目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidenc...目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidence of relapse,CIR),并探讨影响复发的危险因素。方法回顾性分析2015年1月—2019年12月接受CCCG-ALL-2015方案治疗的852例患儿的临床资料,计算CIR并分析影响儿童急性B淋巴细胞白血病(B-ALL)复发的危险因素。结果852例ALL患儿中,146例(17.1%)发生复发,8年CIR为(19.8±1.6)%。B-ALL与急性T淋巴细胞白血病患儿的8年CIR比较差异无统计学意义(P>0.05)。146例复发患儿中,复发时间主要集中于极早期(62例,42.5%)和早期(46例,31.5%),极早期单纯骨髓复发42例(28.8%),早期单纯骨髓复发27例(18.5%)。Cox比例风险回归模型分析显示,融合基因MLLr阳性(HR=4.177,95%CI:2.086~8.364,P<0.001)和第46天微小残留病≥0.01%(HR=2.013,95%CI:1.163~3.483,P=0.012)是B-ALL患儿经CCCG-ALL-2015方案治疗后复发的危险因素。结论儿童ALL经CCCG-ALL-2015方案治疗后仍有较高的复发率,以极早期和早期单纯骨髓复发常见;第46天微小残留病≥0.01%、融合基因MLLr阳性与B-ALL复发密切相关。展开更多
The impact of typhoon Kujira(2015)on the ocean environment around Yongxing Island in the South China Sea was observed using multiple-satellite sensors and on-site data.A subsurface buoy and Agro float were located to ...The impact of typhoon Kujira(2015)on the ocean environment around Yongxing Island in the South China Sea was observed using multiple-satellite sensors and on-site data.A subsurface buoy and Agro float were located to the left and lower right of the track of the typhoon.Satellite observations revealed sea surface cooling of up to 2.5℃,a maximum decrease in sea surface salinity of 2 in the main study area because of heavy rain,and increases in the chlorophyll concentration induced by the slow-moving typhoon with a maximum observed instantaneous wind speed of 35.1 m/s.The sea surface temperature to the right of the typhoon track changed more than that on the left owing to a right bias of the typhoon associated with coupling of the typhoon with wind stress on the sea surface.In the ocean interior,there was obvious downwelling at 24.7 m and upwelling at a depth of 35.7 m with the vertical entrainment and agitation of the typhoon,and the ef fects extended to different depths of up to more than 1000 m.When the typhoon passed through the main study area,the maximum flow velocity change at depths of 51 and 660 m was about 0.44 and 0.04 m/s,respectively.The typhoon af fected the flow field to a depth of 660 m as it formed and decayed in 11 h,moved at an average speed of 60 m/h,and af fected the sea surface over a range exceeding 700 km as it moved slowly and stayed at sea for 2 d.Vertical entrainment and agitation generated by the typhoon,as well as rainfall,cooled the sea surface.This inhibited the strengthening of the typhoon,but the energy transmitted to the ocean led to divergence-convergence flow from a shallow to deep layer.展开更多
本文为2015年毛细管电泳(CE)技术的年度回顾。归纳了ISI Web of Science中检索的2015年度CE技术相关的论文,从毛细管电泳-质谱(CE-MS)联用技术、方法学研究、检测与富集、手性分子拆分及CE技术应用5个方面进行了分类说明;简要介绍了201...本文为2015年毛细管电泳(CE)技术的年度回顾。归纳了ISI Web of Science中检索的2015年度CE技术相关的论文,从毛细管电泳-质谱(CE-MS)联用技术、方法学研究、检测与富集、手性分子拆分及CE技术应用5个方面进行了分类说明;简要介绍了2015年涉及CE技术的国际会议6个,国内会议2个以及各会议的研究报道情况。最后,介绍了目前国内外的单克隆抗体、水质、酒类和食品分析中涉及的毛细管电泳的方法标准。展开更多
文摘目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidence of relapse,CIR),并探讨影响复发的危险因素。方法回顾性分析2015年1月—2019年12月接受CCCG-ALL-2015方案治疗的852例患儿的临床资料,计算CIR并分析影响儿童急性B淋巴细胞白血病(B-ALL)复发的危险因素。结果852例ALL患儿中,146例(17.1%)发生复发,8年CIR为(19.8±1.6)%。B-ALL与急性T淋巴细胞白血病患儿的8年CIR比较差异无统计学意义(P>0.05)。146例复发患儿中,复发时间主要集中于极早期(62例,42.5%)和早期(46例,31.5%),极早期单纯骨髓复发42例(28.8%),早期单纯骨髓复发27例(18.5%)。Cox比例风险回归模型分析显示,融合基因MLLr阳性(HR=4.177,95%CI:2.086~8.364,P<0.001)和第46天微小残留病≥0.01%(HR=2.013,95%CI:1.163~3.483,P=0.012)是B-ALL患儿经CCCG-ALL-2015方案治疗后复发的危险因素。结论儿童ALL经CCCG-ALL-2015方案治疗后仍有较高的复发率,以极早期和早期单纯骨髓复发常见;第46天微小残留病≥0.01%、融合基因MLLr阳性与B-ALL复发密切相关。
基金Supported by the National Natural Science Foundation of China(Nos.41576032,41176160)the International Cooperation,CAS,ChineseForeign Cooperation in Key Projects(No.133337KYSB20160002)the National Key R&D Program of China(No.2017YFC1405600)
文摘The impact of typhoon Kujira(2015)on the ocean environment around Yongxing Island in the South China Sea was observed using multiple-satellite sensors and on-site data.A subsurface buoy and Agro float were located to the left and lower right of the track of the typhoon.Satellite observations revealed sea surface cooling of up to 2.5℃,a maximum decrease in sea surface salinity of 2 in the main study area because of heavy rain,and increases in the chlorophyll concentration induced by the slow-moving typhoon with a maximum observed instantaneous wind speed of 35.1 m/s.The sea surface temperature to the right of the typhoon track changed more than that on the left owing to a right bias of the typhoon associated with coupling of the typhoon with wind stress on the sea surface.In the ocean interior,there was obvious downwelling at 24.7 m and upwelling at a depth of 35.7 m with the vertical entrainment and agitation of the typhoon,and the ef fects extended to different depths of up to more than 1000 m.When the typhoon passed through the main study area,the maximum flow velocity change at depths of 51 and 660 m was about 0.44 and 0.04 m/s,respectively.The typhoon af fected the flow field to a depth of 660 m as it formed and decayed in 11 h,moved at an average speed of 60 m/h,and af fected the sea surface over a range exceeding 700 km as it moved slowly and stayed at sea for 2 d.Vertical entrainment and agitation generated by the typhoon,as well as rainfall,cooled the sea surface.This inhibited the strengthening of the typhoon,but the energy transmitted to the ocean led to divergence-convergence flow from a shallow to deep layer.
文摘本文为2015年毛细管电泳(CE)技术的年度回顾。归纳了ISI Web of Science中检索的2015年度CE技术相关的论文,从毛细管电泳-质谱(CE-MS)联用技术、方法学研究、检测与富集、手性分子拆分及CE技术应用5个方面进行了分类说明;简要介绍了2015年涉及CE技术的国际会议6个,国内会议2个以及各会议的研究报道情况。最后,介绍了目前国内外的单克隆抗体、水质、酒类和食品分析中涉及的毛细管电泳的方法标准。
