A New Lignan from Isodon lophanthoides var. gerardianus (Labiatae)

A new lignan, together with a known one, was isolated from Isodon lophanthoides var. gerardianus [Bentham] H. Hara. The structure of the new lignan was elucidated as 1_acetoxyl_2e_piperonyl_6e_[6_methoxyl_piperonyl]_3,7_dioxabicyclo_[3,3,0]_octane mainly by 1D and 2D NMR techniques.

Advances in Research on Anti-tumor Active Components of Labiatae Plants

In recent years, the antibacterial and anti-inflammatory effects of the Labiatae plants have been widely recognized, and have been used in clinical practice, and their anti-tumor effects are also very significant, and receiving more and more attention. At present, malignant tumors are still the first killer threatening human health. Because of the long-term use of chemical anti-tumor drugs with certain drug resistance and obvious side effects, finding high-efficiency anti-tumor active ingredients from natural plants and Chinese herbal medicines has become a hot spot in the field of pharmacy. Literature survey indicates that the active ingredients in Labiatae plants have anti-tumor effects. Therefore, this paper summarized and discussed the anti-tumor types, mechanisms and active components of the Labiatae plants, so as to provide a basis and reference for the development of new anti-tumor drugs or preparations.

The Chemical Constituents of Elsholtzia blanda

Nine compounds were isolated from Elsholtzia blanda (Benth.) Benth. Their structures were identified with spectral and chemical methods as follows: 5,6-dihydro-6-styry-2-pyrone (1), friedelin (2), 4-hydroxy-3-methoxystyrene (3), 5,2'-dimethoxy-6, 7-methylene dioxyflavanone (4), 5-hydroxy-7-methoxy-6-O-[alpha -L-rhamnopyranosyl(1 -->2) -beta -D-fucopyranosyl] flavone glycoside (5), 5, 5'-dihydroxy-7-acetoxyl-6, 8, 3',3'-tetramethylpyran (3',4') navone (6), 5, 5'-dihydroxy-7-(alpha -methyl) butyroxyl-6, 8, 3 ', 3'-tetramethylpyran (3',4') flavone (7), 5,5'-dihydroxy-6, 7-methylenedioxy-8, 3', 3'-trimethylpyran (3',4') navone (8), glucosyringic acid (9). Among them, 6, 7 and 8 are new compounds, named as sifanghaoine I,II and III, respectively.

Chemical Components from Craniotome furcata

Four compounds, craniosides A (1) and B (2), mussaenoside (3) and ningpogenin (4) were isolated from the ethyl acetate fraction of Craniotome furcata ( Link.) O. Kuntze for the first time. Among them, craniosides A (1) and B (2) were identified as new compounds. The structures of the two new compounds were assigned mainly by spectral methods.

Elsholtzia:review of traditional uses,chemistry and pharmacology

The chemical constituents, pharmacological activity and traditional uses of 20 species attributed to the genus Elsholtzia （Labiatae） used in China are reviewed and compared. A survey of the literature available shows that these species are used mostly for the treatment of respiratory and gastrointestinal disorders. Additionally, some of these Elsholtzia species show antibacterial, anti-inflammatory, relieving fever, analgesic activities and myocardial ischemia protection. Generally, the essential oils or flavonoids from these plant extracts are assumed to be the active principles.

Two New ent-Kauranoids from Isodon tenuifolia

Two new ent-kauranoids, tenuifolin A (3beta,6alpha, 15beta-trihydroxy-1alpha, 7beta-diacetoxy-11beta, 16beta-epoxy-ent-kaurane) (1) and tenuifolin B (1alpha,6alpha, 11beta-trihydroxy-3beta,7beta-diacetoxy-ent-kaur-16-en-15-one) (2), together with four known compounds were isolated from the aerial parts of Isodon tenuifolia (W. W. Smith) Kudo collected from Zhongdian County, Yunnan Province, China. Their structures were determined by the spectral methods (including 2D NMR techniques).

甘露的栽培管理

甘露也称甘露子（Stachys siebordii Miq.）是唇形科（Labiatae）水苏属（Stachys）多年生草本。其地下块茎（是一短而肥厚的地下茎）味甘甜而得名甘露、地露。因其地下块茎似蚕蛹又名地蚕、草石蚕、土蛹;依其块茎形状有地区叫地螺丝菜、宝塔菜、地纽、地环、土虫草、蜗儿菜、地瓜儿。

马郁兰资源的综合开发利用

马郁兰（Origanum marjorana）为唇形科（Labiatae）牛至属多年生草本植物,也称马约兰、甘牛至。其原生地为地中海沿岸和北美等地区,主要分布在法国、德国、意大利、西班牙等欧洲大陆的温和地区。马郁兰在我国野生资源十分丰富[1],尚未大规模种植,仅在广东、广西等地有少量庭院种植,作为世界范围内受欢迎的食用香料作物之一,应用于食用、药用、日化、园林等方面。

