基于ILVD的多分量LFM信号重构算法

针对线性调频(linear frequency modulated, LFM)信号参数估计技术面向多目标产生的多分量信号会产生交叉项,从而降低参数估计精度的问题,提出了基于逆吕氏分布(inverse Lv’s distribution, ILVD)的多分量LFM信号重构算法。利用特征值分解结合最小误差准则方法的中心频率-调频斜率(centroid frequency-chirp rate, CFCR)域信号分析与合成,克服传统时频变换方法中的交叉项干扰问题;采用特征值分解思想构造ILVD变换核函数;使用最小误差准则校正CFCR域随机相位误差,重构出分布在CFCR域吕氏分布中不同位置对应的各个目标信号。实验结果表明,提出的算法在重构信号的准确度和抗噪声干扰方面的有效性均有较大提高。

Competitive oxidation behavior of Ni-based superalloy GH4738 at extreme temperature

A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.

Competitive effect, but not competitive response, varies along a climatic gradient depending on tree species identity

Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic gradient.Methods: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to climate.Likelihood methods and information theory were used to select the best model.Results: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their maximum.Conclusions: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of the target tree to competition. The modelling approach should be useful in future research to expand our knowledge of how competition modulates forest communities across environmental gradients.

Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy.

Extensive numerical simulations on competitive growth between the Edwards–Wilkinson and Kardar–Parisi–Zhang universality classes

Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(BD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.

Impact of coupling coordination development of port and city environments on urban economic competitiveness:Evidence from the coastal port cities in eastern China

Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern China from 2000 to 2018,this study explores the coupling coordination development of port and city environments and its impact on urban economic competitiveness by constructing the coupling coordination degree model and the panel threshold model.The research results show that:(1)In terms of the coupling coordination development of port and city environments,most coastal ports and their hinterland cities are in a state of moderate or serious disorder.Overall,the degree of coupling coordination of port and city environments needs to be further improved;(2)The coupling coordination degree of port and city environments has a significant impact on urban economic competitiveness,and this effect gradually increases with the development of the ports and the urban economy.Among the variables that impact the urban economic competitiveness,fixed assets investment and foreign trade are significant factors that can enhance urban economic competitiveness.(3)At present,there is a“U-shaped”relationship between the coupling coordination degree of port-city environments and the urban economic competitiveness.This relationship lies on the right side of the inflection point of the“U-shaped”curve.Therefore,following the concept of assigning priority to ecological development,expanding fixed assets investment and actively developing foreign trade can further enhance the urban economic competitiveness.

基于LV-DBSCAN算法的大坝安全监测数据异常检测

大坝安全监测数据原始序列中常存在异常测值,极大影响了大坝安全监测资料分析的可靠性和准确性。为此,在分析异常值特性及传统异常检测方法优缺点的基础上,分别从局部与整体角度研究监测数据异常检测方法。首先针对多重局部异常系数法要求数据序列较长且数据等时间间距等缺陷,提出了局部变化异常系数法(LV)及局部方法与整体方法协同判别策略;进一步引入密度聚类算法(DBSCAN),提出了兼顾数据整体与局部特性的LV-DBSCAN异常检测方法。以某混凝土重力坝两垂线测点顺流向位移监测数据为实例,对比分析了不同方法在不同类型数据集上的检测精度。研究结果表明,所提LV-DBSCAN方法适用性更广,准确率更高,误判率更低。

具有免疫调节功能的鼠李糖乳杆菌LV108对大鼠粪便菌群及其代谢物的影响

利用鼠李糖乳杆菌LV108干预由环磷酰胺建立的免疫低下模型大鼠,研究其对免疫低下大鼠的免疫调节作用,并探究其对大鼠粪便菌群及其代谢物的影响。结果表明,环磷酰胺建立的免疫低下模型大鼠血清中白细胞介素-2(Interleukin-2,IL-2)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白G(Immunoglobulin G,IgG)及溶血素的水平以及吞噬指数和廓清指数显著低于对照组(P<0.05),脾淋巴细胞的增殖也显著降低(P<0.05);鼠李糖乳杆菌LV108的干预显著提高了免疫低下大鼠血清中TNF-α、总IgG及溶血素的水平和廓清指数(P<0.05),并显著促进了脾淋巴细胞的增殖(P<0.05);环磷酰胺显著降低了大鼠粪便中乳杆菌和双歧杆菌的数量(P<0.05),并显著提高了肠杆菌和肠球菌的数量(P<0.05),粪便中的丙氨酸、异亮氨酸、丁酸、琥珀酸、肌酸、β-葡萄糖和α-葡萄糖的含量均低于对照组;而鼠李糖乳杆菌LV108的干预使得大鼠粪便中乳杆菌和双歧杆菌的数量显著升高(P<0.05),并显著降低了肠杆菌和肠球菌的数量(P<0.05);同时,增加了大鼠粪便中丙氨酸、异亮氨酸、赖氨酸、N-乙酰糖蛋白和β-葡萄糖的含量。具有免疫调节功能的鼠李糖乳杆菌LV108能够改善大鼠肠道中的乳杆菌和双歧杆菌数量及氨基酸和糖类等代谢物。

