AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were rando...AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.展开更多
A novel Enterococcus faecalis strain designated N J402 was found with high activity of arginine deiminase （ADI）. The optimum condition for catalytic activity was determined in terms of temperature （about 40℃）, th...A novel Enterococcus faecalis strain designated N J402 was found with high activity of arginine deiminase （ADI）. The optimum condition for catalytic activity was determined in terms of temperature （about 40℃）, thermostability （available 37℃） and pH （6-7）. The effects of substrate and product concentration were studied. The effects of various metal ions added in reaction mixtures on the biocatalyst were investigated and ADI of N J402 was found to exhibit Co^2＋ dependence, different from previous reports. Surfactant, cetyl trimethyl ammonium bromide, was one of the most important keys for producing L-citrulline. The enzyme in resting cells possessed the quality of high stability for reuse.展开更多
In this paper, we revisit foundations of the applications of physical measurement and Lindenmayer system to the modeling of plants. The measurement is proposed to a formal procedure and measuring the mass of leaves on...In this paper, we revisit foundations of the applications of physical measurement and Lindenmayer system to the modeling of plants. The measurement is proposed to a formal procedure and measuring the mass of leaves on a tree, tailored to branching plant structures with Simpson＇ s rule and Monte Carlo Methods. L-system is possible to visualize mathematical models of biological structures and processes. The formalism is illustrated using theoretical branching systems, and applied to analyze total leaves number as well as total weight of them.展开更多
The dynamical equations of a thin rectangle plate subjected to the friction support boundary and its plane force are established in this paper. The local bifurcation of this system is investigated by using L S method...The dynamical equations of a thin rectangle plate subjected to the friction support boundary and its plane force are established in this paper. The local bifurcation of this system is investigated by using L S method and the singularity theory. The Z 2 bifurcation in non degenerate case is discussed. The local bifurcation diagrams of the unfolding parameters and the bifurcation response characters referred to the physical parameters of the system are obtained by numerical simulation. The results of the computer simulation are coincident with the theoretical analysis and experimental results.展开更多
Using carbon tetrachloride （CCl4） as extraction agent, the activated sludge from Tianjin Jizhuangzi Sewage Treatment Plant as inoculum, the test study on biodegradability of lubricants was carried out. The test flas...Using carbon tetrachloride （CCl4） as extraction agent, the activated sludge from Tianjin Jizhuangzi Sewage Treatment Plant as inoculum, the test study on biodegradability of lubricants was carried out. The test flasks containing the mineral medium, the test oil and the inoculum were placed in incubation together with flasks containing poisoned blanks for periods of 0 and 21 days, respectively. Flasks containing the reference materials in place of the test oil were run in parallel. At the end of the incubation period, the contents of the flasks were subjected to sonic vibration, and were acidified and extracted by using CCI4. The extracts were then analysed by infra-red （IR） spectrometer to measure the maximum absorption of the C-H stretch of CH2-CH3 band at wavelength of 2 930 cm^-1. The absorption values were used to calculate the residual oil contents of the poisoned and test flasks. Consequently the biodegradability of the test oil was calculated. The test results indicate that the differences in the biodegradability of test materials in different tests are within 5.5%, and consistent with the data described in Coordinating European Council （CEC） L-33- A-93. The biodegradability of lubricants can be evaluated by this method effectively.展开更多
objective： to analyze the application value of the PBL in the surgical experimental teaching mode. Methods： choose between September 2013 and September 2013 128 clinical professional students, average by using the l...objective： to analyze the application value of the PBL in the surgical experimental teaching mode. Methods： choose between September 2013 and September 2013 128 clinical professional students, average by using the lottery will be divided into control group and the team, every 64 students for 1 set, in surgical experimental teaching as a research courses, the teaching methods for the traditional teaching method in the control group, while the team gives PBL teaching mode, the teaching effect of the final will be two groups of students are analyzed and compared. Results： through different teaching methods for teaching, compared with control group, the group at the student＇s test scores, and the ability to significantly higher, the difference of both P 〈 0.05, there is statistically significant. Conclusion： using PBL teaching mode in the surgical experimental teaching effect is remarkable, can promote the students＇ comprehensive ability and is worth popularizing application.展开更多
基金Direccion General de Investigación, No. SAF2004-06289Contract Art. 83 L.O.U. with Cytochrome, No. UAH 64/2003 and the Instituto de Salud Carlos Ⅲ, No. C03/02
文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.
