An Analysis of Interpersonal Function of the Dialogues in the Film The King's Speech

Based on the framework of Halliday's theory of interpersonal function, this study intends to analyze the dialogues in the film The King's Speech from the three aspects of mood type, modal operator and vocative address by adopting both quantitative and qualitative methods. The significances of successful realizations of interpersonal function to the role characterization, plot development and thematic construction in the film are also demonstrated, thus deepening the understanding and appreciation of the film.

The Christian Doctrines of Salvation at the Earlier Stages of The Pilgrim's Progress

John Bunyan's The Pilgrim's Progress has been written to preach the Christian doctrines of salvation.Therefore its allegorical protagonists have gradually gone through four stages of development on the path to salvation.This paper is focused on the earlier two stages,that is,the repentance of sins and the temptations after conversion.

基于King达标理论的培训方案对临床护士叙事能力及人文关怀能力的影响

目的:探讨基于King达标理论构建临床护士叙事护理培训方案对临床护士叙事护理能力、人文关怀能力及共情能力的影响。方法:2023年3月—5月选取淄博市某三级甲等医院138名护士,采用随机数字表法分为试验组和对照组。对照组实施常规叙事护理培训,试验组在对照组的基础上实施基于King达标理论指导下的叙事护理方案。采用医学叙事能力量表(NCS)、关怀能力评价量表(CAI)、杰弗逊共情量表(JSE-HP)进行效果评价。结果:干预后,试验组护士NCS、CAI及JSE-HP得分均高于对照组,差异均有统计学意义(P<0.05)。结论:基于King达标理论构建的临床护士叙事培训方案可有效提高临床护士叙事护理能力、促进人文关怀能力并提升护士共情能力。

STAGE在C3I仿真测试系统中的应用

针对C3I系统面临的测试问题,提出一种将STAGE应用于C3I系统的仿真测试系统,并分析了STAGE的优点,介绍其组成结构、功能和STAGE在该系统中的应用。该系统已应用于某实际C3I系统的测试。

基于MRI影像组学构建PD-1/PD-L1抑制剂治疗dMMR/MSI-H直肠癌疗效的预测模型

目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例错配修复基因缺陷(dMMR)/微卫星高度不稳定(MSI-H)基因型中低位LARC患者的临床和影像资料。将入组患者按7∶3比例分为训练集和测试集,提取影像组学特征,从中筛选并构建影像组学模型。描绘影像组学模型的Rad-score与病理金标准之间的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并评价模型的诊断效能。采用决策曲线分析(DCA)计算风险阈值的范围,并评估临床获益情况。收集湖南省人民医院25例dMMR/MSI-H基因型LARC患者的影像资料作为外部验证集。结果:训练集、测试集及外部验证集三者之间的临床特征无统计学差异(P>0.05)。经过降维处理、t检验及一致性检验以及LASSO交叉验证后,筛选出一阶偏度特征和体积2个特征构建影像组学模型。训练集、测试集和外部验证集的影像组学预测模型ROC曲线的AUC、灵敏度、特异度、阳性预测值和阴性预测值分别为0.920、97.1%、85.7%、91.9%、94.7%;0.885、80.0%、88.9%、92.3%、72.7%;0.875、87.5%、88.9%、93.3%、80.0%。DCA曲线显示,当风险阈值范围为0%~82%时,采用影像组学模型预测LARC患者为病理完全缓解(pCR)的获益大于将所有患者都视为pCR或者无病理完全缓解(npCR)。结论:基于MRI影像组学构建的dMMR/MSI-H型局部进展期直肠癌PD-1/PD-L1抑制剂联合全程新辅助放化疗疗效预测模型,有较大潜力为不同基因分型的直肠癌患者制定个体化治疗策略提供量化依据。

Microbiome changes in the gastric mucosa and gastric juice in different histological stages of Helicobacter pylori-negative gastric cancers

