Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is common...Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is commonly associated with pain, numbness, tingling, burning, and cramping in the feet and legs. Current treatment options are limited to controlling pain, seizures and use of antidepressant medications. These treatments have undesirable side effects and don’t stop PN progression. Here we utilized a combination of individual-specific modalities to improve local circulation and relieve PN symptoms. Methods: We conducted an open-label, multicenter pilot trial with 34 subjects (19 males and 15 females ranging from 40 - 85 years of age). All of the participants were diagnosed with peripheral neuropathy and had bilateral symptoms in their feet, and many reported the same symptoms (pain, numbness, tingling, burning, and cramping) in their lower legs. The duration of symptoms ranged from four months to over six years. On Day 0, subjects were given a 90-day supply of the oral supplement with dosing instructions and a LED light therapy device. They also received three platelet-rich plasma (PRP) injections in their lower extremities. Subjects also received an extracorporeal shockwave therapy (ESWT) treatment for each foot and subsequently twice per week for the first six weeks, then once weekly for the duration of the study. Subjects filled out the Brief Pain Index (BPI) at weekly intervals. On Day 90, subjects completed the Patient Global Impression of Change (PGIC) survey. Results: There were significant responses to pain, as evidenced by BPI scores at weeks 8, 9, 10 and 11 (p = 0.02, 0.01, 0.02, and 0.003, respectively). Analysis of the final day PGIC survey showed a favorable outcome for 73% of participants (p = 0.003), with the majority reporting Very Much Improved. Conclusions: By utilizing a multi-modality treatment protocol that includes PRP, LED light therapy, ESWT and an oral dietary supplement, we observed significant reductions in BPI scores. Quality of life and their overall impression of change (PGIC) were significantly improved, and there were no significant side effects.展开更多
为研究LED补光对温室樱桃番茄产量和品质的影响,探讨设施栽培中利用补光手段实现增产和提高品质的调控新途径,以哈金龙樱桃番茄为试验材料,在温室条件下采用LED灯带和LED灯管对定植后樱桃番茄进行侧面补光,光源光通量密度为100 μmol/m2...为研究LED补光对温室樱桃番茄产量和品质的影响,探讨设施栽培中利用补光手段实现增产和提高品质的调控新途径,以哈金龙樱桃番茄为试验材料,在温室条件下采用LED灯带和LED灯管对定植后樱桃番茄进行侧面补光,光源光通量密度为100 μmol/m2·s,每天补光12 h （8：00～20：00）,测定分析不同补光处理下樱桃番茄果实产量和品质的变化.结果表明,LED灯管和LED灯带补光处理的樱桃番茄挂果数、总产量和单果重均显著高于对照,且LED灯管处理效果较好,挂果数、总产量和单果重分别提高48.91％、94.86％和30.86％.LED灯管补光处理能显著提高樱桃番茄果实的品质指标,Vc可溶性蛋白、游离氨基酸、可溶性糖和蔗糖含量均显著高于对照,番茄红素、花色苷、类黄酮和可溶性酚含量均最高,番茄着色最好.展开更多
文摘Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is commonly associated with pain, numbness, tingling, burning, and cramping in the feet and legs. Current treatment options are limited to controlling pain, seizures and use of antidepressant medications. These treatments have undesirable side effects and don’t stop PN progression. Here we utilized a combination of individual-specific modalities to improve local circulation and relieve PN symptoms. Methods: We conducted an open-label, multicenter pilot trial with 34 subjects (19 males and 15 females ranging from 40 - 85 years of age). All of the participants were diagnosed with peripheral neuropathy and had bilateral symptoms in their feet, and many reported the same symptoms (pain, numbness, tingling, burning, and cramping) in their lower legs. The duration of symptoms ranged from four months to over six years. On Day 0, subjects were given a 90-day supply of the oral supplement with dosing instructions and a LED light therapy device. They also received three platelet-rich plasma (PRP) injections in their lower extremities. Subjects also received an extracorporeal shockwave therapy (ESWT) treatment for each foot and subsequently twice per week for the first six weeks, then once weekly for the duration of the study. Subjects filled out the Brief Pain Index (BPI) at weekly intervals. On Day 90, subjects completed the Patient Global Impression of Change (PGIC) survey. Results: There were significant responses to pain, as evidenced by BPI scores at weeks 8, 9, 10 and 11 (p = 0.02, 0.01, 0.02, and 0.003, respectively). Analysis of the final day PGIC survey showed a favorable outcome for 73% of participants (p = 0.003), with the majority reporting Very Much Improved. Conclusions: By utilizing a multi-modality treatment protocol that includes PRP, LED light therapy, ESWT and an oral dietary supplement, we observed significant reductions in BPI scores. Quality of life and their overall impression of change (PGIC) were significantly improved, and there were no significant side effects.
文摘为研究LED补光对温室樱桃番茄产量和品质的影响,探讨设施栽培中利用补光手段实现增产和提高品质的调控新途径,以哈金龙樱桃番茄为试验材料,在温室条件下采用LED灯带和LED灯管对定植后樱桃番茄进行侧面补光,光源光通量密度为100 μmol/m2·s,每天补光12 h （8：00～20：00）,测定分析不同补光处理下樱桃番茄果实产量和品质的变化.结果表明,LED灯管和LED灯带补光处理的樱桃番茄挂果数、总产量和单果重均显著高于对照,且LED灯管处理效果较好,挂果数、总产量和单果重分别提高48.91％、94.86％和30.86％.LED灯管补光处理能显著提高樱桃番茄果实的品质指标,Vc可溶性蛋白、游离氨基酸、可溶性糖和蔗糖含量均显著高于对照,番茄红素、花色苷、类黄酮和可溶性酚含量均最高,番茄着色最好.