香薷类中药的微量元素分析

中药香薷(Herba E1sh01tZiac),又名香菜。药用历史悠久,始载于《名医別录》列为中品,其基源为唇形科(Labiatae)香薷属(Elsholtzia)的多种植物。这类药有发汗解表,和中利湿之功效,用于暑湿感冒,恶寒发热无汗,腹痛,吐泻等症;药理学研究表明具有抗菌性能,对预防流感有一定效果。经研究这类中药均含有挥发油。

ent-Kaurene Diterpenoids from Isodon adenanthus

Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,1 2,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound I showed significant cytotoxic activity against K562 cells with IC50 = 0.45 mug/mL.

Diterpenoids from the Roots of Agastache rugosa

Agastol (2), a new diterpene, was isolated from the roots of Agastache rugosa together with its isomer, named isoagastol (3) Their structures were established on the basis of spectral methods The structures of agastol (2) and isoagastol (3) was elucidated as 11,14 dihydroxy 12 methoxy 19(4→3) abeo abieta 4(18),8,11,13 tetraen 7 one and 11,14 dihydroxy 12 methoxy 19(4→3) abeo abieta 3,8,11,13 tetraen 7 one Isoagastol was isolated for the first time from natural sources

Antioxidant and antibacterial activity of different parts of Leucas aspera

Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products.

Two New Triterpenoid Glycosides from Elsholtzia bodinieri Vant

Two new triterpenoid glycosides, hederagenin-3-O-b-D-xylopyranoside (1), dodecandral 3-O-b-D-xylopyranoside(2), were isolated from Elsholtzia bodinieri Vant. The structures of 1 and 2 were established by spectroscopic and chemical methods.

Oleanane-triterpene Saponins from Clinopodium urticifolium

Four new oleanane triterpene saponins were isolated and purified from the whole plant of Clinopodium urticifolium. They were 3B 16B, 23, 28-tetrahydroxyoleana-9 (11), 12(13)-diene-3-yl-[B-D-glucopyranosyl-(1-2)]-[B-D-glucopyranosyl-(1-3)]- B-D-fucopyranoside 1; 3B, 16B, 21B, 23, 28-pentahydroxyoleana-9(11), 12(13)-diene-3-yl-[B-D-glucopyranosyl-(1-2)]-[B-D-glucopyranosyl-(1-3)]- B-D-fucopyranoside 2; 3B, 16B, 23, 28-tetrahydroxyoleana-9(11), 12(13)-diene-3-yl-[B-D-glucopyranosyl-(1-6)-B-D-glucopyranosyl-(1-3)]-[B-D-glucopyranosyl-(1-2)]-B-D-fucopyranoside 3; 3B, 16B, 23, 28-tetrahydroxyoleana-9(11), 12(13)-diene-3-yl-[B-D-gluco-pyranosyl-(1-4)-B-D-glucopyranosyl-(1-6)-B-D-glucopyranosyl-(1-3)]-[B-D-glucopyranosyl-(1-2)]- B-D-fucopyranoside 4. Their structures were elucidated on the basis of interpretation of NMR and MS data and from chemical evidence.

A new ent-kaurane diterpenoid from Isodon japonica

One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis.

A New Flavanone and a New Flavanone Glycoside from Scutellaria baicalensis

A new flavanone （2S）-5, 7, 2＇, 5＇-tetrahydroxy-flavanone 1 together with a new flavanone glycoside （2S）-5, 7, 2＇, 5＇-tetrahydroxy-flavanone 7-O-13-D-glucopyranoside 2, were isolated from the dry roots of Scutellaria baicalensis. Their structures were elucidated on the basis of spectroscopic data.

Two new diterpenoids from Isodon serra

From the aerial part of Isodon serra, two new ent-6,7-seco-kaurane-type diterpenoids, 15α,20β-dihydroxy-6β- methoxy-6,7- seco-6,20-epoxy-1,7-olide-ent-kaur-16-ene （1） and 6α,15α-dihydroxy-20-aldehyde-6,7-seco-6,11α-epoxy-1,7-olide-ent-kaur-16- ene （2） were isolated. Their structures were elucidated by spectroscopic means.

New ent-kaurane-type diterpenoids from Isodon nervosus

Two new ent-kaurane-type diterpenoids,6β,7β,13α-trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one（1）and 15β- hydroxy-6,7-seco-6,11β：6,20-diepoxy-1α,7-olide-ent-kaur-16-ene（2）were isolated from the Isodon nervosus,and the structures were elucidated by spectroscopic analysis.

Sesquiterpene Esters from Salvia roborowskii

Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim. Their structures were elucidated by means of spectral data (2DNMR and HRMS).

Two New ent-Kauranoids from Isodon sculponeata

Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 and T24 were tested.