BACKGROUND The gastric microbiota in patients with gastric cancer(GC)has received increasing attention,but the profiling of the gastric microbiome through the histological stages of gastric tumorigenesis remains poorly understood,especially for patients with Helicobacter pylori-negative GC(HPNGC).AIM To characterize microbial profiles of gastric mucosa and juice for HPNGC carcinogenesis and identify distinct taxa in precancerous lesions.METHODS The 16S rRNA gene analysis was performed on gastric mucosa from 134 Helicobacter pylori-negative cases,including 56 superficial gastritis(SG),9 atrophic gastritis(AG),27 intestinal metaplasia(IM),29 dysplasia(Dys),and 13 GC cases,to investigate differences in gastric microbial diversity and composition across the disease stages.In addition,paired gastric mucosa and juice samples from 18 SG,18 IM,and 18 Dys samples were analyzed.α-Diversity was measured by Shannon and Chao1 indexes,andβ-diversity was calculated using partial least squares discrimination analysis(PLS-DA).Differences in the microbial composition across disease stages in different sample types were assessed using the linear discriminant analysis effect size.RESULTS The diversity and composition of the bacterial microbiota in the gastric mucosa changed progressively across stages of gastric carcinogenesis.The diversity of the gastric mucosa microbiota was found to be significantly lower in the IM and Dys groups than in the SG group,and the patients with GC had the lowest bacterial community richness(P<0.05).Patients with IM and those with Dys had similar gastric mucosa microbiota profiles with Ralstonia and Rhodococcus as the predominant genera.Microbial network analysis showed that there was increasing correlation strength between IM and Dys(|correlation threshold|≥0.5,P<0.05).GC and its precancerous lesions have distinguishable bacterial taxa;our results identified HPNGC-associated bacteria Streptococcaceae and Lactobacillaceae(P<0.05).Additionally,across precancerous lesion stages from AG to Dys in Helicobacter pylori-negative patients,Burkholderiaceae abundance continuously increased,while Streptococcaceae and Prevotellaceae abundance presented a continuous downward trend.Furthermore,the microbial diversity was higher in gastric juice(P<0.001)than in the mucosa,while PLS-DA revealed a statistically significant difference between the two groups(ANOSIM,P=0.001).A significant difference in the microbial structure was identified,with Proteobacteria being more prevalent in the gastric mucosa and Firmicutes being more abundant in gastric juice.CONCLUSION Our results provide insights into potential taxonomic biomarkers for HPNGC and its precancerous stages and assist in predicting the prognosis of IM and Dys based on the mucosal microbiota profile.

Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation

Deep brain stimulation is a therapy for Alzheimer＇s disease（AD） that has previously been used for mainly mild to moderate cases. This study provides the first evidence of early alterations in performance induced by stimulation targeted at the fornix in severe AD patients. The performance of the five cases enrolled in this study was scored with specialized assessments including the Mini-Mental State Examination and Clinical Dementia Rating, both before and at an early stage after deep brain stimulation. The burden of caregivers was also evaluated using the Zarit Caregiver Burden Interview. As a whole, the cognitive performance of patients remained stable or improved to varying degrees, and caregiver burden was decreased. Individually, an improved mental state or social performance was observed in three patients, and one of these three patients showed remarkable improvement in long-term memory. The conditions of another patient deteriorated because of inappropriate antipsychotic medications that were administered by his caregivers. Taken together, deep brain stimulation was capable of improving some cognitive aspects in patients with severe AD, and of ameliorating their emotional and social performance, at least at an early stage. However, long-term effects induced by deep brain stimulation in patients with severe AD need to be further validated. More research should focus on clarifying the mechanism of deep brain stimulation. This study was registered with ClinicalTrials.gov（NCT03115814） on April 14, 2017.

