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L-脯氨酸类离子液体催化醛自身缩合反应 被引量:3
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作者 权南南 鲍少华 +2 位作者 张敬 王箭 杨建国 《化工时刊》 CAS 2008年第11期17-18,77,共3页
研究了在L-脯氨酸类离子液体催化下,羰基化合物自身羟醛缩合反应。系统考察了反应时间、催化剂的用量及催化剂重复使用等因素对反应的影响,优化了反应条件。结果表明,当反应时间为2.0 h,催化剂用量为2 g/1 mol醛(酮),转化率可达80%以上... 研究了在L-脯氨酸类离子液体催化下,羰基化合物自身羟醛缩合反应。系统考察了反应时间、催化剂的用量及催化剂重复使用等因素对反应的影响,优化了反应条件。结果表明,当反应时间为2.0 h,催化剂用量为2 g/1 mol醛(酮),转化率可达80%以上,选择性可达99%以上。同时该催化剂能够选择性地催化醛类化合物的自身缩合,而酮类化合物不参与反应。 展开更多
关键词 l-脯氨酸离子液体 羟醛缩合 选择性 合成 催化
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关于L-内射类
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作者 赵良 《河西学院学报》 2004年第2期16-17,共2页
设L是一个模类,引人了L-内射类的概念,并用来刻画L-Noether环.推广了文[4],[5]中关于Noether环的相应结论.
关键词 l-内射 l-Noether环 结合环 l-内射模 内射包
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L-核糖的生物合成及其在药物中的应用 被引量:1
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作者 王静 武首香 《化学与生物工程》 CAS 2016年第7期7-10,14,共5页
L-核糖是一种重要的药物中间体。综述了以核糖醇及L-阿拉伯糖为原料的L-核糖的生物合成方法,介绍了L-核糖在L-核苷类药物、糖缀合物、寡核苷酸中的应用进展。
关键词 l-核糖 生物合成 l-核苷药物 糖缀合物 寡核苷酸
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2-脱氧-L-核糖的合成方法改进 被引量:1
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作者 叶素梅 任宇红 魏东芝 《精细化工》 EI CAS CSCD 北大核心 2007年第11期1099-1101,1105,共4页
以L-阿拉伯糖为起始物,通过羟基保护、还原、脱保护等5步反应得到一种重要的L-脱氧核苷类药物中间体2-脱氧-L-核糖。在最后一步脱保护过程中,改用在醋酸水溶液中脱去苯甲基保护基团,单步产率由70%提高到92%,总收率提高到40%。化合物的... 以L-阿拉伯糖为起始物,通过羟基保护、还原、脱保护等5步反应得到一种重要的L-脱氧核苷类药物中间体2-脱氧-L-核糖。在最后一步脱保护过程中,改用在醋酸水溶液中脱去苯甲基保护基团,单步产率由70%提高到92%,总收率提高到40%。化合物的结构用1HNMR、MS及元素分析法进行了表征。 展开更多
关键词 2-脱氧-l-核糖 l-脱氧核苷药物 抗病毒活性 药物中间体
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格序群的上扭类 被引量:1
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作者 杨胜良 《西北师范大学学报(自然科学版)》 CAS 1994年第4期94-95,共2页
格序群的上扭类杨胜良(张掖师专数学系)作者简介杨胜良,男,30岁.1989于江西大学获硕士学位。现为张掖师范高等专科学校数学系讲师。中图分类号O153.1用L记全体l-群组成的类,对任意G∈L,C(G)表示G的固子群... 格序群的上扭类杨胜良(张掖师专数学系)作者简介杨胜良,男,30岁.1989于江西大学获硕士学位。现为张掖师范高等专科学校数学系讲师。中图分类号O153.1用L记全体l-群组成的类,对任意G∈L,C(G)表示G的固子群格,I(G)表示G的l-理想格。一... 展开更多
关键词 格序群 l-
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两个品种枸杞0℃贮藏差异代谢物的比较 被引量:1
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作者 张琪 奚琬茹 +3 位作者 黄帅 雷雅馨 王新宇 王静 《北方园艺》 CAS 北大核心 2023年第23期92-99,共8页
