Matrix-assisted laser desorption/ionization (MALDI) is a preferred and widely used mass spectrometric technique for the analysis of macromolecules. Limited UV-LDI matrices are available for the analysis of biomolecule...Matrix-assisted laser desorption/ionization (MALDI) is a preferred and widely used mass spectrometric technique for the analysis of macromolecules. Limited UV-LDI matrices are available for the analysis of biomolecules due to the restricted structural features to serve in the laser desorption/ionization mechanism with a problem of background signals appearing in the low mass region. This paper describes the application of Schiff base derivatives of acylhydrazide and isatin as alternate UV-LDI matrices for the analysis of peptides with significantly low background signals. Thirty one compounds have been successfully employed as matrices for the analysis of low molecular weight (LMW) peptides (α-Cyano-4-hydroxycinnamic acid (HCCA), a preferred choice for peptide analysis.展开更多
THE study on metallofullerenes which gives rise to novel molecules and materials has alwaysbeen one of the most attractive directions of fullerenes research since the discovery of LaC<sub>82</sub>.But it d...THE study on metallofullerenes which gives rise to novel molecules and materials has alwaysbeen one of the most attractive directions of fullerenes research since the discovery of LaC<sub>82</sub>.But it did not develop rapidly until K-H method was used to prepare metallofullerenes inbulk.Now most lanthanides including La,Ce,Nd,Sm,Eu,Gd,Tb,Dy,Ho and Er can展开更多
文摘Matrix-assisted laser desorption/ionization (MALDI) is a preferred and widely used mass spectrometric technique for the analysis of macromolecules. Limited UV-LDI matrices are available for the analysis of biomolecules due to the restricted structural features to serve in the laser desorption/ionization mechanism with a problem of background signals appearing in the low mass region. This paper describes the application of Schiff base derivatives of acylhydrazide and isatin as alternate UV-LDI matrices for the analysis of peptides with significantly low background signals. Thirty one compounds have been successfully employed as matrices for the analysis of low molecular weight (LMW) peptides (α-Cyano-4-hydroxycinnamic acid (HCCA), a preferred choice for peptide analysis.
文摘THE study on metallofullerenes which gives rise to novel molecules and materials has alwaysbeen one of the most attractive directions of fullerenes research since the discovery of LaC<sub>82</sub>.But it did not develop rapidly until K-H method was used to prepare metallofullerenes inbulk.Now most lanthanides including La,Ce,Nd,Sm,Eu,Gd,Tb,Dy,Ho and Er can