基于King达标理论的心理干预结合亲情干预模式对BPH患者行PKEP术后恢复情况及GQOLI-74、IPSS评分的影响

目的研究基于King达标理论的心理干预结合亲情干预模式对前列腺增生(BPH)患者行经尿道双极等离子前列腺剜除术(PKEP)术后恢复情况及生活质量综合评定问卷(GQOLI-74)、国际前列腺症状评分(IPSS)的影响。方法选择2017年8月~2019年2月浙江省嘉兴市第二医院收治的BPH患者120例作为研究对象,采用随机数字表法将其分为对照组和观察组,每组60例.两组患者均采取PKEP治疗,手术治疗后,对照组患者采取常规护理措施,观察组患者采取基于King达标理论的心理干预结合亲情干预模式,两组患者的护理时间均为4周。比较两组患者的围术期指标、症状改善情况、并发症、生命质量以及依从性之间的差异。结果两组IPSS评分、最大尿流速(Qmax)、残余尿量(RUV)组内治疗前后比较,差异均有统计学意义(均P<0.05),治疗后两组手术时间、术中出血量、切除组织量、IPSS评分、Qmax、RUV之间比较,差异均无统计学意义(P>0.05);治疗后,两组患者的生命质量评分均升高,且观察组患者的生命质量评分均显著高于对照组,差异有统计学意义(P<0.05),两组患者的遵医嘱服药行为以及不良服药行为、日常生活管理行为、烟酒嗜好管理行为、依从性总分均高于治疗前,且观察组各项评分均高于对照组,差异均有统计学意义(P<0.05)。结论通过对BPH患者基于King达标理论的心理干预结合亲情干预模式护理,患者GQOLI-74、IPSS评分显著改善,患者的并发症显著下降,对患者的治疗具有积极的意义。

Anodal transcranial direct current stimulation alleviates cognitive impairment in an APP/PS1 model of Alzheimer’s disease in the preclinical stage

Anodal transcranial direct current stimulation(AtDCS)has been shown to alleviate cognitive impairment in an APP/PS1 model of Alzheimer’s disease in the preclinical stage.However,this enhancement was only observed immediately after AtDCS,and the long-term effect of AtDCS remains unknown.In this study,we treated 26-week-old mouse models of Alzheimer’s disease in the preclinical stage with 10 AtDCS sessions or sham stimulation.The Morris water maze,novel object recognition task,and novel object location test were implemented to evaluate spatial learning memory and recognition memory of mice.Western blotting was used to detect the relevant protein content.Morphological changes were observed using immunohistochemistry and immunofluorescence staining.Six weeks after treatment,the mice subjected to AtDCS sessions had a shorter escape latency,a shorter path length,more platform area crossings,and spent more time in the target quadrant than sham-stimulated mice.The mice subjected to AtDCS sessions also performed better in the novel object recognition and novel object location tests than sham-stimulated mice.Furthermore,AtDCS reduced the levels of amyloid-β42 and glial fibrillary acidic protein,a marker of astrocyte activation,and increased the level of neuronal marker NeuN in hippocampal tissue.These findings suggest that AtDCS can improve the spatial learning and memory abilities and pathological state of an APP/PS1 mouse model of Alzheimer’s disease in the preclinical stage,with improvements that last for at least 6 weeks.

TRUE KINGLY HONOUR IN SHAKESPEARE′S HENRY IV PART I

Honour, one of the eternal themes in Shakespeare, is again in the spotlightin Henry IV Part I. In this play, the rivalry between Prince Hal and Hotspuremerges actually out of their cravings for the title of royal honour and valour.Hotspur appears to be formidable, courageous and energetic. He is exactly

Unicentric Castleman's disease associated with end stage renal disease caused by amyloidosis

Castleman's disease(CD), also known as angiofolicular lymph node hyperplasia, is a rare heterogenous group of lymphoproliferative disorders. Histologically, it can be classified as hyaline vascular type, plasma cell type, or mixed type. Clinically two different subtypes of the CD are present: Unicentric and multicentric. Unicentric CD is generally asymptomatic and associated with hyaline vascular type, and its diagnoses depend on the localized lymphadenopathy on examination or imaging studies. However, multicentric CD presents with generalized lymphadenopathy and systemic symptoms including malaise, fever, night sweats, weight loss, and it is associated with the plasma cell type and mix type. Herein, we report a patient with unicentric CD of the plasma cell type without systemic symptoms, who developed end stage renal failure caused by amyloidosis 6 years after onset of CD.

