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ONECUT2高表达介导胃癌复发患者5-FU化疗耐药
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作者 朱海峰 陈述 +1 位作者 龙卫国 王旭 《江苏大学学报(医学版)》 CAS 2024年第1期19-24,共6页
目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONE... 目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONECUT2表达量与药物代谢相关生物学过程的相关性。利用CCK-8细胞毒性实验评估胃癌细胞敲低或过表达ONECUT2对5-FU的耐药情况。分析30例胃癌术后复发患者ONECUT2表达量与5-FU治疗效果的相关性。结果:TCGA数据库分析显示,在经受过化疗且复发的胃癌患者中,ONECUT2高表达的患者无病间隔期(disease-free interval,DFI)更短。GSEA分析结果表明,ONECUT2高表达与异生药物代谢通路呈正相关,这提示可能与胃癌患者的耐药相关。体外实验中,敲低ONECUT2降低胃癌细胞对5-FU的半数抑制浓度(IC_(50))值;反之,过表达ONECUT2增加细胞对5-FU的IC_(50)值。30例胃癌复发患者对5-FU的药物敏感性与ONECUT2表达量相关。结论:胃癌复发患者的ONECUT2表达量更高,ONECUT2高表达与胃癌复发患者的5-FU耐药相关,可能是潜在的治疗靶点。 展开更多
关键词 One cut结构域家族成员2 胃癌复发 5-FU耐药 GSEA 细胞毒性 半数抑制浓度
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冠菌素诱导橡胶树次生乳管分化的形成层细胞CUT&Tag文库构建和初步分析
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作者 张世鑫 葛立鑫 +5 位作者 吴绍华 晁金泉 杨署光 史敏晶 张华 田维敏 《热带作物学报》 CSCD 北大核心 2024年第10期2010-2024,共15页
CUT&Tag技术是一种研究蛋白质-DNA互作的新方法,使用超高活性的新型pG-Tn5转座酶,在抗体引导下精准靶向切割目的蛋白附近的DNA序列,从而进行cDNA建库和测序分析。此技术在人类和动物研究中应用广泛,由于植物细胞结构特殊,该技术在... CUT&Tag技术是一种研究蛋白质-DNA互作的新方法,使用超高活性的新型pG-Tn5转座酶,在抗体引导下精准靶向切割目的蛋白附近的DNA序列,从而进行cDNA建库和测序分析。此技术在人类和动物研究中应用广泛,由于植物细胞结构特殊,该技术在植物研究中应用较少。在前期研究中,我们发现组蛋白乙酰化修饰参与茉莉酸诱导橡胶树次生乳管分化的调控,但其分子机制尚未阐明。本研究利用冠菌素(COR)诱导橡胶树萌条维管形成层分化次生乳管的实验系统,通过酶解法获取高质量的形成层区细胞原生质体,使用组蛋白H3乙酰化修饰抗体对次生乳管分化过程中发生组蛋白乙酰化修饰的区域进行原位识别,采用CUT&Tag技术成功构建COR处理橡胶树树皮形成层细胞的cDNA文库。对构建cDNA文库进行质检和测序分析,发现文库质量较好,并通过差异基因的GO和KEGG富集分析,发现生长素、类黄酮代谢和蛋白质泛素化等相关基因得到富集。本研究结果为使用CUT&Tag技术构建植物组织的cDNA文库提供操作方法,为解析组蛋白乙酰化修饰调控橡胶树次生乳管分化的分子机制提供理论基础。 展开更多
关键词 巴西橡胶树 次生乳管分化 维管形成层 原生质体 组蛋白乙酰化 cut&Tag
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Instability mechanism of mining roadway passing through fault at different angles in kilometre-deep mine and control measures of roof cutting and NPR cables 被引量:2
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作者 SUN Xiaoming WANG Jian +6 位作者 ZHAO Wenchao MING Jiang ZHANG Yong LI Zhihu MIAO Chengyu GUO Zhibiao HE Manchao 《Journal of Mountain Science》 SCIE CSCD 2024年第1期236-251,共16页
The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and ... The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway. 展开更多
关键词 Kilometre-deep mine Fault Mining roadway Failure mechanism Pre-splitting cutting roof High pre-stress NPR anchor cable
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Hole cleaning evaluation and installation spacing optimization of cuttings bed remover in extended-reach drilling
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作者 Shuo Peng Wen-Jun Huang De-Li Gao 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期2005-2022,共18页
In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the annulus.Once cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,an... In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the annulus.Once cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,and pipe stuck probably occur,which results in a lot of non-productive time and remedial operations.Cuttings bed remover can efficiently destroy deposited cuttings in time through hydraulic and mechanical stirring effects.This paper aims to build a method for hole cleaning evaluation and installation spacing optimization of cuttings bed remover to improve the wellbore cleaning effect.Firstly,a Computational Fluid Dynamics approach with Eulerian—Eulerian multiphase model was utilized to investigate the mechanism of cuttings transportation,and a new type of cuttings bed remover was designed.Next,an evaluation method of hole cleaning effect of remover was established.After that,the effects of several drilling parameters on hole cleaning including flow rate of drilling fluid,rotational speed of drillpipe,rate of penetration,wellbore size,rheological property of drilling fluid,and remover eccentricity on the performance of cuttings bed remover were investigated.The results demonstrate that the new type of remover with streamline blade performs better than conventional removers.The efficiency of hole cleaning is greatly improved by increasing the rotational speed of drillpipe,flow rate of drilling fluid,remover eccentricity,and 6 rpm Fann dial reading for drilling fluid.While higher rate of penetration and large wellbore size result in worse hole cleaning.These findings can serve as an important guide for the structure optimization design of cuttings bed remover and installation spacing of removers. 展开更多