以贮藏36 d的2个品种的枸杞鲜果“圆果”(Y)和“宁杞七号”(Q)为试材,研究其在0℃条件下贮藏时所产生的差异代谢物对2个品种枸杞鲜果贮藏保鲜的影响,以期为“圆果”(Y)延长贮藏期提供参考依据。结果表明:相同的贮藏条件下,“宁杞七号”... 以贮藏36 d的2个品种的枸杞鲜果“圆果”(Y)和“宁杞七号”(Q)为试材,研究其在0℃条件下贮藏时所产生的差异代谢物对2个品种枸杞鲜果贮藏保鲜的影响,以期为“圆果”(Y)延长贮藏期提供参考依据。结果表明:相同的贮藏条件下,“宁杞七号”(Q)在0℃贮藏时显著的差异代谢物主要为磷酸酯、磷酸核糖、葡萄糖醛酸、苏氨酸、磷酸精氨酸,而“圆果”(Y)枸杞鲜果中的差异代谢物多为花生四烯酸、二十碳三烯酸、亚麻酸等不饱和脂肪酸,这些物质有利于“圆果”(Y)在贮藏过程中抵御低温逆境,延长其贮藏期。 展开更多
关键词 枸杞 不同品种 差异代谢物 保鲜 贮藏
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半群OEXn的组合结果
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作者 王芳 杨秀良 《杭州师范大学学报(自然科学版)》 CAS 2020年第6期630-635,共6页
文章得到了半群OEX n={α∈IO n|x,y∈dom(α),|x-y|≤|xα-yα|}∪{}的阶,以及OEX n的L-类、R-类和D-类的个数.
关键词 保序扩张变换半群 l-类 R- D-
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神经激肽1受体非肽类拮抗剂L-703,606对严重烫伤大鼠早期组织水肿的影响 被引量:3
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作者 陶克 陈璧 +1 位作者 胡大海 王波涛 《中华烧伤杂志》 CAS CSCD 北大核心 2005年第6期455-458,共4页
目的观察神经激肽(NK)1受体非肽类拮抗剂L-703,606对严重烫伤大鼠早期组织水肿及血管通透性的影响.方法将152只SD大鼠随机分为正常对照组(8只),不作烫伤;烫伤对照组(48只),作20%TBSA深Ⅱ度烫伤;L-703,606组(48只)及β-七叶皂苷钠组(48... 目的观察神经激肽(NK)1受体非肽类拮抗剂L-703,606对严重烫伤大鼠早期组织水肿及血管通透性的影响.方法将152只SD大鼠随机分为正常对照组(8只),不作烫伤;烫伤对照组(48只),作20%TBSA深Ⅱ度烫伤;L-703,606组(48只)及β-七叶皂苷钠组(48只),分别从大鼠尾静脉注射250 nmol/kg的L-703,606和1.8 mg/kg β-七叶皂苷钠,之后30 min作20%TBSA深Ⅱ度烫伤.各致伤组大鼠创面伤后不予处理,并于烫伤后1、4、8、24、48、72 h处死,取创周及肠组织标本待测,每组每时相点8只大鼠,并取正常对照组标本待测.用改良伊文思蓝渗出法及称取组织干湿重法测定各组大鼠创周和空肠组织血管通透性、组织含水量.结果伤后1 h各致伤组大鼠创周及空肠组织血管通透性均较正常对照组增高(P<0.01),伤后4 h开始逐渐下降.L-703,606组及β-七叶皂苷钠组创周组织血管通透性均低于烫伤对照组(P<0.01);伤后48、72 h,L-703,606组高于β-七叶皂苷钠组(P<0.01).β-七叶皂苷钠组、L-703,606组空肠组织血管通透性伤后24 h内低于烫伤对照组(P<0.01),β-七叶皂苷钠组伤后早期低于L-703,606组(P<0.01),伤后72 h两组比较差异无统计学意义(P>0.05).组织含水量变化:伤后1 h,各致伤组创周组织均呈现缺水状态,以后含水量逐渐升高,于伤后8~24 h达峰值.伤后早期各致伤组空肠组织均出现一定的缺水状态,L-703,606组轻于烫伤对照组和β-七叶皂苷钠组(P<0.05或0.01),8 h后表现出一定的水肿状态,伤后48 h为甚,以L-703,606组水肿最轻,随后逐渐恢复.结论NK1受体非肽类拮抗剂L-703,606能降低严重烫伤大鼠早期创周和空肠组织血管的通透性,减轻组织水肿. 展开更多
关键词 烧伤 水肿 毛细血管通透性 受体 神经激肽1 非肽拈抗剂l-703 606
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双循环半群上与Green关系相关的问题 被引量:2
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作者 陈忠 《韶关学院学报》 2007年第3期14-17,共4页
双循环半群在逆半群的研究中有着重要的作用,对此类半群上与Green关系相关的问题作进一步探讨,从而得到一些与Green关系相关的重要结论.
