This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)mouse.In the control and sham mice,the walls of deep vein were regular ...This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)mouse.In the control and sham mice,the walls of deep vein were regular and smooth with intact intima,myometrium and adventitia.The blood vessel was wrapped with the tissue and there was no thrombosis in the lumen.In the DVT model,the wall was uneven with thicken intima,myometrium and adventitia.After treated with fucoidans LF1 and LF2,the thrombus was dissolved and the blood vessel was recanalized.Compared with the control group,the ROS content,ET-1 and VWF content and the expression of PKC-βand NF-κB in the model were significantly higher(P<0.05);these levels were significantly reduced following treatments with LF2 and LF1.Compared with H_(2)O_(2)treated-HUVECs,combined LF1 and LF2 treatment resulted in significant decrease in the expression of PKC-β,NF-κB,VWF and TM protein(P<0.05).It is clear that LF1 and LF2 reduces DVT-induced ET-1,VWF and TM expressions and production of ROS,thus inhibiting the activation of PKC-β/NF-κB signal pathway and the activation of coagulation system and ultimately reducing the formation of venous thrombus.展开更多
The thorium molten salt reactor–liquid fuel(TMSR-LF1) has inherent safety features. The accident occurrence possibility and their consequences are much lower for the TMSR-LF1 than that of traditional reactors.Based o...The thorium molten salt reactor–liquid fuel(TMSR-LF1) has inherent safety features. The accident occurrence possibility and their consequences are much lower for the TMSR-LF1 than that of traditional reactors.Based on accident analysis, the maximum credible accident and the radioactive source terms of the TMSR-LF1 were first estimated. Then, the total effective dose of the maximum credible accident was calculated. Based on calculations, the cover gas flow rate can significantly affect the radiation consequences of the maximum credible accident when it changes from 0 to 10 L/min. If no cover gas is flowing, a site-area emergency would be required within the range of 50–73 m from the reactor. In the case of cover gas flow, only an abnormal notification and an alert two emergency class would be required within the range of 50 m.展开更多
Tritium release is one of the most concerning topics in nuclear power plants. Here, the tritium production in a 2 MW liquid-fueled molten salt experimental reactor(TMSR-LF1) was calculated by ORIGEN-S with an updated ...Tritium release is one of the most concerning topics in nuclear power plants. Here, the tritium production in a 2 MW liquid-fueled molten salt experimental reactor(TMSR-LF1) was calculated by ORIGEN-S with an updated cross-section library generated by TRITON in SCALE 6.1.3 code system. The results show that the tritium production rate and normalized tritium production rate of TMSR-LF1 are 8.90x10^(11)Bq/day and4.45x10^(11)Bq/(MW day), respectively. The environmental impact of tritium was analyzed via PC-CREAM 08 with an assumed 36 % release rate of tritium referring to the molten salt reactor experiment. During normal operations, the maximum tritium concentration is 1.4 Bq/m^3 under normal condition, and the corresponding individual dose to the public is about 1 μSv/a; under extreme conditions, the maximum concentration and corresponding individual doses are 11.8 Bq/m^3 and 9 μSv/a, respectively.Ingestion is the main exposure pathway and accounts for62 % of the total dose. Of this, 35 % is from organically bound tritium.展开更多
基金supported by the Special Fund for Clinical Scientific Research of Shandong Medical Association(No.YXH2020ZX058).
文摘This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)mouse.In the control and sham mice,the walls of deep vein were regular and smooth with intact intima,myometrium and adventitia.The blood vessel was wrapped with the tissue and there was no thrombosis in the lumen.In the DVT model,the wall was uneven with thicken intima,myometrium and adventitia.After treated with fucoidans LF1 and LF2,the thrombus was dissolved and the blood vessel was recanalized.Compared with the control group,the ROS content,ET-1 and VWF content and the expression of PKC-βand NF-κB in the model were significantly higher(P<0.05);these levels were significantly reduced following treatments with LF2 and LF1.Compared with H_(2)O_(2)treated-HUVECs,combined LF1 and LF2 treatment resulted in significant decrease in the expression of PKC-β,NF-κB,VWF and TM protein(P<0.05).It is clear that LF1 and LF2 reduces DVT-induced ET-1,VWF and TM expressions and production of ROS,thus inhibiting the activation of PKC-β/NF-κB signal pathway and the activation of coagulation system and ultimately reducing the formation of venous thrombus.
文摘The thorium molten salt reactor–liquid fuel(TMSR-LF1) has inherent safety features. The accident occurrence possibility and their consequences are much lower for the TMSR-LF1 than that of traditional reactors.Based on accident analysis, the maximum credible accident and the radioactive source terms of the TMSR-LF1 were first estimated. Then, the total effective dose of the maximum credible accident was calculated. Based on calculations, the cover gas flow rate can significantly affect the radiation consequences of the maximum credible accident when it changes from 0 to 10 L/min. If no cover gas is flowing, a site-area emergency would be required within the range of 50–73 m from the reactor. In the case of cover gas flow, only an abnormal notification and an alert two emergency class would be required within the range of 50 m.
文摘Tritium release is one of the most concerning topics in nuclear power plants. Here, the tritium production in a 2 MW liquid-fueled molten salt experimental reactor(TMSR-LF1) was calculated by ORIGEN-S with an updated cross-section library generated by TRITON in SCALE 6.1.3 code system. The results show that the tritium production rate and normalized tritium production rate of TMSR-LF1 are 8.90x10^(11)Bq/day and4.45x10^(11)Bq/(MW day), respectively. The environmental impact of tritium was analyzed via PC-CREAM 08 with an assumed 36 % release rate of tritium referring to the molten salt reactor experiment. During normal operations, the maximum tritium concentration is 1.4 Bq/m^3 under normal condition, and the corresponding individual dose to the public is about 1 μSv/a; under extreme conditions, the maximum concentration and corresponding individual doses are 11.8 Bq/m^3 and 9 μSv/a, respectively.Ingestion is the main exposure pathway and accounts for62 % of the total dose. Of this, 35 % is from organically bound tritium.
