Kruppel-like factors(KLFs) are a subclass of the zinc finger family of DNA-binding transcription factors. The nomenclature is based on the homology to the DNA-binding domain of the drosophila protein kruppel.To date,1...Kruppel-like factors(KLFs) are a subclass of the zinc finger family of DNA-binding transcription factors. The nomenclature is based on the homology to the DNA-binding domain of the drosophila protein kruppel.To date,17 members of KLF family have been identified in mammalian cells.KLF family is implicated in many bio-展开更多
Purpose:To study the association of blood pressure(BP)status on the optic disk structure as measured with the Heidelberg Retina Tomograph(HRT)in people without glaucoma.Design:Cross-sectional population-based setting ...Purpose:To study the association of blood pressure(BP)status on the optic disk structure as measured with the Heidelberg Retina Tomograph(HRT)in people without glaucoma.Design:Cross-sectional population-based setting study.Methods:Consecutive participants in the Thessaloniki Eye Study were included in this study.HRT images of the optic disk and BP measurements were taken.Hypertension was defined as a systolic BP(SBP)≥ 140 mmHg,diastolic BP(DBP)≥ 90 mmHg,or both.Subjects were classified in three groups by SBP and DBP.The Kruskal-Wallis test was used to compare the three groups with respect to the HRT parameters.Regression models adjusted for age,gender,height,disk size,intraocular pressure,cardiovascular disease,diabetes,and duration of antihypertensive treatment were used for each HRT parameter to compare values among the different groups.The P value was considered significant at<.05.Results:A total of 232 subjects were included in the analysis.Rim area was signifi cantly different among groups when DBP was considered as the criterion to classify subjects(P=.005).In regression models,cup area,and cup-to-disk(c/d)ratio were increased in subjects with normal DBP that was the result of treatment,as compared with both the high DBP and untreated normal DBP groups.Conclusions:In patients without glaucoma,the DBP< 90 mm Hg that results from antihypertensive treatment is associated with increased cupping and decreased rim area of the optic disk.This information should be considered in research aiming to define the role of the BP status as an independent factor initiating optic disk changes and/or as a contributing factor to glaucoma damage.展开更多
The equation arising from Prandtl boundary layer theory (e)u/(e)t-(e)/(e)x1(a(u,x,t)(e)u/(e)xi)-fi(x)Diu+c(x,t)u=g(x,t)is considered.The existence of the entropy solution can be proved by BV estimate method.The intere...The equation arising from Prandtl boundary layer theory (e)u/(e)t-(e)/(e)x1(a(u,x,t)(e)u/(e)xi)-fi(x)Diu+c(x,t)u=g(x,t)is considered.The existence of the entropy solution can be proved by BV estimate method.The interesting problem is that,since a(·,x,t) may be degenerate on the boundary,the usual boundary value condition may be overdetermined.Accordingly,only dependent on a partial boundary value condition,the stability of solutions can be expected.This expectation is turned to reality by Kru(z)kov's bi-variables method,a reasonable partial boundary value condition matching up with the equation is found first time.Moreover,if axi(·,x,t)|x∈(e)Ω=a(·,x,t)|x∈(e)Ω=0 and fi(x)|x∈(e)Ω=0,the stability can be proved even without any boundary value condition.展开更多
文摘Kruppel-like factors(KLFs) are a subclass of the zinc finger family of DNA-binding transcription factors. The nomenclature is based on the homology to the DNA-binding domain of the drosophila protein kruppel.To date,17 members of KLF family have been identified in mammalian cells.KLF family is implicated in many bio-
文摘Purpose:To study the association of blood pressure(BP)status on the optic disk structure as measured with the Heidelberg Retina Tomograph(HRT)in people without glaucoma.Design:Cross-sectional population-based setting study.Methods:Consecutive participants in the Thessaloniki Eye Study were included in this study.HRT images of the optic disk and BP measurements were taken.Hypertension was defined as a systolic BP(SBP)≥ 140 mmHg,diastolic BP(DBP)≥ 90 mmHg,or both.Subjects were classified in three groups by SBP and DBP.The Kruskal-Wallis test was used to compare the three groups with respect to the HRT parameters.Regression models adjusted for age,gender,height,disk size,intraocular pressure,cardiovascular disease,diabetes,and duration of antihypertensive treatment were used for each HRT parameter to compare values among the different groups.The P value was considered significant at<.05.Results:A total of 232 subjects were included in the analysis.Rim area was signifi cantly different among groups when DBP was considered as the criterion to classify subjects(P=.005).In regression models,cup area,and cup-to-disk(c/d)ratio were increased in subjects with normal DBP that was the result of treatment,as compared with both the high DBP and untreated normal DBP groups.Conclusions:In patients without glaucoma,the DBP< 90 mm Hg that results from antihypertensive treatment is associated with increased cupping and decreased rim area of the optic disk.This information should be considered in research aiming to define the role of the BP status as an independent factor initiating optic disk changes and/or as a contributing factor to glaucoma damage.
基金The paper is supported by Natural Science Foundation of Fujian province(2019J01858)supported by SF of Xiamen University of Technology,China.The author would like to think reviewers for their good comments.
文摘The equation arising from Prandtl boundary layer theory (e)u/(e)t-(e)/(e)x1(a(u,x,t)(e)u/(e)xi)-fi(x)Diu+c(x,t)u=g(x,t)is considered.The existence of the entropy solution can be proved by BV estimate method.The interesting problem is that,since a(·,x,t) may be degenerate on the boundary,the usual boundary value condition may be overdetermined.Accordingly,only dependent on a partial boundary value condition,the stability of solutions can be expected.This expectation is turned to reality by Kru(z)kov's bi-variables method,a reasonable partial boundary value condition matching up with the equation is found first time.Moreover,if axi(·,x,t)|x∈(e)Ω=a(·,x,t)|x∈(e)Ω=0 and fi(x)|x∈(e)Ω=0,the stability can be proved even without any boundary value condition.
