At a meeting on cultural inheritance and development held in Beijing,June 2,2023,President Xi Jinping put forward a holistic and systematic explanation of the distinctive features of Chinese civilisation-consistency,o...At a meeting on cultural inheritance and development held in Beijing,June 2,2023,President Xi Jinping put forward a holistic and systematic explanation of the distinctive features of Chinese civilisation-consistency,originality,unity,inclusiveness,and a peaceful nature.President Xi Jinping's profound exposition has granted us a deeper understanding of the laws underlying the development of Chinese civilisation by shedding light on its intrinsic characteristics.展开更多
Last week, I read news about school bullying with my parents, and it made me feel very sad. School bullying is a serious problem nowadays. It can happen in the classroom or even after school.
Correction to:Acta Geochimica(2022)41:968–981 https://doi.org/10.1007/s11631-022-00555-w In the original publication of the article,the affi liation of“Behzad Aghabarari”was published incorrectly.The correct affi l...Correction to:Acta Geochimica(2022)41:968–981 https://doi.org/10.1007/s11631-022-00555-w In the original publication of the article,the affi liation of“Behzad Aghabarari”was published incorrectly.The correct affi liation should read as follows“Department of Nanotechnology and Advanced Materials,Material and Energy Research Center,Karaj,Iran”.展开更多
Lying flat(Tang Ping)is a prevalent way of life in contemporary countries throughout the world.It is an avoidance behavior chosen by individuals in response to limited social resources and ongoing harsh social competi...Lying flat(Tang Ping)is a prevalent way of life in contemporary countries throughout the world.It is an avoidance behavior chosen by individuals in response to limited social resources and ongoing harsh social competition.Previous studies have demonstrated that the phenomena of“lying flat”has a major negative effect on student learning.In order to investigate the impact of educational innovation on the phenomenon of“lying flat”,we will observe students’learning behaviors under the traditional education model and innovative teaching methods in our Bali teaching practice to determine the causes of“lying flat”and the means to improve educational innovation.The study found that“lying flat”is caused not just by students’discontent with their level difference,but also by the conflict between external resources and internal pressure.In addition,educational reforms on three levels,including further stratified education,strengthening teacher education and promoting effective communication between students and teachers,and employing online resources to promote students’interest in learning,can ameliorate the phenomenon of pupils“lying flat”.This study contends that educational innovation can have a positive effect on the phenomena of“lying flat”.展开更多
Background Ears play an important role in facial profiles.Lying ears are not perceived favorably in Asian cultures;therefore,surgical procedures are implemented to adjust this defect.However,surgery has complications ...Background Ears play an important role in facial profiles.Lying ears are not perceived favorably in Asian cultures;therefore,surgical procedures are implemented to adjust this defect.However,surgery has complications and requires recovery time.We introduced a hyaluronic acid(HA)injection technique to aesthetically improve ear prominence.Methods This retrospective study examined 25 Chinese patients aged 20-47 years with congenital lying ears who received HA injections in the auricular base at Shanghai Ninth People’s Hospital and Hangzhou Yijie Medical Cosmetology Clinic between November 2019 and December 2022.The average injection volume was 6.32±1.22 mL in the auricular base unilaterally,and the follow-up time ranged from 6 to 24 months.Morphological measurement data were recorded.Two-dimensional(2D)and three-dimensional(3D)images were obtained to evaluate the effects.Results All patients showed improvements in ear prominence.The cranioauricular angle(CAA)increased from 22.24°±4.53°to 65.90°±5.38°immediately post-injection and was maintained at 49.18°±4.74°6 months later.The ear projection(EP)increased from 14.75±2.72 mm to 26.26±2.94 mm immediately post-injection and was 22.51±2.68 mm after 6 months.No serious complications were noted.Conclusion HA injection in the auricular base effectively corrected the lying ears and aesthetically optimized the facial profile.It also had a face-lift effect that made the face look younger and more compact.The injection procedure was minimally invasive and required no recovery period.The effect was maintained for a long time and was satisfactory.展开更多
Most of China's wetland areas are located in the Sanjiang Plain.This area has 207×10 4 hm 2 of wet and low lying farmland,of which 59% is cropped.During the 1970s and 1980s,the Chinese government organize...Most of China's wetland areas are located in the Sanjiang Plain.This area has 207×10 4 hm 2 of wet and low lying farmland,of which 59% is cropped.During the 1970s and 1980s,the Chinese government organized intensive scientific research into potential changes to existing natural resources conditions for these farmlands.The aim was to change the water resources regime to one that was beneficial to crop production.Arterial drainage,field drainage and appropriate sub soil treatments were required.The relation between plant products industry and the Four Waters distribution,also the main measures of the Four Waters converting in wet and low lying farmland were discussed in the paper.展开更多
Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial...Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial conducted at the delivery department of Damanhour Educational Institute,El Behira Governorate,Egypt.The study sample involved 150 parturient women equally divided into intervention and control groups using randomization block technique.The researchers used four tools for data collection:Demographic data interview schedule,World Health Organization Partograph,Apgar’s score,to evaluate neonatal outcomes,and visual analogue pain intensity scale.For the study group,the parturient women were encouraged to assume one of the upright positions or ambulating around the bed so as to maintain the pelvis in vertical plane as far as possible for 20-25 min for every 1 h.The control group received routine hospital care,which includes lying down in bed.IBM SPSS 23.0 was used to analyze the data.Results:Significant differences(P<0.05)were observed between the study and control groups in relation to cervical dilation,fetal head descent,uterine contractions interval,and frequency.The duration of the first stage of labor significantly reduced(P=0.018)in the intervention group compared with control group.No significant differences(P>0.05)were observed between both groups in term of emergency cesarean birth rates,oxytocin use,and neonatal outcomes.Conclusions:This study proves that upright and ambulant positions significantly enhance uterine contractility,cervical dilatation,and fetal head descent and reduce the first stage duration.展开更多
The Decay of Lying,one of Wilde’s famous critic dialogues,is a demonstration of his aesthetic opinions,such as Art is telling lies,Life imitates art etc,which gives full expression of his pursue of art’s purity and ...The Decay of Lying,one of Wilde’s famous critic dialogues,is a demonstration of his aesthetic opinions,such as Art is telling lies,Life imitates art etc,which gives full expression of his pursue of art’s purity and independence.Wilde absolutely takes the side of art and is against the forced interference of art as the subject by politics,utilitarianism,morality and ethics,against the erosion of the artistic realm of beauty by over-realness,against taking the form of art as the accessory to certain content or subject.However,Wilde totally isolates art from reality by putting them in the position of dual antithesis,and this is the root of the internal contradictions in his Aestheticism.This essay aims to discuss the contradictions from four aspects:contradiction between art and real life,art and morality,art and truth and then contradiction between art’s form and content,so as to get a better understanding and correct evaluation of Wilde and his aestheticism.展开更多
Understanding how brain activity encodes information and controls behavior is a long-standing question in neuroscience.This complex problem requires converging efforts from neuroscience and engineering,including techn...Understanding how brain activity encodes information and controls behavior is a long-standing question in neuroscience.This complex problem requires converging efforts from neuroscience and engineering,including technological solutions to perform high-precision and large-scale recordings of neuronal activity in vivo as well as unbiased methods to reliably measure and quantify behavior.Thanks to advances in genetics,molecular biology,engineering,and neuroscience,in recent decades,a variety of optical imaging and electrophysiological approaches for recording neuronal activity in awake animals have been developed and widely applied in the field.Moreover,sophisticated computer vision and machine learning algorithms have been developed to analyze animal behavior.In this review,we provide an overview of the current state of technology for neuronal recordings with a focus on optical and electrophysiological methods in rodents.In addition,we discuss areas that future technological development will need to cover in order to further our understanding of the neural activity underlying behavior.展开更多
In November 2001,Jim O’Neill,former Chief Economist at Goldman Sachs,formally put forward the concept of BRIC after an in-depth analysis of the growth potential of Brazil,Russia,India,and China.1 In June 2006,Goldman...In November 2001,Jim O’Neill,former Chief Economist at Goldman Sachs,formally put forward the concept of BRIC after an in-depth analysis of the growth potential of Brazil,Russia,India,and China.1 In June 2006,Goldman Sachs launched its BRIC fund,trying to gain from the growth potential of the four countries.展开更多
Have you experienced bullying? You’re not alone. Read this article to understand more about bullying and find out what you can do to stop it.Why do we need to take action against bullying?
