Radiating frequency of three-loop mesoscopic LC circuit with mutual inductance obtained by IEO method

Instead of normally tackling electric circuits by virtue oI the Klrctllaott＇s theorem wnose aim is to uerlvc voxt^gc, electric current, and electric impedence, our aim in this paper is to derive the characteristic frequency of a three-loop mesoscopic LC circuit with three mutual inductances, e.g., for the radiating frequency of the three-loop LC oscillator, we adopt the invariant eigen-operator （lEO） method to realize our aim.

Optimization of synthesis of upconversion luminescence material NaYF_4:Er^(3+),Yb^(3+) nanometer-phosphor by low-temperature combustion synthesis method

A kind of Er^3＋-yb^3＋ co-doped natrium yttrium fluoride nanometer-phosphor sensitive to 980 nm was syntlaeslzecl by me low-temperature combustion synthesis method, which expanded the application range of the low-temperature combustion synthesis （LCS） method which is always used in the synthesis of oxides and compotmd oxides. The synthesis conditions were optimized with orthogonal experiments and the optimum technological parameters were obtained. Intense upconversion emissions at 522, 540 and 653 nm corresponding to the 2H11/2, 4S3/2, and 4F9/2 transitions to the 4115/2 ground state were observed when excited by continuous wave- length （CW） laser radiation at 980 nm. The effect of the carbamide amount on the phase formation and the luminescence intensity was analyzed. The average particle size of the sample was 3040 nm.

A sensitive and validated LC-MS/MS method for high-throughput determination of pomalidomide in human plasma and pharmacokinetic studies

Pomalidomide is an immunomodulatory agent (IMiD) that has been approved by the US Food and Drug Administration (FDA) for clinical treatment of patients with multiple myeloma.In this work,we developed a sensitive and validated LC-MS/MS method for high-throughput determination of pomalidomide over the range of 1.006-100.6 ng/mL(R^(2)=0.9991) in human plasma and pharmacokinetic studies.A liquid-liquid extraction method using ethyl acetate was applied to extract pomalidomide and afatinib (as an internal standard,IS) from human plasma.Chromatographic separation was performed on a Hedera ODS column (150 mm×2.1 mm,5μm) with security guard C18 column (4 mm×2.0 mm) at 40℃.Methanol and 10 mmol/L aqueous solution of ammonium acetate containing 0.1%formic acid were used as a gradient elution mobile phase,and the flow rate was 0.4 mL/min.A triple quadruple tandem mass spectrometer using multiplex reaction monitoring mode (MRM) with electrospray ionization (ESI) positive ionization was employed.The precursor to product ion transitions for the quantitative analysis of pomalidomide and the IS were m/z 274.2→163.1 and m/z 486.1→371.1,respectively.This established method has been validated according to regulatory guideline,and the results were all within the acceptance criteria.The validated LC-MS/MS method was successfully applied to analyze samples obtained from clinical pharmacokinetics study after oral administration of pomalidomide (4 mg) capsules in human.