关键词 双循环半群 l-等价 Green关系
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弱Hamilton格群的合并性质
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作者 仝道荣 《河海大学学报(自然科学版)》 CAS CSCD 1993年第3期15-20,共6页
本文证明了弱HamiIton 1-群的类中特殊V-构形具有合并性质.这一结果对解决如下著名猜想有重要意义,即猜想可换1-群的簇是仅有的满足合并性质的1-群的簇.
关键词 合并性质 V-构形 l-
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Evolution of Main Characteristics of the Registered Cotton Cultivars in National Cotton Regional Trials in Yangtze River Valley 被引量:1
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作者 许乃银 李健 《Agricultural Science & Technology》 CAS 2014年第6期964-969,共6页
[Objective] The aim of this study was to characterize the national regis- tered varieties selected from cotton regional trials in Yangtze River Valley (YaRV) in recent years. [Method] Cotton cultivar classification ... [Objective] The aim of this study was to characterize the national regis- tered varieties selected from cotton regional trials in Yangtze River Valley (YaRV) in recent years. [Method] Cotton cultivar classification and comprehensive evaluation index were set up based on national cotton registration standard. GGE biplot method was adopted to analyze the correlation of major breeding target characters of 53 national registered cotton varieties in cotton regional trials in YaRV during 1981-2012. According to the shift of check cultivars in cotton regional trials in the past, the cotton regional trial practice since 1981 was divided into five periods. The dynamic of cultivar type's proportion and the evaluation index scores was analyzed across the five periods. [Result] There existed intricate interrelationship among cotton breeding target traits, which constrained it necessary to construct indices for com- prehensive evaluation of cotton varieties. The dynamic of cultivar types in the five periods indicated that type II varieties emerged since Simian 3 period and then its proportion decreased gradually; type Ⅲ varieties maintained a certain proportion in each period and kept on the rise overall; type Ⅳvarieties occupied the majority pro- portion of registered cultivars before 1993, but a minor proportion since Simian 3 period. On the other side, the change trend of the evaluation index demonstrated that the varieties registered before 2003 did not pass the qualified line at present. The peak scores appeared in the varieties registered during 2004-2008. The scores of the varieties registered after 2009 were only slightly over the qualified line. [Conclusion] More attention should be paid to the improvement and evaluation of micronaire, so as to guide the simultaneous development of high yielding and fiber quality in cotton breeding and registration procedure in YaRV. 展开更多
关键词 Cotton (Gossypium hirsutum L.) GGE biplot Variety type classification The Yangtze River Valley (YaRV)
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布西拉明的合成
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作者 单世明 罗红波 《中国医药工业杂志》 CAS CSCD 北大核心 1991年第2期61-62,共2页
布西拉明(bucillamine,1)化学名 N-(2-巯基-2-甲基丙酰)-L-半胱氨酸为日本参天制药株式会社开发研制的抗类风湿新药,属免疫调节剂,与左旋咪唑、D-青霉胺等比较,具有疗效好、副作用小并可长期给药的优点。
关键词 布西拉明 合成 l-半脱氨酸
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DHPCOOH的合成改进
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作者 谢菊冲 李凌光 +2 位作者 徐旋 俞永杰 张礼兵 《广州化工》 CAS 2011年第6期69-70,共2页
盐酸乐卡地平(Lercanidipinehydrochloride)为第三代1,4—二氢比啶类血管选择性L—型钙通道阻断药,本文对母核DHPCOOH合成进行改进,选择对称酯水解法,用价格便宜相转移催化剂三乙胺(TEA)代替价格较贵四丁基溴化胺,并考察了三乙胺用量和... 盐酸乐卡地平(Lercanidipinehydrochloride)为第三代1,4—二氢比啶类血管选择性L—型钙通道阻断药,本文对母核DHPCOOH合成进行改进,选择对称酯水解法,用价格便宜相转移催化剂三乙胺(TEA)代替价格较贵四丁基溴化胺,并考察了三乙胺用量和氢氧化钠浓度等因素的影响。粗品收率为76%,用甲醇精制收率80%,含量98%(HPLC)。 展开更多
关键词 14 -二氢吡啶l-型钙通道阻断剂 母核DHPCOOH 新合成方法
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Design and synthesis of L-5'-noraristeromycin analogues as potent antitumor agents 被引量:1
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作者 黄民俊 杨振军 +1 位作者 张亮仁 张礼和 《Journal of Chinese Pharmaceutical Sciences》 CAS 2009年第4期313-319,共7页
