Recently,Kidokoro et al.found that protein complex LNK3,4-RVE4,8 and LNK1,2-RVE4,8 of the circadian clock modulates plant cold-and high-temperature tolerance,respectively.Here,we reviewed the discovery of LNKs,the dyn...Recently,Kidokoro et al.found that protein complex LNK3,4-RVE4,8 and LNK1,2-RVE4,8 of the circadian clock modulates plant cold-and high-temperature tolerance,respectively.Here,we reviewed the discovery of LNKs,the dynamically formed morning-phased clock complexes,and their critical role on endogenous circadian rhythms.In addition,we summarized the research work on LNKs with the interacting proteins RVEs,CCA1 in temperature responses and discussed how the circadian clock confer increased fitness via gating the rhythmic expression of their target genes.展开更多
目的:探讨LNK基因在急性白血病患者中的表达及其与临床特征的相关性。方法:采用实时荧光定量PCR检测80例AL(ALL 42例,AM L 38例)患者骨髓中LNK m RNA的表达水平,分析其表达水平与临床特征的相关性,应用Western blot检测患者的LNK蛋白表...目的:探讨LNK基因在急性白血病患者中的表达及其与临床特征的相关性。方法:采用实时荧光定量PCR检测80例AL(ALL 42例,AM L 38例)患者骨髓中LNK m RNA的表达水平,分析其表达水平与临床特征的相关性,应用Western blot检测患者的LNK蛋白表达量。以正常的志愿者(16例)骨髓作为对照组。结果:ALL和AM L组的LNK水平均明显高于正常对照组(P=0.007,P=0.021),ALL组与AM L组之间LNK水平无统计学差异;ALL和AML组中的LNK表达水平均与危险程度呈正相关(P=0.000,P=0.004,r=0.5,r=0.386),且ALL和AML组中高危组的LNK水平均明显高于对照组(P=0.035,P=0.032),AML和ALL组的中危组(P=0.239,P=0.609)及标危组(P=0.974,P=1)LNK水平均高于对照组,但无统计学意义,各组之间危险程度无统计学差异。急性白血病患者LNK蛋白表达量较对照组增加。结论:急性白血病患者LNK基因表达高于正常人,与患者危险度呈正相关。展开更多
基金supported by National Key R&D Program of China to X.X.(2021YFA1300402)the National Natural Science Foundation of China to Q.X.(32170259),X.X.(U1904202,32170275).
文摘Recently,Kidokoro et al.found that protein complex LNK3,4-RVE4,8 and LNK1,2-RVE4,8 of the circadian clock modulates plant cold-and high-temperature tolerance,respectively.Here,we reviewed the discovery of LNKs,the dynamically formed morning-phased clock complexes,and their critical role on endogenous circadian rhythms.In addition,we summarized the research work on LNKs with the interacting proteins RVEs,CCA1 in temperature responses and discussed how the circadian clock confer increased fitness via gating the rhythmic expression of their target genes.
文摘目的:探讨LNK基因在急性白血病患者中的表达及其与临床特征的相关性。方法:采用实时荧光定量PCR检测80例AL(ALL 42例,AM L 38例)患者骨髓中LNK m RNA的表达水平,分析其表达水平与临床特征的相关性,应用Western blot检测患者的LNK蛋白表达量。以正常的志愿者(16例)骨髓作为对照组。结果:ALL和AM L组的LNK水平均明显高于正常对照组(P=0.007,P=0.021),ALL组与AM L组之间LNK水平无统计学差异;ALL和AML组中的LNK表达水平均与危险程度呈正相关(P=0.000,P=0.004,r=0.5,r=0.386),且ALL和AML组中高危组的LNK水平均明显高于对照组(P=0.035,P=0.032),AML和ALL组的中危组(P=0.239,P=0.609)及标危组(P=0.974,P=1)LNK水平均高于对照组,但无统计学意义,各组之间危险程度无统计学差异。急性白血病患者LNK蛋白表达量较对照组增加。结论:急性白血病患者LNK基因表达高于正常人,与患者危险度呈正相关。