关键词 Extended-reach drlling Drilling hydraulics cuttings transport Hole cleaning cuttings bed remover
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Unraveling engineering disturbance effects on deformation in red-bed mudstone railway cuttings:incorporating crack-facilitated moisture diffusion
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作者 HUANG Kang DAI Zhangjun +3 位作者 YAN Chengzeng YAO Junkai CHI Zecheng CHEN Shanxiong 《Journal of Mountain Science》 SCIE CSCD 2024年第5期1663-1682,共20页
Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses upli... Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses uplift deformation disasters in high-speed railways by employing a moisture diffusion-deformation-fracture coupling model based on the finite-discrete element method(FDEM). The model integrates the influence of cracks on moisture diffusion. The investigation into various excavation depths reveals a direct correlation between depth and the formation of tensile cracks at the bottom of the railway cutting. These cracks expedite moisture migration, significantly impacting the temporal and spatial evolution of the moisture field. Additionally, crack expansion dominates hygroscopic deformation, with the lateral coordinate of the crack zone determining peak vertical displacement. Furthermore, key factors influencing deformation in railway cuttings, including the swelling factor and initial moisture content at the bottom of the cutting, are explored. The number of tensile and shear cracks increases with greater excavation depth, particularly concerning shear cracks. Higher swelling factors and initial moisture contents result in an increased total number of cracks, predominantly shear cracks. Numerical calculations provide valuable insights, offering a scientific foundation and directional guidance for the precise prevention, control, prediction, and comprehensive treatment of mudstone-related issues in high-speed railways. 展开更多
关键词 Red-bed mudstone Railway cutting FDEM Moisture diffusion DEFORMATION CRACK
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Assessing cutter-rock interaction during TBM tunnelling in granite:Large-scale standing rotary cutting tests and 3D DEM simulations
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作者 Xin Huang Miaoyuan Tang +4 位作者 Shuaifeng Wang Yixin Zhai Qianwei Zhuang Chi Zhang Qinghua Lei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第9期3595-3615,共21页
The widespread utilisation of tunnel boring machines(TBMs)in underground construction engineering requires a detailed investigation of the cutter-rock interaction.In this paper,we conduct a series of largescale standi... The widespread utilisation of tunnel boring machines(TBMs)in underground construction engineering requires a detailed investigation of the cutter-rock interaction.In this paper,we conduct a series of largescale standing rotary cutting tests on granite in conjunction with high-fidelity numerical simulations based on a particle-type discrete element method(DEM)to explore the effects of key cutting parameters on the TBM cutter performance and the distribution of cutter-rock contact stresses.The assessment results of cutter performance obtained from the cutting tests and numerical simulations reveal similar dependencies on the key cutting parameters.More specifically,the normal and rolling forces exhibit a positive correlation with penetration but are slightly influenced by the cutting radius.In contrast,the side force decreases as the cutting radius increases.Additionally,the side force shows a positive relationship with the penetration for smaller cutting radii but tends to become negative as the cutting radius increases.The cutter's relative effectiveness in rock breaking is significantly impacted by the penetration but shows little dependency on the cutting radius.Consequently,an optimal penetration is identified,leading to a low boreability index and specific energy.A combined Hertz-Weibull function is developed to fit the cutter-rock contact stress distribution obtained in DEM simulations,whereby an improved CSM(Colorado School of Mines)model is proposed by replacing the original monotonic cutting force distribution with this combined Hertz-Weibull model.The proposed model outperforms the original CSM model as demonstrated by a comparison of the estimated cutting forces with those from the tests/simulations.The findings from this work that advance our understanding of TBM cutter performance have important implications for improving the efficiency and reliability of TBM tunnelling in granite. 展开更多