Prey Predator Fishery Model with Stage Structure in Two Patchy Marine Aquatic Environment

In this paper, we propose and analyze a mathematical model to study the dynamics of a fishery resource system with stage structure in an aquatic environment that consists of two zones namely unreserved zone (fishing permitted) and reserved zone (fishing is strictly prohibited). In this model we introduce a stage structure in which predators are split into two kinds as immature predators and mature predators. It is assumed that immature predators cannot catch the prey and their foods are given by their parents (mature predators). It is also assumed that the fishing of immature predators prohibited in the unreserved zone and predator species are not allowed to enter inside the reserved zone. The local and global stability analysis has been specified. Biological and Bionomical equilibriums of the system are derived. Mathematical formulation of the optimal harvesting policy is given and its solution is derived in the equilibrium case by using Pontryagin’s maximum principle.

Jordan＇s King Hussein＇s Peace Initiative and the Treaty with Israel： Overcoming Domestic and Foreign Pressures

The Wadi ＇Araba peace treaty which Jordan＇s King Hussein signed with Israel on October 26, 1994 became a target of criticism ever since it became known to the Jordanian public. Intense pressure was exerted on the Jordanian government to revoke the treaty even before its signature. The opposition to it reached its peak in the following year, when the tension in the holy sites in Jerusalem mounted. Given the persistence of the Arab-Israeli conflict and the fact that the Palestinian issue remained unresolved, it was clear that the King was aware of the potential danger of signing a peace accord with Israel, and that he was prepared to face criticism not only from the Arab states but also from nationalists, Islamists and Leftists all of whom disapproved of his decision. Yet the King remained undeterred and boldly carried on the discussions that culminated in the peace treaty＇s signature. Bearing in mind the fact the Egypt was the first country to sign a peace treaty with Israel it seemed as if there was little risk involved in the normalization process, and that the opposition to the treaty would soon subside. As it turned out, however, the pressure to abrogate it continues to mount.

“Malaysia Has Certainly Benefited from China’s Prominence on the World Stage”——Exclusive Interview with See Chee Kong Leonard, Business Minister of Embassy of Malaysia in PRC

Relations between China and Malaysia have been developing steadily.Recently,See Chee Kong Leonard,Business Minister of Embassy of Malaysia in PRC,accepted an interview with Chinas Foreign Tradey and talked about the 45 years of economic and trade cooperation and achievements of the two countries.

＂From a Utopia to a Dystopia＂ On Mark Twain＇s Compliance with and Deviation from Heterotopology in A Connecticut Yankee in King Arthur＇s Court

In this paper, the author intends to parallelize Mark Twain＇s A Connecticut Yankee in King Arthur＇s Court with Foucault＇s theorizations about heterotopia, or heterotopology. For Foucault, heterotopia is a paradox because it is paces that are both real and placeless. Twain＇s novel is a time travel story, which juxtaposes the temporalities of the 6th and 19th centuries. In the story, Hank, the hero, is allowed access to Camelot, King Arthur＇s court. Above all, he has introduced to it quite a few elements of modem technology and civilization. So far Twain seems to have complied with Foucault＇s heterotopology. That is, there is a textual heterotopia created in his novel. However, the last principle of Foucault＇s heterotopology states that a heterotopia can be comparable to a utopia because of its contrastive function. A typical time travel story has the same contrastive function as well. That is, in either case there should be a utopia, a dystopia, or a mixture of them. However, Twain＇s novel fails to contrast the 6th century with the 19th century simply because the heterotopia Hank has created leaps from a utopia to a dystopia. It is at this point where Twain has deviated from heterotopology. The shifting nature of this heterotopia not only disables its contrastive mechanism but also jeopardizes its thematic clarity. Most of all, it indicates that Twain has a considerably ambivalent attitude towards the industrial civilization, and that as a consequence, he is indecisive about the direction of this novel.

