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海洋溴酚衍生物LXQ-5的PTP1B的结合作用和体内降糖活性研究 被引量:1
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作者 李超 李妍 +1 位作者 李祥乾 史大永 《海洋科学》 CAS 北大核心 2019年第1期61-66,共6页
二型糖尿病是一种代谢性疾病,对人类健康造成了极大的威胁。蛋白酪氨酸磷酸酶 1B(PTP1B)是胰岛素信号通路中的负调控蛋白酶,是二型糖尿病治疗的重要研究靶点。本文利用酶动力学实验和分子互作技术检测了溴酚衍生物 LXQ-5 的 PTP1B 抑制... 二型糖尿病是一种代谢性疾病,对人类健康造成了极大的威胁。蛋白酪氨酸磷酸酶 1B(PTP1B)是胰岛素信号通路中的负调控蛋白酶,是二型糖尿病治疗的重要研究靶点。本文利用酶动力学实验和分子互作技术检测了溴酚衍生物 LXQ-5 的 PTP1B 抑制作用类型和体外特异性结合作用的特点。测定糖尿病小鼠口服给药后的空腹血糖水平和血清中糖化血红蛋白以及糖化血清蛋白水平等糖尿病相关指标的变化,研究了化合物 LXQ-5 在小鼠体内的降糖活性。实验结果表明, LXQ-5 是 PTP1B 的一种非竞争性抑制剂,且在体外能够与 PTP1B 特异性结合。LXQ-5 在糖尿病小鼠体内能显著的降低空腹血糖水平和血清中糖化血红蛋白、糖化血清蛋白含量,在新型降糖药物的研发方面具有重要的研究价值。 展开更多
关键词 二型糖尿病 蛋白酪氨酸磷酸酶 1B 溴酚衍生物 lxq-5 降糖活性
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LXQ螺旋气流筛分机的研制与应用
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作者 张合军 《矿山机械》 北大核心 2002年第4期51-52,共2页
关键词 lxq螺旋气流筛分机 螺旋叶片 驱动轮
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Flood Hazard Mapping at Long Xuyen Quadrangle in2015 Using Geographic Information System and RemoteSensing Technologies
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作者 Nguyen Thi Hong Diep Tran Huu Duy +2 位作者 Phan Kieu Diem Nguyen Thi Be Nam Nguyen Thi ThanhHuong 《Journal of Environmental Science and Engineering(B)》 2019年第5期197-203,共7页
In recent year,the flooding has occurred with high frequency at LXQ(Long Xuyen Quadrangle)areas of Mekong Delta,Vietnam.It was considered as a major natural disaster which has effects on the physic and spirit in peopl... In recent year,the flooding has occurred with high frequency at LXQ(Long Xuyen Quadrangle)areas of Mekong Delta,Vietnam.It was considered as a major natural disaster which has effects on the physic and spirit in people’s life in this area.This research aims to generate a flood hazard map and assess the flood situation at LXQ in 2015.The MNDWI(Modification of Normalized Difference Water Index)extracting from Sentinel-2 image was used to map the flood extent at LXQ during rainy season in 2015.The statistics method estimated correlation coefficient between flooding spatial distribution and hydrological stations on SPSS(Statistical Product and Services Solutions)software.The results showed that the severe flood occurred from August to December in 2015.There were about 47.6%and 28.2%of the total areas that were inundated in October and August,respectively.The correlation between inundated areas and water level at Ha Tien and Chau Doc hydrological stations was 0.73 and 0.65(p<0.01),respectively.The derived information was very essential and valuable for local managers in making decision on responding and mitigating to the flood disaster. 展开更多
关键词 FLOOD distribution MNDWI lxq correlation COEFFICIENT
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