A recent study published in Neuron unraveled the computational mechanism of a specifically defined neural circuit in the cerebral cortex underlying the rule-based flexible decision-making behavior.This work was perfor...A recent study published in Neuron unraveled the computational mechanism of a specifically defined neural circuit in the cerebral cortex underlying the rule-based flexible decision-making behavior.This work was performed by a team led by Dr.XU Ninglong at the CAS Institute of Neuroscience(ION),Center for Excellence in Brain Science and Intelligence Technology(CEBSIT).展开更多
Radiotherapy is widely used for the definitive and adjuvant treatment of numerous cancers[1].However,resistance to radiotherapy remains an important concern[2].Various factors including p53 mutation or deletion[3],ove...Radiotherapy is widely used for the definitive and adjuvant treatment of numerous cancers[1].However,resistance to radiotherapy remains an important concern[2].Various factors including p53 mutation or deletion[3],overexpression of DNA repair proteins[4],and tumor microenvironment[5]have been proposed to play roles in radioresistance.Among the radioresistant factors,p53 mutation or deletion is regarded as a good candidate for radioresistant markers[6].The tumor suppressor p53 is well established as the guardian of the genome,regulating cell cycle arrest,DNA repair,senescence,and apoptosis[7].Mutation of p53 occurs in more than 50%of human cancers,which significantly increases cellular resistance to-irradiation[8].Additionally,there is growing evidence that mutation or deletion of p53 tumors cells is inherently resistant to radiation and perhaps other conventional anticancer treatments,i.e.,chemotherapy[9].This intrinsic mechanism of resistance is responsible for a significant number of tumor recurrences[10].展开更多
Let X denote a finite or infinite dimensional Lie algebra of Cartan type W, S, H or K over a field of characteristic p 〉 3. In this paper it is proved that certain filtrations of the underlying algebras are invariant...Let X denote a finite or infinite dimensional Lie algebra of Cartan type W, S, H or K over a field of characteristic p 〉 3. In this paper it is proved that certain filtrations of the underlying algebras are invariant under the admissible groups relative to Lie algebras of Cartan type X.展开更多
Correction to:Neurosci.Bull.https://doi.org/10.1007/s12264-023-01088-9 The original version of this article unfortunately contained some mistakes,and the corrections are as follows,Some sentences contain incorrect ref...Correction to:Neurosci.Bull.https://doi.org/10.1007/s12264-023-01088-9 The original version of this article unfortunately contained some mistakes,and the corrections are as follows,Some sentences contain incorrect references.The corrected content is provided below.展开更多
Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;3...Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;31 classes)and mitochondria(587 lipids;27 classes)across prenatal and postnatal developmental stages in mice.We uncovered the progressive formation of docosahexaenoyl-phospholipids and enhanced remodeling of C18:2,C20:3,and C20:4 fatty acyl moieties into cardiolipins as cardiac development progresses.A preferential flow of ceramides toward sphingomyelin biosynthesis over complex glycosphingolipid formation was also noted.Using maSigPro and GPclust algorithms,we identified a repertoire of 448 developmentally dynamic lipids and mapped their expression patterns to a library of 550 biologically relevant developmentally dynamic genes.Our combinatorial transcriptomics and lipidomics approaches identified Hadha,Lclat1,and Lpcat3 as candidate molecular drivers governing the dynamic remodeling of cardiolipins and phospholipids,respectively,in heart development.Our analyses revealed that postnatal cardiolipin remodeling in the heart constitutes a biphasic process,which first accumulates polyunsaturated C78-cardiolipins prior to tetralinoleoyl cardiolipin forming the predominant species.Multiomics analyses supplemented with transmission electron microscopy imaging uncovered enhanced mitochondria–lipid droplet contacts mediated by perilipin-5.Our combinatorial analyses of multiomics data uncovered an association between mitochondrial-resident,docosahexaenoic acid-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitochondrial membranes,which adds credence to the membrane pacemaker theory of metabolism.The current findings offer lipid-centric biological insights potentially important to understanding the molecular basis of cardiac metabolic flexibility and disease pathology.展开更多