Re-Formulation of Mean King’s Problem Using Shannon’s Entropy

Mean King’s problem is formulated as a retrodiction problem among noncommutative observables. In this paper, we reformulate Mean King’s problem using Shannon’s entropy as a first step of introducing quantum uncertainty relation with delayed classical information. As a result, we give informational and statistical meanings to the estimation on Mean King problem. As its application, we give an alternative proof of nonexistence of solutions of Mean King’s problem for qubit system without using entanglement.

TCL——King Brand Colour TV Rivals the World's Famous Brands

World famous colour TVs,such asSony,National and Toshiba,usedto monopolize China’s large-screencolour TV market.But recently the KingBrand colour TV made by the TCL ElectronicsGroup has begun to challenge them.In1995,the TCL King Brand colour TV notonly ranked first for its sales volume on theChinese market among the domestically-produced TVs of its kind,but also

帕金森病患者血清LCN2、PROS1水平变化及其与疾病分期、认知障碍的相关性

目的探讨帕金森病(PD)患者血清脂质运载蛋白2(LCN2)、蛋白S基因(PROS1)水平变化及其与疾病分期、认知障碍的相关性。方法选取2019年1月至2022年12月该院诊治的PD患者120例为研究对象(PD组),参考改良版Hoehn-Yahr分级(H-Y分级),分为早期PD组(0~1.5级,n=50),中期PD组(>1.5~3.0级,n=39),晚期PD组(>3.0~5.0级,n=31)。以同期健康体检的60例体检健康者为对照组。检测两组血清LCN2、PROS1水平。比较不同PD疾病分期PD患者血清LCN2、PROS1水平差异。Spearman秩相关分析血清LCN2、PROS1水平与简易智力状态检查量表(MMSE),蒙特利尔认知评估量表(MoCA)及H-Y分级的相关性。多因素Logistic回归分析影响PD患者认知功能障碍的相关因素。绘制受试者工作特征(ROC)曲线分析血清LCN2、PROS1水平对PD患者认知障碍的评估价值。结果PD组血清LCN2、PROS1水平分别为(97.47±11.28)μg/L、(77.52±8.69)μg/L,明显高于对照组(40.15±6.22)μg/L、(32.49±4.37)μg/L,差异均有统计学意义(t=36.641、37.783,均P<0.05)。晚期PD组血清LCN2、PROS1水平高于早期、中期PD组,差异均有统计学意义(均P<0.05)。认知障碍组PD患者病程、血清LCN2、PROS1、H-Y分级均高于认知正常组患者,而MoCA评分、MMSE评分低于认知正常组,差异均有统计学意义(P<0.05)。血清LCN2、PROS1水平与MoCA评分,MMSE评分呈负相关(r=-0.634、-0.489,均P<0.05),与H-Y分级呈正相关(r=0.467、0.625,均P<0.05)。血清LCN2、PROS1是影响PD患者认知功能障碍的相关危险因素。血清LCN2、PROS1单独及联合对PD患者认知功能障碍预测的曲线下面积(AUC)为0.905(95%CI:0.868~0.955),0.803(95%CI:0.764~0.849),0.836(95%CI:0.770~0.867),血清LCN2、PROS1联合检测AUC明显高于单独检测,差异具有统计学意义(Z=5.558,4.974,均P<0.001)。结论PD患者血清LCN2、PROS1水平升高,与PD疾病分期、认知障碍有关,两者联合检测对PD患者认知障碍具有较高的评估价值。