Co-evolution of the brand effect and competitiveness in evolving networks

The principle that ＇the brand effect is attractive＇ underlies the preferential attachment. Here we show that the brand effect is just one dimension of attractiveness. Another dimension is competitiveness. We firstly introduce a general frame- work that allows us to investigate the competitive aspect of real networks, instead of simply preferring popular nodes. Our model accurately describes the evolution of social and technological networks. The phenomenon that more competitive nodes become richer can help us to understand the evolution of many competitive systems in nature and society. In general, the paper provides an explicit analytical expression of degree distributions of the network. In particular, the model yields a nontrivial time evolution of nodes＇ properties and the scale-free behavior with exponents depending on the microscopic parameters characterizing the competition rules. Secondly, through theoretical analyses and numerical simulations, we reveal that our model has not only the universality for the homogeneous weighted network, but also the character for the heterogeneous weighted network. Thirdly, we also develop a model based on the profit-driven mechanism. It can better describe the observed phenomenon in enterprise cooperation networks. We show that the standard preferential attachment, the growing random graph, the initial attractiveness model, the fitness model, and weighted networks can all be seen as degenerate cases of our model.

Existence of Two Limit Cycles in Zeeman’s Class 30 for 3D Lotka-Volterra Competitive System

Gyllenberg and Yan(Discrete Contin Dyn Syst Ser B 11(2):347–352,2009)presented a system in Zeeman’s class 30 of 3-dimensional Lotka-Volterra(3D LV)competitive systems to admit at least two limit cycles,one of which is generated by the Hopf bifurcation and the other is obtained by the Poincaré-Bendixson theorem.Yu et al.(J Math Anal Appl 436:521–555,2016,Sect.3.4)recalculated the first Liapunov coefficient of Gyllenberg and Yan’s system to be positive,rather than negative as in Gyllenberg and Yan(2009),and pointed out that the Poincaré-Bendixson theorem is not applicable for that system.Jiang et al.(J Differ Equ 284:183–218,2021,p.213)proposed an open question:“whether Zeeman’s class 30 can be rigorously proved to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem?”This paper provides four systems in Zeeman’s class 30 to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem and gives an answer to the above question.

基于Cadence Integrity 3D-IC的异构集成封装系统级LVS检查

随着硅工艺尺寸发展到单纳米水平,摩尔定律的延续越来越困难。2D Flip-Chip、2.5D、3D等异构集成的先进封装解决方案将继续满足小型化、高性能、低成本的市场需求,成为延续摩尔定律的主要方向。但它也提出了新的挑战,特别是对于系统级的LVS检查。采用Cadence Integrity 3D-IC平台工具,针对不同类型的先进封装,进行了系统级LVS检查验证,充分验证了该工具的有效性和实用性,保证了异构集成封装系统解决方案的可靠性。

Forge ahead and improve the core competitiveness of Animal Models and Experimental Medicine(AMEM)

After 5 years of accumulation, Animal Models and Experimental Medicine(AMEM) has received 396 manuscripts from 46 countries and regions, including Chinese mainland, Iran, the United States, India, Israel, Nigeria, Brazil, Bangladesh, Sri Lanka, the Netherlands, Denmark, Australia, Japan, and Spain. It has become an important international exchange and display platform for innovative research results in the field of laboratory animal science and basic medicine.

亏格不为1的二次可逆LV系统的极限环分支

主要研究两个亏格不为1的二次可逆Lotka-Volterra系统的周期环域在小扰动下产生极限环的个数问题.应用完全切比雪夫系统的性质来判定该系统的二阶Melnikov函数的零点个数,从而证明了在二次扰动下,这两个系统的周期环域能分支出两个极限环.

Assessing quinoline removal performances of an aerobic continuous moving bed biofilm reactor(MBBR) bioaugmented with Pseudomonas citronellolis LV1

This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD.

