Objective To investigate the effect of(-)-Stepholidine(SPD)on enhancing D1 receptor mediated contraction of cardiac muscle in isolated rat heart and to examine whether SPD has a direct effect on the heart dopamine D1 ...Objective To investigate the effect of(-)-Stepholidine(SPD)on enhancing D1 receptor mediated contraction of cardiac muscle in isolated rat heart and to examine whether SPD has a direct effect on the heart dopamine D1 receptors.SPD an active ingredient of the Chinese herb Stephania intermedia,binds to dopamine D1 and D2 like receptors.Biochemical,electrophysiological and behavioural experiments have provided strong evidence that SPD is both a D(1/5)agonist and a D(2/4)antagonist,which could indicate unique antipsychotic properties.Methods Normal adult rat working hearts were isolated by Langendorff technique.Results SPD significantly increased the cardiac muscle contraction in a dose-dependent manner.The selective D1 dopamine receptor antagonist SCH23390(1 μM)blocked the SPD induced heart contraction,however,neither the β-receptor antagonist propranolol(1 μM)nor the α1-receptor antagonist prazosin(1 μM)had any effect on blocking SPD induced heart contractions.Moreover,the L-type Ca2+ channel inhibitor nimodipine(1 μM)completely blocked the effect of SPD on cardiac muscle contraction.Conclusions SPD show the effect on enhancing contraction of isolated rat heart through activating L-type Ca2+ channel mediated by heart D1 receptors.展开更多
An L（d0,d2,...,dt）-labeling of a graph G is a function f from its vertex set V（G） to the set {0,1,..., k} for some positive integer k such that If（x） - f（y）l ≥di, if the distance between vertices x and y in G...An L（d0,d2,...,dt）-labeling of a graph G is a function f from its vertex set V（G） to the set {0,1,..., k} for some positive integer k such that If（x） - f（y）l ≥di, if the distance between vertices x and y in G is equal to i for i = 1,2,...,t. The L（d1,d2,...,dt）-number λ（G;d1,d2,... ,dt） of G is the smallest integer number k such that G has an L（d1,d2,...,dr）- labeling with max{f （x）｜x ∈ V（G）} = k. In this paper, we obtain the exact values for λ（Cn; 2, 2, 1） and λ（Cn; 3, 2, 1）, and present lower and upper bounds for λ（Cn; 2,..., 2, 1,..., 1）展开更多
文摘Objective To investigate the effect of(-)-Stepholidine(SPD)on enhancing D1 receptor mediated contraction of cardiac muscle in isolated rat heart and to examine whether SPD has a direct effect on the heart dopamine D1 receptors.SPD an active ingredient of the Chinese herb Stephania intermedia,binds to dopamine D1 and D2 like receptors.Biochemical,electrophysiological and behavioural experiments have provided strong evidence that SPD is both a D(1/5)agonist and a D(2/4)antagonist,which could indicate unique antipsychotic properties.Methods Normal adult rat working hearts were isolated by Langendorff technique.Results SPD significantly increased the cardiac muscle contraction in a dose-dependent manner.The selective D1 dopamine receptor antagonist SCH23390(1 μM)blocked the SPD induced heart contraction,however,neither the β-receptor antagonist propranolol(1 μM)nor the α1-receptor antagonist prazosin(1 μM)had any effect on blocking SPD induced heart contractions.Moreover,the L-type Ca2+ channel inhibitor nimodipine(1 μM)completely blocked the effect of SPD on cardiac muscle contraction.Conclusions SPD show the effect on enhancing contraction of isolated rat heart through activating L-type Ca2+ channel mediated by heart D1 receptors.
基金the National Natural Science Foundation of China (No.10531070)the National Basic Research Program of China 973 Program (No.2006AA11Z209)the Natural Science Foundation of Shanghai City (No.06ZR14049)
文摘An L（d0,d2,...,dt）-labeling of a graph G is a function f from its vertex set V（G） to the set {0,1,..., k} for some positive integer k such that If（x） - f（y）l ≥di, if the distance between vertices x and y in G is equal to i for i = 1,2,...,t. The L（d1,d2,...,dt）-number λ（G;d1,d2,... ,dt） of G is the smallest integer number k such that G has an L（d1,d2,...,dr）- labeling with max{f （x）｜x ∈ V（G）} = k. In this paper, we obtain the exact values for λ（Cn; 2, 2, 1） and λ（Cn; 3, 2, 1）, and present lower and upper bounds for λ（Cn; 2,..., 2, 1,..., 1）
基金Project supported by the National Natural Science Foundation of China, № 39130091, 39670853, and the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, № K016.
