Integrated sensing and communication(ISAC)is regarded as a pivotal technology for 6G communication.In this paper,we employ Kullback-Leibler divergence(KLD)as the unified performance metric for ISAC systems and investi...Integrated sensing and communication(ISAC)is regarded as a pivotal technology for 6G communication.In this paper,we employ Kullback-Leibler divergence(KLD)as the unified performance metric for ISAC systems and investigate constellation and beamforming design in the presence of clutters.In particular,the constellation design problem is solved via the successive convex approximation(SCA)technique,and the optimal beamforming in terms of sensing KLD is proven to be equivalent to maximizing the signal-to-interference-plus-noise ratio(SINR)of echo signals.Numerical results demonstrate the tradeoff between sensing and communication performance under different parameter setups.Additionally,the beampattern generated by the proposed algorithm achieves significant clutter suppression and higher SINR of echo signals compared with the conventional scheme.展开更多
A Kullback-Leibler（KL）distance based algorithm is presented to find the matches between concepts from different ontologies. First, each concept is represented as a specific probability distribution which is estimate...A Kullback-Leibler（KL）distance based algorithm is presented to find the matches between concepts from different ontologies. First, each concept is represented as a specific probability distribution which is estimated from its own instances. Then, the similarity of two concepts from different ontologies is measured by the KL distance between the corresponding distributions. Finally, the concept-mapping relationship between different ontologies is obtained. Compared with other traditional instance-based algorithms, the computing complexity of the proposed algorithm is largely reduced. Moreover, because it proposes different estimation and smoothing methods of the concept distribution for different data types, it is suitable for various concepts mapping with different data types. The experimental results on real-world ontology mapping illustrate the effectiveness of the proposed algorithm.展开更多
背景:不同于非炎症性细胞凋亡,细胞焦亡是炎症性细胞死亡的一种形式,它伴随着膜完整性的破坏和促炎性细胞内物质的释放,因而与多种疾病有关。沉默信息调节因子家族是依赖于烟酰胺腺嘌呤二核苷酸的组蛋白去乙酰化酶家族。除了去乙酰化外...背景:不同于非炎症性细胞凋亡,细胞焦亡是炎症性细胞死亡的一种形式,它伴随着膜完整性的破坏和促炎性细胞内物质的释放,因而与多种疾病有关。沉默信息调节因子家族是依赖于烟酰胺腺嘌呤二核苷酸的组蛋白去乙酰化酶家族。除了去乙酰化外,还具有其他酶活性,如脱琥珀酸化、脱丙酰化和腺苷二磷酸-核糖基化等,在参与细胞焦亡调控中发挥重要的作用。目的:综述沉默信息调节因子家族在细胞焦亡中的作用及影响。方法:第一作者通过检索PubMed、Web of Science、中国知网、万方数据库,检索时限为各数据库建库至2024年3月,中文检索词为“沉默信息调节因子,沉默信息调节因子1,沉默信息调节因子2,沉默信息调节因子3,沉默信息调节因子4,沉默信息调节因子5,沉默信息调节因子6,沉默信息调节因子7,细胞焦亡”,英文检索词为“Sirtuins,Sirtuin1,Sirtuin2,Sirtuin3,Sirtuin4,Sirtuin5,Sirtuin6,Sirtuin7,pyroptosis”,最后纳入71篇文献进行综述。结果与结论:①沉默信息调节因子家族均参与了对细胞焦亡的调控;②过表达沉默信息调节因子1、沉默信息调节因子4可通过多种通路抑制细胞焦亡,从而缓解细胞焦亡对机体的损害;③沉默信息调节因子3除了影响细胞焦亡经典通路外,还能通过增强线粒体活性氧的清除能力、有丝分裂来抑制细胞焦亡;④沉默信息调节因子5参与细胞内代谢和能量平衡的调节,包括能量的摄入、储存和消耗;⑤沉默信息调节因子6既能通过多种通路影响细胞焦亡,还能影响巨噬细胞M1极化、活性氧的生成以及细胞焦亡相关因子消皮素D的裂解以抑制细胞焦亡;⑥过表达沉默信息调节因子7可抑制细胞焦亡;⑦沉默信息调节因子2与其他家族成员不同,其被敲降后才可抑制细胞焦亡,但报道较少,需要更为深入与全面的研究。展开更多
基金supported in part by National Key R&D Program of China under Grant No.2021YFB2900200in part by National Natural Science Foundation of China under Grant Nos.U20B2039 and 62301032in part by China Postdoctoral Science Foundation under Grant No.2023TQ0028.