关键词 Large-scale standing rotary cutting test Discrete element method(DEM)simulation cutter-rock interaction Improved CSM(Colorado School of Mines) model cutting force
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Precipitates Generation Mechanism and Surface Quality Improvement for Aluminum Alloy 6061 in Diamond Cutting
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作者 王海龙 DENG Wenping 王素娟 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第1期150-159,共10页
To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the p... To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the precipitates generation of Al6061 on surface integrity and surface roughness.Based on the Johnson-Mehl-Avrami solid phase transformation kinetics equation, theoretical and experimental studies were conducted to build the relationship between the aging condition and the type, size and number of the precipitates for Al6061. Diamond cutting experiments were conducted to machine Al6061 samples under different aging conditions. The experimental results show that, the protruding on the chip surface is mainly Mg_(2)Si and the scratches on the machined surface mostly come from the iron-containing phase(α-, β-AlFeSi).Moreover, the generated Mg_(2)Si and α-, β-AlFeSi affect the surface integrity and the diamond turned surface roughness. Especially, the achieved surface roughness in SPDT is consistent with the variation of the number of AlFeSi and Mg_(2)Si with the medium size(more than 1 μm and less than 2 μm) in Al6061. 展开更多
关键词 Al6061 PRECIPITATES aging treatment diamond cutting surface roughness
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Ground response and failure mechanism of gob-side entry by roof cutting with hard main roof
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作者 ZHU Heng-zhong XU Lei WEN Zhi-jie 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2488-2512,共25页
This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensi... This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensive field measurement program was conducted to determine entry deformation,roof fracture zone,and anchor bolt(cable)loading.The results indicate that GSERC deformation presents asymmetric characteristics.The maximum convergence near roof cutting side is 458 mm during the primary use process and 1120 mm during the secondary reuse process.The entry deformation is closely associated with the primary development stage,primary use stage,and secondary reuse stage.The key block movement of roof cutting structure,a complex stress environment,and a mismatch in the supporting design scheme are the failure mechanism of GSERC.A controlling ideology for mining states,including regional and stage divisions,was proposed.Both dynamic and permanent support schemes have been implemented in the field.Engineering practice results indicate that the new support scheme can efficiently ensure long-term entry safety and could be a reliable approach for other engineering practices. 展开更多
关键词 gob-side entry by roof cutting ground response failure mechanism following mining states control hard main roof
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Cutting Propagation Technique of Pennisetum purpureum Schum
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作者 Yuanbin HU Jing ZHANG +2 位作者 Yanan LIU Xiaoyu LIANG Yang JI 《Plant Diseases and Pests》 2024年第2期27-31,共5页
