Particulate matter(PM) plays an important role in air pollution, especially in China. European and American researchers conducted several cohort-based studies to examine the potential relationship between PM and lung ...Particulate matter(PM) plays an important role in air pollution, especially in China. European and American researchers conducted several cohort-based studies to examine the potential relationship between PM and lung cancer and found a positive association between PM and lung cancer mortality. In contrast, the results regarding PM and lung cancer risk remain inconsistent. Most of the previous studies had limitations such as misclassification of PM exposure and residual confounders, diminishing the impact of their findings. In addition, prospective studies on this topic are very limited in Chinese populations. This is an important problem because China has one of the highest concentrations of PM in the world and has had an increased mortality risk due to lung cancer. In this context, more prospective studies in Chinese populations are warranted to investigate the relationship between PM and lung cancer.展开更多
Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nicke...Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nickel,and silica are well-established risk factors,many lung cancer cases cannot be explained by these known risk factors.Over the last two decades the incidence of adenocarcinoma has risen,and it now surpasses squamous cell carcinoma as the most common histologic subtype.This increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future studies.Given the myriad exposures individuals experience in real-world settings,it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.展开更多
文摘Particulate matter(PM) plays an important role in air pollution, especially in China. European and American researchers conducted several cohort-based studies to examine the potential relationship between PM and lung cancer and found a positive association between PM and lung cancer mortality. In contrast, the results regarding PM and lung cancer risk remain inconsistent. Most of the previous studies had limitations such as misclassification of PM exposure and residual confounders, diminishing the impact of their findings. In addition, prospective studies on this topic are very limited in Chinese populations. This is an important problem because China has one of the highest concentrations of PM in the world and has had an increased mortality risk due to lung cancer. In this context, more prospective studies in Chinese populations are warranted to investigate the relationship between PM and lung cancer.
基金supported by the Non-profit Central Research Insti-tute Fund of Chinese Academy of Medical Sciences(grant number:2021-RC310-009).
文摘Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nickel,and silica are well-established risk factors,many lung cancer cases cannot be explained by these known risk factors.Over the last two decades the incidence of adenocarcinoma has risen,and it now surpasses squamous cell carcinoma as the most common histologic subtype.This increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future studies.Given the myriad exposures individuals experience in real-world settings,it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.
