In this paper, we present a noise removal technique by combining the P-M model with the LLT model. The combined technique takes full use of the advantage of both filters which is able to preserve edges and simultaneou...In this paper, we present a noise removal technique by combining the P-M model with the LLT model. The combined technique takes full use of the advantage of both filters which is able to preserve edges and simultaneously overcomes the staircase effect. We use a weighting function in our model, and compare this model with the P-M model as well as other fourth-order functional both in theory and numerical experiment.展开更多
AIM To evaluate the validity of LLT in prevention and therapy of acute graft versus host disease and to clarify the underlying mechanisms. LLT is a new compound derived from triptolide, which is the major immunosuppre...AIM To evaluate the validity of LLT in prevention and therapy of acute graft versus host disease and to clarify the underlying mechanisms. LLT is a new compound derived from triptolide, which is the major immunosuppressive fraction of Tripterygium wilfordii Hook. F (TWHF). Studies in vitro and in vivo demonstrated that LLT had potent immunosuppressive activities. Here we tested the immunosuppressive effects of LLT in murine allogeneic bone marrow transplantation (BMT) and investigated the mechanisms underlying its suppressive effects. METHODS LLT was administered to recipients in BALB/cA→C57BL/6 murine BMT model, in which donor and recipient differ at major and minor histocompatibility antigens.Survival and weight change were recorded in recipients after alloBMT. Spleen size, chimerism and splenic T cell subpopulation were analysed by using flow cytometry.展开更多
AIM To evaluate the therapeutic effects of LLT on the type II collagen-induced arthritis in DBA/1 mice. LLT is a new compound derived from triptolide. LLT had been demonstrated in vitro and in vivo for its immunosuppr...AIM To evaluate the therapeutic effects of LLT on the type II collagen-induced arthritis in DBA/1 mice. LLT is a new compound derived from triptolide. LLT had been demonstrated in vitro and in vivo for its immunosuppressive activities, and our results showed LLT with low toxicity and high efficiency. LLTis a more drug-like compound comparing with the parent compound. METHODS Male DBA/1 mice were immunized at the tail base with 125 ( g of Bovine type II collagen emulsified in CFA containing Mycobacterium tuberculosis and boosted with collagen emulsified in IFA 3 weeks later. The severity of arthritis was graded visually and expressed using the arthritic index. The arthritic score of each mouse was obtained by scoring each limb as severity 0 to 4 and taken the sum of the scores of the four limbs.展开更多
We propose an efficient gradient-type algorithm to solve the fourth-order LLT denoising model for both gray-scale and vector-valued images.Based on the primal-dual formulation of the original nondifferentiable model,t...We propose an efficient gradient-type algorithm to solve the fourth-order LLT denoising model for both gray-scale and vector-valued images.Based on the primal-dual formulation of the original nondifferentiable model,the new algorithm updates the primal and dual variables alternately using the gradient descent/ascent flows.Numerical examples are provided to demonstrate the superiority of our algorithm.展开更多
文摘In this paper, we present a noise removal technique by combining the P-M model with the LLT model. The combined technique takes full use of the advantage of both filters which is able to preserve edges and simultaneously overcomes the staircase effect. We use a weighting function in our model, and compare this model with the P-M model as well as other fourth-order functional both in theory and numerical experiment.
文摘AIM To evaluate the validity of LLT in prevention and therapy of acute graft versus host disease and to clarify the underlying mechanisms. LLT is a new compound derived from triptolide, which is the major immunosuppressive fraction of Tripterygium wilfordii Hook. F (TWHF). Studies in vitro and in vivo demonstrated that LLT had potent immunosuppressive activities. Here we tested the immunosuppressive effects of LLT in murine allogeneic bone marrow transplantation (BMT) and investigated the mechanisms underlying its suppressive effects. METHODS LLT was administered to recipients in BALB/cA→C57BL/6 murine BMT model, in which donor and recipient differ at major and minor histocompatibility antigens.Survival and weight change were recorded in recipients after alloBMT. Spleen size, chimerism and splenic T cell subpopulation were analysed by using flow cytometry.
文摘AIM To evaluate the therapeutic effects of LLT on the type II collagen-induced arthritis in DBA/1 mice. LLT is a new compound derived from triptolide. LLT had been demonstrated in vitro and in vivo for its immunosuppressive activities, and our results showed LLT with low toxicity and high efficiency. LLTis a more drug-like compound comparing with the parent compound. METHODS Male DBA/1 mice were immunized at the tail base with 125 ( g of Bovine type II collagen emulsified in CFA containing Mycobacterium tuberculosis and boosted with collagen emulsified in IFA 3 weeks later. The severity of arthritis was graded visually and expressed using the arthritic index. The arthritic score of each mouse was obtained by scoring each limb as severity 0 to 4 and taken the sum of the scores of the four limbs.
文摘We propose an efficient gradient-type algorithm to solve the fourth-order LLT denoising model for both gray-scale and vector-valued images.Based on the primal-dual formulation of the original nondifferentiable model,the new algorithm updates the primal and dual variables alternately using the gradient descent/ascent flows.Numerical examples are provided to demonstrate the superiority of our algorithm.