Effect of Bt traits on transgenic rice's growth and weed competitiveness

Transgene escape could lead to genetically modified rice establishing wild populations in the natural environment and competing for survival space with weeds.However,whether the expression of the Bacillus thuringiensis(Bt)gene in rice will alter the relationship between transgene plants and weeds and induce undesirable environmental consequences are poorly understood.Thus,field experiments were conducted to investigate the weed competitiveness and assess the ecological risk of transgenic Bt rice under herbicide-free and lepidopterous pest-controlled environments.Results showed that weed–rice competition in the direct-sowing(DS)field was earlier and more severe than that in the transplanting(TP)field,which resulted in a significant decrease in biomass and yield in DS.However,conventional Bt and non-Bt rice yield was not significantly different.The weed number,weed coverage ratio,and weed diversity of conventional Bt rice were significantly higher than those of non-Bt rice at the early growth and mature stages,especially in DS plots,suggesting that Bt traits did not increase the weed competitiveness of transgenic rice and had no negative effect on weed diversity.Grain yield and weed number varied between different hybrid rice lines,but those differences were insignificant between Bt and non-Bt rice.The number of insects increased with the increase of weeds in hybrid rice plots,whereas the insect number and diversity did not display a significant difference between Bt and non-Bt rice.Therefore,the ecological risk of transgenic Bt rice is comparable to non-Bt rice.

Core Competitiveness Construction of Clothing Brands in Low-Carbon Economy

The climate issue has become an environmental concern for all sectors of the world and the low-carbon economy has thus become a new economic development model to combat climate change.With the development of low-carbon economy era,the textile and clothing industry plays an important role in stabilizing the development of low-carbon economy and society,and China has put forward the development requirements of low-carbon transformation for the textile and clothing industry,and also it has an important strategic value to promote the high-quality development of low-carbon economy and society,and the construction of brands’ core competitiveness is an inevitable choice for clothing brands in the face of the new form of international competition.As a result,the evaluation indicator of clothing brands’ core competitiveness in the low-carbon economy is used to measure the core competitiveness of clothing brands.Based on the corresponding verification results obtained by analytic hierarchy process(AHP) analysis,it can guide the low-carbon development of the clothing industry,thus proposing a more reasonable way to build the core competitiveness of clothing brands.It can promote the low-carbon transformation and upgrading of the clothing industry,effectively increase the market share of clothing brands,and promote the high-quality development of clothing brands.

Method for Evaluating Bolt Competitive Failure Life Under Composite Excitation

In this study,the competitive failure mechanism of bolt loosening and fatigue is elucidated via competitive failure tests on bolts under composite excitation.Based on the competitive failure mechanism,the mode prediction model and“load ratio-life prediction curve”(ξ-N curve)of the bolt competitive failure are established.Given the poor correlation of theξ-N curve,an evaluation model of the bolt competitive failure life is proposed based on Miner’s linear damage accumulation theory.Based on the force analysis of the thread surface and simulation of the bolt connection under composite excitation,a theoretical equation of the bolt competitive failure life is established to validate the model for evaluating the bolt competitive failure life.The results reveal that the proposed model can accurately predict the competitive failure life of bolts under composite excitation,and thereby,it can provide guidance to engineering applications.

基于ACCF-LVD-KT的距离扩展目标运动参数估计与HRRP重构方法

越来越多的空天威胁目标兼具低可观测性和高机动性,因此从低信噪比的距离扩展目标回波中重构高分辨距离像(HRRP)面临很高的技术挑战。文中提出了一种基于相邻互相关-吕分布-Keystone变换的长时间相参积累方法,能够实现变加速运动距离扩展目标的运动参数估计和HRRP重构。首先,利用相邻互相关函数与吕分布实现机动参数估计;然后,根据机动参数估计值进行相位补偿,并联合Keystone变换校正距离徙动;最后,进行相参积累并实现HRRP重构。仿真实验和实测数据处理结果表明:该方法能够实现运动参数估计与HRRP稳健重构。此外,该方法避免了高维参数搜索,计算效率高,具有良好的工程应用前景。

Optimal Allocation of STATCOM to Enhance Transient Stability Using Imperialist Competitive Algorithm

With the daily expansion of global energy consumption,developing the power grids is of uttermost importance.However,building a new trans-mission line is costly and time-consuming,so utilizing the same lines with possible higher transmission capacity is very cost-effective.In this regard,to increase the capacity of the transmission lines,the flexible alternating current transmission system(FACTS)has been widely used in power grids in recent years by industrialized countries.One of the essential topics in electrical power systems is the reactive power compensation,and the FACTS plays a significant role in controlling the reactive power current in the power grid and the system voltage oscillations and stability.When a static synchronous compensator(STATCOM)is embedded in a power system to increase the bus voltage,a supplementary damping controller can be designed to enhance the system oscillation damping.Given the expansion of the grids in the power system,the complexity of their optimization and the extraordinary ability of the imperialist competitive algorithm(ICA)for solving such problems,in this paper,the ICA has been used to determine the optimal position and size of the FACTS devices.