[Objectives]The paper was to study the cutting propagation technique of Pennisetum purpureum Schum and to provide a technical reference for establishing an efficient cutting propagation method.[Methods]Six treatments ... [Objectives]The paper was to study the cutting propagation technique of Pennisetum purpureum Schum and to provide a technical reference for establishing an efficient cutting propagation method.[Methods]Six treatments were set up using P.purpureum cv.Guiminyin and P.purpureum cv.Guimu-1 as test materials,including 1-node oblique insertion,1-node oblique insertion+rooting powder,1-node transverse burial,2-node oblique insertion,2-node oblique insertion+rooting powder and 2-node transverse burial.The following indices were observed and determined for P.purpureum cuttings:emergence rate,rooting rate,root number,longest root length,fresh root weight,plant height,number of tillers,number of leaves,and fresh stem and leaf weight.[Results]In the 2-node cutting+rooting powder treatment,Guiminyin and Guimu-1 exhibited the highest survival rate,root growth indices,and stem and leaf growth indices,with the emergence rates of 94.29%and 90.26%,respectively.The 2-node cutting treatment followed closely behind,while the 1-node cutting treatment had the lowest indices.Under the same treatment,Guimuyin exhibited higher mean values for plant height,number of leaves,fresh stem and leaf weight,longest root length,and fresh root weight compared to Guimu-1.However,it had lower mean number of tillers,and emergence rate and rooting rate of the 1-node cutting treatment compared to Guimu-1.[Conclusions]The P.purpureum cuttings thrived in the 2-node cutting+rooting powder treatment,and the overall cutting effect of Guiminyin was superior to that of Guimu-1. 展开更多
关键词 Pennisetum purpureum Schum cutTING PROPAGATION Emergence rate
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Cutting-edge Technological Innovation Outcome Displayed at 2024 Beijing Science and Technology Week
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作者 Zhang Yida 《China's Foreign Trade》 2024年第3期47-49,共3页
The 2024 National Science and Technology Week and Beijing Science and Technology Week opened in Shougang Park in Shijingshan District from May 25 to June 1.Under the theme of“Carrying forward the spirit of scientists... The 2024 National Science and Technology Week and Beijing Science and Technology Week opened in Shougang Park in Shijingshan District from May 25 to June 1.Under the theme of“Carrying forward the spirit of scientists and inspiring societal innovation,”this event focused on the new-generation IT technology,medical health,energy and technology,modern agriculture and intelligent manufacturing industries. 展开更多
关键词 DISTRICT cutTING opened
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Endoscopic radial incision and cutting method for adult congenital duodenal webs:A case report
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作者 Hyun Deok Shin 《World Journal of Clinical Cases》 SCIE 2024年第18期3622-3628,共7页
BACKGROUND Congenital duodenal webs are rare in adults and can lead to various symptoms such as nausea,vomiting,and postprandial fullness.The treatment for this disease is mostly surgical.Endoscopic treatment techniqu... BACKGROUND Congenital duodenal webs are rare in adults and can lead to various symptoms such as nausea,vomiting,and postprandial fullness.The treatment for this disease is mostly surgical.Endoscopic treatment techniques have been developed and attempted for this disease.Endoscopic radial incision and cutting(RIC)techniques are reportedly very effective in benign anastomotic stricture.This case report highlights the effectiveness and safety of endoscopic RIC as a minimally invasive treatment for adult congenital duodenal webs.CASE SUMMARY A 23-year-old female patient with indigestion was referred to a tertiary hospital.The patient complained of postprandial fullness in the epigastric region.Previous physical examinations or blood tests indicated no abnormalities.Computed tomography revealed an eccentric broad-based delayed-enhancing mass-like lesion in the second portion of the duodenum.Endoscopy showed an enlarged gastric cavity and a significantly dilated duodenal bulb;a very small hole was observed in the distal part of the second portion,and scope passage was not possible.Gastrografin upper gastrointestinal series was performed,revealing an intraduodenal barium contrast-filled sac with a curvilinear narrow radiolucent rim,a typical"windsock"sign.Endoscopic RIC was performed on the duodenal web.The patient recovered uneventfully.Follow-up endoscopy showed a patent duodenal lumen without any residual stenosis.The patient reported complete resolution of symptoms at the 18-month follow-up.CONCLUSION Endoscopic RIC may be an effective treatment for congenital duodenal webs in adults. 展开更多