Nucleoside analogues show a variety of biological activities. To prepare new purine nucleoside analogues that could inhibit the proliferation of tumor cells and resist enzyrne hydrolysis, we designed and synthesized 1... Nucleoside analogues show a variety of biological activities. To prepare new purine nucleoside analogues that could inhibit the proliferation of tumor cells and resist enzyrne hydrolysis, we designed and synthesized 15 different L-5'noraristeromycin analogues, in which thioether, sulfoxide or sulfone function was introduced to replace the 5'-hydroxymethyl group. Their anti-tumor activities were assayed in vitro. One compound showed potent anti-tumor activity. 展开更多
关键词 Carbocyclic nucleoside l-Nucleoside analogue ANTITUMOR
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L-invariants and logarithm derivatives of eigenvalues of Frobenius 被引量:1
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作者 ZHANG YuanCao 《Science China Mathematics》 SCIE 2014年第8期1587-1604,共18页
Let K be a p-adic local field.We study a special kind of p-adic Galois representations of it.These representations are similar to the Galois representations occurred in the exceptional zero conjecture for modular form... Let K be a p-adic local field.We study a special kind of p-adic Galois representations of it.These representations are similar to the Galois representations occurred in the exceptional zero conjecture for modular forms.In particular,we verify that a formula of Colmez can be generalized to our case.We also include a degenerated version of Colmez’s formula. 展开更多
关键词 l-invariant eigenvalues of Frobenius exceptional zeros
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Coculture of elongated neuron axon with poly (D,L-lactide-co-glycolide) biomembrane in vitro 被引量:1
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作者 程飚 陈峥嵘 《Chinese Journal of Traumatology》 CAS 2004年第4期217-219,共3页
Objective: To elongate human nerve axon in cultu re and search for suitable support matrices for peripheral nervous system trans plantation. Methods: Human embryo cortical neuronal cells,seeded on poly ( D,L-lactide-c... Objective: To elongate human nerve axon in cultu re and search for suitable support matrices for peripheral nervous system trans plantation. Methods: Human embryo cortical neuronal cells,seeded on poly ( D,L-lactide-co-glycolide) (PLGA) membrane scaffolds,were elongated with a se lf-made neuro-axon extending device. The growth and morphological changes of n euron axons were observed to measure axolemmal permeability after elongation. Ne urofilament protein was stained by immunohistochemical technique.Results: Human embryo neuron axon could be elongated and cultur ed on the PLGA membrane and retain their normal form and function. Conclusions: Three dimensional scaffolds with elongated neuron axon have the basic characteristics of artificial nerves,indicating a fundement al theory of nerve repair with elongated neuron axon. 展开更多
关键词 AXONS Cells culture Tissue engineering
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正则半群的一个定理到拟正则半群的推广
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作者 喻秉钧 《数学学报(中文版)》 SCIE CSCD 北大核心 1990年第6期764-768,共5页
1973年,T.E.Hall 证明了:“若正则半群 S 的每个(?)-类最多只含 m(一固定正整数)个(?)-类,则对 S 的任元 a,a^m 在 S 的子群中.”本文将该定理推广到拟正则半群上,即证明了:“若拟正则半群 S 的每个正则(?)-类最多只含m(一固定正整数)个... 1973年,T.E.Hall 证明了:“若正则半群 S 的每个(?)-类最多只含 m(一固定正整数)个(?)-类,则对 S 的任元 a,a^m 在 S 的子群中.”本文将该定理推广到拟正则半群上,即证明了:“若拟正则半群 S 的每个正则(?)-类最多只含m(一固定正整数)个(?)-类,则对 S 的任元 a,a^(mn)在 S 的子群中,其中 n 为 a^m的正则指数.” 展开更多
关键词 正则半群 D- l-类 拟正则半群
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Assessment of genetic diversity by simple sequence repeat markers among forty elite varieties in the germplasm for malting barley breeding 被引量:5
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作者 Jun-mei WANG Jian-ming YANG Jing-huan ZHU Qiao-jun JIA Yue-zhi TAO 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2010年第10期792-800,共9页
