The study was carried out to observe the effects of heparin,dexamethasone and ibuprofen on the clearance function of the Kupffer cell complement receptors(KCCR) in experimental acute obstructive cholangitis (AOC) in r...The study was carried out to observe the effects of heparin,dexamethasone and ibuprofen on the clearance function of the Kupffer cell complement receptors(KCCR) in experimental acute obstructive cholangitis (AOC) in rats.It was found that in AOC,the mortality rate was far higher in not treated group and dexamethasone treated group than in ibuprofen and heparin treated groups and the clearance function of KCCR was significantly decreased 48h after the onset of AOC but it was strengthened with the administration of heparin and ibuprofen.The prominent pathological changes of AOC were the damages on the hepatocytes,degeneration of Kupffer cells with reduction of their functions and damages of the pulmonary alveolar walls. The phagocytic function of Kupffer cells were restored and damages of the liver and lungs abated after the administration of heparin.This study was financially suppoited by the National Funds for Natural Science of China (Approval certificate numberof NSFC 38870770).展开更多
文摘The study was carried out to observe the effects of heparin,dexamethasone and ibuprofen on the clearance function of the Kupffer cell complement receptors(KCCR) in experimental acute obstructive cholangitis (AOC) in rats.It was found that in AOC,the mortality rate was far higher in not treated group and dexamethasone treated group than in ibuprofen and heparin treated groups and the clearance function of KCCR was significantly decreased 48h after the onset of AOC but it was strengthened with the administration of heparin and ibuprofen.The prominent pathological changes of AOC were the damages on the hepatocytes,degeneration of Kupffer cells with reduction of their functions and damages of the pulmonary alveolar walls. The phagocytic function of Kupffer cells were restored and damages of the liver and lungs abated after the administration of heparin.This study was financially suppoited by the National Funds for Natural Science of China (Approval certificate numberof NSFC 38870770).