1 Skateboarder Robert Glovers skateboarding skills are truly remarkable,but what sets him apart is his unique style that is out of expectations.2 Born with a condition called sacral agenesis(骶骨发育不全症),which prev...1 Skateboarder Robert Glovers skateboarding skills are truly remarkable,but what sets him apart is his unique style that is out of expectations.2 Born with a condition called sacral agenesis(骶骨发育不全症),which prevents the growth of his legs,Mr Glover relies on his upper body strength to navigate his skateboard.Rather than relying on legs like most skateboarders,he skillfully controls the board using his arms and torso(躯干).展开更多
文摘At a meeting on cultural inheritance and development held in Beijing,June 2,2023,President Xi Jinping put forward a holistic and systematic explanation of the distinctive features of Chinese civilisation-consistency,originality,unity,inclusiveness,and a peaceful nature.President Xi Jinping's profound exposition has granted us a deeper understanding of the laws underlying the development of Chinese civilisation by shedding light on its intrinsic characteristics.
文摘Last week, I read news about school bullying with my parents, and it made me feel very sad. School bullying is a serious problem nowadays. It can happen in the classroom or even after school.
文摘Correction to:Acta Geochimica(2022)41:968–981 https://doi.org/10.1007/s11631-022-00555-w In the original publication of the article,the affi liation of“Behzad Aghabarari”was published incorrectly.The correct affi liation should read as follows“Department of Nanotechnology and Advanced Materials,Material and Energy Research Center,Karaj,Iran”.
文摘Lying flat(Tang Ping)is a prevalent way of life in contemporary countries throughout the world.It is an avoidance behavior chosen by individuals in response to limited social resources and ongoing harsh social competition.Previous studies have demonstrated that the phenomena of“lying flat”has a major negative effect on student learning.In order to investigate the impact of educational innovation on the phenomenon of“lying flat”,we will observe students’learning behaviors under the traditional education model and innovative teaching methods in our Bali teaching practice to determine the causes of“lying flat”and the means to improve educational innovation.The study found that“lying flat”is caused not just by students’discontent with their level difference,but also by the conflict between external resources and internal pressure.In addition,educational reforms on three levels,including further stratified education,strengthening teacher education and promoting effective communication between students and teachers,and employing online resources to promote students’interest in learning,can ameliorate the phenomenon of pupils“lying flat”.This study contends that educational innovation can have a positive effect on the phenomena of“lying flat”.
文摘Background Ears play an important role in facial profiles.Lying ears are not perceived favorably in Asian cultures;therefore,surgical procedures are implemented to adjust this defect.However,surgery has complications and requires recovery time.We introduced a hyaluronic acid(HA)injection technique to aesthetically improve ear prominence.Methods This retrospective study examined 25 Chinese patients aged 20-47 years with congenital lying ears who received HA injections in the auricular base at Shanghai Ninth People’s Hospital and Hangzhou Yijie Medical Cosmetology Clinic between November 2019 and December 2022.The average injection volume was 6.32±1.22 mL in the auricular base unilaterally,and the follow-up time ranged from 6 to 24 months.Morphological measurement data were recorded.Two-dimensional(2D)and three-dimensional(3D)images were obtained to evaluate the effects.Results All patients showed improvements in ear prominence.The cranioauricular angle(CAA)increased from 22.24°±4.53°to 65.90°±5.38°immediately post-injection and was maintained at 49.18°±4.74°6 months later.The ear projection(EP)increased from 14.75±2.72 mm to 26.26±2.94 mm immediately post-injection and was 22.51±2.68 mm after 6 months.No serious complications were noted.Conclusion HA injection in the auricular base effectively corrected the lying ears and aesthetically optimized the facial profile.It also had a face-lift effect that made the face look younger and more compact.The injection procedure was minimally invasive and required no recovery period.The effect was maintained for a long time and was satisfactory.
