Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of ch...Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage.展开更多
Valeriaquinone A(1),an unprecedented anthraquinone–coumarin hybrid,was isolated from the roots of Knoxia valerianoides.Its structure was determined by extensive spectroscopic analyses and X-ray diffraction.The plausi...Valeriaquinone A(1),an unprecedented anthraquinone–coumarin hybrid,was isolated from the roots of Knoxia valerianoides.Its structure was determined by extensive spectroscopic analyses and X-ray diffraction.The plausible biosynthetic pathways for 1 were proposed.Compound 1 exhibited strong protein tyrosine phosphatase 1 B(PTP1 B)inhibition with high selectivity(>30 fold)over homologous T cell protein tyrosine phosphatase(TCPTP)potentially by binding to an allosteric site predicted by kinetic analysis and molecular docking.Moreover,compound 1 showed significant cytotoxic activities against three human hepatoma cell lines(HepG2,QGY-7703,and SMMC-7721)with half maximal inhibitory concentration(IC_(50))values of 1.39±0.2,10.34±2.09,and 5.56±0.47μmol/L,respectively.展开更多
基金Financial support from the National Natural Sciences Foundation of China(NNSFC,grant Nos.30825044 and 20932007)the National Science and Technology Project of China(No.2009ZX09311-004)is acknowledged.
文摘Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage.
基金National Natural Science Foundation of China(No.81703391)Shandong Provincial Natural Science Foundation of China(No.ZR2020KB015)Key R&D Program of Shandong Province(No.2019JZZY011104,China)。
文摘Valeriaquinone A(1),an unprecedented anthraquinone–coumarin hybrid,was isolated from the roots of Knoxia valerianoides.Its structure was determined by extensive spectroscopic analyses and X-ray diffraction.The plausible biosynthetic pathways for 1 were proposed.Compound 1 exhibited strong protein tyrosine phosphatase 1 B(PTP1 B)inhibition with high selectivity(>30 fold)over homologous T cell protein tyrosine phosphatase(TCPTP)potentially by binding to an allosteric site predicted by kinetic analysis and molecular docking.Moreover,compound 1 showed significant cytotoxic activities against three human hepatoma cell lines(HepG2,QGY-7703,and SMMC-7721)with half maximal inhibitory concentration(IC_(50))values of 1.39±0.2,10.34±2.09,and 5.56±0.47μmol/L,respectively.
