B(n=36;individual focused shock wave[ESWT based on magnetic resonance imaging three-dimensional(MRI-3D)reconstruction]+alendronate).The outcomes were assessed at baseline,at the end of treatment,and at an 8-wk follow-up.The primary outcome measure was treatment efficiency after 2 wk of intervention using the Harris hip score(HHS)(improvement of 10 points or more from the baseline was deemed sufficient).Secondary outcome measures were post-treatment HHS,visual analog scale(VAS),and Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)scores.RESULTS After treatment,the pain treatment efficiency of group B was greater than that of group A(69%vs 51%;95%CI:4.56%to 40.56%),with non-inferiority thresholds of-4.56%and-10%,respectively.Furthermore,the HHS,WOMAC,and VAS scores in group B dramatically improved during the follow-up period as compared to those in group A(P<0.001).After therapy,the VAS and WOMAC in group A were significantly improved from the 2nd to 8th wk(P<0.001),although HHS was only significantly altered at the 2 wk point(P<0.001).On the 1st d and 2nd wk after treatment,HHS and VAS scores were different between groups,with the difference in HHS lasting until week 4.Neither group had severe complications such as skin ulcer infection or lower limb motorsensory disturbance.CONCLUSION Individual shock wave therapy(ESWT)based on MRI-3D reconstruction was not inferior to celecoxib in managing hip pain and restrictions associated with ONFH.
文摘Editor’s Note:The column China Keywords aims to facilitate readers’understanding of China’s political thinking,policies,and approach to development.Its content mainly comes from the“China Keywords”platform,a national-level project undertaken by the China International Publishing Group,Academy of Contemporary China and World Studies,and China Academy of Translation.This issue continues to center on the book Keywords to Understand China:The Belt and Road Initiative,briefing our readers about cooperation priorities of the initiative.