关键词 Congenital duodenal web Endoscopic treatment Radial incision and cutting method Surgery Case report
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Application of Fuyang Paper Cutting Art in Cultural and Creative Design from the Perspective of Rural Revitalization
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作者 KANG Wenwen 《Journal of Landscape Research》 2024年第3期59-62,共4页
The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying ... The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying the elements and techniques of Fuyang traditional paper cutting art in cultural and creative products with local features were analyzed to provide reference for rural revitalization and development of cultural industry. 展开更多
关键词 Rural revitalization Fuyang paper cutting Cultural and creative design
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Experimental investigation on using CO_(2)/H_(2)O emulsion with high water cut in enhanced oil recovery
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作者 Xi-Dao Wu Peng Xiao +2 位作者 Bei Liu Guang-Jin Chen Jian-Hua Pang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期974-986,共13页
CO_(2) emulsions used for EOR have received a lot of interest because of its good performance on CO_(2)mobility reduction.However,most of them have been focusing on the high quality CO_(2) emulsion(high CO_(2) fractio... CO_(2) emulsions used for EOR have received a lot of interest because of its good performance on CO_(2)mobility reduction.However,most of them have been focusing on the high quality CO_(2) emulsion(high CO_(2) fraction),while CO_(2) emulsion with high water cut has been rarely researched.In this paper,we carried out a comprehensive experimental study of using high water cut CO_(2)/H_(2)O emulsion for enhancing oil recovery.Firstly,a nonionic surfactant,alkyl glycosides(APG),was selected to stabilize CO_(2)/H_(2)O emulsion,and the corresponding morphology and stability were evaluated with a transparent PVT cell.Subsequently,plugging capacity and apparent viscosity of CO_(2)/H_(2)O emulsion were measured systematically by a sand pack displacement apparatus connected with a 1.95-m long capillary tube.Furthermore,a high water cut(40 vol%) CO_(2)/H_(2)O emulsion was selected for flooding experiments in a long sand pack and a core sample,and the oil recovery,the rate of oil recovery,and the pressure gradients were analyzed.The results indicated that APG had a good performance on emulsifying and stabilizing CO_(2) emulsion.An inversion from H_(2)O/CO_(2) emulsion to CO_(2)/H_(2)O emulsion with the increase in water cut was confirmed.CO_(2)/H_(2)O emulsions with lower water cuts presented higher apparent viscosity,while the optimal plugging capacity of CO_(2)/H_(2)O emulsion occurred at a certain water cut.Eventually,the displacement using CO_(2)/H_(2)O emulsion provided 18.98% and 13.36% additional oil recovery than that using pure CO_(2) in long sand pack and core tests,respectively.This work may provide guidelines for EOR using CO_(2) emulsions with high water cut. 展开更多
关键词 CO_(2)/H_(2)O emulsion High water cut CO_(2) mobility control Enhanced oil recovery
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Multicut L-Shaped Algorithm for Stochastic Convex Programming with Fuzzy Probability Distribution
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作者 Miaomiao Han Xinshun MA 《Open Journal of Applied Sciences》 2012年第4期219-222,共4页
Two-stage problem of stochastic convex programming with fuzzy probability distribution is studied in this paper. Multicut L-shaped algorithm is proposed to solve the problem based on the fuzzy cutting and the minimax ... Two-stage problem of stochastic convex programming with fuzzy probability distribution is studied in this paper. Multicut L-shaped algorithm is proposed to solve the problem based on the fuzzy cutting and the minimax rule. Theorem of the convergence for the algorithm is proved. Finally, a numerical example about two-stage convex recourse problem shows the essential character and the efficiency. 展开更多
