The manuscript titled "Vacuoles of Candida yeast behave as a specialized niche for Helicobacter pylori(H.pylori)" not only has not been prepared in a scientific manner but the methodology used was not adequa...The manuscript titled "Vacuoles of Candida yeast behave as a specialized niche for Helicobacter pylori(H.pylori)" not only has not been prepared in a scientific manner but the methodology used was not adequate, and therefore the conclusion reached was not correct. First of all, "yeast" is a broad terminology covering a great number of genera and species of unicellular micro-organisms. The authors should have defined the organism with its binary scientific name. This measure would allow experiment reproduction by the scientific community. Moreover, the criteria established by Robert Koch to identify a specific microorganism or pathogen was not adopted in the methodology used. Regarding the methodology applied, use of the chicken eggyolk(Ig Y) antibody and PCR of the apparently tainted yeast population to prove H. pylori existence in the yeast vacuoles might be main factors for their wrong conclusions. Bacterial tropism toward yeast extract is a known phenomenon, and yeast extract is one of the main ingredients in culture media. Their internalization through phagocytosis or similar pathways does not seem possible or practical because of the thick and cellulosic yeast wall. While the small size of yeast cells does not support their ability in harboring several H. pylori, other observations such as inefficiency of antifungal therapy as anti-Helicobacter therapy strongly reject the conclusion reached by the above-mentioned article.展开更多
Offshore triceratops is one of the successful manifestations of the form-dominant design approaches deployable in ultra-deepwater oil and gas exploration.The deck’s geometric shape and partial isolation from the legs...Offshore triceratops is one of the successful manifestations of the form-dominant design approaches deployable in ultra-deepwater oil and gas exploration.The deck’s geometric shape and partial isolation from the legs counteract lateral loads.Legs are position-restrained to the sea bed by taut-moored tendons,while ball joints partially isolate the deck from the buoyant legs.However,compliance in the horizontal plane imposes large displacements,intuiting the necessity to examine tendon failure.Numerical analysis of triceratops under wave and wind combined action is carried out under the postulated conditions of a tendon failure.10-yr,100-yr,and 1000-yr post-Katrina hurricane conditions are assumed as loading to the platform.Results confirm a marginal increase in the natural periods of stiff degrees of freedom even under postulated failure conditions,ensuring good adaptability to ultra-deep water.Under postulated failure,the tension of adjacent tendons varies significantly,causing a shift to the mean position of the platform.Fatigue life is significantly reduced under the postulated failure of tendons,making the platform free-floating without affecting its stability.Results also show that the pitch response of the deck is a clear manifestation of the postulated failure,which is otherwise absent due to the presence of ball joints.The attempted study deliberates on the fatigue life of tendons,assessing the platform’s suitability to ultra-deep waters and identifying the vulnerable legs for the chosen load combinations.展开更多
In this technologically advancing world,the demand for more energy,oil and gas production is rapidly escalating.To accomplish this,people have inclined more towards completely floating offshore structures,deployed in ...In this technologically advancing world,the demand for more energy,oil and gas production is rapidly escalating.To accomplish this,people have inclined more towards completely floating offshore structures,deployed in deep waters.A semi-submersible is selected in the present study,due to its better response characteristics and stability under harsh environmental conditions.The semi-submersible is position restrain with spread mooring lines incorporated with submerged buoy at different locations has been studied.A detailed numerical analysis is carried out using Ansys Aqwa for dynamic response analysis of semi-submersible under the combination of wind,wave,and current forces for 0°,45°,and 90°directions.It was observed that damping ratios and natural periods had been affected based on the position and number of submerged buoys in the mooring system.Also,reduction in mooring force after incorporating buoy in the mooring lines was observed.Subsequently,a Matlab code based on the S-N curve approach was generated and employed to investigate the fatigue damage of mooring lines under dynamic variation of mooring forces.When pegged with submerged buoys,fatigue life of mooring lines is increased under intact and postulated damaged mooring conditions.Moreover,coupling of motion responses of semi-submersible is observed,and unbounded response is not seen in any degrees-offreedom,even during damaged condition of mooring lines.展开更多
In this paper, we prove Legendre’s conjecture: There is a prime number between n<sup>2</sup> and (n +1)<sup>2</sup> for every positive integer n. We also prove three related conjectures. The m...In this paper, we prove Legendre’s conjecture: There is a prime number between n<sup>2</sup> and (n +1)<sup>2</sup> for every positive integer n. We also prove three related conjectures. The method that we use is to analyze binomial coefficients. It is developed by the author from the method of analyzing binomial central coefficients, that was used by Paul Erdős in his proof of Bertrand’s postulate - Chebyshev’s theorem.展开更多