文摘Integrated sensing and communication(ISAC)is regarded as a pivotal technology for 6G communication.In this paper,we employ Kullback-Leibler divergence(KLD)as the unified performance metric for ISAC systems and investigate constellation and beamforming design in the presence of clutters.In particular,the constellation design problem is solved via the successive convex approximation(SCA)technique,and the optimal beamforming in terms of sensing KLD is proven to be equivalent to maximizing the signal-to-interference-plus-noise ratio(SINR)of echo signals.Numerical results demonstrate the tradeoff between sensing and communication performance under different parameter setups.Additionally,the beampattern generated by the proposed algorithm achieves significant clutter suppression and higher SINR of echo signals compared with the conventional scheme.
文摘A Kullback-Leibler（KL）distance based algorithm is presented to find the matches between concepts from different ontologies. First, each concept is represented as a specific probability distribution which is estimated from its own instances. Then, the similarity of two concepts from different ontologies is measured by the KL distance between the corresponding distributions. Finally, the concept-mapping relationship between different ontologies is obtained. Compared with other traditional instance-based algorithms, the computing complexity of the proposed algorithm is largely reduced. Moreover, because it proposes different estimation and smoothing methods of the concept distribution for different data types, it is suitable for various concepts mapping with different data types. The experimental results on real-world ontology mapping illustrate the effectiveness of the proposed algorithm.
文摘背景:不同于非炎症性细胞凋亡,细胞焦亡是炎症性细胞死亡的一种形式,它伴随着膜完整性的破坏和促炎性细胞内物质的释放,因而与多种疾病有关。沉默信息调节因子家族是依赖于烟酰胺腺嘌呤二核苷酸的组蛋白去乙酰化酶家族。除了去乙酰化外,还具有其他酶活性,如脱琥珀酸化、脱丙酰化和腺苷二磷酸-核糖基化等,在参与细胞焦亡调控中发挥重要的作用。目的:综述沉默信息调节因子家族在细胞焦亡中的作用及影响。方法:第一作者通过检索PubMed、Web of Science、中国知网、万方数据库,检索时限为各数据库建库至2024年3月,中文检索词为“沉默信息调节因子,沉默信息调节因子1,沉默信息调节因子2,沉默信息调节因子3,沉默信息调节因子4,沉默信息调节因子5,沉默信息调节因子6,沉默信息调节因子7,细胞焦亡”,英文检索词为“Sirtuins,Sirtuin1,Sirtuin2,Sirtuin3,Sirtuin4,Sirtuin5,Sirtuin6,Sirtuin7,pyroptosis”,最后纳入71篇文献进行综述。结果与结论:①沉默信息调节因子家族均参与了对细胞焦亡的调控;②过表达沉默信息调节因子1、沉默信息调节因子4可通过多种通路抑制细胞焦亡,从而缓解细胞焦亡对机体的损害;③沉默信息调节因子3除了影响细胞焦亡经典通路外,还能通过增强线粒体活性氧的清除能力、有丝分裂来抑制细胞焦亡;④沉默信息调节因子5参与细胞内代谢和能量平衡的调节,包括能量的摄入、储存和消耗;⑤沉默信息调节因子6既能通过多种通路影响细胞焦亡,还能影响巨噬细胞M1极化、活性氧的生成以及细胞焦亡相关因子消皮素D的裂解以抑制细胞焦亡;⑥过表达沉默信息调节因子7可抑制细胞焦亡;⑦沉默信息调节因子2与其他家族成员不同,其被敲降后才可抑制细胞焦亡,但报道较少,需要更为深入与全面的研究。