关键词 STOCHASTIC CONVEX PROGRAMMING fuzzy probability DISTRIBUTION TWO-STAGE problem multicut l-shaped algorithm
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Design and Numerical Simulation of Dust Removal System for Sutomotive Iongitudinal Beam Plasma Cutting
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作者 Wenqiang GAO Xudong MA Heyu TIAN 《Mechanical Engineering Science》 2024年第1期30-34,共5页
To improve the poor efficiency of the dust removal system in the plasma cutting station of automotive longitudinal beams,and reduce the cutting surface quality degradation due to dust,a bottom-side suction dust remova... To improve the poor efficiency of the dust removal system in the plasma cutting station of automotive longitudinal beams,and reduce the cutting surface quality degradation due to dust,a bottom-side suction dust removal system is designed,and the dust removal effect is optimized through the setting of the following dampers and diversion plates.The result of numerical simulation indicates that the particle collection rate can reach 99.44%,and the field test also proves the effectiveness of the dust removal system,which is of guiding significance for the transformation of other similar dust removal systems. 展开更多
关键词 plasma cutting dust removal equipment SIMULATION
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Research on the Resistance of Cutting Mechanism of Mining Longitudinal Roadheader
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作者 Mengjiao NIU Yong ZHAO Yongliang YUAN 《Mechanical Engineering Science》 2024年第1期8-12,共5页
In order to accurately obtain the dynamic characteristics of the cutting mechanism of the mining longitudinal roadheader,combined with the working principle of the mining longitudinal roadheader,the theoretical analys... In order to accurately obtain the dynamic characteristics of the cutting mechanism of the mining longitudinal roadheader,combined with the working principle of the mining longitudinal roadheader,the theoretical analysis and derivation are carried out in detail.By using ADAMS to simulate,the resistance curve and torque curve of the cutting mechanism in different directions are obtained.The results show that ADAMS can effectively predict the excavation resistance and torque of the cutting mechanism of mining longitudinal roadheader,which has certain reference value for future optimization design. 展开更多
关键词 longitudinal roadheader cutting mechanism dynamic characteristics DYNAMICS
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百超(上海)精密机床有限公司 百超全新一代激光切割机:ByCut Nova
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《现代制造》 2024年第8期50-50,共1页
百超全新一代激光切割机ByCut Nova,具有超高性价比和高品质切割技术的特性。采用百超自主研发的高性能BD切割头和高品质激光切割技术,使得板材在加工时具有较高的切割精度和质量,同时还可实现快速切割,大大提高了生产速度和效率;该设... 百超全新一代激光切割机ByCut Nova,具有超高性价比和高品质切割技术的特性。采用百超自主研发的高性能BD切割头和高品质激光切割技术,使得板材在加工时具有较高的切割精度和质量,同时还可实现快速切割,大大提高了生产速度和效率;该设备适用于各类金属板材加工,无论是碳钢、不锈钢、铝还是有色金属,都能获得一流的切割质量。 展开更多
关键词 激光切割机 激光切割技术 精密机床 切割精度 切割质量 切割头 cut 有色金属
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Severe Cut Throat Injury in a Child: A Case Report and Review of Literature
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作者 Nafisatu Bello-Muhammad Hamisu Abdullahi +3 位作者 Yasir Nuhu Jibril Auwal Adamu Manir Hamza Anka Muhammad Ghazali Hasheem 《International Journal of Otolaryngology and Head & Neck Surgery》 2024年第4期285-292,共8页
Background: Cut-throat injury is a potentially fatal condition that may be associated with serious morbidity and mortality. The neck region is particularly at risk of serious injuries due to the location of vital stru... Background: Cut-throat injury is a potentially fatal condition that may be associated with serious morbidity and mortality. The neck region is particularly at risk of serious injuries due to the location of vital structures, including nerves, viscera, and major vessels. Although cut-throat injury is said to be rare in children, its occurrence has been reported in some series. Management of this condition requires a multidisciplinary approach for a better outcome. Aim: The aim of this report is to highlight the successful management of an alarming case of severe cut-throat injury with associated laryngeal injury in a child. Case presentation: A 12-year-old boy presented with a cut-throat following an assault by