In this paper along with the previous studies on analyzing the binomial coefficients, we will complete the proof of a theorem. The theorem states that for two positive integers n and k, when n ≥ k - 1, there always e...In this paper along with the previous studies on analyzing the binomial coefficients, we will complete the proof of a theorem. The theorem states that for two positive integers n and k, when n ≥ k - 1, there always exists at least a prime number p such that kn p ≤ (k +1)n. The Bertrand-Chebyshev’s theorem is a special case of this theorem when k = 1. In the field of prime number distribution, just as the prime number theorem provides the approximate number of prime numbers relative to natural numbers, while the new theory indicates that prime numbers exist in the specific intervals between natural numbers, that is, the new theorem provides the approximate positions of prime numbers among natural numbers.展开更多
文摘The manuscript titled "Vacuoles of Candida yeast behave as a specialized niche for Helicobacter pylori(H.pylori)" not only has not been prepared in a scientific manner but the methodology used was not adequate, and therefore the conclusion reached was not correct. First of all, "yeast" is a broad terminology covering a great number of genera and species of unicellular micro-organisms. The authors should have defined the organism with its binary scientific name. This measure would allow experiment reproduction by the scientific community. Moreover, the criteria established by Robert Koch to identify a specific microorganism or pathogen was not adopted in the methodology used. Regarding the methodology applied, use of the chicken eggyolk(Ig Y) antibody and PCR of the apparently tainted yeast population to prove H. pylori existence in the yeast vacuoles might be main factors for their wrong conclusions. Bacterial tropism toward yeast extract is a known phenomenon, and yeast extract is one of the main ingredients in culture media. Their internalization through phagocytosis or similar pathways does not seem possible or practical because of the thick and cellulosic yeast wall. While the small size of yeast cells does not support their ability in harboring several H. pylori, other observations such as inefficiency of antifungal therapy as anti-Helicobacter therapy strongly reject the conclusion reached by the above-mentioned article.
文摘Offshore triceratops is one of the successful manifestations of the form-dominant design approaches deployable in ultra-deepwater oil and gas exploration.The deck’s geometric shape and partial isolation from the legs counteract lateral loads.Legs are position-restrained to the sea bed by taut-moored tendons,while ball joints partially isolate the deck from the buoyant legs.However,compliance in the horizontal plane imposes large displacements,intuiting the necessity to examine tendon failure.Numerical analysis of triceratops under wave and wind combined action is carried out under the postulated conditions of a tendon failure.10-yr,100-yr,and 1000-yr post-Katrina hurricane conditions are assumed as loading to the platform.Results confirm a marginal increase in the natural periods of stiff degrees of freedom even under postulated failure conditions,ensuring good adaptability to ultra-deep water.Under postulated failure,the tension of adjacent tendons varies significantly,causing a shift to the mean position of the platform.Fatigue life is significantly reduced under the postulated failure of tendons,making the platform free-floating without affecting its stability.Results also show that the pitch response of the deck is a clear manifestation of the postulated failure,which is otherwise absent due to the presence of ball joints.The attempted study deliberates on the fatigue life of tendons,assessing the platform’s suitability to ultra-deep waters and identifying the vulnerable legs for the chosen load combinations.
文摘In this technologically advancing world,the demand for more energy,oil and gas production is rapidly escalating.To accomplish this,people have inclined more towards completely floating offshore structures,deployed in deep waters.A semi-submersible is selected in the present study,due to its better response characteristics and stability under harsh environmental conditions.The semi-submersible is position restrain with spread mooring lines incorporated with submerged buoy at different locations has been studied.A detailed numerical analysis is carried out using Ansys Aqwa for dynamic response analysis of semi-submersible under the combination of wind,wave,and current forces for 0°,45°,and 90°directions.It was observed that damping ratios and natural periods had been affected based on the position and number of submerged buoys in the mooring system.Also,reduction in mooring force after incorporating buoy in the mooring lines was observed.Subsequently,a Matlab code based on the S-N curve approach was generated and employed to investigate the fatigue damage of mooring lines under dynamic variation of mooring forces.When pegged with submerged buoys,fatigue life of mooring lines is increased under intact and postulated damaged mooring conditions.Moreover,coupling of motion responses of semi-submersible is observed,and unbounded response is not seen in any degrees-offreedom,even during damaged condition of mooring lines.
文摘In this paper, we prove Legendre’s conjecture: There is a prime number between n<sup>2</sup> and (n +1)<sup>2</sup> for every positive integer n. We also prove three related conjectures. The method that we use is to analyze binomial coefficients. It is developed by the author from the method of analyzing binomial central coefficients, that was used by Paul Erdős in his proof of Bertrand’s postulate - Chebyshev’s theorem.
文摘In this paper along with the previous studies on analyzing the binomial coefficients, we will complete the proof of a theorem. The theorem states that for two positive integers n and k, when n ≥ k - 1, there always exists at least a prime number p such that kn p ≤ (k +1)n. The Bertrand-Chebyshev’s theorem is a special case of this theorem when k = 1. In the field of prime number distribution, just as the prime number theorem provides the approximate number of prime numbers relative to natural numbers, while the new theory indicates that prime numbers exist in the specific intervals between natural numbers, that is, the new theorem provides the approximate positions of prime numbers among natural numbers.