基金Supported by the Innovation Foundation of China (No. 02CJ-13-01-16).
文摘A novel Enterococcus faecalis strain designated N J402 was found with high activity of arginine deiminase （ADI）. The optimum condition for catalytic activity was determined in terms of temperature （about 40℃）, thermostability （available 37℃） and pH （6-7）. The effects of substrate and product concentration were studied. The effects of various metal ions added in reaction mixtures on the biocatalyst were investigated and ADI of N J402 was found to exhibit Co^2＋ dependence, different from previous reports. Surfactant, cetyl trimethyl ammonium bromide, was one of the most important keys for producing L-citrulline. The enzyme in resting cells possessed the quality of high stability for reuse.
文摘In this paper, we revisit foundations of the applications of physical measurement and Lindenmayer system to the modeling of plants. The measurement is proposed to a formal procedure and measuring the mass of leaves on a tree, tailored to branching plant structures with Simpson＇ s rule and Monte Carlo Methods. L-system is possible to visualize mathematical models of biological structures and processes. The formalism is illustrated using theoretical branching systems, and applied to analyze total leaves number as well as total weight of them.
文摘The dynamical equations of a thin rectangle plate subjected to the friction support boundary and its plane force are established in this paper. The local bifurcation of this system is investigated by using L S method and the singularity theory. The Z 2 bifurcation in non degenerate case is discussed. The local bifurcation diagrams of the unfolding parameters and the bifurcation response characters referred to the physical parameters of the system are obtained by numerical simulation. The results of the computer simulation are coincident with the theoretical analysis and experimental results.
基金China Petroleum & Chemical Corporation (No. 104141)
文摘Using carbon tetrachloride （CCl4） as extraction agent, the activated sludge from Tianjin Jizhuangzi Sewage Treatment Plant as inoculum, the test study on biodegradability of lubricants was carried out. The test flasks containing the mineral medium, the test oil and the inoculum were placed in incubation together with flasks containing poisoned blanks for periods of 0 and 21 days, respectively. Flasks containing the reference materials in place of the test oil were run in parallel. At the end of the incubation period, the contents of the flasks were subjected to sonic vibration, and were acidified and extracted by using CCI4. The extracts were then analysed by infra-red （IR） spectrometer to measure the maximum absorption of the C-H stretch of CH2-CH3 band at wavelength of 2 930 cm^-1. The absorption values were used to calculate the residual oil contents of the poisoned and test flasks. Consequently the biodegradability of the test oil was calculated. The test results indicate that the differences in the biodegradability of test materials in different tests are within 5.5%, and consistent with the data described in Coordinating European Council （CEC） L-33- A-93. The biodegradability of lubricants can be evaluated by this method effectively.
文摘objective： to analyze the application value of the PBL in the surgical experimental teaching mode. Methods： choose between September 2013 and September 2013 128 clinical professional students, average by using the lottery will be divided into control group and the team, every 64 students for 1 set, in surgical experimental teaching as a research courses, the teaching methods for the traditional teaching method in the control group, while the team gives PBL teaching mode, the teaching effect of the final will be two groups of students are analyzed and compared. Results： through different teaching methods for teaching, compared with control group, the group at the student＇s test scores, and the ability to significantly higher, the difference of both P 〈 0.05, there is statistically significant. Conclusion： using PBL teaching mode in the surgical experimental teaching effect is remarkable, can promote the students＇ comprehensive ability and is worth popularizing application.