文摘Most of China's wetland areas are located in the Sanjiang Plain.This area has 207×10 4 hm 2 of wet and low lying farmland,of which 59% is cropped.During the 1970s and 1980s,the Chinese government organized intensive scientific research into potential changes to existing natural resources conditions for these farmlands.The aim was to change the water resources regime to one that was beneficial to crop production.Arterial drainage,field drainage and appropriate sub soil treatments were required.The relation between plant products industry and the Four Waters distribution,also the main measures of the Four Waters converting in wet and low lying farmland were discussed in the paper.
文摘Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial conducted at the delivery department of Damanhour Educational Institute,El Behira Governorate,Egypt.The study sample involved 150 parturient women equally divided into intervention and control groups using randomization block technique.The researchers used four tools for data collection:Demographic data interview schedule,World Health Organization Partograph,Apgar’s score,to evaluate neonatal outcomes,and visual analogue pain intensity scale.For the study group,the parturient women were encouraged to assume one of the upright positions or ambulating around the bed so as to maintain the pelvis in vertical plane as far as possible for 20-25 min for every 1 h.The control group received routine hospital care,which includes lying down in bed.IBM SPSS 23.0 was used to analyze the data.Results:Significant differences(P<0.05)were observed between the study and control groups in relation to cervical dilation,fetal head descent,uterine contractions interval,and frequency.The duration of the first stage of labor significantly reduced(P=0.018)in the intervention group compared with control group.No significant differences(P>0.05)were observed between both groups in term of emergency cesarean birth rates,oxytocin use,and neonatal outcomes.Conclusions:This study proves that upright and ambulant positions significantly enhance uterine contractility,cervical dilatation,and fetal head descent and reduce the first stage duration.
文摘The Decay of Lying,one of Wilde’s famous critic dialogues,is a demonstration of his aesthetic opinions,such as Art is telling lies,Life imitates art etc,which gives full expression of his pursue of art’s purity and independence.Wilde absolutely takes the side of art and is against the forced interference of art as the subject by politics,utilitarianism,morality and ethics,against the erosion of the artistic realm of beauty by over-realness,against taking the form of art as the accessory to certain content or subject.However,Wilde totally isolates art from reality by putting them in the position of dual antithesis,and this is the root of the internal contradictions in his Aestheticism.This essay aims to discuss the contradictions from four aspects:contradiction between art and real life,art and morality,art and truth and then contradiction between art’s form and content,so as to get a better understanding and correct evaluation of Wilde and his aestheticism.
基金This work was supported by grants from the NINDS/NIH(NS091144,NS103037,NS104861,and NS113358),NIMH/-NIH(MH114227)(J.B.D.),GG Technologies Gift fund(J.B.D.),and Parkinson’s Foundation Postdoctoral Fellowship(R.H.R.).
文摘Understanding how brain activity encodes information and controls behavior is a long-standing question in neuroscience.This complex problem requires converging efforts from neuroscience and engineering,including technological solutions to perform high-precision and large-scale recordings of neuronal activity in vivo as well as unbiased methods to reliably measure and quantify behavior.Thanks to advances in genetics,molecular biology,engineering,and neuroscience,in recent decades,a variety of optical imaging and electrophysiological approaches for recording neuronal activity in awake animals have been developed and widely applied in the field.Moreover,sophisticated computer vision and machine learning algorithms have been developed to analyze animal behavior.In this review,we provide an overview of the current state of technology for neuronal recordings with a focus on optical and electrophysiological methods in rodents.In addition,we discuss areas that future technological development will need to cover in order to further our understanding of the neural activity underlying behavior.
文摘In November 2001,Jim O’Neill,former Chief Economist at Goldman Sachs,formally put forward the concept of BRIC after an in-depth analysis of the growth potential of Brazil,Russia,India,and China.1 In June 2006,Goldman Sachs launched its BRIC fund,trying to gain from the growth potential of the four countries.