The genetic diversity and relationship among 40 elite barley varieties were analyzed based on simple sequence repeat (SSR) genotyping data. The amplified fragments from SSR primers were highly polymorphic in the bad... The genetic diversity and relationship among 40 elite barley varieties were analyzed based on simple sequence repeat (SSR) genotyping data. The amplified fragments from SSR primers were highly polymorphic in the badey accessions investigated. A total of 85 alleles were detected at 35 SSR loci, and allelic variations existed at 29 SSR loci. The allele number per locus ranged from 1 to 5 with an average of 2.4 alleles per locus detected from the 40 badey accessions. A cluster analysis based on the genetic similarity coefficients was conducted and the 40 varieties were classified into two groups. Seven malting barley varieties from China fell into the same subgroup. It was found that the genetic diversity within the Chinese malting barley varieties was narrower than that in other barley germplasm sources, suggesting the importance and feasibility of introducing elite genotypes from different origins for malting barley breeding in China. 展开更多
关键词 Barley (Hordeum vu/gare L.) Genetic similarity Simple sequence repeat (SSR) marker Cluster analysis Genetic diversity
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The dehydration dynamics of a model cell membrane induced by cholesterol analogue 6-ketocholestanol investigated using sum frequency generation vibrational spectroscopy 被引量:1
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作者 Sulan Ma Kangzhen Tian Shuji Ye 《Science China Chemistry》 SCIE EI CAS CSCD 2015年第7期1176-1186,共11页
Dehydration of a surface is the first step for the interaction between biomolecules and the surface. In this study, we systemati- cally investigated the influence of cholesterol analog 6-ketocholestanol (6-KC) on th... Dehydration of a surface is the first step for the interaction between biomolecules and the surface. In this study, we systemati- cally investigated the influence of cholesterol analog 6-ketocholestanol (6-KC) on the dehydration of model cell membrane, using sum frequency generation vibrational spectroscopy. In pure DI water environment, two separate dehydration dynamic components were observed in neutrally charged and isotopically labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and positively charged 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine(chloride salt) (DMEPC) bilayer: a large-amplitude fast component and a small-amplitude slow component, which originated from the water molecules with a weak and a strong water-membrane bound strengths, respectively. Dehydration of a negatively charged mixed DMPC/DMPG bilayer lead to the membrane-bound water being reorganized to ordered structures quickly. It is evident that the water-membrane bound strengths depend largely on the charge status of the lipid and has an order of neutrally charged membrane〈〈positively charged mem- brane〈〈negatively charged membrane. In an ionic environment, KC1 solution can not only dehydrate DMPC bilayer, but also prevent the 6-KC fiom further dehydrating this model cell membrane. We observed that the dehydration dynamics behavior of DMPC bilayer in the presence of the chaotropic anions is similar to that of the negatively charged DMPG bilayer because of the penetration of chaotropic anions into the DMPC bilayer. The degree of dehydration difficulty in kosmotropic anions fol- lows a Hofmeister series and linearly correlates with the hydration Gibbs free energy of the anions. Our results provide a molecular basis for the interpretation of the Hofmeister effect of kosmotropic anions on ion transport proteins. 展开更多
关键词 membrane dehydration sum frequency generation membrane-bound water membrane dipole potential Hofmeistereffect
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The centralizer of an element in a Lie algebra of type L
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作者 LU Caihui SHAO Wenwu 《Science China Mathematics》 SCIE 2004年第6期854-861,共8页
In this paper, we investigate the Lie algebra L(A,α,δ) of type L and obtain the respective sufficient conditions for L(A,α,δ δ to be semisimple, and for Z(ω) = Fω as well, where 0 ≠ ω ? L(A, α, δ, δ) and Z... In this paper, we investigate the Lie algebra L(A,α,δ) of type L and obtain the respective sufficient conditions for L(A,α,δ δ to be semisimple, and for Z(ω) = Fω as well, where 0 ≠ ω ? L(A, α, δ, δ) and Z(ω) is the centralizer of ω. 展开更多
关键词 Lie algebra of type L semisimple Lie algebra CENTRALIZER total ordering
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