an unknown person. Examination revealed an acutely ill child, conscious but pale. He sustained a deep transverse laceration that transected the thyroid cartilage, exposing the laryngeal cavity. An assessment of Zone II penetrating neck injury was made. He was resuscitated, and had emergency neck exploration, tracheostomy, and repair of the injuries. The patient was followed up for 6 months, and had a good voice outcome, with no significant complication. Conclusion: Cut-throat injury is rare in children. But it is a potentially life-threatening condition. It is therefore important to recognize this entity and develop effective protocol of management in our environment. 展开更多
关键词 cut-Throat Neck Trauma Penetrating Neck Injury Neck Exploration TRACHEOSTOMY
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The wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges 被引量:7
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作者 Chun-Chuan Liu Feng-Ming Li Ting-Wei Liang Wen-Hu Huang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2011年第5期785-795,共11页
In this paper,wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges are investigated using the wave approach.The dynamic responses,active and reactive power ... In this paper,wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges are investigated using the wave approach.The dynamic responses,active and reactive power flow in the finite plate are calculated by the Mindlin plate theory (MPT) and classic plate theory (CPT).To satisfy the boundary conditions and continuous conditions at the coupled junction of the finite L-shaped plate,the near-field and far-field waves are entirely contained in the wave approach.The in-plane longitudinal and shear waves are also considered.The results indicate that the vibratory power flow based on the MPT is different from that based on the CPT not only at high frequencies but also at low and medium frequencies.The influence of the plate thickness on the vibrational power flow is investigated.From the results it is seen that the shear and rotary inertia correction of the MPT can influence the active and reactive power at the junction of the L-shaped plate not only at high frequencies but also at low and medium frequencies.Furthermore,the effects of structural damping on the active and reactive power flow at the junction are also analyzed. 展开更多
关键词 Finite l-shaped Mindlin plate Active power flow Reactive power flow Wave approach
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Axial Compression Behavior and Analytical Method of L-Shaped Column Composed of Concrete-Filled Square Steel Tubes 被引量:5
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作者 荣彬 陈志华 +1 位作者 APOSTOLOS Fafitis 杨楠 《Transactions of Tianjin University》 EI CAS 2012年第3期180-187,共8页
Based on the characteristics of an L-shaped column composed of concrete-filled square steel tubes, the axial compression experiment and nonlinear finite element analysis were carried out to study the mechanical proper... Based on the characteristics of an L-shaped column composed of concrete-filled square steel tubes, the axial compression experiment and nonlinear finite element analysis were carried out to study the mechanical property of the L-shaped column. The load-displacement curve for the L-shaped column, the deflection and load-strain curves for the mono columns were obtained by the axial compression experiment. The results show that the L-shaped column exhibits a flexural-torsional buckling failure mode. The numerical simulation by the finite element analysis shows that the bearing capacity and failure mode are in accordance with those of the axial compression experiment and the feasi- bility of the finite element analysis is proved. For the calculation of the bearing capacity of the L-shaped column com- posed of concrete-filled square steel tubes, an analytical method is proposed based on the theory of the elastic stability and spatial truss model. The results of the analytical method are in good agreement with those of the axial compression experiment and the finite element analysis. 展开更多
关键词 l-shaped column concrete-filled square steel tube axial compression experiment finite element analy-sis analytical method
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