文摘Have you experienced bullying? You’re not alone. Read this article to understand more about bullying and find out what you can do to stop it.Why do we need to take action against bullying?
文摘A recent study published in Neuron unraveled the computational mechanism of a specifically defined neural circuit in the cerebral cortex underlying the rule-based flexible decision-making behavior.This work was performed by a team led by Dr.XU Ninglong at the CAS Institute of Neuroscience(ION),Center for Excellence in Brain Science and Intelligence Technology(CEBSIT).
文摘Radiotherapy is widely used for the definitive and adjuvant treatment of numerous cancers[1].However,resistance to radiotherapy remains an important concern[2].Various factors including p53 mutation or deletion[3],overexpression of DNA repair proteins[4],and tumor microenvironment[5]have been proposed to play roles in radioresistance.Among the radioresistant factors,p53 mutation or deletion is regarded as a good candidate for radioresistant markers[6].The tumor suppressor p53 is well established as the guardian of the genome,regulating cell cycle arrest,DNA repair,senescence,and apoptosis[7].Mutation of p53 occurs in more than 50%of human cancers,which significantly increases cellular resistance to-irradiation[8].Additionally,there is growing evidence that mutation or deletion of p53 tumors cells is inherently resistant to radiation and perhaps other conventional anticancer treatments,i.e.,chemotherapy[9].This intrinsic mechanism of resistance is responsible for a significant number of tumor recurrences[10].
基金The NSF(11171055)of Chinathe NSF(JC201004 and A200903)of Heilongjiang Province of Chinathe NSF(12511349)of Heilongjiang Educational Committee of China
文摘Let X denote a finite or infinite dimensional Lie algebra of Cartan type W, S, H or K over a field of characteristic p 〉 3. In this paper it is proved that certain filtrations of the underlying algebras are invariant under the admissible groups relative to Lie algebras of Cartan type X.
文摘Correction to:Neurosci.Bull.https://doi.org/10.1007/s12264-023-01088-9 The original version of this article unfortunately contained some mistakes,and the corrections are as follows,Some sentences contain incorrect references.The corrected content is provided below.
基金the National Key R&D Program of China(2018YFA0800901 and 2018YFA0506900)the National Natural Science Foundation of China(31871194 and 92057202).
文摘Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;31 classes)and mitochondria(587 lipids;27 classes)across prenatal and postnatal developmental stages in mice.We uncovered the progressive formation of docosahexaenoyl-phospholipids and enhanced remodeling of C18:2,C20:3,and C20:4 fatty acyl moieties into cardiolipins as cardiac development progresses.A preferential flow of ceramides toward sphingomyelin biosynthesis over complex glycosphingolipid formation was also noted.Using maSigPro and GPclust algorithms,we identified a repertoire of 448 developmentally dynamic lipids and mapped their expression patterns to a library of 550 biologically relevant developmentally dynamic genes.Our combinatorial transcriptomics and lipidomics approaches identified Hadha,Lclat1,and Lpcat3 as candidate molecular drivers governing the dynamic remodeling of cardiolipins and phospholipids,respectively,in heart development.Our analyses revealed that postnatal cardiolipin remodeling in the heart constitutes a biphasic process,which first accumulates polyunsaturated C78-cardiolipins prior to tetralinoleoyl cardiolipin forming the predominant species.Multiomics analyses supplemented with transmission electron microscopy imaging uncovered enhanced mitochondria–lipid droplet contacts mediated by perilipin-5.Our combinatorial analyses of multiomics data uncovered an association between mitochondrial-resident,docosahexaenoic acid-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitochondrial membranes,which adds credence to the membrane pacemaker theory of metabolism.The current findings offer lipid-centric biological insights potentially important to understanding the molecular basis of cardiac metabolic flexibility and disease pathology.
文摘1 Skateboarder Robert Glovers skateboarding skills are truly remarkable,but what sets him apart is his unique style that is out of expectations.2 Born with a condition called sacral agenesis(骶骨发育不全症),which prevents the growth of his legs,Mr Glover relies on his upper body strength to navigate his skateboard.Rather than relying on legs like most skateboarders,he skillfully controls the board using his arms and torso(躯干).